Expression of the Adipocyte Progenitor Markers MSCA1 and CD36 is Associated With Adipose Tissue Function in Children

Abstract Context MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function. Objective With the early manifestation of obesity in childre...

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Published inThe journal of clinical endocrinology and metabolism Vol. 107; no. 2; pp. e836 - e851
Main Authors Hanschkow, Martha, Boulet, Nathalie, Kempf, Elena, Bouloumié, Anne, Kiess, Wieland, Stein, Robert, Körner, Antje, Landgraf, Kathrin
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.02.2022
Endocrine Society
Subjects
Adipocytes
Adipocytes - metabolism
Adipogenesis
Adipose tissue
Adipose tissues
Adolescent
Antigens, Surface
Antigens, Surface - analysis
Antigens, Surface - metabolism
Body fat
C-reactive protein
CD36 antigen
Cell differentiation
Cell proliferation
Child
Child, Preschool
Children
Cross-Sectional Studies
Female
Health aspects
Humans
Hyperplasia
Hypertrophy
Infant
Life Sciences
Male
Mesenchymal stem cells
Obesity
Obesity in children
Online Only
Pediatric Obesity
Pediatric Obesity - physiopathology
Physiological aspects
Stem cell antigen 1
Stem cells
Stroma
Stromal Vascular Fraction
Stromal Vascular Fraction - metabolism
Subcutaneous Fat
Subcutaneous Fat - cytology
Subcutaneous Fat - metabolism
Subcutaneous Fat - physiopathology
Germany
adipose tissue
adipose tissue dysfunction
adipocyte differentiation
children
adipocyte progenitor cells
obesity
ORCiD numbers: 0000-0003-1011-3474 (N Boulet)
Boulet
ORCiD numbers: 0000-0003-1011-3474 (N
Landgraf
0000-0002-6878-6033 (K
0000-0002-6878-6033 (K Landgraf)
Online AccessGet full text
ISSN0021-972X
1945-7197
1945-7197
DOI10.1210/clinem/dgab630

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Abstract Abstract Context MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function. Objective With the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and related disease. Methods We investigated MSCA1 and CD36 expression in adipocytes and stroma vascular fraction (SVF) cells from 133 children of the Leipzig AT Childhood cohort with regard to AT accumulation and biology. In a subsample we analyzed how MSCA1 and CD36 expression is related to adipose progenitor capacities in vitro (ie, proliferation, differentiation and mitochondrial function). Results Both MSCA1 and CD36 are differentially expressed in adipocytes and SVF cells of children. MSCA1 expression is positively correlated to obesity-associated AT dysfunction (ie, adipocyte hypertrophy and serum high-sensitivity C-reactive protein), and high SVF MSCA1 expression is associated with increased mitochondrial respiration in vitro. CD36 expression is not associated with AT dysfunction but SVF CD36 expression is downregulated in children with overweight and obesity and shows a positive association with the differentiation capacity of SVF cells ex vivo and in vitro. Conclusion Both MSCA1 and CD36 are associated with obesity-related alterations in AT of children. In particular, CD36 expression predicts adipogenic potential of SVF cells, indicating a potential role in the regulation of adipocyte hyperplasia and hypertrophy with obesity development in children.
AbstractList MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function. With the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and related disease. We investigated MSCA1 and CD36 expression in adipocytes and stroma vascular fraction (SVF) cells from 133 children of the Leipzig AT Childhood cohort with regard to AT accumulation and biology. In a subsample we analyzed how MSCA1 and CD36 expression is related to adipose progenitor capacities in vitro (ie, proliferation, differentiation and mitochondrial function). Both MSCA1 and CD36 are differentially expressed in adipocytes and SVF cells of children. MSCA1 expression is positively correlated to obesity-associated AT dysfunction (ie, adipocyte hypertrophy and serum high-sensitivity C-reactive protein), and high SVF MSCA1 expression is associated with increased mitochondrial respiration in vitro. CD36 expression is not associated with AT dysfunction but SVF CD36 expression is downregulated in children with overweight and obesity and shows a positive association with the differentiation capacity of SVF cells ex vivo and in vitro. Both MSCA1 and CD36 are associated with obesity-related alterations in AT of children. In particular, CD36 expression predicts adipogenic potential of SVF cells, indicating a potential role in the regulation of adipocyte hyperplasia and hypertrophy with obesity development in children.
