Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions

• Published in: Angewandte Chemie International Edition Vol. 58; no. 6; pp. 1562 - 1573
• Main Authors: Ping, Yuanyuan, Li, Yuxiu, Zhu, Jieping, Kong, Wangqing
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 04.02.2019
• Edition: International ed. in English
• Subjects: asymmetric synthesis; Cascade chemical reactions; Chemical reactions; Chemical synthesis; C−H functionalization; domino process; Enantiomers; homogeneous catalysis; Palladium; quaternary stereocenters; Transformations; C−H functionalization; asymmetric synthesis; homogeneous catalysis; quaternary stereocenters; domino process
• ISSN: 1433-7851; 1521-3773; 1521-3773
• DOI: 10.1002/anie.201806088

The enantioselective synthesis of molecules containing quaternary stereocenters is a field of intense research interest and development. Among the known organic transformations, carbopalladation‐initiated domino transformations constitutes a general method for the construction of compounds containing cyclic or spiro quaternary stereocenters. In this Minireview, recent achievements in palladium‐catalyzed domino Heck/C−H functionalizations and developments in enantioselective carbopalladation‐initiated domino processes are summarized. Domino effect: Recent advances in palladium‐catalyzed domino reactions initiated by intramolecular carbopalladation are summarized. Particular emphasis is given to C−H functionalization by transient σ‐alkylpalladium species and enantioselective domino Heck cyclization/nucleophilic trapping cascades.