Altered Calcium Metabolism in Aging CA1 Hippocampal Pyramidal Neurons

Altered neuronal calcium homeostasis is widely hypothesized to underlie cognitive deficits in normal aging subjects, but the mechanisms that underlie this change are unknown, possibly due to a paucity of direct measurements from aging neurons. Using CCD and two-photon calcium imaging techniques on C...

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Published inThe Journal of neuroscience Vol. 33; no. 18; pp. 7905 - 7911
Main Authors Oh, M. Matthew, Oliveira, Fernando A., Waters, Jack, Disterhoft, John F.
Format Journal Article
LanguageEnglish
Published United States Society for Neuroscience 01.05.2013
Subjects
Age Factors
Aging - physiology
Analysis of Variance
Animals
Biophysics
CA1 Region, Hippocampal - cytology
Calcium - metabolism
Chelating Agents - pharmacokinetics
Egtazic Acid - analogs & derivatives
Egtazic Acid - pharmacokinetics
Electric Stimulation
Fluorescent Dyes - metabolism
In Vitro Techniques
Male
Membrane Potentials - drug effects
Membrane Potentials - physiology
Microscopy, Confocal
Patch-Clamp Techniques
Pyramidal Cells - drug effects
Pyramidal Cells - physiology
Rats
Rats, Inbred F344
Time Factors
Online AccessGet full text
ISSN0270-6474
1529-2401
1529-2401
DOI10.1523/JNEUROSCI.5457-12.2013

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Abstract Altered neuronal calcium homeostasis is widely hypothesized to underlie cognitive deficits in normal aging subjects, but the mechanisms that underlie this change are unknown, possibly due to a paucity of direct measurements from aging neurons. Using CCD and two-photon calcium imaging techniques on CA1 pyramidal neurons from young and aged rats, we show that calcium influx across the plasma membrane increases with aging, and that this change is countered by increased intracellular calcium buffering. The additional buffer in aging neurons balances the increased calcium influx following a small number (<3) action potentials, but is overwhelmed during sustained or theta-like activity which leads to a greater rise in intracellular calcium concentration in aging than that in young neurons. Our results demonstrate that calcium overload occurs regularly in aging CA1 pyramidal neurons under physiological conditions. This overload may be a critical factor in age-related decline in hippocampus-dependent cognitive function.
AbstractList Altered neuronal calcium homeostasis is widely hypothesized to underlie cognitive deficits in normal aging subjects, but the mechanisms that underlie this change are unknown, possibly due to a paucity of direct measurements from aging neurons. Using CCD and two-photon calcium imaging techniques on CA1 pyramidal neurons from young and aged rats, we show that calcium influx across the plasma membrane increases with aging, and that this change is countered by increased intracellular calcium buffering. The additional buffer in aging neurons balances the increased calcium influx following a small number (<3) action potentials, but is overwhelmed during sustained or theta-like activity which leads to a greater rise in intracellular calcium concentration in aging than that in young neurons. Our results demonstrate that calcium overload occurs regularly in aging CA1 pyramidal neurons under physiological conditions. This overload may be a critical factor in age-related decline in hippocampus-dependent cognitive function.Altered neuronal calcium homeostasis is widely hypothesized to underlie cognitive deficits in normal aging subjects, but the mechanisms that underlie this change are unknown, possibly due to a paucity of direct measurements from aging neurons. Using CCD and two-photon calcium imaging techniques on CA1 pyramidal neurons from young and aged rats, we show that calcium influx across the plasma membrane increases with aging, and that this change is countered by increased intracellular calcium buffering. The additional buffer in aging neurons balances the increased calcium influx following a small number (<3) action potentials, but is overwhelmed during sustained or theta-like activity which leads to a greater rise in intracellular calcium concentration in aging than that in young neurons. Our results demonstrate that calcium overload occurs regularly in aging CA1 pyramidal neurons under physiological conditions. This overload may be a critical factor in age-related decline in hippocampus-dependent cognitive function.