Context MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function. Objective With the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and related disease. Methods We investigated MSCA1 and CD36 expression in adipocytes and stroma vascular fraction (SVF) cells from 133 children of the Leipzig AT Childhood cohort with regard to AT accumulation and biology. In a subsample we analyzed how MSCA1 and CD36 expression is related to adipose progenitor capacities in vitro (ie, proliferation, differentiation and mitochondrial function). Results Both MSCA1 and CD36 are differentially expressed in adipocytes and SVF cells of children. MSCA1 expression is positively correlated to obesity-associated AT dysfunction (ie, adipocyte hypertrophy and serum high-sensitivity C-reactive protein), and high SVF MSCA1 expression is associated with increased mitochondrial respiration in vitro. CD36 expression is not associated with AT dysfunction but SVF CD36 expression is downregulated in children with overweight and obesity and shows a positive association with the differentiation capacity of SVF cells ex vivo and in vitro. Conclusion Both MSCA1 and CD36 are associated with obesity-related alterations in AT of children. In particular, CD36 expression predicts adipogenic potential of SVF cells, indicating a potential role in the regulation of adipocyte hyperplasia and hypertrophy with obesity development in children.
Context: MSCA1 (mesenchymal stem cell antigen 1)and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function. Objective: With the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and related disease. Methods: We investigated MSCA1 and CD36 expression in adipocytes and stroma vascular fraction (SVF) cells from 133 children of the Leipzig AT Childhood cohort with regard to AT accumulation and biology. In a subsample we analyzed how MSCA1 and CD36 expression is related to adipose progenitor capacities in vitro (ie, proliferation, differentiation and mitochondrial function). Results: Both MSCA1 and CD36 are differentially expressed in adipocytes and SVF cells of children. MSCA1 expression is positively correlated to obesity-associated AT dysfunction (ie, adipocyte hypertrophy and serum high-sensitivity C-reactive protein), and high SVF MSCA1 expression is associated with increased mitochondrial respiration in vitro. CD36 expression is not associated with AT dysfunction but SVF CD36 expression is downregulated in children with overweight and obesity and shows a positive association with the differentiation capacity of SVF cells ex vivo and in vitro. Conclusion: Both MSCA1 and CD36 are associated with obesity-related alterations in AT of children. In particular, CD36 expression predicts adipogenic potential of SVF cells, indicating a potential role in the regulation of adipocyte hyperplasia and hypertrophy with obesity development in children. Key Words: adipocyte progenitor cells, adipose tissue, adipose tissue dysfunction, adipocyte differentiation, children, obesity
Abstract Context MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function. Objective With the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and related disease. Methods We investigated MSCA1 and CD36 expression in adipocytes and stroma vascular fraction (SVF) cells from 133 children of the Leipzig AT Childhood cohort with regard to AT accumulation and biology. In a subsample we analyzed how MSCA1 and CD36 expression is related to adipose progenitor capacities in vitro (ie, proliferation, differentiation and mitochondrial function). Results Both MSCA1 and CD36 are differentially expressed in adipocytes and SVF cells of children. MSCA1 expression is positively correlated to obesity-associated AT dysfunction (ie, adipocyte hypertrophy and serum high-sensitivity C-reactive protein), and high SVF MSCA1 expression is associated with increased mitochondrial respiration in vitro. CD36 expression is not associated with AT dysfunction but SVF CD36 expression is downregulated in children with overweight and obesity and shows a positive association with the differentiation capacity of SVF cells ex vivo and in vitro. Conclusion Both MSCA1 and CD36 are associated with obesity-related alterations in AT of children. In particular, CD36 expression predicts adipogenic potential of SVF cells, indicating a potential role in the regulation of adipocyte hyperplasia and hypertrophy with obesity development in children.
MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function.CONTEXTMSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function.With the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and related disease.OBJECTIVEWith the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and related disease.We investigated MSCA1 and CD36 expression in adipocytes and stroma vascular fraction (SVF) cells from 133 children of the Leipzig AT Childhood cohort with regard to AT accumulation and biology. In a subsample we analyzed how MSCA1 and CD36 expression is related to adipose progenitor capacities in vitro (ie, proliferation, differentiation and mitochondrial function).METHODSWe investigated MSCA1 and CD36 expression in adipocytes and stroma vascular fraction (SVF) cells from 133 children of the Leipzig AT Childhood cohort with regard to AT accumulation and biology. In a subsample we analyzed how MSCA1 and CD36 expression is related to adipose progenitor capacities in vitro (ie, proliferation, differentiation and mitochondrial function).Both MSCA1 and CD36 are differentially expressed in adipocytes and SVF cells of children. MSCA1 expression is positively correlated to obesity-associated AT dysfunction (ie, adipocyte hypertrophy and serum high-sensitivity C-reactive protein), and high SVF MSCA1 expression is associated with increased mitochondrial respiration in vitro. CD36 expression is not associated with AT dysfunction but SVF CD36 expression is downregulated in children with overweight and obesity and shows a positive association with the differentiation capacity of SVF cells ex vivo and in vitro.RESULTSBoth MSCA1 and CD36 are differentially expressed in adipocytes and SVF cells of children. MSCA1 expression is positively correlated to obesity-associated AT dysfunction (ie, adipocyte hypertrophy and serum high-sensitivity C-reactive protein), and high SVF MSCA1 expression is associated with increased mitochondrial respiration in vitro. CD36 expression is not associated with AT dysfunction but SVF CD36 expression is downregulated in children with overweight and obesity and shows a positive association with the differentiation capacity of SVF cells ex vivo and in vitro.Both MSCA1 and CD36 are associated with obesity-related alterations in AT of children. In particular, CD36 expression predicts adipogenic potential of SVF cells, indicating a potential role in the regulation of adipocyte hyperplasia and hypertrophy with obesity development in children.CONCLUSIONBoth MSCA1 and CD36 are associated with obesity-related alterations in AT of children. In particular, CD36 expression predicts adipogenic potential of SVF cells, indicating a potential role in the regulation of adipocyte hyperplasia and hypertrophy with obesity development in children.
Context: MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a potential relevance for obesity and adipocyte progenitor function. Objective: With the early manifestation of obesity in children and formation of adipose tissue (AT) dysfunction, children provide the opportunity to characterize the function of MSCA1 and CD36 during physiological AT accumulation and with obesity and related disease. Methods: We investigated MSCA1 and CD36 expression in adipocytes and stroma vascular fraction (SVF) cells from 133 children of the Leipzig AT Childhood cohort with regard to AT accumulation and biology. In a subsample we analyzed how MSCA1 and CD36 expression is related to adipose progenitor capacities in vitro (ie, proliferation, differentiation and mitochondrial function). Results: Both MSCA1 and CD36 are differentially expressed in adipocytes and SVF cells of children. MSCA1 expression is positively correlated to obesity-associated AT dysfunction (ie, adipocyte hypertrophy and serum high-sensitivity C-reactive protein), and high SVF MSCA1 expression is associated with increased mitochondrial respiration in vitro. CD36 expression is not associated with AT dysfunction but SVF CD36 expression is downregulated in children with overweight and obesity and shows a positive association with the differentiation capacity of SVF cells ex vivo and in vitro.
