A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects
Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW intervent...
Saved in:
| Published in | The American journal of clinical nutrition Vol. 108; no. 6; pp. 1264 - 1274 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.12.2018
Oxford University Press American Society for Clinical Nutrition, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9165 1938-3207 1938-3207 |
| DOI | 10.1093/ajcn/nqy204 |
Cover
| Abstract | Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions.
The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters.
We performed a double-blind, parallel trial in which 50 overweight 45- to 70-y-old men and postmenopausal women were randomly allocated to a 12-wk intervention with either WGW (98 g/d) or RW (98 g/d) products. Before and after the intervention we assessed intrahepatic triglycerides (IHTGs) and fat distribution by proton magnetic resonance spectroscopy/magnetic resonance imaging, fecal microbiota composition, adipose tissue gene expression, and several fasting plasma parameters, as well as postprandial plasma lipids after a mixed meal.
Fasting plasma cholesterol, triglycerides, nonesterified fatty acids, and insulin were not affected by RW or WGW intervention. We observed a substantial increase of 49.1% in IHTGs in the RW when compared with the WGW group (P = 0.033). Baseline microbiota composition could not predict the increase in IHTGs after RW, but gut microbiota diversity decreased in the RW group when compared with the WGW group (P = 0.010). In the WGW group, we observed increased postprandial triglyceride levels compared with the RW group (P = 0.020). In addition, the WGW intervention resulted in a trend towards lower fasting levels of the liver acute-phase proteins serum amyloid A (P = 0.057) and C-reactive protein (P = 0.064) when compared to the RW intervention.
A 12-wk RW intervention increases liver fat and might contribute to the development of nonalcoholic fatty liver disease, whereas a 12-wk 98-g/d WGW intervention prevents a substantial increase in liver fat. Our results show that incorporating feasible doses of WGW in the diet at the expense of RW maintains liver health. The study was registered at clinicaltrials.gov as NCT02385149. |
|---|---|
| AbstractList | Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions.
The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters.
We performed a double-blind, parallel trial in which 50 overweight 45- to 70-y-old men and postmenopausal women were randomly allocated to a 12-wk intervention with either WGW (98 g/d) or RW (98 g/d) products. Before and after the intervention we assessed intrahepatic triglycerides (IHTGs) and fat distribution by proton magnetic resonance spectroscopy/magnetic resonance imaging, fecal microbiota composition, adipose tissue gene expression, and several fasting plasma parameters, as well as postprandial plasma lipids after a mixed meal.
Fasting plasma cholesterol, triglycerides, nonesterified fatty acids, and insulin were not affected by RW or WGW intervention. We observed a substantial increase of 49.1% in IHTGs in the RW when compared with the WGW group (P = 0.033). Baseline microbiota composition could not predict the increase in IHTGs after RW, but gut microbiota diversity decreased in the RW group when compared with the WGW group (P = 0.010). In the WGW group, we observed increased postprandial triglyceride levels compared with the RW group (P = 0.020). In addition, the WGW intervention resulted in a trend towards lower fasting levels of the liver acute-phase proteins serum amyloid A (P = 0.057) and C-reactive protein (P = 0.064) when compared to the RW intervention.
A 12-wk RW intervention increases liver fat and might contribute to the development of nonalcoholic fatty liver disease, whereas a 12-wk 98-g/d WGW intervention prevents a substantial increase in liver fat. Our results show that incorporating feasible doses of WGW in the diet at the expense of RW maintains liver health. The study was registered at clinicaltrials.gov as NCT02385149. Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions.BackgroundWhole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions.The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters.ObjectiveThe aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters.We performed a double-blind, parallel trial in which 50 overweight 45- to 70-y-old men and postmenopausal women were randomly allocated to a 12-wk intervention with either WGW (98 g/d) or RW (98 g/d) products. Before and after the intervention we assessed intrahepatic triglycerides (IHTGs) and fat distribution by proton magnetic resonance spectroscopy/magnetic resonance imaging, fecal microbiota composition, adipose tissue gene expression, and several fasting plasma parameters, as well as postprandial plasma lipids after a mixed meal.DesignWe performed a double-blind, parallel trial in which 50 overweight 45- to 70-y-old men and postmenopausal women were randomly allocated to a 12-wk intervention with either WGW (98 g/d) or RW (98 g/d) products. Before and after the intervention we assessed intrahepatic triglycerides (IHTGs) and fat distribution by proton magnetic resonance spectroscopy/magnetic resonance imaging, fecal microbiota composition, adipose tissue gene expression, and several fasting plasma parameters, as well as postprandial plasma lipids after a mixed meal.Fasting plasma cholesterol, triglycerides, nonesterified fatty acids, and insulin were not affected by RW or WGW intervention. We observed a substantial increase of 49.1% in IHTGs in the RW when compared with the WGW group (P = 0.033). Baseline microbiota composition could not predict the increase in IHTGs after RW, but gut microbiota diversity decreased in the RW group when compared with the WGW group (P = 0.010). In the WGW group, we observed increased postprandial triglyceride levels compared with the RW group (P = 0.020). In addition, the WGW intervention resulted in a trend towards lower fasting levels of the liver acute-phase proteins serum amyloid A (P = 0.057) and C-reactive protein (P = 0.064) when compared to the RW intervention.ResultsFasting plasma cholesterol, triglycerides, nonesterified fatty acids, and insulin were not affected by RW or WGW intervention. We observed a substantial increase of 49.1% in IHTGs in the RW when compared with the WGW group (P = 0.033). Baseline microbiota composition could not predict the increase in IHTGs after RW, but gut microbiota diversity decreased in the RW group when compared with the WGW group (P = 0.010). In the WGW group, we observed increased postprandial triglyceride levels compared with the RW group (P = 0.020). In addition, the WGW intervention resulted in a trend towards lower fasting levels of the liver acute-phase proteins serum amyloid A (P = 0.057) and C-reactive protein (P = 0.064) when compared to the RW intervention.A 12-wk RW intervention increases liver fat and might contribute to the development of