A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3‐WG1C: Phenotyping working group of the ILAE/AES joint translational task force

Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar...

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Published inEpilepsia open Vol. 10; no. S1; pp. S87 - S111
Main Authors Barker‐Haliski, Melissa, Pitsch, Julika, Galanopoulou, Aristea S., Köhling, Rüdiger
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.08.2025
John Wiley and Sons Inc
Wiley
Subjects
Advisory Committees
Animals
Behavior
Case reports
Chronic illnesses
Convulsions & seizures
Diagnostic tests
Disease Models, Animal
Electroencephalography
Epilepsy
Epilepsy - diagnosis
Epilepsy - physiopathology
Hypothesis testing
Infections
Investigations
Laboratories
Mice
Phenotype
preclinical models
Rats
Reproducibility
Rodents
seizure monitoring
seizure semiology
Seizures - diagnosis
Seizures - physiopathology
Special Report
Task forces
Translational Research, Biomedical - methods
Viral infections
Working groups
electroencephalography
preclinical models
seizure semiology
seizure monitoring
Online AccessGet full text
ISSN2470-9239
2470-9239
DOI10.1002/epi4.12676

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Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events. Preclinical seizure and epilepsy models can be evoked through many different protocols, leaving the phenotypic reporting subject to diverse interpretations. Serendipity can also play an outsized role in uncovering novel drivers of seizures or epilepsy, with some investigators even stumbling into epilepsy research because of a new genetic cross or unintentional drug effect. The heightened emphasis on rigor and reproducibility in preclinical research, including that which is conducted for epilepsy, underscores the need for standardized phenotyping strategies. To address this goal as part of the TASK3‐WG1C Working Group of the International League Against Epilepsy (ILAE)/American Epilepsy Society (AES) Joint Translational Task Force, we developed a case report form (CRF) to describe the common data elements (CDEs) necessary for the phenotyping of seizure‐like behaviors in rodents. This companion manuscript describes the use of the proposed CDEs and CRF for the visual, behavioral phenotyping of seizure‐like behaviors. These phenotyping CDEs and accompanying CRF can be used in parallel with video‐electroencephalography (EEG) studies or as a first visual screen to determine whether a model manifests seizure‐like behaviors before utilizing more specialized diagnostic tests, like video‐EEG. Systematic logging of seizure‐like behaviors may help identify models that could benefit from more specialized diagnostic tests to determine whether these are epileptic seizures, such as video‐EEG.
AbstractList Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events. Preclinical seizure and epilepsy models can be evoked through many different protocols, leaving the phenotypic reporting subject to diverse interpretations. Serendipity can also play an outsized role in uncovering novel drivers of seizures or epilepsy, with some investigators even stumbling into epilepsy research because of a new genetic cross or unintentional drug effect. The heightened emphasis on rigor and reproducibility in preclinical research, including that which is conducted for epilepsy, underscores the need for standardized phenotyping strategies. To address this goal as part of the TASK3-WG1C Working Group of the International League Against Epilepsy (ILAE)/American Epilepsy Society (AES) Joint Translational Task Force, we developed a case report form (CRF) to describe the common data elements (CDEs) necessary for the phenotyping of seizure-like behaviors in rodents. This companion manuscript describes the use of the proposed CDEs and CRF for the visual, behavioral phenotyping of seizure-like behaviors. These phenotyping CDEs and accompanying CRF can be used in parallel with video-electroencephalography (EEG) studies or as a first visual screen to determine whether a model manifests seizure-like behaviors before utilizing more specialized diagnostic tests, like video-EEG. Systematic logging of seizure-like behaviors may help identify models that could benefit from more specialized diagnostic tests to determine whether these are epileptic seizures, such as video-EEG.
Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events. Preclinical seizure and epilepsy models can be evoked through many different protocols, leaving the phenotypic reporting subject to diverse interpretations. Serendipity can also play an outsized role in uncovering novel drivers of seizures or epilepsy, with some investigators even stumbling into epilepsy research because of a new genetic cross or unintentional drug effect. The heightened emphasis on rigor and reproducibility in preclinical research, including that which is conducted for epilepsy, underscores the need for standardized phenotyping strategies. To address this goal as part of the TASK3‐WG1C Working Group of the International League Against Epilepsy (ILAE)/American Epilepsy Society (AES) Joint Translational Task Force, we developed a case report form (CRF) to describe the common data elements (CDEs) necessary for the phenotyping of seizure‐like behaviors in rodents. This companion manuscript describes the use of the proposed CDEs and CRF for the visual, behavioral phenotyping of seizure‐like behaviors. These phenotyping CDEs and accompanying CRF can be used in parallel with video‐electroencephalography (EEG) studies or as a first visual screen to determine whether a model manifests seizure‐like behaviors before utilizing more specialized diagnostic tests, like video‐EEG. Systematic logging of seizure‐like behaviors may help identify models that could benefit from more specialized diagnostic tests to determine whether these are epileptic seizures, such as video‐EEG.
Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events. Preclinical seizure and epilepsy models can be evoked through many different protocols, leaving the phenotypic reporting subject to diverse interpretations. Serendipity can also play an outsized role in uncovering novel drivers of seizures or epilepsy, with some investigators even stumbling into epilepsy research because of a new genetic cross or unintentional drug effect. The heightened emphasis on rigor and reproducibility in preclinical research, including that which is conducted for epilepsy, underscores the need for standardized phenotyping strategies. To address this goal as part of the TASK3-WG1C Working Group of the International League Against Epilepsy (ILAE)/American Epilepsy Society (AES) Joint Translational Task Force, we developed a case report form (CRF) to describe the common data elements (CDEs) necessary for the phenotyping of seizure-like behaviors in rodents. This companion manuscript describes the use of the proposed CDEs and CRF for the visual, behavioral phenotyping of seizure-like behaviors. These phenotyping CDEs and accompanying CRF can be used in parallel with video-electroencephalography (EEG) studies or as a first visual screen to determine whether a model manifests seizure-like behaviors before utilizing more specialized diagnostic tests, like video-EEG. Systematic logging of seizure-like behaviors may help identify models that could benefit from more specialized diagnostic tests to determine whether these are epileptic seizures, such as video-EEG.Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events. Preclinical seizure and epilepsy models can be evoked through many different protocols, leaving the phenotypic reporting subject to diverse interpretations. Serendipity can also play an outsized role in uncovering novel drivers of seizures or epilepsy, with some investigators even stumbling into epilepsy research because of a new genetic cross or unintentional drug effect. The heightened emphasis on rigor and reproducibility in preclinical research, including that which is conducted for epilepsy, underscores the need for standardized phenotyping strategies. To address this goal as part of the TASK3-WG1C Working Group of the International League Against Epilepsy (ILAE)/American Epilepsy Society (AES) Joint Translational Task Force, we developed a case report form (CRF) to describe the common data elements (CDEs) necessary for the phenotyping of seizure-like behaviors in rodents. This companion manuscript describes the use of the proposed CDEs and CRF for the visual, behavioral phenotyping of seizure-like behaviors. These phenotyping CDEs and accompanying CRF can be used in parallel with video-electroencephalography (EEG) studies or as a first visual screen to determine whether a model manifests seizure-like behaviors before utilizing more specialized diagnostic tests, like video-EEG. Systematic logging of seizure-like behaviors may help identify models that could benefit from more specialized diagnostic tests to determine whether these are epileptic seizures, such as video-EEG.
Author Köhling, Rüdiger
Barker‐Haliski, Melissa
Pitsch, Julika
Galanopoulou, Aristea S.
AuthorAffiliation 1 Department of Pharmacy, School of Pharmacy University of Washington Seattle Washington USA
3 Saul R. Korey Department of Neurology, Isabelle Rapin Division of Child Neurology, Laboratory of Developmental Epilepsy Albert Einstein College of Medicine Bronx New York USA
2 Department of Epileptology University Hospital Bonn Bonn Germany
4 Dominick P Purpura Department of Neuroscience, Isabelle Rapin Division of Child Neurology, Laboratory of Developmental Epilepsy Albert Einstein College of Medicine Bronx New York USA
5 Oscar‐Langendorff‐Institut für Physiologie Universitätsmedizin Rostock Rostock Germany
AuthorAffiliation_xml – name: 5 Oscar‐Langendorff‐Institut für Physiologie Universitätsmedizin Rostock Rostock Germany
– name: 2 Department of Epileptology University Hospital Bonn Bonn Germany
– name: 1 Department of Pharmacy, School of Pharmacy University of Washington Seattle Washington USA
– name: 4 Dominick P Purpura Department of Neuroscience, Isabelle Rapin Division of Child Neurology, Laboratory of Developmental Epilepsy Albert Einstein College of Medicine Bronx New York USA
– name: 3 Saul R. Korey Department of Neurology, Isabelle Rapin Division of Child Neurology, Laboratory of Developmental Epilepsy Albert Einstein College of Medicine Bronx New York USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36461665$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1002_epi4_13010
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Copyright 2022 The Authors. published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
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Issue S1
Keywords electroencephalography
preclinical models
seizure semiology
seizure monitoring
Language English
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SSID ssj0001921160
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Snippet Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy...
Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and...
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SubjectTerms Advisory Committees
Animals
Behavior
Case reports
Chronic illnesses
Convulsions & seizures
Diagnostic tests
Disease Models, Animal
Electroencephalography
Epilepsy
Epilepsy - diagnosis
Epilepsy - physiopathology
Hypothesis testing
Infections
Investigations
Laboratories
Mice
Phenotype
preclinical models
Rats
Reproducibility
Rodents
seizure monitoring
seizure semiology
Seizures - diagnosis
Seizures - physiopathology
Special Report
Task forces
Translational Research, Biomedical - methods
Viral infections
Working groups
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Title A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3‐WG1C: Phenotyping working group of the ILAE/AES joint translational task force
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