Altered neuronal calcium homeostasis is widely hypothesized to underlie cognitive deficits in normal aging subjects, but the mechanisms that underlie this change are unknown, possibly due to a paucity of direct measurements from aging neurons. Using CCD and two-photon calcium imaging techniques on CA1 pyramidal neurons from young and aged rats, we show that calcium influx across the plasma membrane increases with aging, and that this change is countered by increased intracellular calcium buffering. The additional buffer in aging neurons balances the increased calcium influx following a small number (<3) action potentials, but is overwhelmed during sustained or theta-like activity which leads to a greater rise in intracellular calcium concentration in aging than that in young neurons. Our results demonstrate that calcium overload occurs regularly in aging CA1 pyramidal neurons under physiological conditions. This overload may be a critical factor in age-related decline in hippocampus-dependent cognitive function.
Author Waters, Jack
Oh, M. Matthew
Disterhoft, John F.
Oliveira, Fernando A.
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Cites_doi 10.3389/neuro.24.002.2009
10.1152/jn.00347.2009
10.1016/S0006-3495(00)76809-3
10.1002/hipo.450040104
10.1023/A:1020700117665
10.1093/acprof:oso/9780195100273.003.0011
10.1016/S0197-4580(97)00166-8
10.1016/j.neulet.2008.11.068
10.1152/jn.1998.80.1.350
10.1016/0197-4580(87)90072-8
10.1523/JNEUROSCI.4171-05.2006
10.1111/j.1474-9726.2007.00275.x
10.1113/jphysiol.1992.sp019127
10.1016/0197-4580(96)00030-9
10.1016/j.tins.2006.08.005
10.1016/j.tins.2004.01.010
10.1111/j.1749-6632.1994.tb44397.x
10.1016/j.expneurol.2005.06.014
10.1113/jphysiol.2007.147298
10.1016/j.neuroscience.2005.05.044
10.1016/0047-6374(92)90114-S
10.1016/j.brainres.2004.10.023
10.1007/s00018-008-8564-6
10.1016/0028-3908(95)00144-U
10.1016/S0165-0270(98)00143-5
10.1016/0301-0082(91)90028-Y
10.1111/j.1460-9568.1994.tb01010.x
10.1152/jn.01148.2003
10.1126/science.272.5264.1017
10.1126/science.6494926
10.1016/j.neuron.2006.12.017
10.1016/S0006-3495(96)79653-4
10.1016/0197-4580(87)90074-1
10.1111/j.1474-9726.2007.00296.x
10.1016/0024-3205(96)00321-9
10.1016/0024-3205(96)00324-4
10.1523/JNEUROSCI.22-16-07234.2002
10.1007/s11011-008-9103-8
10.1111/j.1749-6632.1989.tb12485.x
10.1523/JNEUROSCI.21-11-04066.2001
10.1113/jphysiol.1995.sp020708
10.1038/35036035
10.1523/JNEUROSCI.21-24-09744.2001
10.1016/S0959-440X(00)00142-1
10.1023/A:1021000425070
10.1523/JNEUROSCI.0384-09.2009
10.1007/s004410051207
10.1111/j.1474-9726.2007.00297.x
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J.W. and J.F.D. contributed equally as second authors.
M.M.O. and F.A.O. contributed equally as first authors.
F.A. Oliveira's present address: Departamento de Ciências Biológicas, Setor de Fisiologia e Farmacologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Author contributions: M.M.O., F.A.O., J.W., and J.D. designed research; M.M.O. and F.A.O. performed research; M.M.O., F.A.O., J.W., and J.D. analyzed data; M.M.O., F.A.O., J.W., and J.D. wrote the paper.
