Signaling roles of sphingolipids in the ischemic brain and their potential utility as therapeutic targets
Sphingolipids comprise a class of lipids, which are composed of a sphingoid base backbone and are essential structural components of cell membranes. Beyond their role in maintaining cellular integrity, several sphingolipids are pivotally involved in signaling pathways controlling cell proliferation,...
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| Published in | Neurobiology of disease Vol. 201; p. 106682 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
15.10.2024
Elsevier |
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| Online Access | Get full text |
| ISSN | 0969-9961 1095-953X 1095-953X |
| DOI | 10.1016/j.nbd.2024.106682 |
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| Abstract | Sphingolipids comprise a class of lipids, which are composed of a sphingoid base backbone and are essential structural components of cell membranes. Beyond their role in maintaining cellular integrity, several sphingolipids are pivotally involved in signaling pathways controlling cell proliferation, differentiation, and death. The brain exhibits a particularly high concentration of sphingolipids and dysregulation of the sphingolipid metabolism due to ischemic injury is implicated in consecutive pathological events. Experimental stroke studies revealed that the stress sphingolipid ceramide accumulates in the ischemic brain post-stroke. Specifically, counteracting ceramide accumulation protects against ischemic damage and promotes brain remodeling, which translates into improved behavioral outcome. Sphingomyelin substantially influences cell membrane fluidity and thereby controls the release of extracellular vesicles, which are important vehicles in cellular communication. By modulating sphingomyelin content, these vesicles were shown to contribute to behavioral recovery in experimental stroke studies. Another important sphingolipid that influences stroke pathology is sphingosine-1-phosphate, which has been attributed a pro-angiogenic function, that is presumably mediated by its effect on endothelial function and/or immune cell trafficking. In experimental and clinical studies, sphingosine-1-phosphate receptor modulators allowed to modify clinically significant stroke recovery. Due to their pivotal roles in cell signaling, pharmacological compounds modulating sphingolipids, their enzymes or receptors hold promise as therapeutics in human stroke patients.
•Ischemic stroke leads to dysregulation of the sphingolipid metabolism.•Ceramide accumulation occurring post-stroke deteriorates injury and inhibiting its metabolizing enzymes enhances recovery.•S1P receptor modulation influences vascular function and immune cell trafficking post-stroke.•Sphingolipids are important for the formation and release of extracellular vesicles that stimulate brain remodeling. |
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| AbstractList | Sphingolipids comprise a class of lipids, which are composed of a sphingoid base backbone and are essential structural components of cell membranes. Beyond their role in maintaining cellular integrity, several sphingolipids are pivotally involved in signaling pathways controlling cell proliferation, differentiation, and death. The brain exhibits a particularly high concentration of sphingolipids and dysregulation of the sphingolipid metabolism due to ischemic injury is implicated in consecutive pathological events. Experimental stroke studies revealed that the stress sphingolipid ceramide accumulates in the ischemic brain post-stroke. Specifically, counteracting ceramide accumulation protects against ischemic damage and promotes brain remodeling, which translates into improved behavioral outcome. Sphingomyelin substantially influences cell membrane fluidity and thereby controls the release of extracellular vesicles, which are important vehicles in cellular communication. By modulating sphingomyelin content, these vesicles were shown to contribute to behavioral recovery in experimental stroke studies. Another important sphingolipid that influences stroke pathology is sphingosine-1-phosphate, which has been attributed a pro-angiogenic function, that is presumably mediated by its effect on endothelial function and/or immune cell trafficking. In experimental and clinical studies, sphingosine-1-phosphate receptor modulators allowed to modify clinically significant stroke recovery. Due to their pivotal roles in cell signaling, pharmacological compounds modulating sphingolipids, their enzymes or receptors hold promise as therapeutics in human stroke patients.Sphingolipids comprise a class of lipids, which are composed of a sphingoid base backbone and are essential structural components of cell membranes. Beyond their role in maintaining cellular integrity, several sphingolipids are pivotally involved in signaling pathways controlling cell proliferation, differentiation, and death. The brain exhibits a particularly high concentration of sphingolipids and dysregulation of the sphingolipid metabolism due to ischemic injury is implicated in consecutive pathological events. Experimental stroke studies revealed that the stress sphingolipid ceramide accumulates in the ischemic brain post-stroke. Specifically, counteracting ceramide accumulation protects against ischemic damage and promotes brain remodeling, which translates into improved behavioral outcome. Sphingomyelin substantially influences cell membrane fluidity and thereby controls the release of extracellular vesicles, which are important vehicles in cellular communication. By modulating sphingomyelin content, these vesicles were shown to contribute to behavioral recovery in experimental stroke studies. Another important sphingolipid that influences stroke pathology is sphingosine-1-phosphate, which has been attributed a pro-angiogenic function, that is presumably mediated by its effect on endothelial function and/or immune cell trafficking. In experimental and clinical studies, sphingosine-1-phosphate receptor modulators allowed to modify clinically significant stroke recovery. Due to their pivotal roles in cell signaling, pharmacological compounds modulating sphingolipids, their enzymes or receptors hold promise as therapeutics in human stroke patients. Sphingolipids comprise a class of lipids, which are composed of a sphingoid base backbone and are essential structural components of cell membranes. Beyond their role in maintaining cellular integrity, several sphingolipids are pivotally involved in signaling pathways controlling cell proliferation, differentiation, and death. The brain exhibits a particularly high concentration of sphingolipids and dysregulation of the sphingolipid metabolism due to ischemic injury is implicated in consecutive pathological events. Experimental stroke studies revealed that the stress sphingolipid ceramide accumulates in the ischemic brain post-stroke. Specifically, counteracting ceramide accumulation protects against ischemic damage and promotes brain remodeling, which translates into improved behavioral outcome. Sphingomyelin substantially influences cell membrane fluidity and thereby controls the release of extracellular vesicles, which are important vehicles in cellular communication. By modulating sphingomyelin content, these vesicles were shown to contribute to behavioral recovery in experimental stroke studies. Another important sphingolipid that influences stroke pathology is sphingosine-1-phosphate, which has been attributed a pro-angiogenic function, that is presumably mediated by its effect on endothelial function and/or immune cell trafficking. In experimental and clinical studies, sphingosine-1-phosphate receptor modulators allowed to modify clinically significant stroke recovery. Due to their pivotal roles in cell signaling, pharmacological compounds modulating sphingolipids, their enzymes or receptors hold promise as therapeutics in human stroke patients. •Ischemic stroke leads to dysregulation of the sphingolipid metabolism.•Ceramide accumulation occurring post-stroke deteriorates injury and inhibiting its metabolizing enzymes enhances recovery.•S1P receptor modulation influences vascular function and immune cell trafficking post-stroke.•Sphingolipids are important for the formation and release of extracellular vesicles that stimulate brain remodeling. Sphingolipids comprise a class of lipids, which are composed of a sphingoid base backbone and are essential structural components of cell membranes. Beyond their role in maintaining cellular integrity, several sphingolipids are pivotally involved in signaling pathways controlling cell proliferation, differentiation, and death. The brain exhibits a particularly high concentration of sphingolipids and dysregulation of the sphingolipid metabolism due to ischemic injury is implicated in consecutive pathological events. Experimental stroke studies revealed that the stress sphingolipid ceramide accumulates in the ischemic brain post-stroke. Specifically, counteracting ceramide accumulation protects against ischemic damage and promotes brain remodeling, which translates into improved behavioral outcome. Sphingomyelin substantially influences cell membrane fluidity and thereby controls the release of extracellular vesicles, which are important vehicles in cellular communication. By modulating sphingomyelin content, these vesicles were shown to contribute to behavioral recovery in experimental stroke studies. Another important sphingolipid that influences stroke pathology is sphingosine-1-phosphate, which has been attributed a pro-angiogenic function, that is presumably mediated by its effect on endothelial function and/or immune cell trafficking. In experimental and clinical studies, sphingosine-1-phosphate receptor modulators allowed to modify clinically significant stroke recovery. Due to their pivotal roles in cell signaling, pharmacological compounds modulating sphingolipids, their enzymes or receptors hold promise as therapeutics in human stroke patients. |
