Inter-observer Reproducibility in the Pathologic Diagnosis of Gastric Intraepithelial Neoplasia and Early Carcinoma in Endoscopic Submucosal Dissection Specimens: A Multi-center Study

• Published in: Cancer Research and Treatment Vol. 51; no. 4; pp. 1568 - 1577
• Main Authors: Kim, Joon Mee, Sohn, Jin Hee, Cho, Mee-Yon, Kim, Woo Ho, Chang, Hee Kyung, Jung, Eun Sun, Kook, Myeong-Cherl, Jin, So-Young, Chae, Yang Seok, Park, Young Soo, Kang, Mi Seon, Kim, Hyunki, Lee, Jae Hyuk, Park, Do Youn, Kim, Kyoung Mee, Kim, Hoguen, Suh, Young Ju, Seol, Sang Yong, Jung, Hwoon-Yong, Kim, Deuck–Hwa, Lee, Na Rae, Park, Seung-Hee, You, Ji Hye
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Cancer Association 01.10.2019; 대한암학회
• Subjects: Carcinoma in Situ; Carcinoma in Situ - diagnosis; Carcinoma in Situ - pathology; Discrepancy; Early Detection of Cancer; Endoscopic Mucosal Resection; Endoscopic Mucosal Resection - methods; Female; Humans; Intraepithelial neoplasia; Male; Observer Variation; Original; Original Article; Reproducibility; Reproducibility of Results; Retrospective Studies; Risk Factors; Stomach neoplasms; Stomach Neoplasms - diagnosis; Stomach Neoplasms - pathology; 의약학; Endoscopic mucosal resection; Discrepancy; Intraepithelial neoplasia; Reproducibility; Stomach neoplasms
• ISSN: 1598-2998; 2005-9256; 2005-9256
• DOI: 10.4143/crt.2019.019

The diagnostic criteria of gastric intraepithelial neoplasia (IEN) are controversial across the world. We investigated how many discrepancies occur in the pathologic diagnosis of IEN and early gastric carcinoma in endoscopic submucosal dissection (ESD) specimens, and evaluated the reasons of the discordance. We retrospectively reviewed 1,202 ESD specimens that were originally diagnosed as gastric IEN and early carcinoma at 12 institutions. The final consensus diagnosis of carcinoma were 756 cases, which were originally 692 carcinomas (91.5%), 43 high-grade dysplasias (5.7%), 20 low-grade dysplasias (2.6%), and 1 others (0.1%), respectively. High- and low-grade dysplasia were finally made in 63 and 342 cases, respectively. The diagnostic concordance with the consensus diagnosis was the highest for carcinoma (91.5%), followed by low-grade dysplasia (86.3%), others (63.4%) and high-grade dysplasia (50.8%). The general kappa value was 0.83, indicating excellent concordance. The kappa values of individual institutions ranged from 0.74 to 1 and correlated with the proportion of carcinoma cases. The cases revised to a final diagnosis of carcinoma exhibited both architectural abnormalities and cytologic atypia. The main differential points between low- and high-grade dysplasias were the glandular distribution and glandular shape. Additional features such as the glandular axis, surface maturation, nuclear stratification and nuclear polarity were also important. The overall concordance of the diagnosis of gastric IEN and early carcinoma in ESD specimens was excellent. It correlated with the proportion of carcinoma cases, demonstrating that the diagnostic criteria for carcinoma are more reproducible than those for dysplasia.