Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis
Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the m...
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| Published in | TheScientificWorld Vol. 10; pp. 1634 - 1645 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
John Wiley & Sons, Inc
01.01.2010
TheScientificWorldJOURNAL Wiley |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1537-744X 2356-6140 1537-744X |
| DOI | 10.1100/tsw.2010.130 |
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| Abstract | Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the modulation of circuit function with particular focus on sleep-related rhythmogenesis. We discuss recent data showing that these glial cells regulate slow oscillations, a specific thalamocortical activity that characterizes non-REM sleep, and sleep-associated behaviors. Based on these findings, we predict that our understanding of the genesis and tuning of thalamocortical rhythms will necessarily go through an integrated view of brain circuits in which non-neuronal cells can play important neuromodulatory roles. |
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| AbstractList | Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the modulation of circuit function with particular focus on sleep-related rhythmogenesis. We discuss recent data showing that these glial cells regulate slow oscillations, a specific thalamocortical activity that characterizes non-REM sleep, and sleep-associated behaviors. Based on these findings, we predict that our understanding of the genesis and tuning of thalamocortical rhythms will necessarily go through an integrated view of brain circuits in which non-neuronal cells can play important neuromodulatory roles. Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the modulation of circuit function with particular focus on sleep-related rhythmogenesis. We discuss recent data showing that these glial cells regulate slow oscillations, a specific thalamocortical activity that characterizes non-REM sleep, and sleep-associated behaviors. Based on these findings, we predict that our understanding of the genesis and tuning of thalamocortical rhythms will necessarily go through an integrated view of brain circuits in which non-neuronal cells can play important neuromodulatory roles.Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the modulation of circuit function with particular focus on sleep-related rhythmogenesis. We discuss recent data showing that these glial cells regulate slow oscillations, a specific thalamocortical activity that characterizes non-REM sleep, and sleep-associated behaviors. Based on these findings, we predict that our understanding of the genesis and tuning of thalamocortical rhythms will necessarily go through an integrated view of brain circuits in which non-neuronal cells can play important neuromodulatory roles. Although astrocytes are increasingly recognized as important modulators of neuronal excitability and information transfer at the synapse, whether these cells regulate neuronal network activity has only recently started to be investigated. In this article, we highlight the role of astrocytes in the modulation of circuit function with particular focus on sleep-related rhythmogenesis. We discuss recent data showing that these glial cells regulate slow oscillations, a specific thalamocortical activity that characterizes non-REM sleep, and sleep-associated behaviors. Based on these findings, we predict that our understanding of the genesis and tuning of thalamocortical rhythms will necessarily go through an integrated view of brain circuits in which non-neuronal cells can play important neuromodulatory roles. KEYWORDS: glia, sleep, slow oscillations, adenosine, A1 receptors, cortical rhythms |
| Audience | Academic |
| Author | Haydon, Philip G. Benfenati, Fabio Halassa, Michael M. Dal Maschio, Marco Beltramo, Riccardo Fellin, Tommaso |
| AuthorAffiliation | 3 Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, USA 2 Department of Psychiatry, McLean Hospital, Belmont, MA, USA 4 Department of Neuroscience and Brain Technologies, Italian Institute of Technology (IIT), Genova, Italy 1 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA 5 Department of Neuroscience, Tufts University, Boston, MA, USA |
| AuthorAffiliation_xml | – name: 5 Department of Neuroscience, Tufts University, Boston, MA, USA – name: 3 Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, USA – name: 1 Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA – name: 4 Department of Neuroscience and Brain Technologies, Italian Institute of Technology (IIT), Genova, Italy – name: 2 Department of Psychiatry, McLean Hospital, Belmont, MA, USA |
| Author_xml | – sequence: 1 givenname: Michael M. surname: Halassa fullname: Halassa, Michael M. organization: Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA, Department of Psychiatry, McLean Hospital, Belmont, MA, USA, Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, USA – sequence: 2 givenname: Marco surname: Dal Maschio fullname: Dal Maschio, Marco organization: Department of Neuroscience and Brain Technologies, Italian Institute of Technology (IIT), Genova, Italy – sequence: 3 givenname: Riccardo surname: Beltramo fullname: Beltramo, Riccardo organization: Department of Neuroscience and Brain Technologies, Italian Institute of Technology (IIT), Genova, Italy – sequence: 4 givenname: Philip G. surname: Haydon fullname: Haydon, Philip G. organization: Department of Neuroscience, Tufts University, Boston, MA, USA – sequence: 5 givenname: Fabio surname: Benfenati fullname: Benfenati, Fabio organization: Department of Neuroscience and Brain Technologies, Italian Institute of Technology (IIT), Genova, Italy – sequence: 6 givenname: Tommaso surname: Fellin fullname: Fellin, Tommaso organization: Department of Neuroscience and Brain Technologies, Italian Institute of Technology (IIT), Genova, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20730381$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2010 John Wiley & Sons, Inc. Copyright © 2010 Michael M. Halassa et al. 2010 |
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| SubjectTerms | Animals Astrocytes Astrocytes - cytology Astrocytes - physiology Brain Brain - cytology Brain - physiology Cell Communication - physiology Circadian rhythms Health aspects Humans Mini-Review Models, Neurological Neurons Neurons - cytology Neurons - physiology Physiological aspects Sleep Sleep - physiology Synapses - physiology |
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| Title | Integrated Brain Circuits: Neuron-Astrocyte Interaction in Sleep-Related Rhythmogenesis |
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