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References 2023041304040316000_33.18.7905.5
2023041304040316000_33.18.7905.4
2023041304040316000_33.18.7905.3
2023041304040316000_33.18.7905.2
2023041304040316000_33.18.7905.9
2023041304040316000_33.18.7905.8
2023041304040316000_33.18.7905.7
2023041304040316000_33.18.7905.40
2023041304040316000_33.18.7905.6
2023041304040316000_33.18.7905.42
2023041304040316000_33.18.7905.44
2023041304040316000_33.18.7905.45
2023041304040316000_33.18.7905.1
2023041304040316000_33.18.7905.47
2023041304040316000_33.18.7905.48
2023041304040316000_33.18.7905.49
Thibault (2023041304040316000_33.18.7905.46) 2001; 21
2023041304040316000_33.18.7905.30
2023041304040316000_33.18.7905.32
2023041304040316000_33.18.7905.33
2023041304040316000_33.18.7905.34
2023041304040316000_33.18.7905.35
2023041304040316000_33.18.7905.36
2023041304040316000_33.18.7905.37
2023041304040316000_33.18.7905.38
Foster (2023041304040316000_33.18.7905.11) 2001; 21
Markram (2023041304040316000_33.18.7905.31) 1995; 485
Neher (2023041304040316000_33.18.7905.41) 1992; 450
2023041304040316000_33.18.7905.20
2023041304040316000_33.18.7905.21
2023041304040316000_33.18.7905.22
2023041304040316000_33.18.7905.23
2023041304040316000_33.18.7905.24
2023041304040316000_33.18.7905.25
2023041304040316000_33.18.7905.26
2023041304040316000_33.18.7905.27
2023041304040316000_33.18.7905.28
2023041304040316000_33.18.7905.29
2023041304040316000_33.18.7905.10
Murchison (2023041304040316000_33.18.7905.39) 1998; 80
2023041304040316000_33.18.7905.12
2023041304040316000_33.18.7905.13
2023041304040316000_33.18.7905.14
2023041304040316000_33.18.7905.15
2023041304040316000_33.18.7905.16
2023041304040316000_33.18.7905.17
2023041304040316000_33.18.7905.18
2023041304040316000_33.18.7905.19
Power (2023041304040316000_33.18.7905.43) 2002; 22
1947178 - Prog Neurobiol. 1991;37(3):255-85
11114499 - Curr Opin Struct Biol. 2000 Dec;10(6):637-43
19726729 - J Neurophysiol. 2009 Nov;102(5):2763-70
10485579 - Neurochem Res. 1999 Sep;24(9):1097-100
15621020 - Brain Res. 2005 Jan 7;1031(1):125-8
1583914 - Mech Ageing Dev. 1992 Mar 1;62(3):291-306
7658365 - J Physiol. 1995 May 15;485 ( Pt 1):1-20
20552053 - Front Aging Neurosci. 2009 Nov 27;1:2
18276734 - J Physiol. 2008 Apr 15;586(8):2061-75
10344594 - Neurochem Res. 1999 May;24(5):651-8
9931348 - Cell Tissue Res. 1999 Jan;295(1):1-12
9658056 - J Neurophysiol. 1998 Jul;80(1):350-64
14762159 - J Neurophysiol. 2004 Jun;91(6):2437-44
8606791 - Neuropharmacology. 1995 Nov;34(11):1423-42
11413485 - Nat Rev Mol Cell Biol. 2000 Oct;1(1):11-21
6494926 - Science. 1984 Nov 30;226(4678):1089-92
3306433 - Neurobiol Aging. 1987 Jul-Aug;8(4):329-43
1331424 - J Physiol. 1992 May;450:273-301
17517038 - Aging Cell. 2007 Jun;6(3):267-73
9562507 - Neurobiol Aging. 1998 Jan-Feb;19(1):77-82
11739583 - J Neurosci. 2001 Dec 15;21(24):9744-56
16942805 - Trends Neurosci. 2006 Oct;29(10):587-99
3627350 - Neurobiol Aging. 1987 Jul-Aug;8(4):346-7
18770014 - Metab Brain Dis. 2008 Dec;23(4):399-409
10777761 - Biophys J. 2000 May;78(5):2655-67
9894784 - J Neurosci Methods. 1998 Dec 31;86(1):35-54
8638124 - Science. 1996 May 17;272(5264):1017-20
19369544 - J Neurosci. 2009 Apr 15;29(15):4750-5