nonalcoholic fatty liver disease, whereas a 12-wk 98-g/d WGW intervention prevents a substantial increase in liver fat. Our results show that incorporating feasible doses of WGW in the diet at the expense of RW maintains liver health. The study was registered at clinicaltrials.gov as NCT02385149.ConclusionsA 12-wk RW intervention increases liver fat and might contribute to the development of nonalcoholic fatty liver disease, whereas a 12-wk 98-g/d WGW intervention prevents a substantial increase in liver fat. Our results show that incorporating feasible doses of WGW in the diet at the expense of RW maintains liver health. The study was registered at clinicaltrials.gov as NCT02385149. ABSTRACT Background Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions. Objective The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters. Design We performed a double-blind, parallel trial in which 50 overweight 45- to 70-y-old men and postmenopausal women were randomly allocated to a 12-wk intervention with either WGW (98 g/d) or RW (98 g/d) products. Before and after the intervention we assessed intrahepatic triglycerides (IHTGs) and fat distribution by proton magnetic resonance spectroscopy/magnetic resonance imaging, fecal microbiota composition, adipose tissue gene expression, and several fasting plasma parameters, as well as postprandial plasma lipids after a mixed meal. Results Fasting plasma cholesterol, triglycerides, nonesterified fatty acids, and insulin were not affected by RW or WGW intervention. We observed a substantial increase of 49.1% in IHTGs in the RW when compared with the WGW group (P = 0.033). Baseline microbiota composition could not predict the increase in IHTGs after RW, but gut microbiota diversity decreased in the RW group when compared with the WGW group (P = 0.010). In the WGW group, we observed increased postprandial triglyceride levels compared with the RW group (P = 0.020). In addition, the WGW intervention resulted in a trend towards lower fasting levels of the liver acute-phase proteins serum amyloid A (P = 0.057) and C-reactive protein (P = 0.064) when compared to the RW intervention. Conclusions A 12-wk RW intervention increases liver fat and might contribute to the development of nonalcoholic fatty liver disease, whereas a 12-wk 98-g/d WGW intervention prevents a substantial increase in liver fat. Our results show that incorporating feasible doses of WGW in the diet at the expense of RW maintains liver health. The study was registered at clinicaltrials.gov as NCT02385149. Background: Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions. Objective: The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters. Design: We performed a double-blind, parallel trial in which 50 overweight 45- to 70-y-old men and postmenopausal women were randomly allocated to a 12-wk intervention with either WGW (98 g/d) or RW (98 g/d) products. Before and after the intervention we assessed intrahepatic triglycerides (IHTGs) and fat distribution by proton magnetic resonance spectroscopy/magnetic resonance imaging, fecal microbiota composition, adipose tissue gene expression, and several fasting plasma parameters, as well as postprandial plasma lipids after a mixed meal. Results: Fasting plasma cholesterol, triglycerides, nonesterified fatty acids, and insulin were not affected by RW or WGW intervention. We observed a substantial increase of 49.1% in IHTGs in the RW when compared with the WGW group (P = 0.033). Baseline microbiota composition could not predict the increase in IHTGs after RW, but gut microbiota diversity decreased in the RW group when compared with the WGW group (P = 0.010). In the WGW group, we observed increased postprandial triglyceride levels compared with the RW group (P = 0.020). In addition, the WGW intervention resulted in a trend towards lower fasting levels of the liver acute-phase proteins serum amyloid A (P = 0.057) and C-reactive protein (P = 0.064) when compared to the RW intervention. Conclusions: A 12-wk RW intervention increases liver fat and might contribute to the development of nonalcoholic fatty liver disease, whereas a 12-wk 98-g/d WGW intervention prevents a substantial increase in liver fat. Our results show that incorporating feasible doses of WGW in the diet at the expense of RW maintains liver health. The study was registered at clinicaltrials.gov as NCT02385149. Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions. The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters. We performed a double-blind, parallel trial in which 50 overweight 45- to 70-y-old men and postmenopausal women were randomly allocated to a 12-wk intervention with either WGW (98 g/d) or RW (98 g/d) products. Before and after the intervention we assessed intrahepatic triglycerides (IHTGs) and fat distribution by proton magnetic resonance spectroscopy/magnetic resonance imaging, fecal microbiota composition, adipose tissue gene expression, and several fasting plasma parameters, as well as postprandial plasma lipids after a mixed meal. Fasting plasma cholesterol, triglycerides, nonesterified fatty acids, and insulin were not affected by RW or WGW intervention. We observed a substantial increase of 49.1% in IHTGs in the RW when compared with the WGW group (P = 0.033). Baseline microbiota composition could not predict the increase in IHTGs after RW, but gut microbiota diversity decreased in the RW group when compared with the WGW group (P = 0.010). In the WGW group, we observed increased postprandial triglyceride levels compared with the RW group (P = 0.020). In addition, the WGW intervention resulted in a trend towards lower fasting levels of the liver acute-phase proteins serum amyloid A (P = 0.057) and C-reactive protein (P = 0.064) when compared to the RW intervention. A 12-wk RW intervention increases liver fat and might contribute to the development of nonalcoholic fatty liver disease, whereas a 12-wk 98-g/d WGW intervention prevents a substantial increase in liver fat. Our results show that incorporating feasible doses of WGW in the diet at the expense of RW maintains liver health. The study was registered at clinicaltrials.gov as NCT02385149. |
| Author | Hooiveld, Guido J E J Wopereis, Suzan Schutte, Sophie Afman, Lydia A Hoevenaars, Femke P M Vonk, Roel J Esser, Diederik Priebe, Marion G |
