CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

• Published in: Aging cell Vol. 21; no. 4; pp. e13589 - n/a
• Main Authors: Peclat, Thais R., Thompson, Katie L., Warner, Gina M., Chini, Claudia C.S., Tarragó, Mariana G., Mazdeh, Delaram Z., Zhang, Chunlian, Zavala‐Solorio, Jose, Kolumam, Ganesh, Liang Wong, Yao, Cohen, Robert L., Chini, Eduardo N.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2022; John Wiley and Sons Inc
• Subjects: Adenine; ADP-ribosyl Cyclase 1 - metabolism; Aging; Aging - metabolism; Animals; Body composition; CD38; CD38 antigen; Enzymes; Experiments; Females; Fitness equipment; Frailty; healthspan; Insulin; Life span; Longevity; Males; Metabolism; Mice; NAD; NAD - metabolism; NAD+ Nucleosidase - metabolism; Senescence; Short Communication; Short Communications; small molecule; Survival analysis; NAD; small molecule; CD38; longevity; aging; healthspan; mice
• ISSN: 1474-9718; 1474-9726; 1474-9726
• DOI: 10.1111/acel.13589

Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age‐related NAD decline. Whether the inhibition of CD38 increases lifespan is not known. Here, we show that the CD38 inhibitor 78c increases lifespan and healthspan of naturally aged mice. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between sexes. Our study is the first to investigate the effect of CD38 inhibition in naturally aged animals. The NADase CD38 plays a key role in age‐related NAD decline. The CD38 inhibitor 78c increases lifespan and healthspan of naturally aged male mice. The increase in median and maximal lifespan was about 10%.