Audience Academic
Author Bouloumié, Anne
Stein, Robert
Körner, Antje
Hanschkow, Martha
Kempf, Elena
Boulet, Nathalie
Kiess, Wieland
Landgraf, Kathrin
AuthorAffiliation 1 University of Leipzig, Medical Faculty, University Hospital for Children and Adolescents, Center for Pediatric Research Leipzig (CPL) , Leipzig , Germany
3 Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig , Leipzig , Germany
2 University of Toulouse, Institute of Metabolic and Cardiovascular Diseases, Inserm , Toulouse , France
AuthorAffiliation_xml – name: 1 University of Leipzig, Medical Faculty, University Hospital for Children and Adolescents, Center for Pediatric Research Leipzig (CPL) , Leipzig , Germany
– name: 2 University of Toulouse, Institute of Metabolic and Cardiovascular Diseases, Inserm , Toulouse , France
– name: 3 Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig , Leipzig , Germany
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Cites_doi 10.1203/01.pdr.0000262638.48304.ef
10.1016/j.gene.2020.144855
10.1016/j.beem.2012.06.002
10.1089/scd.2011.0349
10.1002/stem.1916
10.1038/s41580-018-0093-z
10.2337/db14-0744
10.1096/fj.12-206862
10.1172/JCI14006
10.1016/S0952-3278(97)90487-7
10.1016/j.bbagen.2015.09.014
10.1186/scrt502
10.1002/stem.2635
10.1038/ni.2639
10.1089/scd.2009.0290
10.1155/2016/1815982
10.1172/JCI109295
10.1038/s41586-021-03533-z
10.1016/j.neulet.2010.09.013
10.1016/j.cmet.2013.10.003
10.3389/fimmu.2017.00897
10.1016/j.bbagen.2012.04.001
10.1056/NEJMoa1803527
10.1016/j.lfs.2009.01.013
10.1002/oby.20354
10.1097/PRS.0b013e318221db33
10.1002/oby.22985
10.1007/BF00280883
10.1016/j.cmet.2010.09.010
10.1189/jlb.0806521
10.1007/978-94-017-7197-9_18
10.1007/s001120170107
10.1016/j.celrep.2020.108295
10.1074/jbc.M116.726737
10.1038/231445a0
10.3324/haematol.13740
10.1038/sj.ijo.0803212
10.1038/ijo.2010.269
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Issue 2
Keywords adipose tissue
adipose tissue dysfunction
adipocyte differentiation
children
adipocyte progenitor cells
obesity
ORCiD numbers: 0000-0003-1011-3474 (N Boulet)
Boulet
ORCiD numbers: 0000-0003-1011-3474 (N
Landgraf
0000-0002-6878-6033 (K
0000-0002-6878-6033 (K Landgraf)
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PublicationTitle The journal of clinical endocrinology and metabolism
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Publisher Oxford University Press
Endocrine Society
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References Seimon (2022011805245969700_CIT0033) 2010; 12
Vimalraj (2022011805245969700_CIT0026) 2020; 754
Estève (2022011805245969700_CIT0009) 2015; 33
Ghaben (2022011805245969700_CIT0003) 2019; 20
Bonen (2022011805245969700_CIT0035) 2006; 30
Barrett (2022011805245969700_CIT0032) 2007; 82
Berry (2022011805245969700_CIT0006) 2014; 19
Landgraf (2022011805245969700_CIT0021) 2015; 64
Rader (2022011805245969700_CIT0015) 2017; 8
Ding (2022011805245969700_CIT0016) 2009; 84
Matthews (2022011805245969700_CIT0023) 1985; 28
Yang (2022011805245969700_CIT0025) 2016; 291
Knittle (2022011805245969700_CIT0004) 1979; 63
Sobiesiak (2022011805245969700_CIT0011) 2010; 19
Diaz-Hernandez (2022011805245969700_CIT0027) 2015; 76
Cyr (2022011805245969700_CIT0036) 2020; 28
Sheedy (2022011805245969700_CIT0034) 2013; 14
Sfeir (2022011805245969700_CIT0037) 1997; 57
Vroegrijk (2022011805245969700_CIT0020) 2013; 21
Estève (2022011805245969700_CIT0012) 2016; 2016
Kermer (2022011805245969700_CIT0014) 2010; 485
Febbraio (2022011805245969700_CIT0019) 2001; 108
Sun (2022011805245969700_CIT0018) 2021; 593
Zhou (2022011805245969700_CIT0031) 2012; 26
Gao (2022011805245969700_CIT0010) 2017; 35
Maumus (2022011805245969700_CIT0007) 2011; 35
Li (2022011805245969700_CIT0008) 2011; 128
Hernández-Mosqueira (2022011805245969700_CIT0017) 2015; 1850
Medina-Gómez (2022011805245969700_CIT0030) 2012; 26
Marble (2022011805245969700_CIT0029) 2014; 5
Kromeyer-Hauschild (2022011805245969700_CIT0022) 2001; 149
Körner (2022011805245969700_CIT0001) 2007; 61
Ng (2022011805245969700_CIT0005) 1971; 231
Landgraf (2022011805245969700_CIT0024) 2020; 33
Kim (2022011805245969700_CIT0028) 2012; 21
Geserick (2022011805245969700_CIT0002) 2018; 379
Battula (2022011805245969700_CIT0013) 2009; 94
Christiaens (2022011805245969700_CIT0038) 2012; 1820
References_xml – volume: 61
  start-page: 640
  issue: 6
  year: 2007
  ident: 2022011805245969700_CIT0001
  article-title: New predictors of the metabolic syndrome in children–role of adipocytokines
  publication-title: Pediatr Res.