| Author_xml | – sequence: 1 givenname: Sophie surname: Schutte fullname: Schutte, Sophie organization: Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands – sequence: 2 givenname: Diederik surname: Esser fullname: Esser, Diederik organization: Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands – sequence: 3 givenname: Femke P M surname: Hoevenaars fullname: Hoevenaars, Femke P M organization: TNO, Netherlands Organization for Applied Scientific Research, Research Group Microbiology & Systems Biology, Zeist, The Netherlands – sequence: 4 givenname: Guido J E J surname: Hooiveld fullname: Hooiveld, Guido J E J organization: Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands – sequence: 5 givenname: Marion G surname: Priebe fullname: Priebe, Marion G organization: University Medical Center Groningen, University of Groningen, Faculty of Medical Sciences, Groningen, The Netherlands – sequence: 6 givenname: Roel J surname: Vonk fullname: Vonk, Roel J organization: University Medical Center Groningen, University of Groningen, Faculty of Medical Sciences, Groningen, The Netherlands – sequence: 7 givenname: Suzan surname: Wopereis fullname: Wopereis, Suzan organization: TNO, Netherlands Organization for Applied Scientific Research, Research Group Microbiology & Systems Biology, Zeist, The Netherlands – sequence: 8 givenname: Lydia A surname: Afman fullname: Afman, Lydia A email: lydia.afman@wur.nl organization: Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30541093$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkkFv1DAQhS1URNuFE3dkCalCoqG2E2c3vVUVFKRKXOBsTZzJrpesndrORsuZH46jFA4VaC8ey_rek2fenJMT6ywS8pqzD5xV-RVstb2yDwfBimfkjFf5KssFW56QM8aYyCpeylNyHsKWMS6KVfmCnOZMFpP2jPy6oVxk4w86blyH2dqDsemOEKmxEf0ebTTO0t67iDoGCutEhEg32EM0mrYQr2ncIL3zALYxzgUa4tAcLilQn17czvzEhkZvoEue1O3Rj2jWm0jDUG8n05fkeQtdwFePdUG-f_r47fZzdv_17svtzX2mJZcxA9bkbVO2VcNrUQhRLJsapRa6qKEVMi81A92Wsmo0r0rJ8lQlA4areoUAkC_I9ew7whqtselQFrw2QTkwqjO1B39Q4-CV7abSD3VQsihZmtWCXM7iwfZwGKHrVO_NbhJwpqZpqikJNSeR8Hcznib3MGCIameCxq4Di24ISuQy9bBaVvw4yqWshKyWy4S-fYJu3eBtGlqiSp5iLeVk-OaRGuodNn__-Sf2BLyfAe1dCB7bI63wJ7Q2Eaa1iGlduv9oLmaNG_oj5nIGMQW_N-hV0Aatxsb4tBuqceafut-aYPQN |
| CitedBy_id | crossref_primary_10_1016_j_tifs_2021_01_055 crossref_primary_10_1111_nyas_15215 crossref_primary_10_1016_j_metabol_2024_156028 crossref_primary_10_1111_eci_13519 crossref_primary_10_3390_nu12102945 crossref_primary_10_3390_nu15051301 crossref_primary_10_3390_pathogens12091087 crossref_primary_10_1017_S0029665122002853 crossref_primary_10_1186_s12902_024_01661_x crossref_primary_10_3390_nu13061763 crossref_primary_10_1111_jdi_13866 crossref_primary_10_1016_j_foodres_2023_113421 crossref_primary_10_1016_j_dsx_2025_103209 crossref_primary_10_3390_nu11092091 crossref_primary_10_3390_nu11102348 crossref_primary_10_1016_j_fochx_2022_100252 crossref_primary_10_1080_10408398_2021_2001429 crossref_primary_10_3390_nu13113887 crossref_primary_10_1007_s00394_020_02359_1 crossref_primary_10_1039_D0FO00830C crossref_primary_10_3389_fnut_2020_613221 crossref_primary_10_3390_metabo15030160 crossref_primary_10_2174_2212798411666200316152252 crossref_primary_10_1016_j_jand_2020_06_021 crossref_primary_10_1080_10408398_2021_2017838 crossref_primary_10_3389_fimmu_2024_1409414 crossref_primary_10_1111_1541_4337_12728 crossref_primary_10_1016_j_numecd_2024_01_028 crossref_primary_10_1039_D4FO01248H crossref_primary_10_2991_efood_k_200824_002 crossref_primary_10_3389_fnut_2022_1026213 crossref_primary_10_1016_j_atherosclerosis_2020_08_028 crossref_primary_10_1021_acs_jafc_1c02662 crossref_primary_10_1007_s00394_021_02520_4 crossref_primary_10_1093_jn_nxaa412 crossref_primary_10_1111_jpn_13429 crossref_primary_10_3390_nu14020374 crossref_primary_10_1007_s00394_025_03627_8 crossref_primary_10_1016_j_metop_2025_100351 crossref_primary_10_1080_09637486_2023_2232949 crossref_primary_10_1016_j_tifs_2023_02_007 crossref_primary_10_1016_j_gaost_2019_09_001 crossref_primary_10_1016_j_jcs_2024_103864 crossref_primary_10_1186_s12916_023_03135_8 crossref_primary_10_1093_jn_nxz177 crossref_primary_10_1038_s41430_020_00778_1 crossref_primary_10_1093_ajcn_nqy300 crossref_primary_10_1016_j_jcs_2022_103505 crossref_primary_10_1017_jns_2020_26 crossref_primary_10_3389_fnut_2022_919838 crossref_primary_10_1093_jn_nxac009 crossref_primary_10_1080_10408398_2022_2087593 crossref_primary_10_1186_s12872_020_01337_z crossref_primary_10_1007_s00394_023_03221_w crossref_primary_10_3390_nu12030859 crossref_primary_10_1093_jn_nxaa312 crossref_primary_10_3390_nu17010084 crossref_primary_10_1186_s40795_024_00961_8 |
| Cites_doi | 10.1016/j.numecd.2009.03.025 10.1172/JCI115260 10.1016/j.numecd.2010.10.018 10.1093/jn/137.6.1401 10.1038/srep32002 10.3920/BM2010.0028 10.1038/nature12820 10.1371/journal.pone.0061217 10.1016/j.cmet.2017.09.008 10.3945/ajcn.115.124271 10.3945/ajcn.2009.28521 10.1016/j.ab.2015.12.023 10.1038/sj.ijo.0803409 10.1089/jmf.2014.3394 10.1002/fes3.64 10.1093/ajcn/75.5.848 10.1152/physrev.00033.2011 10.3945/jn.116.230508 10.1016/S0010-4825(01)00006-3 10.1016/j.clnu.2009.05.011 10.1016/j.cmet.2017.05.002 10.1073/pnas.1000080107 10.3390/molecules200915666 10.2337/db14-1213 10.3945/ajcn.2009.29106 10.1111/j.1467-789X.2012.01035.x 10.1128/AEM.01541-09 10.1001/jamainternmed.2014.6283 10.1136/bmj.i2716 10.1016/j.nut.2015.08.006 10.1128/AEM.00062-07 10.1016/j.cmet.2013.06.016 10.3945/ajcn.2010.29417 10.3402/fnr.v58.22100 10.2337/db11-0231 10.1080/10408398.2010.549596 10.1152/ajpendo.00064.2004 10.1017/S0954422410000041 10.2337/db06-0822 10.1186/s12263-017-0570-6 10.1038/ismej.2011.139 10.2337/db16-0924 10.1155/2013/585876 10.1016/j.bbalip.2009.12.006 10.3945/ajcn.115.109165 10.1016/j.mehy.2009.07.022 10.3945/ajcn.114.088120 10.3945/ajcn.116.146928 |
| ContentType | Journal Article |
| Copyright | 2018 American Society for Nutrition. 2018 American Society for Nutrition. 2018 Copyright American Society for Clinical Nutrition, Inc. Dec 2018 Wageningen University & Research |
| Copyright_xml | – notice: 2018 American Society for Nutrition. – notice: 2018 American Society for Nutrition. 2018 – notice: Copyright American Society for Clinical Nutrition, Inc. Dec 2018 – notice: Wageningen University & Research |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QP 7T7 7TS 8FD C1K FR3 K9. NAPCQ P64 7X8 7S9 L.6 ADTOC UNPAY QVL |
| DOI | 10.1093/ajcn/nqy204 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Physical Education Index Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts MEDLINE - Academic AGRICOLA AGRICOLA - Academic Unpaywall for CDI: Periodical Content Unpaywall NARCIS:Publications |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Nursing & Allied Health Premium Technology Research Database ProQuest Health & Medical Complete (Alumni) Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Calcium & Calcified Tissue Abstracts Physical Education Index Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Nursing & Allied Health Premium AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Diet & Clinical Nutrition |
| EISSN | 1938-3207 |
| EndPage | 1274 |
| ExternalDocumentID | oai_library_wur_nl_wurpubs_546009 10.1093/ajcn/nqy204 30541093 10_1093_ajcn_nqy204 S0002916522030386 |
| Genre | Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Netherlands |
| GeographicLocations_xml | – name: Netherlands |
| GrantInformation_xml | – fundername: European Commission in the 7th Framework Programme grantid: 613979 funderid: 10.13039/100011102 |