19073233 - Neurosci Lett. 2009 Feb 20;451(2):119-23
2629579 - Ann N Y Acad Sci. 1989;568:1-4
17517042 - Aging Cell. 2007 Jun;6(3):327-36
8725908 - Neurobiol Aging. 1996 May-Jun;17(3):459-65
17328689 - Aging Cell. 2007 Jun;6(3):337-50
16571755 - J Neurosci. 2006 Mar 29;26(13):3482-90
16112472 - Neuroscience. 2005;135(2):413-20
11356894 - J Neurosci. 2001 Jun 1;21(11):4066-73
17224406 - Neuron. 2007 Jan 18;53(2):249-60
8000572 - Eur J Neurosci. 1994 Sep 1;6(9):1491-9
15046879 - Trends Neurosci. 2004 Apr;27(4):203-9
8789126 - Biophys J. 1996 Feb;70(2):1069-81
8761333 - Life Sci. 1996;59(5-6):451-9
12177218 - J Neurosci. 2002 Aug 15;22(16):7234-43
8061749 - Hippocampus. 1994 Feb;4(1):11-7
16039651 - Exp Neurol. 2006 Feb;197(2):291-300
19099190 - Cell Mol Life Sci. 2009 Jan;66(2):275-300
8761330 - Life Sci. 1996;59(5-6):421-8
References_xml – ident: 2023041304040316000_33.18.7905.26
  doi: 10.3389/neuro.24.002.2009
– ident: 2023041304040316000_33.18.7905.34
  doi: 10.1152/jn.00347.2009
– ident: 2023041304040316000_33.18.7905.30
  doi: 10.1016/S0006-3495(00)76809-3
– ident: 2023041304040316000_33.18.7905.37
  doi: 10.1002/hipo.450040104
– ident: 2023041304040316000_33.18.7905.16
  doi: 10.1023/A:1020700117665
– ident: 2023041304040316000_33.18.7905.42
  doi: 10.1093/acprof:oso/9780195100273.003.0011
– ident: 2023041304040316000_33.18.7905.22
  doi: 10.1016/S0197-4580(97)00166-8
– ident: 2023041304040316000_33.18.7905.15
  doi: 10.1016/j.neulet.2008.11.068
– volume: 80
  start-page: 350
  year: 1998
  ident: 2023041304040316000_33.18.7905.39
  article-title: Increased calcium buffering in basal forebrain neurons during aging
  publication-title: J Neurophysiol
  doi: 10.1152/jn.1998.80.1.350
– ident: 2023041304040316000_33.18.7905.14
  doi: 10.1016/0197-4580(87)90072-8
– ident: 2023041304040316000_33.18.7905.13
  doi: 10.1523/JNEUROSCI.4171-05.2006
– ident: 2023041304040316000_33.18.7905.33
  doi: 10.1111/j.1474-9726.2007.00275.x
– volume: 450
  start-page: 273
  year: 1992
  ident: 2023041304040316000_33.18.7905.41
  article-title: Calcium gradients and buffers in bovine chromaffin cells
  publication-title: J Physiol
  doi: 10.1113/jphysiol.1992.sp019127
– ident: 2023041304040316000_33.18.7905.6
  doi: 10.1016/0197-4580(96)00030-9
– ident: 2023041304040316000_33.18.7905.7
  doi: 10.1016/j.tins.2006.08.005
– ident: 2023041304040316000_33.18.7905.5
  doi: 10.1016/j.tins.2004.01.010
– ident: 2023041304040316000_33.18.7905.9
  doi: 10.1111/j.1749-6632.1994.tb44397.x
– ident: 2023041304040316000_33.18.7905.48
  doi: 10.1016/j.expneurol.2005.06.014
– ident: 2023041304040316000_33.18.7905.1
  doi: 10.1113/jphysiol.2007.147298
– ident: 2023041304040316000_33.18.7905.19
  doi: 10.1016/j.neuroscience.2005.05.044
– ident: 2023041304040316000_33.18.7905.35
  doi: 10.1016/0047-6374(92)90114-S
– ident: 2023041304040316000_33.18.7905.25
  doi: 10.1016/j.brainres.2004.10.023
– ident: 2023041304040316000_33.18.7905.44
  doi: 10.1007/s00018-008-8564-6
– ident: 2023041304040316000_33.18.7905.40
  doi: 10.1016/0028-3908(95)00144-U
– ident: 2023041304040316000_33.18.7905.38
  doi: 10.1016/S0165-0270(98)00143-5
– ident: 2023041304040316000_33.18.7905.36
  doi: 10.1016/0301-0082(91)90028-Y
