Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses - Macháčková, Kateřina; Mlčochová, Květoslava; Potalitsyn, Pavlo; Hanková, Kateřina; Socha, Ondřej; Buděšínský, Miloš; Muždalo, Anja; Lepšík, Martin; Černeková, Michaela; Radosavljević, Jelena; Fábry, Milan; Mitrová, Katarína; et al. (The Journal of biological chemistry, 2019)
Keywords: Abnormalities, Multiple - genetics; Amino Acid Sequence - genetics; Binding Sites - genetics; complex; Growth Disorders - genetics; hormone analog; Humans; insulin; Insulin - analogs & derivatives; Insulin - chemical synthesis; Insulin - chemistry; Insulin - genetics; insulin-like growth factor (IGF); Insulin-Like Growth Factor I - chemistry; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor II - chemistry; Insulin-Like Growth Factor II - genetics; molecular dynamics; mutagenesis; Mutation - genetics; NMR structure; Nuclear Magnetic Resonance, Biomolecular; peptide hormone; Protein Binding - genetics; Protein Domains - genetics; Protein Structure and Folding; receptor autophosphorylation; receptor binding; receptor tyrosine kinase; Receptor, IGF Type 1 - chemistry; Receptor, IGF Type 1 - genetics; Receptor, Insulin - chemistry; Receptor, Insulin - genetics; structural biology; structure-function; NMR structure; insulin; structure-function; hormone analog; peptide hormone; molecular dynamics; mutagenesis; insulin-like growth factor (IGF); complex; receptor autophosphorylation; receptor binding; structural biology; receptor tyrosine kinase