| GroupedDBID | --- -ET -~X ..I .55 .GJ 0R~ 0SF 1HT 23M 2FS 2WC 3O- 4.4 476 48X 53G 5GY 5RE 5VS 6I. 6J9 85S 8R4 8R5 A8Z AABZA AACZT AAFTH AAHBH AAIKC AAJQQ AALRI AAMNW AAPGJ AAPQZ AAUQX AAUTI AAVAP AAWDT AAWTL AAXUO AAYOK ABBTP ABDNZ ABJNI ABLJU ABOCM ABPTD ABSAR ABWST ACFRR ACGFO ACGFS ACGOD ACNCT ACPRK ACPVT ACUFI ACUTJ ADBBV ADGZP ADHUB ADRTK ADUKH ADVEK ADVLN AEGXH AENEX AETBJ AFFDN AFFNX AFFZL AFJKZ AFOFC AFRAH AFRQD AFXAL AGINJ AGKRT AGNAY AGQXC AGUTN AHMBA AI. AIAGR AITUG AJEEA AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ ANFBD AQDSO AQKUS BAWUL BAYMD BCRHZ BKOMP BTRTY C1A CDBKE DAKXR DIK E3Z EBS EIHJH EJD ENERS EX3 F5P F9R FDB FECEO FLUFQ FOEOM FOTVD FQBLK FRP G8K GAUVT GJXCC GX1 H13 HF~ HZ~ I4R IH2 J5H KBUDW KOP KQ8 KSI KSN L7B LPU MBLQV MHKGH MV1 MVM N4W NEJ NHB NHCRO NOMLY NOYVH NVLIB O9- ODMLO OHT OK1 OVD P2P P6G PCD PQQKQ PRG Q2X R0Z RHF RHI RNS ROL ROX SJN SV3 TCN TEORI TMA TNT TR2 TWZ UBH UHB UKR VH1 W2D W8F WH7 WHG WOQ WOW X7M XOL XSW YBU YHG YOJ YQJ YRY YSK YV5 YYQ YZZ ZCA ZCG ZGI ZUP ZXP ~KM AAGQS AAYWO AAYXX ABDPE ABIME ACVFH ADCNI ADMTO AEUPX AFPUW AIGII AKBMS AKYEP APXCP CITATION EFKBS NU- YR5 CGR CUY CVF ECM EIF NPM Z5M 7QP 7T7 7TS 8FD ABUFD C1K FR3 K9. NAPCQ P64 7X8 7S9 L.6 ADTOC AGCQF UNPAY 08R AABJS AABMN ABFLS ACEMF ACIMA ADEIU AFDAS AFMIJ AGVJH AIKOY AIMBJ ASMCH AZQFJ BEYMZ BYORX DPPUQ EBD EMOBN K-O PQEST QVL ZA5 |
| ID | FETCH-LOGICAL-c515t-a0d3fd6f9d1b242247dbe5c2c4baf2536c0acf659dc196503dc150a0e8b8eaaa3 |
| IEDL.DBID | UNPAY |
| ISSN | 0002-9165 1938-3207 |
| IngestDate | Thu Oct 13 09:31:39 EDT 2022 Wed Aug 20 00:20:00 EDT 2025 Thu Oct 02 08:34:49 EDT 2025 Sat Sep 27 18:41:35 EDT 2025 Mon Oct 06 18:29:24 EDT 2025 Wed Feb 19 02:25:37 EST 2025 Wed Oct 01 01:34:31 EDT 2025 Thu Apr 24 23:02:46 EDT 2025 Wed Aug 28 03:31:50 EDT 2024 Tue Oct 01 06:57:03 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | microbiota CRP NAFLD whole grain wheat RW WGW SAT VAT mixed-meal challenge test ALT fatty liver WAT TRL OTU 1H-MRS NEFA steatosis CD AST adipose tissue health refined wheat SCFA IHTG SAA TG overweight/obesity dietary intervention |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) publisher-specific-oa |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c515t-a0d3fd6f9d1b242247dbe5c2c4baf2536c0acf659dc196503dc150a0e8b8eaaa3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://academic.oup.com/ajcn/article-pdf/108/6/1264/28887140/nqy204.pdf |
| PMID | 30541093 |
| PQID | 2161054651 |
| PQPubID | 41076 |
| PageCount | 11 |
| ParticipantIDs | wageningen_narcis_oai_library_wur_nl_wurpubs_546009 unpaywall_primary_10_1093_ajcn_nqy204 proquest_miscellaneous_2352428791 proquest_miscellaneous_2155925977 proquest_journals_2161054651 pubmed_primary_30541093 crossref_primary_10_1093_ajcn_nqy204 crossref_citationtrail_10_1093_ajcn_nqy204 oup_primary_10_1093_ajcn_nqy204 elsevier_sciencedirect_doi_10_1093_ajcn_nqy204 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-12-01 |
| PublicationDateYYYYMMDD | 2018-12-01 |
| PublicationDate_xml | – month: 12 year: 2018 text: 2018-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Bethesda |
| PublicationTitle | The American journal of clinical nutrition |
| PublicationTitleAlternate | Am J Clin Nutr |
| PublicationYear | 2018 |
| Publisher | Elsevier Inc Oxford University Press American Society for Clinical Nutrition, Inc |
| Publisher_xml | – name: Elsevier Inc – name: Oxford University Press – name: American Society for Clinical Nutrition, Inc |
| References | Roelofsen, Priebe, Vonk (bib47) 2010; 1 McDonald, Price, Goodrich, Nawrocki, DeSantis, Probst, Andersen, Knight, Hugenholtz (bib24) 2012; 6 Virtue, Vidal-Puig (bib43) 2010; 1801 Item, Konrad (bib42) 2012; 13 Suppl 2 Andersson, Tengblad, Karlstrom, Kamal-Eldin, Landberg, Basu, Aman, Vessby (bib48) 2007; 137 Vanegas, Meydani, Barnett, Goldin, Kane, Rasmussen, Brown, Vangay, Knights, Jonnalagadda (bib33) 2017; 105 Anderson, Hoffman, Balon, Sinkey, Mark (bib14) 1991; 87 McMurdie, Holmes (bib25) 2013; 8 Kirwan, Malin, Scelsi, Kullman, Navaneethan, Pagadala, Haus, Filion, Godin, Kochhar (bib8) 2016; 146 Schloss, Westcott, Ryabin, Hall, Hartmann, Hollister, Lesniewski, Oakley, Parks, Robinson (bib22) 2009; 75 Demerath, Ritter, Couch, Rogers, Moreno, Choh, Lee, Remsberg, Czerwinski, Chumlea (bib19) 2007; 31 den Besten, Bleeker, Gerding, van Eunen, Havinga, van Dijk, Oosterveer, Jonker, Groen, Reijngoud (bib28) 2015; 64 Laddomada, Caretto, Mita (bib45) 2015; 20 Hollaender, Ross, Kristensen (bib9) 2015; 102 Mollica, Raso, Cavaliere, Trinchese, De Filippo, Aceto, Prisco, Pirozzi, Di Guida, Lama (bib30) 2017; 66 Ross, Svelander, Savolainen, Lind, Kirwan, Breton, Godin, Sandberg (bib17) 2016; 499 Fardet, Chardigny (bib38) 2013; 53 Kootte, Levin, Salojarvi, Smits, Hartstra, Udayappan, Hermes, Bouter, Koopen, Holst (bib36) 2017; 26 Sun, Tordjman, Clement, Scherer (bib20) 2013; 18 McKeown, Troy, Jacques, Hoffmann, O'Donnell, Fox (bib3) 2010; 92 van der Kamp, Poutanen, Seal, Richardson (bib1) 2014; 58 Szczepaniak, Nurenberg, Leonard, Browning, Reingold, Grundy, Hobbs, Dobbins (bib26) 2005; 288 Wang, Jiang, Cao, Ge, Bao, Tang, Chen, Li (bib34) 2016; 6 Vetrani, Costabile, Luongo, Naviglio, Rivellese, Riccardi, Giacco (bib32) 2016; 32 Bloemen, Venema, van de Poll, Olde Damink, Buurman, Dejong (bib31) 2009; 28 Bickerton, Roberts, Fielding, Hodson, Blaak, Wagenmakers, Gilbert, Karpe, Frayn (bib40) 2007; 56 Aune, Keum, Giovannucci, Fadnes, Boffetta, Greenwood, Tonstad, Vatten, Riboli, Norat (bib5) 2016; 353 Pereira, Jacobs, Pins, Raatz, Gross, Slavin, Seaquist (bib13) 2002; 75 Tighe, Duthie, Vaughan, Brittenden, Simpson, Duthie, Mutch, Wahle, Horgan, Thies (bib10) 2010; 92 Wu, Flint, Qi, van Dam, Sampson, Rimm, Holmes, Willett, Hu, Sun (bib7) 2015; 175 Wang, Garrity, Tiedje, Cole (bib23) 2007; 73 Vitaglione, Mennella, Ferracane, Rivellese, Giacco, Ercolini, Gibbons, La Storia, Gilbert, Jonnalagadda (bib49) 2015; 101 Helnaes, Kyro, Andersen, Lacoppidan, Overvad, Christensen, Tjonneland, Olsen (bib6) 2016; 103 Tchernof, Despres (bib41) 2013; 93 Lee, Han, Song, Yeum (bib44) 2015; 18 Korem, Zeevi, Zmora, Weissbrod, Bar, Lotan-Pompan, Avnit-Sagi, Kosower, Malka, Rein (bib35) 2017; 25 Ross, Godin, Minehira, Kirwan (bib27) 2013; 2013 Naressi, Couturier, Castang, de Beer, Graveron-Demilly (bib18) 2001; 31 Priebe, Wang, Weening, Schepers, Preston, Vonk (bib46) 2010; 91 Caporaso, Lauber, Walters, Berg-Lyons, Lozupone, Turnbaugh, Fierer, Knight (bib21) 2011; 108 Suppl 1 Shewry, Hey (bib2) 2015; 4 Stefan, Haring (bib12) 2011; 60 MacKay, Tucker, Duncan, Graham, Robinson (bib15) 2012; 22 Hu, Chen, Xu, Ge, Lin (bib29) 2010; 74 Wopereis, Stroeve, Stafleu, Bakker, Burggraaf, van Erk, Pellis, Boessen, Kardinaal, van Ommen (bib16) 2017; 12 David, Maurice, Carmody, Gootenberg, Button, Wolfe, Ling, Devlin, Varma, Fischbach (bib37) 2014; 505 Fardet (bib39) 2010; 23 Priebe, van Binsbergen, de Vos, Vonk (bib4) 2008 Giacco, Clemente, Cipriano, Luongo, Viscovo, Patti, Di Marino, Giacco, Naviglio, Bianchi (bib11) 2010; 20 Vanegas (10.1093/ajcn/nqy204_bib33) 2017; 105 Bloemen (10.1093/ajcn/nqy204_bib31) 2009; 28 Roelofsen (10.1093/ajcn/nqy204_bib47) 2010; 1 Fardet (10.1093/ajcn/nqy204_bib39) 2010; 23 Vitaglione (10.1093/ajcn/nqy204_bib49) 2015; 101 Shewry (10.1093/ajcn/nqy204_bib2) 