– ident: 2023041304040316000_33.18.7905.49
  doi: 10.1111/j.1460-9568.1994.tb01010.x
– ident: 2023041304040316000_33.18.7905.17
– ident: 2023041304040316000_33.18.7905.24
  doi: 10.1152/jn.01148.2003
– ident: 2023041304040316000_33.18.7905.45
  doi: 10.1126/science.272.5264.1017
– ident: 2023041304040316000_33.18.7905.28
  doi: 10.1126/science.6494926
– ident: 2023041304040316000_33.18.7905.3
  doi: 10.1016/j.neuron.2006.12.017
– ident: 2023041304040316000_33.18.7905.18
  doi: 10.1016/S0006-3495(96)79653-4
– ident: 2023041304040316000_33.18.7905.27
  doi: 10.1016/0197-4580(87)90074-1
– ident: 2023041304040316000_33.18.7905.47
  doi: 10.1111/j.1474-9726.2007.00296.x
– ident: 2023041304040316000_33.18.7905.23
  doi: 10.1016/0024-3205(96)00321-9
– ident: 2023041304040316000_33.18.7905.21
  doi: 10.1016/0024-3205(96)00324-4
– volume: 22
  start-page: 7234
  year: 2002
  ident: 2023041304040316000_33.18.7905.43
  article-title: Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.22-16-07234.2002
– ident: 2023041304040316000_33.18.7905.10
  doi: 10.1007/s11011-008-9103-8
– ident: 2023041304040316000_33.18.7905.20
  doi: 10.1111/j.1749-6632.1989.tb12485.x
– volume: 21
  start-page: 4066
  year: 2001
  ident: 2023041304040316000_33.18.7905.11
  article-title: Calcineurin links Ca2+ dysregulation with brain aging
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-11-04066.2001
– volume: 485
  start-page: 1
  year: 1995
  ident: 2023041304040316000_33.18.7905.31
  article-title: Dendritic calcium transients evoked by single back-propagating action potentials in rat neocortical pyramidal neurons
  publication-title: J Physiol
  doi: 10.1113/jphysiol.1995.sp020708
– ident: 2023041304040316000_33.18.7905.2
  doi: 10.1038/35036035
– volume: 21
  start-page: 9744
  year: 2001
  ident: 2023041304040316000_33.18.7905.46
  article-title: Elevated postsynaptic [Ca2+]i and l-type calcium channel activity in aged hippocampal neurons: relationship to impaired synaptic plasticity
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-24-09744.2001
– ident: 2023041304040316000_33.18.7905.29
  doi: 10.1016/S0959-440X(00)00142-1
– ident: 2023041304040316000_33.18.7905.12
  doi: 10.1023/A:1021000425070
– ident: 2023041304040316000_33.18.7905.32
  doi: 10.1523/JNEUROSCI.0384-09.2009
– ident: 2023041304040316000_33.18.7905.4
  doi: 10.1007/s004410051207
– ident: 2023041304040316000_33.18.7905.8
  doi: 10.1111/j.1474-9726.2007.00297.x
– reference: 2629579 - Ann N Y Acad Sci. 1989;568:1-4
– reference: 1331424 - J Physiol. 1992 May;450:273-301
– reference: 17517038 - Aging Cell. 2007 Jun;6(3):267-73
– reference: 8638124 - Science. 1996 May 17;272(5264):1017-20
– reference: 11413485 - Nat Rev Mol Cell Biol. 2000 Oct;1(1):11-21
– reference: 9658056 - J Neurophysiol. 1998 Jul;80(1):350-64
– reference: 17517042 - Aging Cell. 2007 Jun;6(3):327-36
– reference: 15046879 - Trends Neurosci. 2004 Apr;27(4):203-9
– reference: 11114499 - Curr Opin Struct Biol. 2000 Dec;10(6):637-43
– reference: 8606791 - Neuropharmacology. 1995 Nov;34(11):1423-42
– reference: 12177218 - J Neurosci. 2002 Aug 15;22(16):7234-43
– reference: 7658365 - J Physiol. 1995 May 15;485 ( Pt 1):1-20
