Histone Deacetylase 9: Its Role in the Pathogenesis of Diabetes and Other Chronic Diseases

• Published in: Diabetes & metabolism journal Vol. 44; no. 2; pp. 234 - 244
• Main Authors: Hu, Siqi, Cho, Eun-Hee, Lee, Ji-Young
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Diabetes Association / Daehan Dangnyobyeong Hakoe 01.04.2020; Korean Diabetes Association; 대한당뇨병학회
• Subjects: Adipocytes - metabolism; Adipocytes - pathology; Amino acids; Animals; autoimmune diseases; Autoimmune Diseases - metabolism; Autoimmune Diseases - physiopathology; cardiovascular diseases; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - physiopathology; Cell cycle; Cell Differentiation; Chronic Disease; Chronic illnesses; Diabetes Mellitus - metabolism; Diabetes Mellitus - physiopathology; Enzymes; epigenomics; Female; Fibroblasts; Genes; Genomes; histone deacetylases; Histone Deacetylases - genetics; Histones - metabolism; Humans; Insulin Resistance - genetics; Liver cancer; Liver Cirrhosis - metabolism; Liver Cirrhosis - physiopathology; Mice; Muscle Cells - metabolism; Muscle Cells - pathology; Musculoskeletal system; neoplasms; Neoplasms - metabolism; Neoplasms - physiopathology; obesity; Obesity - metabolism; Obesity - physiopathology; Osteoporosis - metabolism; Osteoporosis - physiopathology; Polymorphism, Single Nucleotide - genetics; Promoter Regions, Genetic - genetics; Proteins; Regulation; Repressor Proteins - genetics; Review; Transcription factors; Transcription Factors - metabolism; 내과학; Obesity; Epigenomics; Chronic disease; Autoimmune diseases; Cardiovascular diseases; Histone deacetylases; Neoplasms
• ISSN: 2233-6079; 2233-6087; 2233-6087
• DOI: 10.4093/dmj.2019.0243

As a member of the class IIa histone deacetylases (HDACs), HDAC9 catalyzes the deacetylation of histones and transcription factors, commonly leading to the suppression of gene transcription. The activity of HDAC9 is regulated transcriptionally and post-translationally. HDAC9 is known to play an essential role in regulating myocyte and adipocyte differentiation and cardiac muscle development. Also, recent studies have suggested that HDAC9 is involved in the pathogenesis of chronic diseases, including cardiovascular diseases, osteoporosis, autoimmune disease, cancer, obesity, insulin resistance, and liver fibrosis. HDAC9 modulates the expression of genes related to the pathogenesis of chronic diseases by altering chromatin structure in their promotor region or reducing the transcriptional activity of their respective transcription factors. This review summarizes the current knowledge of the regulation of HDAC9 expression and activity. Also, the roles of HDAC9 in the pathogenesis of chronic diseases are discussed, along with potential underlying mechanisms.