2015; 4 Schloss (10.1093/ajcn/nqy204_bib22) 2009; 75 Virtue (10.1093/ajcn/nqy204_bib43) 2010; 1801 MacKay (10.1093/ajcn/nqy204_bib15) 2012; 22 den Besten (10.1093/ajcn/nqy204_bib28) 2015; 64 Demerath (10.1093/ajcn/nqy204_bib19) 2007; 31 McDonald (10.1093/ajcn/nqy204_bib24) 2012; 6 Ross (10.1093/ajcn/nqy204_bib17) 2016; 499 van der Kamp (10.1093/ajcn/nqy204_bib1) 2014; 58 Tchernof (10.1093/ajcn/nqy204_bib41) 2013; 93 Priebe (10.1093/ajcn/nqy204_bib4) 2008 Stefan (10.1093/ajcn/nqy204_bib12) 2011; 60 Giacco (10.1093/ajcn/nqy204_bib11) 2010; 20 Wang (10.1093/ajcn/nqy204_bib34) 2016; 6 Fardet (10.1093/ajcn/nqy204_bib38) 2013; 53 David (10.1093/ajcn/nqy204_bib37) 2014; 505 Kootte (10.1093/ajcn/nqy204_bib36) 2017; 26 Tighe (10.1093/ajcn/nqy204_bib10) 2010; 92 Kirwan (10.1093/ajcn/nqy204_bib8) 2016; 146 Ross (10.1093/ajcn/nqy204_bib27) 2013; 2013 Aune (10.1093/ajcn/nqy204_bib5) 2016; 353 Wopereis (10.1093/ajcn/nqy204_bib16) 2017; 12 Laddomada (10.1093/ajcn/nqy204_bib45) 2015; 20 Naressi (10.1093/ajcn/nqy204_bib18) 2001; 31 Vetrani (10.1093/ajcn/nqy204_bib32) 2016; 32 Sun (10.1093/ajcn/nqy204_bib20) 2013; 18 McMurdie (10.1093/ajcn/nqy204_bib25) 2013; 8 Pereira (10.1093/ajcn/nqy204_bib13) 2002; 75 Andersson (10.1093/ajcn/nqy204_bib48) 2007; 137 Szczepaniak (10.1093/ajcn/nqy204_bib26) 2005; 288 Mollica (10.1093/ajcn/nqy204_bib30) 2017; 66 Anderson (10.1093/ajcn/nqy204_bib14) 1991; 87 Wang (10.1093/ajcn/nqy204_bib23) 2007; 73 Helnaes (10.1093/ajcn/nqy204_bib6) 2016; 103 Hollaender (10.1093/ajcn/nqy204_bib9) 2015; 102 Caporaso (10.1093/ajcn/nqy204_bib21) 2011; 108 Suppl 1 Wu (10.1093/ajcn/nqy204_bib7) 2015; 175 Priebe (10.1093/ajcn/nqy204_bib46) 2010; 91 Hu (10.1093/ajcn/nqy204_bib29) 2010; 74 Korem (10.1093/ajcn/nqy204_bib35) 2017; 25 Lee (10.1093/ajcn/nqy204_bib44) 2015; 18 McKeown (10.1093/ajcn/nqy204_bib3) 2010; 92 Item (10.1093/ajcn/nqy204_bib42) 2012; 13 Suppl 2 Bickerton (10.1093/ajcn/nqy204_bib40) 2007; 56 30541092 - Am J Clin Nutr. 2018 Dec 1;108(6):1162-1163 |
| References_xml | – volume: 92 start-page: 733 year: 2010 end-page: 740 ident: bib10 article-title: Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial publication-title: Am J Clin Nutr – volume: 6 start-page: 32002 year: 2016 ident: bib34 article-title: Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease publication-title: Sci Rep – volume: 13 Suppl 2 start-page: 30 year: 2012 end-page: 39 ident: bib42 article-title: Visceral fat and metabolic inflammation: the portal theory revisited publication-title: Obes Rev – volume: 102 start-page: 556 year: 2015 end-page: 572 ident: bib9 article-title: Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies publication-title: Am J Clin Nutr – volume: 103 start-page: 999 year: 2016 end-page: 1007 ident: bib6 article-title: Intake of whole grains is associated with lower risk of myocardial infarction: the Danish Diet, Cancer and Health Cohort publication-title: Am J Clin Nutr – volume: 31 start-page: 285 year: 2007 end-page: 291 ident: bib19 article-title: Validity of a new automated software program for visceral adipose tissue estimation publication-title: Int J Obes – volume: 8 start-page: e61217 year: 2013 ident: bib25 article-title: phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data publication-title: PLoS One – volume: 73 start-page: 5261 year: 2007 end-page: 5267 ident: bib23 article-title: Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy publication-title: Appl Environ Microbiol – volume: 66 start-page: 1405 year: 2017 end-page: 1418 ident: bib30 article-title: Butyrate regulates liver mitochondrial function, efficiency, and dynamic, in insulin resistant obese mice publication-title: Diabetes – volume: 105 start-page: 635 year: 2017 end-page: 650 ident: bib33 article-title: Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults publication-title: Am J Clin Nutr – volume: 108 Suppl 1 start-page: 4516 year: 2011 end-page: 4522 ident: bib21 article-title: Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample publication-title: Proc Natl Aacad Sci U S A – volume: 101 start-page: 251 year: 2015 end-page: 261 ident: bib49 article-title: Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber publication-title: Am J Clin Nutr – volume: 175 start-page: 373 year: 2015 end-page: 384 ident: bib7 article-title: Association between dietary whole grain intake and risk of mortality: two large prospective studies in US men and women publication-title: JAMA Intern Med – volume: 26 start-page: 611 year: 2017 end-page: 619 ident: bib36 article-title: Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition publication-title: Cell Metab – volume: 93 start-page: 359 year: 2013 end-page: 404 ident: bib41 article-title: Pathophysiology of human visceral obesity: an update publication-title: Physiol Rev – volume: 137 start-page: 1401 year: 2007 end-page: 1407 ident: bib48 article-title: Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects publication-title: J Nutr – volume: 1 start-page: 433 year: 2010 end-page: 437 ident: bib47 article-title: The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes publication-title: Benef Microbes – volume: 58 start-page: 22100 year: 2014 ident: bib1 article-title: The HEALTHGRAIN definition of ‘whole grain’ publication-title: Food Nutr Res – volume: 53 start-page: 535 year: 2013 end-page: 590 ident: bib38 article-title: Plant-based foods as a source of lipotropes for human nutrition: a survey of in vivo studies publication-title: Crit Rev Food Sci Nutr – volume: 28 start-page: 657 year: 2009 end-page: 661 ident: bib31 article-title: Short chain fatty acids exchange across the gut and liver in humans measured at surgery publication-title: Clin Nutr – volume: 20 start-page: 15666 year: 2015 end-page: 15685 ident: bib45 article-title: Wheat bran phenolic acids: bioavailability and stability in whole wheat-based foods publication-title: Molecules – start-page: CD006061 year: 2008 ident: bib4 article-title: Whole grain foods for the prevention of type 2 diabetes mellitus publication-title: Cochrane Database Syst Rev – volume: 288 start-page: E462 year: 2005 end-page: E468 ident: bib26 article-title: Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population publication-title: Am J Physiol Endocrinol Metab – volume: 505 start-page: 559 year: 2014 end-page: 563 ident: bib37 article-title: Diet rapidly and reproducibly alters the human gut microbiome publication-title: Nature – volume: 74 start-page: 123 year: 2010 end-page: 126 ident: bib29 article-title: Activation of the AMP activated protein kinase by short-chain fatty acids is the main mechanism underlying the beneficial effect of a high fiber diet on the metabolic syndrome publication-title: Med Hypotheses – volume: 6 start-page: 610 year: 2012 end-page: 618 ident: bib24 article-title: An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea publication-title: ISME J – volume: 87 start-page: 2246 year: 1991 end-page: 2252 ident: bib14 article-title: Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans publication-title: J Clin Invest – volume: 60 start-page: 2011 year: 2011 end-page: 2017 ident: bib12 article-title: The metabolically benign and malignant fatty liver publication-title: Diabetes – volume: 75 start-page: 848 year: 2002 end-page: 855 ident: bib13 article-title: Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults publication-title: Am J Clin Nutr – volume: 25 start-page: 1243 year: 2017 end-page: 1253 ident: bib35 article-title: Bread affects clinical parameters and induces gut microbiome-associated personal glycemic responses publication-title: Cell Metab – volume: 56 start-page: 168 year: 2007 end-page: 176 ident: bib40 article-title: Preferential uptake of dietary fatty acids in adipose tissue and muscle in the postprandial period publication-title: Diabetes – volume: 353 start-page: i2716 year: 2016 ident: bib5 article-title: Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies publication-title: BMJ – volume: 146 start-page: 2244 year: 2016 end-page: 2251 ident: bib8 article-title: A whole-grain diet reduces cardiovascular risk factors in overweight and obese adults: a randomized controlled trial publication-title: J Nutr – volume: 4 start-page: 178 year: 2015 end-page: 202 ident: bib2 article-title: The contribution of wheat to human diet and health publication-title: Food Energy Secur – volume: 20 start-page: 186 year: 2010 end-page: 194 ident: bib11 article-title: Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people publication-title: Nutr Metab Cardiovasc Dis – volume: 23 start-page: 65 year: 2010 end-page: 134 ident: bib39 article-title: New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? publication-title: Nutr Res Rev – volume: 2013 start-page: 585876 year: 2013 ident: bib27 article-title: Increasing whole grain intake as part of prevention and treatment of nonalcoholic fatty liver disease publication-title: Int J Endocrinol – volume: 64 start-page: 2398 year: 2015 end-page: 2408 ident: bib28 article-title: Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARgamma-dependent switch from lipogenesis to fat oxidation publication-title: Diabetes – volume: 31 start-page: 269 year: 2001 end-page: 286 ident: bib18 article-title: Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals publication-title: Comput Biol Med – volume: 91 start-page: 90 year: 2010 end-page: 97 ident: bib46 article-title: Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation publication-title: Am J Clin Nutr – volume: 18 start-page: 470 year: 2013 end-page: 477 ident: bib20 article-title: Fibrosis and adipose tissue dysfunction publication-title: Cell Metab – volume: 75 start-page: 7537 year: 2009 end-page: 7541 ident: bib22 article-title: Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities publication-title: Appl Environ Microbiol – volume: 1801 start-page: 338 year: 2010 end-page: 349 ident: bib43 article-title: Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome–an allostatic perspective publication-title: Biochim Biophys Acta – volume: 12 start-page: 21 year: 2017 ident: bib16 article-title: Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge publication-title: Genes Nutr – volume: 92 start-page: 1165 year: 2010 end-page: 1171 ident: bib3 article-title: Whole- and refined-grain intakes are differentially associated with abdominal visceral and subcutaneous adiposity in healthy adults: the Framingham Heart Study publication-title: Am J Clin Nutr – volume: 32 start-page: 217 year: 2016 end-page: 221 ident: bib32 article-title: Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome publication-title: Nutrition – volume: 499 start-page: 1 year: 2016 end-page: 7 ident: bib17 article-title: A high-throughput method for liquid chromatography-tandem mass spectrometry determination of plasma alkylresorcinols, biomarkers of whole grain wheat and rye intake publication-title: Anal Biochem – volume: 18 start-page: 1179 year: 2015 end-page: 1186 ident: bib44 article-title: Bioactives in commonly consumed cereal grains: implications for oxidative stress and inflammation publication-title: J Med Food – volume: 22 start-page: 704 year: 2012 end-page: 711 ident: bib15 article-title: Whole grain wheat sourdough bread does not affect plasminogen activator inhibitor-1 in adults with normal or impaired carbohydrate metabolism publication-title: Nutr Metab Cardiovasc Dis – volume: 20 start-page: 186 year: 2010 ident: 10.1093/ajcn/nqy204_bib11 article-title: Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2009.03.025 – volume: 87 start-page: 2246 year: 1991 ident: 10.1093/ajcn/nqy204_bib14 article-title: Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans publication-title: J Clin Invest doi: 10.1172/JCI115260 – volume: 22 start-page: 704 year: 2012 ident: 10.1093/ajcn/nqy204_bib15 article-title: Whole grain wheat sourdough bread does not affect plasminogen activator inhibitor-1 in adults with normal or impaired carbohydrate metabolism publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2010.10.018 – volume: 137 start-page: 1401 year: 2007 ident: 10.1093/ajcn/nqy204_bib48 article-title: Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects publication-title: J Nutr doi: 10.1093/jn/137.6.1401 – volume: 6 start-page: 32002 year: 2016 ident: 10.1093/ajcn/nqy204_bib34 article-title: Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease publication-title: Sci Rep doi: 10.1038/srep32002 – volume: 1 start-page: 433 year: 2010 ident: 10.1093/ajcn/nqy204_bib47 article-title: The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes publication-title: Benef Microbes doi: 10.3920/BM2010.0028 – volume: 505 start-page: 559 year: 2014 ident: 10.1093/ajcn/nqy204_bib37 article-title: Diet rapidly and reproducibly alters the human gut microbiome publication-title: Nature doi: 10.1038/nature12820 – volume: 8 start-page: e61217 year: 2013 ident: 10.1093/ajcn/nqy204_bib25 article-title: phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data publication-title: PLoS One doi: 10.1371/journal.pone.0061217 – volume: 26 start-page: 611 year: 2017 ident: 10.1093/ajcn/nqy204_bib36 article-title: Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition publication-title: Cell Metab doi: 10.1016/j.cmet.2017.09.008 – volume: 103 start-page: 999 year: 2016 ident: 10.1093/ajcn/nqy204_bib6 article-title: Intake of whole grains is associated with lower risk of myocardial infarction: the Danish Diet, Cancer and Health Cohort publication-title: Am J Clin Nutr doi: 10.3945/ajcn.115.124271 – volume: 91 start-page: 90 year: 2010 ident: 10.1093/ajcn/nqy204_bib46 article-title: Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation publication-title: Am J Clin Nutr doi: 10.3945/ajcn.2009.28521 – volume: 499 start-page: 1 year: 2016 ident: 10.1093/ajcn/nqy204_bib17 article-title: A high-throughput method for liquid chromatography-tandem mass spectrometry determination of plasma alkylresorcinols, biomarkers of whole grain wheat and rye intake publication-title: Anal Biochem doi: 10.1016/j.ab.2015.12.023 – volume: 31 