| ArticleNumber | 106682 |
| Author | Hermann, Dirk M. Mohamud Yusuf, Ayan Gulbins, Erich Peng, Ying Hagemann, Nina Zhang, Xiaoni |
| Author_xml | – sequence: 1 givenname: Ayan surname: Mohamud Yusuf fullname: Mohamud Yusuf, Ayan organization: Department of Neurology, University Hospital Essen, Essen, Germany – sequence: 2 givenname: Xiaoni surname: Zhang fullname: Zhang, Xiaoni organization: Department of Neurology, University Hospital Essen, Essen, Germany – sequence: 3 givenname: Erich surname: Gulbins fullname: Gulbins, Erich organization: Institute of Molecular Biology, University Hospital Essen, Essen, Germany – sequence: 4 givenname: Ying surname: Peng fullname: Peng, Ying organization: Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China – sequence: 5 givenname: Nina surname: Hagemann fullname: Hagemann, Nina organization: Department of Neurology, University Hospital Essen, Essen, Germany – sequence: 6 givenname: Dirk M. surname: Hermann fullname: Hermann, Dirk M. email: dirk.hermann@uk-essen.de organization: Department of Neurology, University Hospital Essen, Essen, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39332507$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_nbd_2025_106865 crossref_primary_10_3892_or_2025_8874 crossref_primary_10_1007_s11306_025_02235_1 |
| Cites_doi | 10.1186/s12933-023-02116-8 10.1016/j.febslet.2010.02.026 10.3390/ijms23179697 10.1007/s00395-020-00823-x 10.1016/0304-3959(89)90108-5 10.1371/journal.pone.0021312 10.1016/j.atherosclerosis.2012.02.042 10.1038/nm.1999 10.1126/science.1153124 10.1634/stemcells.2006-0223 10.1016/S0140-6736(18)32823-X 10.1074/jbc.M109.041152 10.1016/S0092-8674(00)80093-8 10.1111/j.1476-5381.2009.00211.x 10.1016/j.brainres.2019.146509 10.1038/sj.onc.1207087 10.1016/S0092-8674(00)81661-X 10.1007/s00395-022-00950-7 10.1161/STROKEAHA.118.022606 10.1038/sj.onc.1206540 10.1016/S1474-4422(10)70314-8 10.1074/jbc.272.36.22432 10.1016/j.neuron.2018.10.038 10.1002/ana.22186 10.1038/nrm2329 10.1016/S1388-1981(02)00341-4 10.1016/S1474-4422(20)30219-2 10.1016/j.brainresbull.2020.03.009 10.1007/s10456-018-9603-z 10.1161/STROKEAHA.108.514612 10.1161/STROKEAHA.113.002880 10.1016/j.chemphyslip.2012.06.003 10.1161/CIRCULATIONAHA.115.016371 10.1021/ja4059876 10.1161/STROKEAHA.109.568899 10.1016/j.expneurol.2007.01.008 10.5966/sctm.2015-0078 10.1074/jbc.R200008200 10.1007/s12035-022-02745-2 10.1002/ana.1257 10.1176/appi.ajp.160.10.1823 10.1161/CIRCRESAHA.120.316711 10.3892/etm.2020.9371 10.1155/2015/503079 10.1161/01.STR.0000025518.34157.51 10.1016/j.jlr.2022.100236 10.1002/glia.20230 10.1248/bpb.33.11 10.1016/S1474-4422(20)30207-6 10.1161/ATVBAHA.123.320339 10.1016/j.expneurol.2020.113494 10.1007/s00018-011-0686-6 10.1002/ana.25352 10.1385/JMN:15:2:85 10.1161/CIRCULATIONAHA.107.691279 10.1194/jlr.R046300 10.1186/1750-1326-7-45 10.1074/jbc.M702423200 10.1007/s12031-022-02036-4 10.1186/1742-2094-10-109 10.1523/JNEUROSCI.1867-14.2014 10.1083/jcb.201208152 10.1038/ni1545 10.1111/jcmm.13596 10.1038/ng0795-288 10.1159/000315101 10.1161/CIRCRESAHA.116.308398 10.1023/A:1011083818452 10.1016/j.cellsig.2007.12.006 10.1371/journal.pone.0129735 10.1007/s12035-009-8096-6 10.1182/blood-2012-04-426734 10.1096/fj.09-150540 10.1016/j.celrep.2021.109250 10.1161/STROKEAHA.115.010620 10.1007/s10545-007-0632-9 10.1016/j.tcb.2011.09.003 10.4049/jimmunol.160.10.5037 10.1161/ATVBAHA.116.305675 10.1097/01.WCB.0000119990.06999.A9 10.1007/s00418-007-0344-0 10.1007/s12035-014-8807-5 10.1016/j.jfma.2021.01.006 10.1007/978-1-4419-6741-1_1 10.1016/S0006-3495(03)74780-8 10.1016/j.plipres.2013.05.001 10.1038/sj.cdd.4400428 10.1016/j.pneurobio.2013.11.005 10.1016/j.brainres.2004.07.024 10.1146/annurev-biophys-070317-033309 10.1016/j.bbi.2020.10.015 10.1002/jnr.21899 10.1111/jnc.14917 10.1007/s12031-022-02014-w 10.3390/ijms21176242 10.1016/j.jstrokecerebrovasdis.2019.104476 10.1016/j.bbalip.2007.05.007 10.1016/j.bbrc.2017.09.049 10.1016/j.semcdb.2017.07.036 10.1038/nm.3214 10.1161/JAHA.119.012885 10.1038/s41598-017-12491-4 10.1371/journal.pone.0018386 10.1073/pnas.1416166111 10.1016/j.brainres.2005.02.060 10.1186/1743-7075-8-89 10.1007/s40263-021-00798-w 10.1016/S1388-1981(02)00338-4 10.1179/016164108X339396 10.1124/pr.110.003111 10.1038/jcbfm.2013.152 10.1038/ncb2987 10.5603/PJNNS.a2019.0063 10.1006/bbrc.1999.1586 10.1523/JNEUROSCI.0458-08.2008 10.1186/s12974-017-0792-y |
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| Keywords | Ceramide Sphingomyelin Ischemic stroke Sphingosine-1-phosphate |
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| References | Fiedorowicz (bb0140) 2019; 53 Slotte (bb0460) 2013; 52 Edsfeldt (bb0130) 2016; 36 Lee (bb0295) 2022; 121 Li (bb0300) 2007; 1771 Gault (bb0150) 2010; 688 Maceyka (bb0330) 2012; 22 Chiu (bb0070) 2003; 85 Lind (bb0315) 2020; 29 Hannun, Obeid (bb0190) 2002; 277 Ho (bb0215) 2022; 23 Vit, Rosselli (bb0510) 2003; 22 Blaho, Hla (bb0030) 2014; 55 Qian (bb0410) 2024; 23 Fu (bb0145) 2014; 111 (bb0100) 2019; 393 Carsana (bb0055) 2022; 72 Kraft (bb0275) 2013; 44 (bb0095) 2020; 19 Schuchman (bb0425) 2007; 30 Mracsko (bb0355) 2014; 34 Dong (bb0125) 2018; 22 Lee (bb0290) 2022; 63 Lucaciu (bb0320) 2020; 21 Kleinschnitz (bb0260) 2007; 115 Bhuiyan (bb0025) 2010; 33 Martinez (bb0335) 2012; 7 Hasegawa (bb0200) 2010; 41 Gladstone (bb0155) 2002; 33 Czubowicz (bb0105) 2015; 51 Roy (bb0415) 2021; 35 Shen (bb0445) 2014; 16 Pham (bb0390) 2011; 6 Shichita (bb0455) 2009; 15 Bleicher, Cabot (bb0035) 2002; 1585 Candelario-Jalil, Paul (bb0050) 2021; 335 Jin (bb0225) 2018; 21 Lee (bb0285) 1999; 264 Alonso, Goni (bb0005) 2018; 47 Ohtani (bb0370) 2004; 1023 Yilmaz (bb0555) 2018; 73 Park (bb0380) 2018; 100 Kim (bb0235) 2007; 204 Liesz (bb0305) 2011; 6 Wadsworth (bb0515) 2013; 135 Nitzsche (bb0365) 2021; 128 Hagemann (bb0185) 2024; 44 Kleinschnitz (bb0265) 2013; 121 Xin (bb0535) 2013; 33 Kitatani (bb0255) 2008; 20 Chun (bb0080) 2010; 62 Grassme (bb0160) 2003; 22 Maceyka (bb0325) 2002; 1585 Wei (bb0525) 2011; 69 (bb0090) 2020; 19 Doeppner (bb0120) 2015; 4 Lee (bb0280) 1999; 99 Kim (bb0240) 2012; 222 Trajkovic (bb0495) 2008; 319 Michel (bb0340) 1997; 272 Sardari (bb0420) 2021; 91 Spinedi (bb0465) 1998; 5 Windle, Corbett (bb0530) 2005; 1044 Ermini (bb0135) 2017; 7 Tian (bb0490) 2018; 84 Chiba (bb0065) 1998; 160 Babu (bb0015) 2022; 59 Zoller (bb0570) 2005; 52 Horinouchi (bb0220) 1995; 10 Jorge (bb0230) 2003; 160 Kornhuber (bb0270) 2010; 26 Brunkhorst (bb0045) 2015; 2015 Leijon, Boivie (bb4001) 1989; 36 Gu (bb0165) 2013; 10 Gui (bb0170) 2020; 158 Hagemann (bb0180) 2020; 115 Sheth (bb0450) 2015; 10 Yu (bb0560) 2000; 15 Herz (bb0205) 2015; 46 Shang (bb0440) 2020; 1726 Chatterjee, Wu (bb0060) 2001; 219 Boehme (bb0040) 2017; 120 Stancevic, Kolesnick (bb0470) 2010; 584 Powers (bb0405) 2019; 50 Kimura (bb0245) 2007; 25 Zhu (bb0565) 2015; 132 Takahashi (bb0485) 2004; 24 Hannun, Obeid (bb0195) 2008; 9 Parolini (bb0385) 2009; 284 Pariente (bb0375) 2001; 50 Chollet (bb0075) 2011; 10 Tafesse (bb0480) 2007; 282 Becker (bb0020) 2008; 129 Kimura (bb0250) 2008; 39 Zoller (bb0575) 2008; 28 Truman (bb0505) 2011; 68 Yang (bb0545) 2020; 20 Yeang (bb0550) 2011; 8 Coetzee (bb0085) 1996; 86 Platt (bb0400) 2012; 199 Schwab, Cyster (bb0435) 2007; 8 Tran (bb0500) 2020; 153 Muralidharan (bb0360) 2021; 35 Morita (bb0350) 2012; 165 Piccinini (bb0395) 2010; 41 Stetler (bb0475) 2014; 114 Lim (bb0310) 2009; 87 Mohamud Yusuf (bb0345) 2022; 117 Gulbins (bb0175) 2013; 19 Hisaki (bb0210) 2008; 30 Wang (bb0520) 2022; 72 Schuhmann (bb0430) 2017; 14 Di (bb0110) 2017; 493 Xue (bb0540) 2019; 8 Anelli (bb0010) 2010; 24 Dirnagl, Macleod (bb0115) 2009; 157 Candelario-Jalil (10.1016/j.nbd.2024.106682_bb0050) 2021; 335 Hannun (10.1016/j.nbd.2024.106682_bb0195) 2008; 9 Kleinschnitz (10.1016/j.nbd.2024.106682_bb0265) 2013; 121 Mohamud Yusuf (10.1016/j.nbd.2024.106682_bb0345) 