  doi: 10.1203/01.pdr.0000262638.48304.ef
– volume: 754
  start-page: 144855
  year: 2020
  ident: 2022011805245969700_CIT0026
  article-title: Alkaline phosphatase: structure, expression and its function in bone mineralization
  publication-title: Gene.
  doi: 10.1016/j.gene.2020.144855
– volume: 26
  start-page: 791
  issue: 6
  year: 2012
  ident: 2022011805245969700_CIT0030
  article-title: Mitochondria and endocrine function of adipose tissue
  publication-title: Best Pract Res Clin Endocrinol Metab.
  doi: 10.1016/j.beem.2012.06.002
– volume: 21
  start-page: 2958
  issue: 16
  year: 2012
  ident: 2022011805245969700_CIT0028
  article-title: Characterization of different subpopulations from bone marrow-derived mesenchymal stromal cells by alkaline phosphatase expression
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2011.0349
– volume: 33
  start-page: 1277
  issue: 4
  year: 2015
  ident: 2022011805245969700_CIT0009
  article-title: Human white and brite adipogenesis is supported by MSCA1 and is impaired by immune cells
  publication-title: Stem Cells
  doi: 10.1002/stem.1916
– volume: 20
  start-page: 242
  issue: 4
  year: 2019
  ident: 2022011805245969700_CIT0003
  article-title: Adipogenesis and metabolic health
  publication-title: Nat Rev Mol Cell Biol.
  doi: 10.1038/s41580-018-0093-z
– volume: 64
  start-page: 1249
  issue: 4
  year: 2015
  ident: 2022011805245969700_CIT0021
  article-title: Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children
  publication-title: Diabetes.
  doi: 10.2337/db14-0744
– volume: 26
  start-page: 4733
  issue: 11
  year: 2012
  ident: 2022011805245969700_CIT0031
  article-title: CD36 level and trafficking are determinants of lipolysis in adipocytes
  publication-title: FASEB J.
  doi: 10.1096/fj.12-206862
– volume: 108
  start-page: 785
  issue: 6
  year: 2001
  ident: 2022011805245969700_CIT0019
  article-title: CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
  publication-title: J Clin Invest.
  doi: 10.1172/JCI14006
– volume: 57
  start-page: 17
  issue: 1
  year: 1997
  ident: 2022011805245969700_CIT0037
  article-title: Regulation of FAT/CD36 gene expression: further evidence in support of a role of the protein in fatty acid binding/transport
  publication-title: Prostaglandins Leukot Essent Fatty Acids.
  doi: 10.1016/S0952-3278(97)90487-7
– volume: 1850
  start-page: 2485
  issue: 12
  year: 2015
  ident: 2022011805245969700_CIT0017
  article-title: Tissue alkaline phosphatase is involved in lipid metabolism and gene expression and secretion of adipokines in adipocytes
  publication-title: Biochim Biophys Acta.
  doi: 10.1016/j.bbagen.2015.09.014
– volume: 5
  start-page: 145
  issue: 5
  year: 2014
  ident: 2022011805245969700_CIT0029
  article-title: Gene expression-based enrichment of live cells from adipose tissue produces subpopulations with improved osteogenic potential
  publication-title: Stem Cell Res Ther.
  doi: 10.1186/scrt502
– volume: 35
  start-page: 1799
  issue: 7
  year: 2017
  ident: 2022011805245969700_CIT0010
  article-title: CD36 is a marker of human adipocyte progenitors with pronounced adipogenic and triglyceride accumulation potential
  publication-title: Stem Cells.
