Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans

Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present stu...

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Published inBiomedical Research Vol. 28; no. 2; pp. 85 - 90
Main Authors MIWA, Kiyoshi, SMRIGA, Miro, MORINAGA, Yasushi, FURUKAWA, Yasushi, ANDO, Toshihiko, AKUTSU, Masahisa
Format Journal Article
LanguageEnglish
Published Japan Biomedical Research Press 01.04.2007
Japan Science and Technology Agency
Subjects
Online AccessGet full text
ISSN0388-6107
1880-313X
1880-313X
DOI10.2220/biomedres.28.85

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Abstract Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.
AbstractList Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.
Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.
Author MORINAGA, Yasushi
ANDO, Toshihiko
SMRIGA, Miro
FURUKAWA, Yasushi
MIWA, Kiyoshi
AKUTSU, Masahisa
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  fullname: ANDO, Toshihiko
  organization: Institute of Life Sciences, Ajinomoto Co., Inc
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  fullname: AKUTSU, Masahisa
  organization: Wellness Promotion Center, Ajinomoto Co., Inc
BackLink https://www.ncbi.nlm.nih.gov/pubmed/17510493$$D View this record in MEDLINE/PubMed
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References_xml – reference: 31. Smriga M and Torii K (2003) Prolonged treatment with L-lysine and L-arginine reduces stress-induced anxiety in an elevated plus maze. Nutr Neurosci 6, 125-128.
– reference: 1. Banderet LE and Lieberman HR (1989) Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull 22, 759-762.
– reference: 27. Saruta J, Tsukinoki K, Sasaguri K, Ishii H, Yasuda M, Osamura YR and Watanabe Y (2005) Expression and localization of chromogranin A gene and protein in human submandibular gland. Cell Tissues Organs 180, 237-244.
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– reference: 26. Sato F, Kanno T, Nagasawa S, Yanaihara N, Ishida N, Hasegawa T and Iwanaga T (2002) Immunohistochemical localization of chromogranin A in the acinar cells of equine salivary glands contrasts with rodent glands. Cells Tissues Organs 172, 29-36.
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Snippet Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A...
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SubjectTerms Administration, Oral
Adult
Anti-Anxiety Agents - pharmacology
Anxiety - blood
Anxiety - drug therapy
Arginine - pharmacology
Chromogranin A - metabolism
Double-Blind Method
Female
Humans
Hydrocortisone - metabolism
Lysine - pharmacology
Male
Middle Aged
Placebos
Time Factors
Title Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans
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