2022; 117 Bhuiyan (10.1016/j.nbd.2024.106682_bb0025) 2010; 33 Alonso (10.1016/j.nbd.2024.106682_bb0005) 2018; 47 Chollet (10.1016/j.nbd.2024.106682_bb0075) 2011; 10 Hagemann (10.1016/j.nbd.2024.106682_bb0185) 2024; 44 Li (10.1016/j.nbd.2024.106682_bb0300) 2007; 1771 Windle (10.1016/j.nbd.2024.106682_bb0530) 2005; 1044 Sardari (10.1016/j.nbd.2024.106682_bb0420) 2021; 91 Kimura (10.1016/j.nbd.2024.106682_bb0250) 2008; 39 Fiedorowicz (10.1016/j.nbd.2024.106682_bb0140) 2019; 53 Xin (10.1016/j.nbd.2024.106682_bb0535) 2013; 33 (10.1016/j.nbd.2024.106682_bb0090) 2020; 19 Nitzsche (10.1016/j.nbd.2024.106682_bb0365) 2021; 128 Shang (10.1016/j.nbd.2024.106682_bb0440) 2020; 1726 Grassme (10.1016/j.nbd.2024.106682_bb0160) 2003; 22 Kim (10.1016/j.nbd.2024.106682_bb0235) 2007; 204 Slotte (10.1016/j.nbd.2024.106682_bb0460) 2013; 52 Vit (10.1016/j.nbd.2024.106682_bb0510) 2003; 22 Xue (10.1016/j.nbd.2024.106682_bb0540) 2019; 8 Zhu (10.1016/j.nbd.2024.106682_bb0565) 2015; 132 Ohtani (10.1016/j.nbd.2024.106682_bb0370) 2004; 1023 Wadsworth (10.1016/j.nbd.2024.106682_bb0515) 2013; 135 Kraft (10.1016/j.nbd.2024.106682_bb0275) 2013; 44 Hagemann (10.1016/j.nbd.2024.106682_bb0180) 2020; 115 Kitatani (10.1016/j.nbd.2024.106682_bb0255) 2008; 20 Yang (10.1016/j.nbd.2024.106682_bb0545) 2020; 20 Herz (10.1016/j.nbd.2024.106682_bb0205) 2015; 46 Jorge (10.1016/j.nbd.2024.106682_bb0230) 2003; 160 Boehme (10.1016/j.nbd.2024.106682_bb0040) 2017; 120 Gladstone (10.1016/j.nbd.2024.106682_bb0155) 2002; 33 Zoller (10.1016/j.nbd.2024.106682_bb0575) 2008; 28 Hisaki (10.1016/j.nbd.2024.106682_bb0210) 2008; 30 Becker (10.1016/j.nbd.2024.106682_bb0020) 2008; 129 Michel (10.1016/j.nbd.2024.106682_bb0340) 1997; 272 Horinouchi (10.1016/j.nbd.2024.106682_bb0220) 1995; 10 Zoller (10.1016/j.nbd.2024.106682_bb0570) 2005; 52 Chiba (10.1016/j.nbd.2024.106682_bb0065) 1998; 160 Powers (10.1016/j.nbd.2024.106682_bb0405) 2019; 50 Kornhuber (10.1016/j.nbd.2024.106682_bb0270) 2010; 26 Gulbins (10.1016/j.nbd.2024.106682_bb0175) 2013; 19 Stancevic (10.1016/j.nbd.2024.106682_bb0470) 2010; 584 Czubowicz (10.1016/j.nbd.2024.106682_bb0105) 2015; 51 Di (10.1016/j.nbd.2024.106682_bb0110) 2017; 493 Kimura (10.1016/j.nbd.2024.106682_bb0245) 2007; 25 Schuchman (10.1016/j.nbd.2024.106682_bb0425) 2007; 30 Qian (10.1016/j.nbd.2024.106682_bb0410) 2024; 23 Yu (10.1016/j.nbd.2024.106682_bb0560) 2000; 15 Yilmaz (10.1016/j.nbd.2024.106682_bb0555) 2018; 73 Lee (10.1016/j.nbd.2024.106682_bb0290) 2022; 63 Tian (10.1016/j.nbd.2024.106682_bb0490) 2018; 84 Truman (10.1016/j.nbd.2024.106682_bb0505) 2011; 68 Muralidharan (10.1016/j.nbd.2024.106682_bb0360) 2021; 35 Platt (10.1016/j.nbd.2024.106682_bb0400) 2012; 199 Leijon (10.1016/j.nbd.2024.106682_bb4001) 1989; 36 Chun (10.1016/j.nbd.2024.106682_bb0080) 2010; 62 Bleicher (10.1016/j.nbd.2024.106682_bb0035) 2002; 1585 Lind (10.1016/j.nbd.2024.106682_bb0315) 2020; 29 Dirnagl (10.1016/j.nbd.2024.106682_bb0115) 2009; 157 Yeang (10.1016/j.nbd.2024.106682_bb0550) 2011; 8 Gault (10.1016/j.nbd.2024.106682_bb0150) 2010; 688 Dong (10.1016/j.nbd.2024.106682_bb0125) 2018; 22 Gui (10.1016/j.nbd.2024.106682_bb0170) 2020; 158 Parolini (10.1016/j.nbd.2024.106682_bb0385) 2009; 284 Gu (10.1016/j.nbd.2024.106682_bb0165) 2013; 10 Shen (10.1016/j.nbd.2024.106682_bb0445) 2014; 16 Fu (10.1016/j.nbd.2024.106682_bb0145) 2014; 111 Brunkhorst (10.1016/j.nbd.2024.106682_bb0045) 2015; 2015 Piccinini (10.1016/j.nbd.2024.106682_bb0395) 2010; 41 Takahashi (10.1016/j.nbd.2024.106682_bb0485) 2004; 24 Doeppner (10.1016/j.nbd.2024.106682_bb0120) 2015; 4 Wang (10.1016/j.nbd.2024.106682_bb0520) 2022; 72 Lee (10.1016/j.nbd.2024.106682_bb0280) 1999; 99 Hannun (10.1016/j.nbd.2024.106682_bb0190) 2002; 277 Mracsko (10.1016/j.nbd.2024.106682_bb0355) 2014; 34 Tran (10.1016/j.nbd.2024.106682_bb0500) 2020; 153 Morita (10.1016/j.nbd.2024.106682_bb0350) 2012; 165 Hasegawa (10.1016/j.nbd.2024.106682_bb0200) 2010; 41 Roy (10.1016/j.nbd.2024.106682_bb0415) 2021; 35 Maceyka (10.1016/j.nbd.2024.106682_bb0330) 2012; 22 Liesz (10.1016/j.nbd.2024.106682_bb0305) 2011; 6 Kim (10.1016/j.nbd.2024.106682_bb0240) 2012; 222 Coetzee (10.1016/j.nbd.2024.106682_bb0085) 1996; 86 Lee (10.1016/j.nbd.2024.106682_bb0285) 1999; 264 Stetler (10.1016/j.nbd.2024.106682_bb0475) 2014; 114 Chatterjee (10.1016/j.nbd.2024.106682_bb0060) 2001; 219 Lucaciu (10.1016/j.nbd.2024.106682_bb0320) 2020; 21 Anelli (10.1016/j.nbd.2024.106682_bb0010) 2010; 24 Tafesse (10.1016/j.nbd.2024.106682_bb0480) 2007; 282 Maceyka (10.1016/j.nbd.2024.106682_bb0325) 2002; 1585 (10.1016/j.nbd.2024.106682_bb0100) 2019; 393 Babu (10.1016/j.nbd.2024.106682_bb0015) 2022; 59 Pariente (10.1016/j.nbd.2024.106682_bb0375) 2001; 50 Spinedi (10.1016/j.nbd.2024.106682_bb0465) 1998; 5 Martinez (10.1016/j.nbd.2024.106682_bb0335) 2012; 7 Park (10.1016/j.nbd.2024.106682_bb0380) 2018; 100 Sheth (10.1016/j.nbd.2024.106682_bb0450) 2015; 10 (10.1016/j.nbd.2024.106682_bb0095) 2020; 19 Trajkovic (10.1016/j.nbd.2024.106682_bb0495) 2008; 319 Carsana (10.1016/j.nbd.2024.106682_bb0055) 2022; 72 Chiu (10.1016/j.nbd.2024.106682_bb0070) 2003; 85 Blaho (10.1016/j.nbd.2024.106682_bb0030) 2014; 55 Schwab (10.1016/j.nbd.2024.106682_bb0435) 2007; 8 Wei (10.1016/j.nbd.2024.106682_bb0525) 2011; 69 Schuhmann (10.1016/j.nbd.2024.106682_bb0430) 2017; 14 Lee (10.1016/j.nbd.2024.106682_bb0295) 2022; 121 Kleinschnitz (10.1016/j.nbd.2024.106682_bb0260) 2007; 115 Ermini (10.1016/j.nbd.2024.106682_bb0135) 2017; 7 Jin (10.1016/j.nbd.2024.106682_bb0225) 2018; 21 Shichita (10.1016/j.nbd.2024.106682_bb0455) 2009; 15 Pham (10.1016/j.nbd.2024.106682_bb0390) 2011; 6 Lim (10.1016/j.nbd.2024.106682_bb0310) 2009; 87 Ho (10.1016/j.nbd.2024.106682_bb0215) 2022; 23 Edsfeldt (10.1016/j.nbd.2024.106682_bb0130) 2016; 36 |
| References_xml | – volume: 72 start-page: 1846 year: 2022 end-page: 1858 ident: bb0520 article-title: Lipidomics analysis reveals a protective effect of Myriocin on cerebral ischemia/reperfusion model rats publication-title: J. Mol. Neurosci. – volume: 22 start-page: 3159 year: 2018 end-page: 3166 ident: bb0125 article-title: S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFkappaB signalling publication-title: J. Cell. Mol. Med. – volume: 7 start-page: 12172 year: 2017 ident: bb0135 article-title: A single sphingomyelin species promotes exosomal release of Endoglin into the maternal circulation in preeclampsia publication-title: Sci. Rep. – volume: 100 year: 2018 ident: bb0380 article-title: Vascular and neurogenic rejuvenation in aging mice by modulation of ASM publication-title: Neuron – volume: 73 start-page: 188 year: 2018 end-page: 198 ident: bb0555 article-title: Molecular mechanisms of action of sphingomyelin-specific pore-forming toxin, lysenin publication-title: Semin. Cell Dev. Biol. – volume: 160 start-page: 5037 year: 1998 end-page: 5044 ident: bb0065 article-title: FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing publication-title: J. Immunol. – volume: 44 start-page: 3202 year: 2013 end-page: 3210 ident: bb0275 article-title: FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection publication-title: Stroke – volume: 63 year: 2022 ident: bb0290 article-title: Identification and characterization of 3-ketosphinganine reductase activity encoded at the BT_0972 locus in Bacteroides thetaiotaomicron publication-title: J. Lipid Res. – volume: 393 start-page: 265 year: 2019 end-page: 274 ident: bb0100 article-title: Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial publication-title: Lancet – volume: 135 start-page: 14276 year: 2013 end-page: 14285 ident: bb0515 article-title: The chemical basis of serine palmitoyltransferase inhibition by myriocin publication-title: J. Am. Chem. Soc. – volume: 165 start-page: 571 year: 2012 end-page: 576 ident: bb0350 article-title: Specific and sensitive enzymatic measurement of sphingomyelin in cultured cells publication-title: Chem. Phys. Lipids – volume: 199 start-page: 723 year: 2012 end-page: 734 ident: bb0400 article-title: The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction publication-title: J. Cell Biol. – volume: 8 start-page: 89 year: 2011 ident: bb0550 article-title: Subcellular targeting domains of sphingomyelin synthase 1 and 2 publication-title: Nutr. Metab. (Lond.) – volume: 2015 year: 2015 ident: bb0045 article-title: Alterations of the ceramide metabolism in the peri-infarct cortex are independent of the sphingomyelinase pathway and not influenced by the acid sphingomyelinase inhibitor fluoxetine publication-title: Neural Plast. – volume: 19 start-page: 661 year: 2020 end-page: 669 ident: bb0095 article-title: Safety and efficacy of fluoxetine on functional recovery after acute stroke (EFFECTS): a randomised, double-blind, placebo-controlled trial publication-title: Lancet Neurol. – volume: 22 start-page: 5457 year: 2003 end-page: 5470 ident: bb0160 article-title: Ceramide-mediated clustering is required for CD95-DISC formation publication-title: Oncogene – volume: 15 start-page: 946 year: 