  doi: 10.1002/stem.2635
– volume: 14
  start-page: 812
  issue: 8
  year: 2013
  ident: 2022011805245969700_CIT0034
  article-title: CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
  publication-title: Nat Immunol.
  doi: 10.1038/ni.2639
– volume: 19
  start-page: 669
  issue: 5
  year: 2010
  ident: 2022011805245969700_CIT0011
  article-title: The mesenchymal stem cell antigen MSCA-1 is identical to tissue non-specific alkaline phosphatase
  publication-title: Stem Cells Dev.
  doi: 10.1089/scd.2009.0290
– volume: 2016
  start-page: 1815982
  year: 2016
  ident: 2022011805245969700_CIT0012
  article-title: Multiple functions of MSCA-1/TNAP in adult mesenchymal progenitor/stromal cells
  publication-title: Stem Cells Int.
  doi: 10.1155/2016/1815982
– volume: 63
  start-page: 239
  issue: 2
  year: 1979
  ident: 2022011805245969700_CIT0004
  article-title: The growth of adipose tissue in children and adolescents. Cross-sectional and longitudinal studies of adipose cell number and size
  publication-title: J Clin Invest.
  doi: 10.1172/JCI109295
– volume: 593
  start-page: 580
  issue: 7860
  year: 2021
  ident: 2022011805245969700_CIT0018
  article-title: Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine
  publication-title: Nature
  doi: 10.1038/s41586-021-03533-z
– volume: 485
  start-page: 208
  issue: 3
  year: 2010
  ident: 2022011805245969700_CIT0014
  article-title: Knockdown of tissue nonspecific alkaline phosphatase impairs neural stem cell proliferation and differentiation
  publication-title: Neurosci Lett.
  doi: 10.1016/j.neulet.2010.09.013
– volume: 19
  start-page: 8
  issue: 1
  year: 2014
  ident: 2022011805245969700_CIT0006
  article-title: Weighing in on adipocyte precursors
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.10.003
– volume: 8
  start-page: 897
  year: 2017
  ident: 2022011805245969700_CIT0015
  article-title: Alkaline phosphatase, an unconventional immune protein
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.00897
– volume: 1820
  start-page: 949
  issue: 7
  year: 2012
  ident: 2022011805245969700_CIT0038
  article-title: CD36 promotes adipocyte differentiation and adipogenesis
  publication-title: Biochim Biophys Acta.
  doi: 10.1016/j.bbagen.2012.04.001
– volume: 379
  start-page: 1303
  issue: 14
  year: 2018
  ident: 2022011805245969700_CIT0002
  article-title: Acceleration of BMI in early childhood and risk of sustained obesity
  publication-title: N Engl J Med.
  doi: 10.1056/NEJMoa1803527
– volume: 84
  start-page: 499
  issue: 15-16
  year: 2009
  ident: 2022011805245969700_CIT0016
  article-title: TNF-alpha and IL-1beta inhibit RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2009.01.013
– volume: 21
  start-page: 2037
  issue: 10
  year: 2013
  ident: 2022011805245969700_CIT0020
  article-title: CD36 is important for adipocyte recruitment and affects lipolysis
  publication-title: Obesity
  doi: 10.1002/oby.20354
– volume: 128
  start-page: 663
  issue: 3
  year: 2011
  ident: 2022011805245969700_CIT0008
  article-title: Adipogenic potential of adipose stem cell subpopulations
  publication-title: Plast Reconstr Surg.
  doi: 10.1097/PRS.0b013e318221db33
– volume: 28
  start-page: 2357
  issue: 12
  year: 2020
  ident: 2022011805245969700_CIT0036
  article-title: White adipose tissue surface expression of LDLR and CD36 is associated with risk factors for type 2 diabetes in adults with obesity
  publication-title: Obesity.
  doi: 10.1002/oby.22985
– volume: 28
  start-page: 412
  issue: 7
  year: 1985
  ident: 2022011805245969700_CIT0023
  article-title: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
  publication-title: Diabetologia.
