The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats - Lee, In-Chul; Kim, Sung-Hwan; Baek, Hyung-Seon; Moon, Changjong; Kang, Seong-Soo; Kim, Sung-Ho; Kim, Yun-Bae; Shin, In-Sik; Kim, Jong-Choon (Food and chemical toxicology, 2014)
Keywords: Allyl Compounds - pharmacology; Animals; antioxidant activity; antioxidants; apoptosis; Apoptosis - drug effects; Base Sequence; Biological and medical sciences; blood serum; Blotting, Western; Carbon tetrachloride; Carbon Tetrachloride - toxicity; Caspase 3 - metabolism; caspase-3; cytochrome c; cytokines; Diallyl disulfide; Disulfides - pharmacology; DNA Primers; enzyme activity; Glutathione - metabolism; Hepatotoxicity; histopathology; IKappaB kinase; inflammation; Inflammation - prevention & control; liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; Medical sciences; NF-E2-Related Factor 2 - physiology; NF-kappa B - metabolism; Nuclear factor E2-related factor 2; Nuclear factor kappaB; oral administration; Oxidative Stress - drug effects; Phosphorylation; protective effect; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Toxicology; transcription factor NF-kappa B; CYPs; Carbon tetrachloride; ALT; HO-1; MDA; NF-κB; DADS; TUNEL; ANOVA; Nrf2; RT-PCR; iNOS; GSH; Hepatotoxicity; NQO1; AST; Diallyl disulfide; H&E; GSTα; IKK; SOD; GR; IL-1β; GPx; IL-6; IκBα; ARE; TNF-α; Cox-2; p-IκBα; CCl4; ROS; Bax; Keap1; GAPDH; Nuclear factor E2-related factor 2; Nuclear factor kappaB; Oxidative stress; Rat; Toxicity; Liver; Rodentia; Hepatic disease; Inflammation; Organic sulfide; Prevention; Vertebrata; Mammalia; Carbon disulfide; Animal; Digestive diseases; Garlic; Transcription factor; Mechanism of action; cyclooxygenase-2