2009 end-page: 950 ident: bb0455 article-title: Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury publication-title: Nat. Med. – volume: 33 start-page: 11 year: 2010 end-page: 17 ident: bb0025 article-title: Involvement of ceramide in ischemic tolerance induced by preconditioning with sublethal oxygen-glucose deprivation in primary cultured cortical neurons of rats publication-title: Biol. Pharm. Bull. – volume: 36 start-page: 1132 year: 2016 end-page: 1140 ident: bb0130 article-title: Sphingolipids contribute to human atherosclerotic plaque inflammation publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 99 start-page: 301 year: 1999 end-page: 312 ident: bb0280 article-title: Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate publication-title: Cell – volume: 41 start-page: 368 year: 2010 end-page: 374 ident: bb0200 article-title: Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats publication-title: Stroke – volume: 153 start-page: 173 year: 2020 end-page: 188 ident: bb0500 article-title: Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes publication-title: J. Neurochem. – volume: 129 start-page: 233 year: 2008 end-page: 241 ident: bb0020 article-title: Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2 publication-title: Histochem. Cell Biol. – volume: 30 start-page: 979 year: 2008 end-page: 984 ident: bb0210 article-title: L-PDMP improves glucosylceramide synthesis and behavior in rats with focal ischemia publication-title: Neurol. Res. – volume: 50 start-page: e344 year: 2019 end-page: e418 ident: bb0405 article-title: Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association publication-title: Stroke – volume: 29 year: 2020 ident: bb0315 article-title: A multi-cohort metabolomics analysis discloses sphingomyelin (32:1) levels to be inversely related to incident ischemic stroke publication-title: J. Stroke Cerebrovasc. Dis. – volume: 69 start-page: 119 year: 2011 end-page: 129 ident: bb0525 article-title: Fingolimod provides long-term protection in rodent models of cerebral ischemia publication-title: Ann. Neurol. – volume: 121 start-page: 679 year: 2013 end-page: 691 ident: bb0265 article-title: Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature publication-title: Blood – volume: 53 start-page: 484 year: 2019 end-page: 491 ident: bb0140 article-title: Ceramides and sphingosine-1-phosphate as potential markers in diagnosis of ischaemic stroke publication-title: Neurol. Neurochir. Pol. – volume: 72 start-page: 1482 year: 2022 end-page: 1499 ident: bb0055 article-title: Massive accumulation of sphingomyelin affects the lysosomal and mitochondria compartments and promotes apoptosis in Niemann-pick disease type a publication-title: J. Mol. Neurosci. – volume: 47 start-page: 633 year: 2018 end-page: 654 ident: bb0005 article-title: The physical properties of ceramides in membranes publication-title: Annu. Rev. Biophys. – volume: 204 start-page: 748 year: 2007 end-page: 758 ident: bb0235 article-title: Effects of fluoxetine on ischemic cells and expressions in BDNF and some antioxidants in the gerbil hippocampal CA1 region induced by transient ischemia publication-title: Exp. Neurol. – volume: 85 start-page: 3624 year: 2003 end-page: 3635 ident: bb0070 article-title: Structure of sphingomyelin bilayers: a simulation study publication-title: Biophys. J. – volume: 21 start-page: 381 year: 2018 end-page: 394 ident: bb0225 article-title: High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation publication-title: Angiogenesis – volume: 59 start-page: 2363 year: 2022 end-page: 2377 ident: bb0015 article-title: In vitro oxygen glucose deprivation model of ischemic stroke: a proteomics-driven systems biological perspective publication-title: Mol. Neurobiol. – volume: 22 start-page: 50 year: 2012 end-page: 60 ident: bb0330 article-title: Sphingosine-1-phosphate signaling and its role in disease publication-title: Trends Cell Biol. – volume: 1023 start-page: 31 year: 2004 end-page: 40 ident: bb0370 article-title: Upregulation of ceramide and its regulating mechanism in a rat model of chronic cerebral ischemia publication-title: Brain Res. – volume: 284 start-page: 34211 year: 2009 end-page: 34222 ident: bb0385 article-title: Microenvironmental pH is a key factor for exosome traffic in tumor cells publication-title: J. Biol. Chem. – volume: 10 start-page: 123 year: 2011 end-page: 130 ident: bb0075 article-title: Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial publication-title: Lancet Neurol. – volume: 26 start-page: 9 year: 2010 end-page: 20 ident: bb0270 article-title: Functional inhibitors of acid sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications publication-title: Cell. Physiol. Biochem. – volume: 9 start-page: 139 year: 2008 end-page: 150 ident: bb0195 article-title: Principles of bioactive lipid signalling: lessons from sphingolipids publication-title: Nat. Rev. Mol. Cell Biol. – volume: 335 year: 2021 ident: bb0050 article-title: Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: a translational perspective publication-title: Exp. Neurol. – volume: 51 start-page: 1300 year: 2015 end-page: 1308 ident: bb0105 article-title: Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival publication-title: Mol. Neurobiol. – volume: 39 start-page: 3411 year: 2008 end-page: 3417 ident: bb0250 article-title: Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain publication-title: Stroke – volume: 493 start-page: 188 year: 2017 end-page: 194 ident: bb0110 article-title: AntagomiR-613 protects neuronal cells from oxygen glucose deprivation/re-oxygenation via increasing SphK2 expression publication-title: Biochem. Biophys. Res. Commun. – volume: 50 start-page: 718 year: 2001 end-page: 729 ident: bb0375 article-title: Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke publication-title: Ann. Neurol. – volume: 28 start-page: 9741 year: 2008 end-page: 9754 ident: bb0575 article-title: Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration publication-title: J. Neurosci. – volume: 20 start-page: 241 year: 2020 ident: bb0545 article-title: Lack of sphingomyelin synthase 2 reduces cerebral ischemia/reperfusion injury by inhibiting microglial inflammation in mice publication-title: Exp. Ther. Med. – volume: 15 start-page: 85 year: 2000 end-page: 97 ident: bb0560 article-title: Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis publication-title: J. Mol. Neurosci. – volume: 584 start-page: 1728 year: 2010 end-page: 1740 ident: bb0470 article-title: Ceramide-rich platforms in transmembrane signaling publication-title: FEBS Lett. – volume: 1585 start-page: 193 year: 2002 end-page: 201 ident: bb0325 article-title: Sphingosine kinase, sphingosine-1-phosphate, and apoptosis publication-title: Biochim. Biophys. Acta – volume: 19 start-page: 934 year: 2013 end-page: 938 ident: bb0175 article-title: Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs publication-title: Nat. Med. – volume: 35 year: 2021 ident: bb0360 article-title: A reference map of sphingolipids in murine tissues publication-title: Cell Rep. – volume: 1044 start-page: 25 year: 2005 end-page: 32 ident: bb0530 article-title: Fluoxetine and recovery of motor function after focal ischemia in rats publication-title: Brain Res. – volume: 36 start-page: 27 year: 1989 end-page: 36 ident: bb4001 article-title: Central post-stroke pain--a controlled trial of amitriptyline and carbamazepine publication-title: Pain – volume: 6 year: 2011 ident: bb0305 article-title: FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia publication-title: PLoS One – volume: 44 start-page: 915 year: 2024 end-page: 929 ident: bb0185 article-title: Microvascular network remodeling in the ischemic mouse brain defined by light sheet microscopy publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 14 start-page: 18 year: 2017 ident: bb0430 article-title: Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke publication-title: J. Neuroinflammation – volume: 21 year: 2020 ident: bb0320 article-title: A sphingosine 1-phosphate gradient is linked to the cerebral recruitment of T helper and regulatory T helper cells during acute ischemic stroke publication-title: Int. J. Mol. Sci. – volume: 30 start-page: 654 year: 2007 end-page: 663 ident: bb0425 article-title: The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-pick disease publication-title: J. Inherit. Metab. Dis. – volume: 87 start-page: 1037 year: 2009 end-page: 1045 ident: bb0310 article-title: Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect publication-title: J. Neurosci. Res. – volume: 33 start-page: 1711 year: 2013 end-page: 1715 ident: bb0535 article-title: Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats publication-title: J. Cereb. Blood Flow Metab. – volume: 688 start-page: 1 year: 2010 end-page: 23 ident: bb0150 article-title: An overview of sphingolipid metabolism: from synthesis to breakdown publication-title: Adv. Exp. Med. Biol. – volume: 