  doi: 10.1007/BF00280883
– volume: 12
  start-page: 467
  issue: 5
  year: 2010
  ident: 2022011805245969700_CIT0033
  article-title: Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2010.09.010
– volume: 82
  start-page: 152
  issue: 1
  year: 2007
  ident: 2022011805245969700_CIT0032
  article-title: Circulating CD14-CD36+ peripheral blood mononuclear cells constitutively produce interleukin-10
  publication-title: J Leukoc Biol.
  doi: 10.1189/jlb.0806521
– volume: 76
  start-page: 375
  year: 2015
  ident: 2022011805245969700_CIT0027
  article-title: TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders
  publication-title: Subcell Biochem.
  doi: 10.1007/978-94-017-7197-9_18
– volume: 149
  start-page: 807
  year: 2001
  ident: 2022011805245969700_CIT0022
  article-title: Perzentilen für den body mass index für das Kindes- und Jugendalter unter Heranziehung verschiedener deutscher Stichproben. [Centiles for body mass index for children and adolescents derived from distinct independent German cohorts]
  publication-title: Monatsschr Kinderheilkd
  doi: 10.1007/s001120170107
– volume: 33
  start-page: 108295
  issue: 3
  year: 2020
  ident: 2022011805245969700_CIT0024
  article-title: The obesity-susceptibility gene TMEM18 promotes adipogenesis through activation of PPARG
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2020.108295
– volume: 291
  start-page: 15108
  issue: 29
  year: 2016
  ident: 2022011805245969700_CIT0025
  article-title: Activation of peroxisome proliferator-activated receptor γ (PPARγ) and CD36 protein expression: the dual pathophysiological roles of progesterone
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M116.726737
– volume: 231
  start-page: 445
  issue: 5303
  year: 1971
  ident: 2022011805245969700_CIT0005
  article-title: Differences in growth in vitro of adipose cells from normal and obese patients
  publication-title: Nature.
  doi: 10.1038/231445a0
– volume: 94
  start-page: 173
  issue: 2
  year: 2009
  ident: 2022011805245969700_CIT0013
  article-title: Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1
  publication-title: Haematologica.
  doi: 10.3324/haematol.13740
– volume: 30
  start-page: 877
  issue: 6
  year: 2006
  ident: 2022011805245969700_CIT0035
  article-title: The fatty acid transporter FAT/CD36 is upregulated in subcutaneous and visceral adipose tissues in human obesity and type 2 diabetes
  publication-title: Int J Obes.
  doi: 10.1038/sj.ijo.0803212
– volume: 35
  start-page: 1141
  issue: 9
  year: 2011
  ident: 2022011805245969700_CIT0007
  article-title: Native human adipose stromal cells: localization, morphology and phenotype
  publication-title: Int J Obes.
  doi: 10.1038/ijo.2010.269
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Snippet Abstract Context MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in...
MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults with a...
Context: MSCA1 (mesenchymal stem cell antigen 1)and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults...
Context MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults...
Context: MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36) have been described as novel adipocyte progenitor markers in adults...
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SubjectTerms Adipocytes
Adipocytes - metabolism
Adipogenesis
Adipose tissue
Adipose tissues
Adolescent
Antigens, Surface
Antigens, Surface - analysis
Antigens, Surface - metabolism
Body fat
C-reactive protein
CD36 antigen
Cell differentiation
Cell proliferation
Child
Child, Preschool
Children
Cross-Sectional Studies
Female
Health aspects
Humans
Hyperplasia
Hypertrophy
Infant
Life Sciences
Male
Mesenchymal stem cells
Obesity
Obesity in children
Online Only
Pediatric Obesity
Pediatric Obesity - physiopathology
Physiological aspects
Stem cell antigen 1
Stem cells
Stroma
Stromal Vascular Fraction
Stromal Vascular Fraction - metabolism
Subcutaneous Fat
Subcutaneous Fat - cytology
Subcutaneous Fat - metabolism
Subcutaneous Fat - physiopathology
Title Expression of the Adipocyte Progenitor Markers MSCA1 and CD36 is Associated With Adipose Tissue Function in Children
URI https://www.ncbi.nlm.nih.gov/pubmed/34448000
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