– reference: 16112472 - Neuroscience. 2005;135(2):413-20
– reference: 3306433 - Neurobiol Aging. 1987 Jul-Aug;8(4):329-43
– reference: 18276734 - J Physiol. 2008 Apr 15;586(8):2061-75
– reference: 19073233 - Neurosci Lett. 2009 Feb 20;451(2):119-23
– reference: 9562507 - Neurobiol Aging. 1998 Jan-Feb;19(1):77-82
– reference: 8061749 - Hippocampus. 1994 Feb;4(1):11-7
– reference: 11356894 - J Neurosci. 2001 Jun 1;21(11):4066-73
– reference: 8789126 - Biophys J. 1996 Feb;70(2):1069-81
– reference: 10344594 - Neurochem Res. 1999 May;24(5):651-8
– reference: 8000572 - Eur J Neurosci. 1994 Sep 1;6(9):1491-9
– reference: 8725908 - Neurobiol Aging. 1996 May-Jun;17(3):459-65
– reference: 19726729 - J Neurophysiol. 2009 Nov;102(5):2763-70
– reference: 20552053 - Front Aging Neurosci. 2009 Nov 27;1:2
– reference: 17224406 - Neuron. 2007 Jan 18;53(2):249-60
– reference: 11739583 - J Neurosci. 2001 Dec 15;21(24):9744-56
– reference: 9931348 - Cell Tissue Res. 1999 Jan;295(1):1-12
– reference: 3627350 - Neurobiol Aging. 1987 Jul-Aug;8(4):346-7
– reference: 9894784 - J Neurosci Methods. 1998 Dec 31;86(1):35-54
– reference: 1583914 - Mech Ageing Dev. 1992 Mar 1;62(3):291-306
– reference: 15621020 - Brain Res. 2005 Jan 7;1031(1):125-8
– reference: 19369544 - J Neurosci. 2009 Apr 15;29(15):4750-5
– reference: 1947178 - Prog Neurobiol. 1991;37(3):255-85
– reference: 18770014 - Metab Brain Dis. 2008 Dec;23(4):399-409
– reference: 19099190 - Cell Mol Life Sci. 2009 Jan;66(2):275-300
– reference: 10485579 - Neurochem Res. 1999 Sep;24(9):1097-100
– reference: 6494926 - Science. 1984 Nov 30;226(4678):1089-92
– reference: 16942805 - Trends Neurosci. 2006 Oct;29(10):587-99
– reference: 16039651 - Exp Neurol. 2006 Feb;197(2):291-300
– reference: 8761330 - Life Sci. 1996;59(5-6):421-8
– reference: 14762159 - J Neurophysiol. 2004 Jun;91(6):2437-44
– reference: 17328689 - Aging Cell. 2007 Jun;6(3):337-50
– reference: 8761333 - Life Sci. 1996;59(5-6):451-9
– reference: 16571755 - J Neurosci. 2006 Mar 29;26(13):3482-90
– reference: 10777761 - Biophys J. 2000 May;78(5):2655-67
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Snippet Altered neuronal calcium homeostasis is widely hypothesized to underlie cognitive deficits in normal aging subjects, but the mechanisms that underlie this...
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StartPage 7905
SubjectTerms Age Factors
Aging - physiology
Analysis of Variance
Animals
Biophysics
CA1 Region, Hippocampal - cytology
Calcium - metabolism
Chelating Agents - pharmacokinetics
Egtazic Acid - analogs & derivatives
Egtazic Acid - pharmacokinetics
Electric Stimulation
Fluorescent Dyes - metabolism
In Vitro Techniques
Male
Membrane Potentials - drug effects
Membrane Potentials - physiology
Microscopy, Confocal
Patch-Clamp Techniques
Pyramidal Cells - drug effects
Pyramidal Cells - physiology
Rats
Rats, Inbred F344
Time Factors
Title Altered Calcium Metabolism in Aging CA1 Hippocampal Pyramidal Neurons
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https://www.proquest.com/docview/1551627598
https://pubmed.ncbi.nlm.nih.gov/PMC3679661
https://www.jneurosci.org/content/jneuro/33/18/7905.full.pdf
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