52 start-page: 424 year: 2013 end-page: 437 ident: bb0460 article-title: Biological functions of sphingomyelins publication-title: Prog. Lipid Res. – volume: 115 start-page: 64 year: 2020 ident: bb0180 article-title: Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia publication-title: Basic Res. Cardiol. – volume: 84 start-page: 717 year: 2018 end-page: 728 ident: bb0490 article-title: Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow publication-title: Ann. Neurol. – volume: 68 start-page: 3293 year: 2011 end-page: 3305 ident: bb0505 article-title: Acid sphingomyelinase in macrophage biology publication-title: Cell. Mol. Life Sci. – volume: 8 year: 2019 ident: bb0540 article-title: Sphingomyelin synthase 2 inhibition ameliorates cerebral ischemic reperfusion injury through reducing the recruitment of toll-like receptor 4 to lipid rafts publication-title: J. Am. Heart Assoc. – volume: 23 year: 2022 ident: bb0215 article-title: Ceramide acyl chain length and its relevance to intracellular lipid regulation publication-title: Int. J. Mol. Sci. – volume: 41 start-page: 314 year: 2010 end-page: 340 ident: bb0395 article-title: Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders publication-title: Mol. Neurobiol. – volume: 1585 start-page: 172 year: 2002 end-page: 178 ident: bb0035 article-title: Glucosylceramide synthase and apoptosis publication-title: Biochim. Biophys. Acta – volume: 115 start-page: 2323 year: 2007 end-page: 2330 ident: bb0260 article-title: Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding publication-title: Circulation – volume: 264 start-page: 743 year: 1999 end-page: 750 ident: bb0285 article-title: Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells publication-title: Biochem. Biophys. Res. Commun. – volume: 7 start-page: 45 year: 2012 ident: bb0335 article-title: Ceramide sphingolipid signaling mediates tumor necrosis factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons publication-title: Mol. Neurodegener. – volume: 1726 year: 2020 ident: bb0440 article-title: Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization publication-title: Brain Res. – volume: 157 start-page: 1154 year: 2009 end-page: 1156 ident: bb0115 article-title: Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice publication-title: Br. J. Pharmacol. – volume: 33 start-page: 2123 year: 2002 end-page: 2136 ident: bb0155 article-title: Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions publication-title: Stroke – volume: 4 start-page: 1131 year: 2015 end-page: 1143 ident: bb0120 article-title: Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression publication-title: Stem Cells Transl. Med. – volume: 55 start-page: 1596 year: 2014 end-page: 1608 ident: bb0030 article-title: An update on the biology of sphingosine 1-phosphate receptors publication-title: J. Lipid Res. – volume: 10 start-page: 288 year: 1995 end-page: 293 ident: bb0220 article-title: Acid sphingomyelinase deficient mice: a model of types a and B Niemann-pick disease publication-title: Nat. Genet. – volume: 8 start-page: 1295 year: 2007 end-page: 1301 ident: bb0435 article-title: Finding a way out: lymphocyte egress from lymphoid organs publication-title: Nat. Immunol. – volume: 19 start-page: 651 year: 2020 end-page: 660 ident: bb0090 article-title: Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial publication-title: Lancet Neurol. – volume: 128 start-page: 363 year: 2021 end-page: 382 ident: bb0365 article-title: Endothelial S1P(1) signaling counteracts infarct expansion in ischemic stroke publication-title: Circ. Res. – volume: 86 start-page: 209 year: 1996 end-page: 219 ident: bb0085 article-title: Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability publication-title: Cell – volume: 272 start-page: 22432 year: 1997 end-page: 22437 ident: bb0340 article-title: Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide publication-title: J. Biol. Chem. – volume: 117 start-page: 43 year: 2022 ident: bb0345 article-title: Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles publication-title: Basic Res. Cardiol. – volume: 22 start-page: 8645 year: 2003 end-page: 8652 ident: bb0510 article-title: Role of the ceramide-signaling pathways in ionizing radiation-induced apoptosis publication-title: Oncogene – volume: 46 start-page: 2916 year: 2015 end-page: 2925 ident: bb0205 article-title: Role of neutrophils in exacerbation of brain injury after focal cerebral ischemia in hyperlipidemic mice publication-title: Stroke – volume: 319 start-page: 1244 year: 2008 end-page: 1247 ident: bb0495 article-title: Ceramide triggers budding of exosome vesicles into multivesicular endosomes publication-title: Science – volume: 24 start-page: 623 year: 2004 end-page: 627 ident: bb0485 article-title: Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning publication-title: J. Cereb. Blood Flow Metab. – volume: 6 year: 2011 ident: bb0390 article-title: Sustained reperfusion after blockade of glycoprotein-receptor-Ib in focal cerebral ischemia: an MRI study at 17.6 tesla publication-title: PLoS One – volume: 111 start-page: 18315 year: 2014 end-page: 18320 ident: bb0145 article-title: Impact of an immune modulator fingolimod on acute ischemic stroke publication-title: Proc. Natl. Acad. Sci. USA – volume: 1771 start-page: 1186 year: 2007 end-page: 1194 ident: bb0300 article-title: Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization publication-title: Biochim. Biophys. Acta – volume: 219 start-page: 21 year: 2001 end-page: 27 ident: bb0060 article-title: Cell line dependent involvement of ceramide in ultraviolet light-induced apoptosis publication-title: Mol. Cell. Biochem. – volume: 132 start-page: 1104 year: 2015 end-page: 1112 ident: bb0565 article-title: Combination of the immune modulator fingolimod with alteplase in acute ischemic stroke: a pilot trial publication-title: Circulation – volume: 158 start-page: 122 year: 2020 end-page: 127 ident: bb0170 article-title: Plasma levels of ceramides relate to ischemic stroke risk and clinical severity publication-title: Brain Res. Bull. – volume: 121 start-page: 43 year: 2022 end-page: 50 ident: bb0295 article-title: Plasma ceramides are associated with outcomes in acute ischemic stroke patients publication-title: J. Formos. Med. Assoc. – volume: 10 start-page: 109 year: 2013 ident: bb0165 article-title: Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi publication-title: J. Neuroinflammation – volume: 24 start-page: 2727 year: 2010 end-page: 2738 ident: bb0010 article-title: Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro publication-title: FASEB J. – volume: 282 start-page: 17537 year: 2007 end-page: 17547 ident: bb0480 article-title: Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells publication-title: J. Biol. Chem. – volume: 160 start-page: 1823 year: 2003 end-page: 1829 ident: bb0230 article-title: Mortality and poststroke depression: a placebo-controlled trial of antidepressants publication-title: Am. J. Psychiatry – volume: 25 start-page: 115 year: 2007 end-page: 124 ident: bb0245 article-title: Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury publication-title: Stem Cells – volume: 23 start-page: 37 year: 2024 ident: bb0410 article-title: Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing diabetes study publication-title: Cardiovasc. Diabetol. – volume: 5 start-page: 785 year: 1998 end-page: 791 ident: bb0465 article-title: Apoptosis induced by N-hexanoylsphingosine in CHP-100 cells associates with accumulation of endogenous ceramide and is potentiated by inhibition of glucocerebroside synthesis publication-title: Cell Death Differ. – volume: 52 start-page: 190 year: 2005 end-page: 198 ident: bb0570 article-title: Oligodendrocyte-specific ceramide galactosyltransferase (CGT) expression phenotypically rescues CGT-deficient mice and demonstrates that CGT activity does not limit brain galactosylceramide level publication-title: Glia – volume: 34 start-page: 16784 year: 2014 end-page: 16795 ident: bb0355 article-title: Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke publication-title: J. Neurosci. – volume: 114 start-page: 58 year: 2014 end-page: 83 ident: bb0475 article-title: Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance publication-title: Prog. Neurobiol. – volume: 16 start-page: 652 year: 2014 end-page: 662 ident: bb0445 article-title: Coupling between endocytosis and sphingosine kinase 1 recruitment publication-title: Nat. Cell Biol. – volume: 10 year: 2015 ident: bb0450 article-title: Targeted lipid profiling discovers plasma biomarkers of acute brain injury publication-title: PLoS One – volume: 120 start-page: 472 year: 2017 end-page: 495 ident: bb0040 article-title: Stroke risk factors, genetics, and prevention publication-title: Circ. Res. – volume: 62 start-page: 579 year: 2010 end-page: 587 ident: bb0080 article-title: International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature publication-title: Pharmacol. Rev. – volume: 91 start-page: 627 year: 2021 end-page: 638 ident: bb0420 article-title: Lipopolysaccharide-induced sepsis-like state compromises post-ischemic neurological recovery, brain tissue survival and remodeling via mechanisms involving microvascular thrombosis and brain T cell infiltration publication-title: Brain Behav. Immun. – volume: 35 start-page: 385 year: 2021 end-page: 402 ident: bb0415 article-title: Sphingosine 1-phosphate receptor modulators for multiple sclerosis publication-title: CNS Drugs – volume: 277 start-page: 25847 year: 2002 end-page: 25850 ident: bb0190 article-title: The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind publication-title: J. Biol. Chem. – volume: 222 start-page: 464 year: 2012 end-page: 467 ident: bb0240 article-title: Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction publication-title: Atherosclerosis – volume: 20 start-page: 1010 year: 2008 end-page: 1018 ident: bb0255 article-title: The sphingolipid salvage pathway in ceramide metabolism and signaling publication-title: Cell. Signal. – volume: 23 start-page: 37 year: 2024 ident: 10.1016/j.nbd.2024.106682_bb0410 article-title: Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing diabetes study publication-title: Cardiovasc. Diabetol. doi: 10.1186/s12933-023-02116-8 – volume: 584 start-page: 1728 year: 2010 ident: 10.1016/j.nbd.2024.106682_bb0470 article-title: Ceramide-rich platforms in transmembrane signaling publication-title: FEBS Lett. doi: 10.1016/j.febslet.2010.02.026 – volume: 23 year: 2022 ident: 10.1016/j.nbd.2024.106682_bb0215 article-title: Ceramide acyl chain length and its relevance to intracellular lipid regulation publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms23179697 – volume: 115 start-page: 64 year: 2020 ident: 10.1016/j.nbd.2024.106682_bb0180 article-title: Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia publication-title: Basic Res. Cardiol. doi: 10.1007/s00395-020-00823-x – volume: 36 start-page: 27 issue: 1 year: 1989 ident: 10.1016/j.nbd.2024.106682_bb4001 article-title: Central post-stroke pain--a controlled trial of amitriptyline and carbamazepine publication-title: Pain doi: 10.1016/0304-3959(89)90108-5 – volume: 6 year: 2011 ident: 10.1016/j.nbd.2024.106682_bb0305 article-title: FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia publication-title: PLoS One doi: 10.1371/journal.pone.0021312 – volume: 222 start-page: 464 year: 2012 ident: 10.1016/j.nbd.2024.106682_bb0240 article-title: Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2012.02.042 – volume: 15 start-page: 946 year: 2009 ident: 10.1016/j.nbd.2024.106682_bb0455 article-title: Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury publication-title: Nat. Med. doi: 10.1038/nm.1999 – volume: 319 start-page: 1244 year: 2008 ident: 10.1016/j.nbd.2024.106682_bb0495 article-title: Ceramide triggers budding of exosome vesicles into multivesicular endosomes publication-title: Science doi: 10.1126/science.1153124 – volume: 25 start-page: 115 year: 2007 ident: 10.1016/j.nbd.2024.106682_bb0245 article-title: Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury publication-title: Stem Cells doi: 10.1634/stemcells.2006-0223 – volume: 393 start-page: 265 year: 2019 ident: 10.1016/j.nbd.2024.106682_bb0100 article-title: Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(18)32823-X – volume: 284 start-page: 34211 year: 2009 ident: 10.1016/j.nbd.2024.106682_bb0385 article-title: Microenvironmental pH is a key factor for exosome traffic in tumor cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.041152 – volume: 86 start-page: 209 year: 1996 ident: 10.1016/j.nbd.2024.106682_bb0085 article-title: Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability publication-title: Cell doi: 10.1016/S0092-8674(00)80093-8 – volume: 157 start-page: 1154 year: 2009 ident: 10.1016/j.nbd.2024.106682_bb0115 article-title: Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2009.00211.x – volume: 1726 year: 2020 ident: 10.1016/j.nbd.2024.106682_bb0440 article-title: Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization publication-title: Brain Res. doi: 10.1016/j.brainres.2019.146509 – volume: 22 start-page: 8645 year: 2003 ident: 10.1016/j.nbd.2024.106682_bb0510 article-title: Role of the ceramide-signaling pathways in ionizing radiation-induced apoptosis publication-title: Oncogene doi: 10.1038/sj.onc.1207087 – volume: 99 start-page: 301 year: 1999 ident: 10.1016/j.nbd.2024.106682_bb0280 article-title: Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate publication-title: Cell doi: 10.1016/S0092-8674(00)81661-X – volume: 117 start-page: 43 year: 2022 ident: 10.1016/j.nbd.2024.106682_bb0345 article-title: Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles publication-title: Basic Res. Cardiol. doi: 10.1007/s00395-022-00950-7 – volume: 50 start-page: e344 year: 2019 ident: 10.1016/j.nbd.2024.106682_bb0405 publication-title: Stroke doi: 10.1161/STROKEAHA.118.022606 – volume: 22 start-page: 5457 year: 2003 ident: 10.1016/j.nbd.2024.106682_bb0160 article-title: Ceramide-mediated clustering is required for CD95-DISC formation publication-title: Oncogene doi: 10.1038/sj.onc.1206540 – volume: 10 start-page: 123 year: 2011 ident: 10.1016/j.nbd.2024.106682_bb0075 article-title: Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(10)70314-8 – volume: 272 start-page: 22432 year: 1997 ident: 10.1016/j.nbd.2024.106682_bb0340 article-title: Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.36.22432 – volume: 100 year: 2018 ident: 10.1016/j.nbd.2024.106682_bb0380 article-title: Vascular and neurogenic rejuvenation in aging mice by modulation of ASM publication-title: Neuron doi: 10.1016/j.neuron.2018.10.038 – volume: 69 start-page: 119 year: 2011 ident: 10.1016/j.nbd.2024.106682_bb0525 article-title: Fingolimod provides long-term protection in rodent models of cerebral ischemia publication-title: Ann. Neurol. doi: 10.1002/ana.22186 – volume: 9 start-page: 139 year: 2008 ident: 10.1016/j.nbd.2024.106682_bb0195 article-title: Principles of bioactive lipid signalling: lessons from sphingolipids publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2329 – volume: 1585 start-page: 193 year: 2002 ident: 10.1016/j.nbd.2024.106682_bb0325 article-title: Sphingosine kinase, sphingosine-1-phosphate, and apoptosis publication-title: Biochim. Biophys. Acta doi: 10.1016/S1388-1981(02)00341-4 – volume: 19 start-page: 661 year: 2020 ident: 10.1016/j.nbd.2024.106682_bb0095 article-title: Safety and efficacy of fluoxetine on functional recovery after acute stroke (EFFECTS): a randomised, double-blind, placebo-controlled trial publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(20)30219-2 – volume: 158 start-page: 122 year: 2020 ident: 10.1016/j.nbd.2024.106682_bb0170 article-title: Plasma levels of ceramides relate to ischemic stroke risk and clinical severity publication-title: Brain Res. Bull. doi: 10.1016/j.brainresbull.2020.03.009 – volume: 21 start-page: 381 year: 2018 ident: 10.1016/j.nbd.2024.106682_bb0225 article-title: High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation publication-title: Angiogenesis doi: 10.1007/s10456-018-9603-z – volume: 39 start-page: 3411 year: 2008 ident: 10.1016/j.nbd.2024.106682_bb0250 article-title: Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain publication-title: Stroke doi: 10.1161/STROKEAHA.108.514612 – volume: 44 start-page: 3202 year: 2013 ident: 10.1016/j.nbd.2024.106682_bb0275 article-title: FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection publication-title: Stroke doi: 10.1161/STROKEAHA.113.002880 – volume: 165 start-page: 571 year: 2012 ident: 10.1016/j.nbd.2024.106682_bb0350 article-title: Specific and sensitive enzymatic measurement of sphingomyelin in cultured cells publication-title: Chem. Phys. Lipids doi: 10.1016/j.chemphyslip.2012.06.003 – volume: 132 start-page: 1104 year: 2015 ident: 10.1016/j.nbd.2024.106682_bb0565 article-title: Combination of the immune modulator fingolimod with alteplase in acute ischemic stroke: a pilot trial publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.115.016371 – volume: 135 start-page: 14276 year: 2013 ident: 10.1016/j.nbd.2024.106682_bb0515 article-title: The chemical basis of serine palmitoyltransferase inhibition by myriocin publication-title: J. Am. Chem. Soc. doi: 10.1021/ja4059876 – volume: 41 start-page: 368 year: 2010 ident: 10.1016/j.nbd.2024.106682_bb0200 article-title: Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats publication-title: Stroke doi: 10.1161/STROKEAHA.109.568899 – volume: 204 start-page: 748 year: 2007 ident: 10.1016/j.nbd.2024.106682_bb0235 article-title: Effects of fluoxetine on ischemic cells and expressions in BDNF and some antioxidants in the gerbil hippocampal CA1 region induced by transient ischemia publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2007.01.008 – volume: 4 start-page: 1131 year: 