Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non–ST-segment elevation myocardial infarction: The TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial - Chin, Chee Tang; Roe, Matthew T.; Fox, Keith A.A.; Prabhakaran, Dorairaj; Marshall, Debra A.; Petitjean, Helene; Lokhnygina, Yuliya; Brown, Eileen; Armstrong, Paul W.; White, Harvey D.; Ohman, E. Magnus (The American heart journal, 2010)
Keywords: Acute coronary syndromes; Administration, Oral; Aged; Angina, Unstable - drug therapy; Angina, Unstable - mortality; Angina, Unstable - physiopathology; Anticoagulants; Aspirin; Biological and medical sciences; Blood platelets; Cardiology. Vascular system; Cardiovascular; Coronary heart disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug dosages; Drug therapy; Drug Therapy, Combination; Electrocardiography; Feedback; Follow-Up Studies; Global Health; Heart; Heart attacks; Humans; Medical imaging; Medical sciences; Middle Aged; Mortality; Myocardial Infarction - drug therapy; Myocardial Infarction - mortality; Myocardial Infarction - physiopathology; Myocarditis. Cardiomyopathies; Nonsteroidal anti-inflammatory drugs; Piperazines - administration & dosage; Piperazines - therapeutic use; Platelet Aggregation Inhibitors - therapeutic use; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Survival Rate; Thiophenes - administration & dosage; Thiophenes - therapeutic use; Thrombosis; Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; Time Factors; Treatment Outcome; Human; Myocardial infarction; Patient; Cardiovascular disease; Coronary heart disease; Myocardial disease; Antiplatelet agent; Design; Prasugrel; ST elevation; Optimal strategy; Platelet; Clopidogrel; Circulatory system; Inhibition; Cardiology; Acute coronary syndrome; Variant angina; Comparative study