start-page: 285 year: 2007 ident: 10.1093/ajcn/nqy204_bib19 article-title: Validity of a new automated software program for visceral adipose tissue estimation publication-title: Int J Obes doi: 10.1038/sj.ijo.0803409 – volume: 18 start-page: 1179 year: 2015 ident: 10.1093/ajcn/nqy204_bib44 article-title: Bioactives in commonly consumed cereal grains: implications for oxidative stress and inflammation publication-title: J Med Food doi: 10.1089/jmf.2014.3394 – volume: 4 start-page: 178 year: 2015 ident: 10.1093/ajcn/nqy204_bib2 article-title: The contribution of wheat to human diet and health publication-title: Food Energy Secur doi: 10.1002/fes3.64 – volume: 75 start-page: 848 year: 2002 ident: 10.1093/ajcn/nqy204_bib13 article-title: Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults publication-title: Am J Clin Nutr doi: 10.1093/ajcn/75.5.848 – volume: 93 start-page: 359 year: 2013 ident: 10.1093/ajcn/nqy204_bib41 article-title: Pathophysiology of human visceral obesity: an update publication-title: Physiol Rev doi: 10.1152/physrev.00033.2011 – volume: 146 start-page: 2244 year: 2016 ident: 10.1093/ajcn/nqy204_bib8 article-title: A whole-grain diet reduces cardiovascular risk factors in overweight and obese adults: a randomized controlled trial publication-title: J Nutr doi: 10.3945/jn.116.230508 – volume: 31 start-page: 269 year: 2001 ident: 10.1093/ajcn/nqy204_bib18 article-title: Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals publication-title: Comput Biol Med doi: 10.1016/S0010-4825(01)00006-3 – volume: 28 start-page: 657 year: 2009 ident: 10.1093/ajcn/nqy204_bib31 article-title: Short chain fatty acids exchange across the gut and liver in humans measured at surgery publication-title: Clin Nutr doi: 10.1016/j.clnu.2009.05.011 – volume: 25 start-page: 1243 year: 2017 ident: 10.1093/ajcn/nqy204_bib35 article-title: Bread affects clinical parameters and induces gut microbiome-associated personal glycemic responses publication-title: Cell Metab doi: 10.1016/j.cmet.2017.05.002 – volume: 108 Suppl 1 start-page: 4516 year: 2011 ident: 10.1093/ajcn/nqy204_bib21 article-title: Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample publication-title: Proc Natl Aacad Sci U S A doi: 10.1073/pnas.1000080107 – volume: 20 start-page: 15666 year: 2015 ident: 10.1093/ajcn/nqy204_bib45 article-title: Wheat bran phenolic acids: bioavailability and stability in whole wheat-based foods publication-title: Molecules doi: 10.3390/molecules200915666 – volume: 64 start-page: 2398 year: 2015 ident: 10.1093/ajcn/nqy204_bib28 article-title: Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARgamma-dependent switch from lipogenesis to fat oxidation publication-title: Diabetes doi: 10.2337/db14-1213 – volume: 92 start-page: 1165 year: 2010 ident: 10.1093/ajcn/nqy204_bib3 article-title: Whole- and refined-grain intakes are differentially associated with abdominal visceral and subcutaneous adiposity in healthy adults: the Framingham Heart Study publication-title: Am J Clin Nutr doi: 10.3945/ajcn.2009.29106 – volume: 13 Suppl 2 start-page: 30 year: 2012 ident: 10.1093/ajcn/nqy204_bib42 article-title: Visceral fat and metabolic inflammation: the portal theory revisited publication-title: Obes Rev doi: 10.1111/j.1467-789X.2012.01035.x – volume: 75 start-page: 7537 year: 2009 ident: 10.1093/ajcn/nqy204_bib22 article-title: Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities publication-title: Appl Environ Microbiol doi: 10.1128/AEM.01541-09 – volume: 175 start-page: 373 year: 2015 ident: 10.1093/ajcn/nqy204_bib7 article-title: Association between dietary whole grain intake and risk of mortality: two large prospective studies in US men and women publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2014.6283 – volume: 353 start-page: i2716 year: 2016 ident: 10.1093/ajcn/nqy204_bib5 article-title: Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies publication-title: BMJ doi: 10.1136/bmj.i2716 – volume: 32 start-page: 217 year: 2016 ident: 10.1093/ajcn/nqy204_bib32 article-title: Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome publication-title: Nutrition doi: 10.1016/j.nut.2015.08.006 – start-page: CD006061 year: 2008 ident: 10.1093/ajcn/nqy204_bib4 article-title: Whole grain foods for the prevention of type 2 diabetes mellitus publication-title: Cochrane Database Syst Rev – volume: 73 start-page: 5261 year: 2007 ident: 10.1093/ajcn/nqy204_bib23 article-title: Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy publication-title: Appl Environ Microbiol doi: 10.1128/AEM.00062-07 – volume: 18 start-page: 470 year: 2013 ident: 10.1093/ajcn/nqy204_bib20 article-title: Fibrosis and adipose tissue dysfunction publication-title: Cell Metab doi: 10.1016/j.cmet.2013.06.016 – volume: 92 start-page: 733 year: 2010 ident: 10.1093/ajcn/nqy204_bib10 article-title: Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial publication-title: Am J Clin Nutr doi: 10.3945/ajcn.2010.29417 – volume: 58 start-page: 22100 year: 2014 ident: 10.1093/ajcn/nqy204_bib1 article-title: The HEALTHGRAIN definition of ‘whole grain’ publication-title: Food Nutr Res doi: 10.3402/fnr.v58.22100 – volume: 60 start-page: 2011 year: 2011 ident: 10.1093/ajcn/nqy204_bib12 article-title: The metabolically benign and malignant fatty liver publication-title: Diabetes doi: 10.2337/db11-0231 – volume: 53 start-page: 535 year: 2013 ident: 10.1093/ajcn/nqy204_bib38 article-title: Plant-based foods as a source of lipotropes for human nutrition: a survey of in vivo studies publication-title: Crit Rev Food Sci Nutr doi: 10.1080/10408398.2010.549596 – volume: 288 start-page: E462 year: 2005 ident: 10.1093/ajcn/nqy204_bib26 article-title: Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00064.2004 – volume: 23 start-page: 65 year: 2010 ident: 10.1093/ajcn/nqy204_bib39 article-title: New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? publication-title: Nutr Res Rev doi: 10.1017/S0954422410000041 – volume: 56 start-page: 168 year: 2007 ident: 10.1093/ajcn/nqy204_bib40 article-title: Preferential uptake of dietary fatty acids in adipose tissue and muscle in the postprandial period publication-title: Diabetes doi: 10.2337/db06-0822 – volume: 12 start-page: 21 year: 2017 ident: 10.1093/ajcn/nqy204_bib16 article-title: Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge publication-title: Genes Nutr doi: 10.1186/s12263-017-0570-6 – volume: 6 start-page: 610 year: 2012 ident: 10.1093/ajcn/nqy204_bib24 article-title: An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea publication-title: ISME J doi: 10.1038/ismej.2011.139 – volume: 66 start-page: 1405 year: 2017 ident: 10.1093/ajcn/nqy204_bib30 article-title: Butyrate regulates liver mitochondrial function, efficiency, and dynamic, in insulin resistant obese mice publication-title: Diabetes doi: 10.2337/db16-0924 – volume: 2013 start-page: 585876 year: 2013 ident: 10.1093/ajcn/nqy204_bib27 article-title: Increasing whole grain intake as part of prevention and treatment of nonalcoholic fatty liver