Increased variability in reaction time is associated with amyloid beta pathology at age 70

Introduction We investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults. Methods Insight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years),...

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Published inAlzheimer's & dementia : diagnosis, assessment & disease monitoring Vol. 12; no. 1; pp. e12076 - n/a
Main Authors Lu, Kirsty, Nicholas, Jennifer M., James, Sarah‐Naomi, Lane, Christopher A., Parker, Thomas D., Keshavan, Ashvini, Keuss, Sarah E., Buchanan, Sarah M., Murray‐Smith, Heidi, Cash, David M., Sudre, Carole H., Malone, Ian B., Coath, William, Wong, Andrew, Henley, Susie M.D., Fox, Nick C., Richards, Marcus, Schott, Jonathan M., Crutch, Sebastian J.
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 2020
John Wiley and Sons Inc
Wiley
Subjects
Age
Alzheimer's disease
amyloid‐positron emission tomography imaging
Biomarkers
birth cohort
Brain research
Clinical trials
cognition
Cognitive & Behavioral Assessment
Cognitive ability
cognitive decline
Dementia
healthy aging
Magnetic resonance imaging
Older people
Pathology
preclinical Alzheimer's disease
reaction time
variability
cognition
birth cohort
amyloid‐positron emission tomography imaging
dementia
reaction time
cognitive decline
healthy aging
variability
preclinical Alzheimer's disease
Online AccessGet full text
ISSN2352-8729
2352-8729
DOI10.1002/dad2.12076

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Abstract Introduction We investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults. Methods Insight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2‐choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra‐individual variability in RT) and life‐course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ‐positivity. Results Cognitively normal Aβ‐positive participants had 10% more variable RTs than Aβ‐negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance. Discussion This study provides novel evidence that Aβ pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.
AbstractList Abstract Introduction We investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults. Methods Insight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2‐choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra‐individual variability in RT) and life‐course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ‐positivity. Results Cognitively normal Aβ‐positive participants had 10% more variable RTs than Aβ‐negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance. Discussion This study provides novel evidence that Aβ pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.
We investigated whether life-course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults. Insight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2-choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra-individual variability in RT) and life-course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ-positivity. Cognitively normal Aβ-positive participants had 10% more variable RTs than Aβ-negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance. This study provides novel evidence that Aβ pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.
We investigated whether life-course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults.INTRODUCTIONWe investigated whether life-course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults.Insight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2-choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra-individual variability in RT) and life-course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ-positivity.METHODSInsight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2-choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra-individual variability in RT) and life-course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ-positivity.Cognitively normal Aβ-positive participants had 10% more variable RTs than Aβ-negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance.RESULTSCognitively normal Aβ-positive participants had 10% more variable RTs than Aβ-negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance.This study provides novel evidence that Aβ pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.DISCUSSIONThis study provides novel evidence that Aβ pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.
Introduction We investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults. Methods Insight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2‐choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra‐individual variability in RT) and life‐course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ‐positivity. Results Cognitively normal Aβ‐positive participants had 10% more variable RTs than Aβ‐negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance. Discussion This study provides novel evidence that Aβ pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.
IntroductionWe investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older adults.MethodsInsight 46 study participants, all born in the same week in 1946 (n = 501; ages at assessment = 69 to 71 years), completed a 2‐choice RT task and amyloid beta (Aβ) positron emission tomography and MR imaging. We tested for associations between task outcomes (RT; error rate; intra‐individual variability in RT) and life‐course predictors including childhood cognitive ability and education. In a subsample of 406 cognitively normal participants, we investigated associations between task outcomes and biomarkers including Aβ‐positivity.ResultsCognitively normal Aβ‐positive participants had 10% more variable RTs than Aβ‐negative participants, despite having similar mean RTs. Childhood cognitive ability and education independently predicted task performance.DiscussionThis study provides novel evidence that Aβ pathology is associated with poorer consistency of RT in cognitively normal older adults, at an age when dementia prevalence is still very low.
Author Parker, Thomas D.
Henley, Susie M.D.
Lane, Christopher A.
Keuss, Sarah E.
Malone, Ian B.
Sudre, Carole H.
Cash, David M.
Nicholas, Jennifer M.
Lu, Kirsty
Richards, Marcus
James, Sarah‐Naomi
Fox, Nick C.
Schott, Jonathan M.
Murray‐Smith, Heidi
Wong, Andrew
Buchanan, Sarah M.
Keshavan, Ashvini
Coath, William
Crutch, Sebastian J.
AuthorAffiliation 5 Department of Medical Physics University College London London UK
2 Department of Medical Statistics London School of Hygiene and Tropical Medicine London UK
3 MRC Unit for Lifelong Health and Ageing at UCL University College London London UK
6 UK Dementia Research Institute at University College London London UK
4 School of Biomedical Engineering and Imaging Sciences King's College London London UK
1 Dementia Research Centre UCL Queen Square Institute of Neurology, University College London London UK
AuthorAffiliation_xml – name: 5 Department of Medical Physics University College London London UK
– name: 4 School of Biomedical Engineering and Imaging Sciences King's College London London UK
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Issue 1
Keywords cognition
birth cohort
amyloid‐positron emission tomography imaging
dementia
reaction time
cognitive decline
healthy aging
variability
preclinical Alzheimer's disease
Language English
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Notes Jonathan M. Schott and Sebastian J. Crutch are joint senior authors.
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Snippet Introduction We investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in...
We investigated whether life-course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in older...
IntroductionWe investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT) performance in...
Abstract Introduction We investigated whether life‐course factors and neuroimaging biomarkers of Alzheimer's disease pathology predict reaction time (RT)...
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StartPage e12076
SubjectTerms Age
Alzheimer's disease
amyloid‐positron emission tomography imaging
Biomarkers
birth cohort
Brain research
Clinical trials
cognition
Cognitive & Behavioral Assessment
Cognitive ability
cognitive decline
Dementia
healthy aging
Magnetic resonance imaging
Older people
Pathology
preclinical Alzheimer's disease
reaction time
variability
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Title Increased variability in reaction time is associated with amyloid beta pathology at age 70
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fdad2.12076
https://www.ncbi.nlm.nih.gov/pubmed/32789161
https://www.proquest.com/docview/2635816790
https://www.proquest.com/docview/2434058192
https://pubmed.ncbi.nlm.nih.gov/PMC7416668
https://doaj.org/article/581b7ddff37a46509cc58782170ae19f
Volume 12
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