Cognitive reserve-mediated neural modulation of emotional control and regulation in people with late-life depression

Abstract Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathol...

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Published inSocial cognitive and affective neuroscience Vol. 14; no. 8; pp. 849 - 860
Main Authors Huang, Chih-Mao, Fan, Yang-Teng, Lee, Shwu-Hua, Liu, Ho-Ling, Chen, Yao-Liang, Lin, Chemin, Lee, Tatia M C
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.08.2019
Subjects
Adult
Aged
Aged, 80 and over
Artificial neural networks
Brain - physiopathology
Cognitive Reserve - physiology
Depression (Mood disorder)
Depression - physiopathology
Depressive Disorder - physiopathology
Disabilities
Elderly
Emotional regulation
Emotions - physiology
Female
Frontal Lobe - physiopathology
Humans
Magnetic Resonance Imaging
Male
Mediation
Middle Aged
Older people
Original Manuscript
Proxy
Taiwan
fMRI
emotional regulation
depression
mediation
aging
cognitive reserve
Online AccessGet full text
ISSN1749-5024
1749-5016
1749-5024
DOI10.1093/scan/nsz054

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Abstract Abstract Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathology. The current functional magnetic resonance imaging study investigated whether and how CR affects emotional regulation, level of depression severity and neural activity associated with affective control during emotional Stroop (eStroop) task. Altogether, 90 older people participated in this study, 50 of whom suffered from LLD. We used years of education and verbal fluency capacity as proxies for CR. Clinical participants with relatively higher CR presented with milder degrees of depression, better eStroop performance and stronger neural activity in the middle frontal gyrus (MFG) involved with exercising affective control. Results of the mediation analysis indicated that both education and verbal fluency significantly mediated the association between the depression severity and MEG activity. These results suggest a negative association between CR and age-related clinical symptoms of emotional dysregulation. Our neurobehavioral findings provide supportive evidence that CR implies efficiency of top-down emotional regulation and operates as a protective factor against emotional and cognitive vulnerability in the aging brain.
AbstractList Abstract Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathology. The current functional magnetic resonance imaging study investigated whether and how CR affects emotional regulation, level of depression severity and neural activity associated with affective control during emotional Stroop (eStroop) task. Altogether, 90 older people participated in this study, 50 of whom suffered from LLD. We used years of education and verbal fluency capacity as proxies for CR. Clinical participants with relatively higher CR presented with milder degrees of depression, better eStroop performance and stronger neural activity in the middle frontal gyrus (MFG) involved with exercising affective control. Results of the mediation analysis indicated that both education and verbal fluency significantly mediated the association between the depression severity and MEG activity. These results suggest a negative association between CR and age-related clinical symptoms of emotional dysregulation. Our neurobehavioral findings provide supportive evidence that CR implies efficiency of top-down emotional regulation and operates as a protective factor against emotional and cognitive vulnerability in the aging brain.
Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathology. The current functional magnetic resonance imaging study investigated whether and how CR affects emotional regulation, level of depression severity and neural activity associated with affective control during emotional Stroop (eStroop) task. Altogether, 90 older people participated in this study, 50 of whom suffered from LLD. We used years of education and verbal fluency capacity as proxies for CR. Clinical participants with relatively higher CR presented with milder degrees of depression, better eStroop performance and stronger neural activity in the middle frontal gyrus (MFG) involved with exercising affective control. Results of the mediation analysis indicated that both education and verbal fluency significantly mediated the association between the depression severity and MEG activity. These results suggest a negative association between CR and age-related clinical symptoms of emotional dysregulation. Our neurobehavioral findings provide supportive evidence that CR implies efficiency of top-down emotional regulation and operates as a protective factor against emotional and cognitive vulnerability in the aging brain.
Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathology. The current functional magnetic resonance imaging study investigated whether and how CR affects emotional regulation, level of depression severity and neural activity associated with affective control during emotional Stroop (eStroop) task. Altogether, 90 older people participated in this study, 50 of whom suffered from LLD. We used years of education and verbal fluency capacity as proxies for CR. Clinical participants with relatively higher CR presented with milder degrees of depression, better eStroop performance and stronger neural activity in the middle frontal gyrus (MFG) involved with exercising affective control. Results of the mediation analysis indicated that both education and verbal fluency significantly mediated the association between the depression severity and MEG activity. These results suggest a negative association between CR and age-related clinical symptoms of emotional dysregulation. Our neurobehavioral findings provide supportive evidence that CR implies efficiency of top-down emotional regulation and operates as a protective factor against emotional and cognitive vulnerability in the aging brain. Key words: cognitive reserve; emotional regulation; fMRI; depression; mediation; aging
Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathology. The current functional magnetic resonance imaging study investigated whether and how CR affects emotional regulation, level of depression severity and neural activity associated with affective control during emotional Stroop (eStroop) task. Altogether, 90 older people participated in this study, 50 of whom suffered from LLD. We used years of education and verbal fluency capacity as proxies for CR. Clinical participants with relatively higher CR presented with milder degrees of depression, better eStroop performance and stronger neural activity in the middle frontal gyrus (MFG) involved with exercising affective control. Results of the mediation analysis indicated that both education and verbal fluency significantly mediated the association between the depression severity and MEG activity. These results suggest a negative association between CR and age-related clinical symptoms of emotional dysregulation. Our neurobehavioral findings provide supportive evidence that CR implies efficiency of top-down emotional regulation and operates as a protective factor against emotional and cognitive vulnerability in the aging brain.Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathology. The current functional magnetic resonance imaging study investigated whether and how CR affects emotional regulation, level of depression severity and neural activity associated with affective control during emotional Stroop (eStroop) task. Altogether, 90 older people participated in this study, 50 of whom suffered from LLD. We used years of education and verbal fluency capacity as proxies for CR. Clinical participants with relatively higher CR presented with milder degrees of depression, better eStroop performance and stronger neural activity in the middle frontal gyrus (MFG) involved with exercising affective control. Results of the mediation analysis indicated that both education and verbal fluency significantly mediated the association between the depression severity and MEG activity. These results suggest a negative association between CR and age-related clinical symptoms of emotional dysregulation. Our neurobehavioral findings provide supportive evidence that CR implies efficiency of top-down emotional regulation and operates as a protective factor against emotional and cognitive vulnerability in the aging brain.
Audience Academic
Author Chen, Yao-Liang
Huang, Chih-Mao
Lin, Chemin
Fan, Yang-Teng
Lee, Tatia M C
Liu, Ho-Ling
Lee, Shwu-Hua
AuthorAffiliation 2 Center for Intelligent Drug Systems and Smart Bio-devices (IDS 2 B), National Chiao Tung University , Hsinchu, Taiwan
9 State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong , Hong Kong, PR China
3 College of Medicine, Chang Gung University, Taoyuan , Taiwan
10 Laboratory of Neuropsychology, The University of Hong Kong , Hong Kong, PR China
4 Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan , Taiwan
1 College of Biological Science and Technology, National Chiao Tung University , Hsinchu, Taiwan
8 Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung , Keelung, Taiwan
5 Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston , TX, USA
6 Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Keelung , Taiwan, Taiwan
7 Department of Psychiatry, Keelung Chang Gung Memorial Hospital, Keelung , Taiwan
AuthorAffiliation_xml – name: 7 Department of Psychiatry, Keelung Chang Gung Memorial Hospital, Keelung , Taiwan
– name: 8 Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung , Keelung, Taiwan
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– name: 5 Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston , TX, USA
– name: 3 College of Medicine, Chang Gung University, Taoyuan , Taiwan
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– name: 9 State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong , Hong Kong, PR China
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  givenname: Tatia M C
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31603228$$D View this record in MEDLINE/PubMed
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Issue 8
Keywords fMRI
emotional regulation
depression
mediation
aging
cognitive reserve
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Snippet Abstract Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process...
Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that...
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StartPage 849
SubjectTerms Adult
Aged
Aged, 80 and over
Artificial neural networks
Brain - physiopathology
Cognitive Reserve - physiology
Depression (Mood disorder)
Depression - physiopathology
Depressive Disorder - physiopathology
Disabilities
Elderly
Emotional regulation
Emotions - physiology
Female
Frontal Lobe - physiopathology
Humans
Magnetic Resonance Imaging
Male
Mediation
Middle Aged
Older people
Original Manuscript
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Title Cognitive reserve-mediated neural modulation of emotional control and regulation in people with late-life depression
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