disease publication-title: Int J Endocrinol doi: 10.1155/2013/585876 – volume: 1801 start-page: 338 year: 2010 ident: 10.1093/ajcn/nqy204_bib43 article-title: Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome–an allostatic perspective publication-title: Biochim Biophys Acta doi: 10.1016/j.bbalip.2009.12.006 – volume: 102 start-page: 556 year: 2015 ident: 10.1093/ajcn/nqy204_bib9 article-title: Whole-grain and blood lipid changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies publication-title: Am J Clin Nutr doi: 10.3945/ajcn.115.109165 – volume: 74 start-page: 123 year: 2010 ident: 10.1093/ajcn/nqy204_bib29 article-title: Activation of the AMP activated protein kinase by short-chain fatty acids is the main mechanism underlying the beneficial effect of a high fiber diet on the metabolic syndrome publication-title: Med Hypotheses doi: 10.1016/j.mehy.2009.07.022 – volume: 101 start-page: 251 year: 2015 ident: 10.1093/ajcn/nqy204_bib49 article-title: Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber publication-title: Am J Clin Nutr doi: 10.3945/ajcn.114.088120 – volume: 105 start-page: 635 year: 2017 ident: 10.1093/ajcn/nqy204_bib33 article-title: Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults publication-title: Am J Clin Nutr doi: 10.3945/ajcn.116.146928 – reference: 30541092 - Am J Clin Nutr. 2018 Dec 1;108(6):1162-1163 |
| SSID | ssj0012486 |
| Score | 2.508218 |
| Snippet | Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from... ABSTRACT Background Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although... Background: Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence... |
| SourceID | wageningen unpaywall proquest pubmed crossref oup elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1264 |
| SubjectTerms | Acute phase proteins Adipocytes Adipose tissue Adipose Tissue - metabolism adipose tissue health Adiposity Aged Amyloid blood lipids blood serum Body Composition Body mass index Body weight C-reactive protein Chair Nutrition Metabolism and Genomics Cholesterol Composition Consumer Science & Health Design parameters Diet Dietary Fiber - administration & dosage dietary intervention Double-Blind Method Energy metabolism Fasting Fatty acids Fatty liver Fatty Liver - etiology Fatty Liver - prevention & control FBR Consumer Science & Health Fecal microflora Feces - microbiology Female Food Handling - methods Food, Health & Consumer Research free fatty acids Gastrointestinal Microbiome - physiology Gene expression Grain HNE Nutrition, Metabolism and Genomics HNE Voeding, Metabolisme en Genomics Humans Insulin Intervention Intestinal microflora intestinal microorganisms Lipid Metabolism - physiology Lipids Liver Liver - metabolism Liver diseases Magnetic resonance imaging Magnetic resonance spectroscopy Male men Metabolism Microbiota Middle Aged mixed-meal challenge test NAFLD Netherlands nuclear magnetic resonance spectroscopy Nutrition, Metabolism and Genomics Overweight Overweight - complications Overweight - diet therapy Overweight - metabolism overweight/obesity Post-menopause Postmenopause Proteins Proton magnetic resonance refined wheat steatosis triacylglycerols Triglycerides Triglycerides - metabolism Triticum VLAG Voeding, Metabolisme en Genomica Weight control Wheat whole grain foods whole grain wheat Whole Grains women |
| Title | A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects |
| URI | https://dx.doi.org/10.1093/ajcn/nqy204 https://www.ncbi.nlm.nih.gov/pubmed/30541093 https://www.proquest.com/docview/2161054651 https://www.proquest.com/docview/2155925977 https://www.proquest.com/docview/2352428791 https://academic.oup.com/ajcn/article-pdf/108/6/1264/28887140/nqy204.pdf http://www.narcis.nl/publication/RecordID/oai:library.wur.nl:wurpubs%2F546009 |
| UnpaywallVersion | publishedVersion |
| Volume | 108 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1938-3207 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0012486 issn: 0002-9165 databaseCode: KQ8 dateStart: 19990101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1938-3207 dateEnd: 20241103 omitProxy: true ssIdentifier: ssj0012486 issn: 0002-9165 databaseCode: DIK dateStart: 19990101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1938-3207 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0012486 issn: 0002-9165 databaseCode: GX1 dateStart: 0 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1938-3207 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0012486 issn: 0002-9165 databaseCode: AKRWK dateStart: 19960101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdGK8H2wMf4KoxhJOABkTR1PprwVgGjYlqFEBXbk2U7zigrSWkSVdszfzh3tVMKGhUPPCVSLhfHufh-tu9-R8hT1Q8kAAnhiDDRThBI5shEx46M0yQFExO-wkTho1E0HAfvj8PjLTJscmGEjQp3m5QG8VXlXduLzizNuli3Jur2wJF3GUzfkHCum38_Z17gwuUrpB2FgMpbpD0efRicNOgXUFBoNphjx2de36bqwXzePMFo-Jtz-i33bQ2C7pBrdT4T5wsxne6Q7QUMAfkyJ2rNRx3cIJPm7UxoyplbV9JVF38QP_6P179JrlsgSwfmpltkS-e7pPNmoiv6nFq20SkdNWT_u-Tqkd3Gv01-DChWOjmjC6zO65ximQo4B7dAJ2sxmNSSSJRUnIJEWdEvGgPAFc1E9YoCdKXv5gLzcoqipEui3JdUUPC-afFtcqFTuqxJAjppsYz_xoUIWtYS157KO2R88PbT66Fjy0E4CkBX5Qgv9bM0ypK0JwFYsKCfSh0qpgIpMhb6kfKEyuDrpwppEj0fjqEnPB3LWAsh_LuklRe5vk-oiFQWYLkkpr1ABJmEnpQhkz3FkjATUYe8aOyAK8uVjiU7ptzs2fscvws3_d4Bi2-EZ4Yi5HIxtzEobtGNQS0cnNflNzwGK9iscq8xSW6HnpIz-PW8ZYn7DnmyugyDBu4EiVwXNcrARJIh9eAGGYDmOJ9OQM89Y-6rtoCTCLAxHfJsZf-bG-r_-jd4jlWySo7E5napki_qOc-neIAnlRyaD9j_wT9qf0i2AcbGJshoj7Sqea0fAVSs5D5pDw4_fj7ct6PBT63kbbU |
| linkProvider | Unpaywall |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdGJ8H2wMf4KgwwEvCASJo6TprwVgGjQlrFA5XGk3V2nFFWktIkqrZn_nDOtVMKGhUPPCVSLhfHufh-tu9-R8gzNeASgQR4EKXa41wyT6Y68WSSpRmaGITKJAofj-PRhH84iU52yKjNhQEXFe63KQ3wVRU914vePMt7pm5N3OujI-8xnL4Zwrle8f2cBdzHy1fIbhwhKu-Q3cn44_Bzi34RBUV2gznxQhYMXKoezuftE6yGvzmn33LfNiDoPrnWFHM4X8Jstk_2ljgEFKucqA0fdXSDTNu3s6EpZ35TS19d_EH8-D9e_ya57oAsHdqbbpEdXRyQ7tuprukL6thGZ3Tckv0fkKvHbhv_NvkxpKbSyRldmuq83qkpU4Hn6BbodCMGkzoSiYrCKUpUNf2iTQC4ojnUrylCV_p-ASYvpywruiLKfUWBovfNym_TC53RVU0S1EnLVfy3WYigVSPN2lN1h0yO3n16M_JcOQhPIeiqPQiyMM_iPM36EoEF44NM6kgxxSXkLApjFYDK8etnytAkBiEeowACnchEA0B4l3SKstD3CYVY5dyUS2I64MBziT0pIyb7iqVRDnGXvGztQCjHlW5KdsyE3bMPhfkuwvZ7Fy2-FZ5bipDLxfzWoIRDNxa1CHRel9_wBK1gu8rD1iSFG3oqwfDXC1Yl7rvk6foyDhpmJwgKXTZGBieSzFAPbpFBaG7m0ynquWfNfd0WdBLcNKZLnq_tf3tDw1__hihMlaxKGGJzt1Qpls1CFDNzwCdVApuP2P_BP2p_SPYQxiY2yOiQdOpFox8hVKzlYzcK_ARIIWwS |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+12-wk+whole-grain+wheat+intervention+protects+against+hepatic+fat%3A+the+Graandioos+study%2C+a+randomized+trial+in+overweight+subjects&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.au=Schutte%2C+Sophie&rft.au=Esser%2C+Diederik&rft.au=Hoevenaars%2C+Femke+P+M&rft.au=Hooiveld%2C+Guido+J+E+J&rft.date=2018-12-01&rft.eissn=1938-3207&rft.volume=108&rft.issue=6&rft.spage=1264&rft_id=info:doi/10.1093%2Fajcn%2Fnqy204&rft_id=info%3Apmid%2F30541093&rft.externalDocID=30541093 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9165&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9165&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9165&client=summon |