2015 ident: 10.1016/j.nbd.2024.106682_bb0120 article-title: Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression publication-title: Stem Cells Transl. Med. doi: 10.5966/sctm.2015-0078 – volume: 277 start-page: 25847 year: 2002 ident: 10.1016/j.nbd.2024.106682_bb0190 article-title: The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind publication-title: J. Biol. Chem. doi: 10.1074/jbc.R200008200 – volume: 59 start-page: 2363 year: 2022 ident: 10.1016/j.nbd.2024.106682_bb0015 article-title: In vitro oxygen glucose deprivation model of ischemic stroke: a proteomics-driven systems biological perspective publication-title: Mol. Neurobiol. doi: 10.1007/s12035-022-02745-2 – volume: 50 start-page: 718 year: 2001 ident: 10.1016/j.nbd.2024.106682_bb0375 article-title: Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke publication-title: Ann. Neurol. doi: 10.1002/ana.1257 – volume: 160 start-page: 1823 year: 2003 ident: 10.1016/j.nbd.2024.106682_bb0230 article-title: Mortality and poststroke depression: a placebo-controlled trial of antidepressants publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.160.10.1823 – volume: 128 start-page: 363 year: 2021 ident: 10.1016/j.nbd.2024.106682_bb0365 article-title: Endothelial S1P(1) signaling counteracts infarct expansion in ischemic stroke publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.120.316711 – volume: 20 start-page: 241 year: 2020 ident: 10.1016/j.nbd.2024.106682_bb0545 article-title: Lack of sphingomyelin synthase 2 reduces cerebral ischemia/reperfusion injury by inhibiting microglial inflammation in mice publication-title: Exp. Ther. Med. doi: 10.3892/etm.2020.9371 – volume: 2015 year: 2015 ident: 10.1016/j.nbd.2024.106682_bb0045 article-title: Alterations of the ceramide metabolism in the peri-infarct cortex are independent of the sphingomyelinase pathway and not influenced by the acid sphingomyelinase inhibitor fluoxetine publication-title: Neural Plast. doi: 10.1155/2015/503079 – volume: 33 start-page: 2123 year: 2002 ident: 10.1016/j.nbd.2024.106682_bb0155 article-title: Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions publication-title: Stroke doi: 10.1161/01.STR.0000025518.34157.51 – volume: 63 year: 2022 ident: 10.1016/j.nbd.2024.106682_bb0290 article-title: Identification and characterization of 3-ketosphinganine reductase activity encoded at the BT_0972 locus in Bacteroides thetaiotaomicron publication-title: J. Lipid Res. doi: 10.1016/j.jlr.2022.100236 – volume: 52 start-page: 190 year: 2005 ident: 10.1016/j.nbd.2024.106682_bb0570 article-title: Oligodendrocyte-specific ceramide galactosyltransferase (CGT) expression phenotypically rescues CGT-deficient mice and demonstrates that CGT activity does not limit brain galactosylceramide level publication-title: Glia doi: 10.1002/glia.20230 – volume: 33 start-page: 11 year: 2010 ident: 10.1016/j.nbd.2024.106682_bb0025 article-title: Involvement of ceramide in ischemic tolerance induced by preconditioning with sublethal oxygen-glucose deprivation in primary cultured cortical neurons of rats publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.33.11 – volume: 19 start-page: 651 year: 2020 ident: 10.1016/j.nbd.2024.106682_bb0090 article-title: Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(20)30207-6 – volume: 44 start-page: 915 year: 2024 ident: 10.1016/j.nbd.2024.106682_bb0185 article-title: Microvascular network remodeling in the ischemic mouse brain defined by light sheet microscopy publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.123.320339 – volume: 335 year: 2021 ident: 10.1016/j.nbd.2024.106682_bb0050 article-title: Impact of aging and comorbidities on ischemic stroke outcomes in preclinical animal models: a translational perspective publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2020.113494 – volume: 68 start-page: 3293 year: 2011 ident: 10.1016/j.nbd.2024.106682_bb0505 article-title: Acid sphingomyelinase in macrophage biology publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-011-0686-6 – volume: 84 start-page: 717 year: 2018 ident: 10.1016/j.nbd.2024.106682_bb0490 article-title: Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow publication-title: Ann. Neurol. doi: 10.1002/ana.25352 – volume: 15 start-page: 85 year: 2000 ident: 10.1016/j.nbd.2024.106682_bb0560 article-title: Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis publication-title: J. Mol. Neurosci. doi: 10.1385/JMN:15:2:85 – volume: 115 start-page: 2323 year: 2007 ident: 10.1016/j.nbd.2024.106682_bb0260 article-title: Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.107.691279 – volume: 55 start-page: 1596 year: 2014 ident: 10.1016/j.nbd.2024.106682_bb0030 article-title: An update on the biology of sphingosine 1-phosphate receptors publication-title: J. Lipid Res. doi: 10.1194/jlr.R046300 – volume: 7 start-page: 45 year: 2012 ident: 10.1016/j.nbd.2024.106682_bb0335 article-title: Ceramide sphingolipid signaling mediates tumor necrosis factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons publication-title: Mol. Neurodegener. doi: 10.1186/1750-1326-7-45 – volume: 282 start-page: 17537 year: 2007 ident: 10.1016/j.nbd.2024.106682_bb0480 article-title: Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M702423200 – volume: 72 start-page: 1482 year: 2022 ident: 10.1016/j.nbd.2024.106682_bb0055 article-title: Massive accumulation of sphingomyelin affects the lysosomal and mitochondria compartments and promotes apoptosis in Niemann-pick disease type a publication-title: J. Mol. Neurosci. doi: 10.1007/s12031-022-02036-4 – volume: 10 start-page: 109 year: 2013 ident: 10.1016/j.nbd.2024.106682_bb0165 article-title: Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi publication-title: J. Neuroinflammation doi: 10.1186/1742-2094-10-109 – volume: 34 start-page: 16784 year: 2014 ident: 10.1016/j.nbd.2024.106682_bb0355 article-title: Antigen dependently activated cluster of differentiation 8-positive T cells cause perforin-mediated neurotoxicity in experimental stroke publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1867-14.2014 – volume: 199 start-page: 723 year: 2012 ident: 10.1016/j.nbd.2024.106682_bb0400 article-title: The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction publication-title: J. Cell Biol. doi: 10.1083/jcb.201208152 – volume: 8 start-page: 1295 year: 2007 ident: 10.1016/j.nbd.2024.106682_bb0435 article-title: Finding a way out: lymphocyte egress from lymphoid organs publication-title: Nat. Immunol. doi: 10.1038/ni1545 – volume: 22 start-page: 3159 year: 2018 ident: 10.1016/j.nbd.2024.106682_bb0125 article-title: S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFkappaB signalling publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.13596 – volume: 10 start-page: 288 year: 1995 ident: 10.1016/j.nbd.2024.106682_bb0220 article-title: Acid sphingomyelinase deficient mice: a model of types a and B Niemann-pick disease publication-title: Nat. Genet. doi: 10.1038/ng0795-288 – volume: 26 start-page: 9 year: 2010 ident: 10.1016/j.nbd.2024.106682_bb0270 article-title: Functional inhibitors of acid sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications publication-title: Cell. Physiol. Biochem. doi: 10.1159/000315101 – volume: 120 start-page: 472 year: 2017 ident: 10.1016/j.nbd.2024.106682_bb0040 article-title: Stroke risk factors, genetics, and prevention publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.116.308398 – volume: 219 start-page: 21 year: 2001 ident: 10.1016/j.nbd.2024.106682_bb0060 article-title: Cell line dependent involvement of ceramide in ultraviolet light-induced apoptosis publication-title: Mol. Cell. Biochem. doi: 10.1023/A:1011083818452 – volume: 20 start-page: 1010 year: 2008 ident: 10.1016/j.nbd.2024.106682_bb0255 article-title: The sphingolipid salvage pathway in ceramide metabolism and signaling publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2007.12.006 – volume: 10 year: 2015 ident: 10.1016/j.nbd.2024.106682_bb0450 article-title: Targeted lipid profiling discovers plasma biomarkers of acute brain injury publication-title: PLoS One doi: 10.1371/journal.pone.0129735 – volume: 41 start-page: 314 year: 2010 ident: 10.1016/j.nbd.2024.106682_bb0395 article-title: Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders publication-title: Mol. Neurobiol. doi: 10.1007/s12035-009-8096-6 – volume: 121 start-page: 679 year: 2013 ident: 10.1016/j.nbd.2024.106682_bb0265 article-title: Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature publication-title: Blood doi: 10.1182/blood-2012-04-426734 – volume: 24 start-page: 2727 year: 2010 ident: 10.1016/j.nbd.2024.106682_bb0010 article-title: Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro publication-title: FASEB J. doi: 10.1096/fj.09-150540 – volume: 35 year: 2021 ident: 10.1016/j.nbd.2024.106682_bb0360 article-title: A reference map of sphingolipids in murine tissues publication-title: Cell Rep. doi: 10.1016/j.celrep.2021.109250 – volume: 46 start-page: 2916 year: 2015 ident: 10.1016/j.nbd.2024.106682_bb0205 article-title: Role of neutrophils in exacerbation of brain injury after focal cerebral ischemia in hyperlipidemic mice publication-title: Stroke doi: 10.1161/STROKEAHA.115.010620 – volume: 30 start-page: 654 year: 2007 ident: 10.1016/j.nbd.2024.106682_bb0425 article-title: The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-pick disease publication-title: J. Inherit. Metab. Dis. doi: 10.1007/s10545-007-0632-9 – volume: 22 start-page: 50 year: 2012 ident: 10.1016/j.nbd.2024.106682_bb0330 article-title: Sphingosine-1-phosphate signaling and its role in disease publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2011.09.003 – volume: 160 start-page: 5037 year: 1998 ident: 10.1016/j.nbd.2024.106682_bb0065 article-title: FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing publication-title: J. Immunol. doi: 10.4049/jimmunol.160.10.5037 – volume: 36 start-page: 1132 year: 2016 ident: 10.1016/j.nbd.2024.106682_bb0130 article-title: Sphingolipids contribute to human atherosclerotic plaque inflammation publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.116.305675 – volume: 24 start-page: 623 year: 2004 ident: 10.1016/j.nbd.2024.106682_bb0485 article-title: Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning publication-title: J. Cereb. Blood Flow Metab. doi: 10.1097/01.WCB.0000119990.06999.A9 – volume: 129 start-page: 233 year: 2008 ident: 10.1016/j.nbd.2024.106682_bb0020 article-title: Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2 publication-title: Histochem. Cell Biol. doi: 10.1007/s00418-007-0344-0 – volume: 51 start-page: 1300 year: 2015 ident: 10.1016/j.nbd.2024.106682_bb0105 article-title: Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival publication-title: Mol. Neurobiol. doi: 10.1007/s12035-014-8807-5 – volume: 121 start-page: 43 year: 2022 ident: 10.1016/j.nbd.2024.106682_bb0295 article-title: Plasma ceramides are associated with outcomes in acute ischemic stroke patients publication-title: J. Formos. Med. Assoc. doi: 10.1016/j.jfma.2021.01.006 – volume: 688 start-page: 1 year: 2010 ident: 10.1016/j.nbd.2024.106682_bb0150 article-title: An overview of sphingolipid metabolism: from synthesis to breakdown publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-1-4419-6741-1_1 – volume: 85 start-page: 3624 year: 2003 ident: 10.1016/j.nbd.2024.106682_bb0070 article-title: Structure of sphingomyelin bilayers: a simulation study publication-title: Biophys. J. doi: 10.1016/S0006-3495(03)74780-8 – volume: 52 start-page: 424 year: 2013 ident: 10.1016/j.nbd.2024.106682_bb0460 article-title: Biological functions of sphingomyelins publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2013.05.001 – volume: 5 start-page: 785 year: 1998 ident: 10.1016/j.nbd.2024.106682_bb0465 article-title: Apoptosis induced by N-hexanoylsphingosine in CHP-100 cells associates with accumulation of endogenous ceramide and is potentiated by inhibition of glucocerebroside synthesis publication-title: Cell Death Differ. doi: 10.1038/sj.cdd.4400428 – volume: 114 start-page: 58 year: 2014 ident: 10.1016/j.nbd.2024.106682_bb0475 article-title: Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2013.11.005 – volume: 1023 start-page: 31 year: 2004 ident: 10.1016/j.nbd.2024.106682_bb0370 article-title: Upregulation of ceramide and its regulating mechanism in a rat model of chronic cerebral ischemia publication-title: Brain Res. doi: 10.1016/j.brainres.2004.07.024 – volume: 47 start-page: 633 year: 2018 ident: 10.1016/j.nbd.2024.106682_bb0005 article-title: The physical properties of ceramides in membranes publication-title: Annu. Rev. Biophys. doi: 10.1146/annurev-biophys-070317-033309 – volume: 91 start-page: 627 year: 2021 ident: 10.1016/j.nbd.2024.106682_bb0420 article-title: Lipopolysaccharide-induced sepsis-like state compromises post-ischemic neurological recovery, brain tissue survival and remodeling via mechanisms involving microvascular thrombosis and brain T cell infiltration publication-title: Brain Behav. Immun. doi: 10.1016/j.bbi.2020.10.015 – volume: 87 start-page: 1037 year: 2009 ident: 10.1016/j.nbd.2024.106682_bb0310 article-title: Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect publication-title: J. Neurosci. Res. doi: 10.1002/jnr.21899 – volume: 153 start-page: 173 year: 2020 ident: 10.1016/j.nbd.2024.106682_bb0500 article-title: Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes publication-title: J. Neurochem. doi: 10.1111/jnc.14917 – volume: 72 start-page: 1846 year: 2022 ident: 10.1016/j.nbd.2024.106682_bb0520 article-title: Lipidomics analysis reveals a protective effect of Myriocin on cerebral ischemia/reperfusion model rats publication-title: J. Mol. Neurosci. doi: 10.1007/s12031-022-02014-w – volume: 21 year: 2020 ident: 10.1016/j.nbd.2024.106682_bb0320 article-title: A sphingosine 1-phosphate gradient is linked to the cerebral recruitment of T helper and regulatory T helper cells during acute ischemic stroke publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21176242 – volume: 29 year: 2020 ident: 10.1016/j.nbd.2024.106682_bb0315 article-title: A multi-cohort metabolomics analysis discloses sphingomyelin (32:1) levels to be inversely related to incident ischemic stroke publication-title: J. Stroke Cerebrovasc. Dis. doi: 10.1016/j.jstrokecerebrovasdis.2019.104476 – volume: 1771 start-page: 1186 year: 2007 ident: 10.1016/j.nbd.2024.106682_bb0300 article-title: Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbalip.2007.05.007 – volume: 493 start-page: 188 year: 2017 ident: 10.1016/j.nbd.2024.106682_bb0110 article-title: AntagomiR-613 protects neuronal cells from oxygen glucose deprivation/re-oxygenation via increasing SphK2 expression publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2017.09.049 – volume: 73 start-page: 188 year: 2018 ident: 10.1016/j.nbd.2024.106682_bb0555 article-title: Molecular mechanisms of action of sphingomyelin-specific pore-forming toxin, lysenin publication-title: Semin. Cell Dev. Biol. doi: 10.1016/j.semcdb.2017.07.036 – volume: 19 start-page: 934 year: 2013 ident: 10.1016/j.nbd.2024.106682_bb0175 article-title: Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs publication-title: Nat. Med. doi: 10.1038/nm.3214 – volume: 8 year: 2019 ident: 10.1016/j.nbd.2024.106682_bb0540 article-title: Sphingomyelin synthase 2 inhibition ameliorates cerebral ischemic reperfusion injury through reducing the recruitment of toll-like receptor 4 to lipid rafts publication-title: J. Am. Heart Assoc. doi: 10.1161/JAHA.119.012885 – volume: 7 start-page: 12172 year: 2017 ident: 10.1016/j.nbd.2024.106682_bb0135 article-title: A single sphingomyelin species promotes exosomal release of Endoglin into the maternal circulation in preeclampsia publication-title: Sci. Rep. doi: 10.1038/s41598-017-12491-4 – volume: 6 year: 2011 ident: 10.1016/j.nbd.2024.106682_bb0390 article-title: Sustained reperfusion after blockade of glycoprotein-receptor-Ib in focal cerebral ischemia: an MRI study at 17.6 tesla publication-title: PLoS One doi: 10.1371/journal.pone.0018386 – volume: 111 start-page: 18315 year: 2014 ident: 10.1016/j.nbd.2024.106682_bb0145 article-title: Impact of an immune modulator fingolimod on acute ischemic stroke publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1416166111 – volume: 1044 start-page: 25 year: 2005 ident: 10.1016/j.nbd.2024.106682_bb0530 article-title: Fluoxetine and recovery of motor function after focal ischemia in rats publication-title: Brain Res. doi: 10.1016/j.brainres.2005.02.060 – volume: 8 start-page: 89 year: 2011 ident: 10.1016/j.nbd.2024.106682_bb0550 article-title: Subcellular targeting domains of sphingomyelin synthase 1 and 2 publication-title: Nutr. Metab. (Lond.) doi: 10.1186/1743-7075-8-89 – volume: 35 start-page: 385 year: 2021 ident: 10.1016/j.nbd.2024.106682_bb0415 article-title: Sphingosine 1-phosphate receptor modulators for multiple sclerosis publication-title: CNS Drugs doi: 10.1007/s40263-021-00798-w – volume: 1585 start-page: 172 year: 2002 ident: 10.1016/j.nbd.2024.106682_bb0035 article-title: Glucosylceramide synthase and apoptosis publication-title: Biochim. Biophys. Acta doi: 10.1016/S1388-1981(02)00338-4 – volume: 30 start-page: 979 year: 2008 ident: 10.1016/j.nbd.2024.106682_bb0210 article-title: L-PDMP improves glucosylceramide synthesis and behavior in rats with focal ischemia publication-title: Neurol. Res. doi: 10.1179/016164108X339396 – volume: 62 start-page: 579 year: 2010 ident: 10.1016/j.nbd.2024.106682_bb0080 article-title: International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature publication-title: Pharmacol. Rev. doi: 10.1124/pr.110.003111 – volume: 33 start-page: 1711 year: 2013 ident: 10.1016/j.nbd.2024.106682_bb0535 article-title: Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2013.152 – volume: 16 start-page: 652 year: 2014 ident: 10.1016/j.nbd.2024.106682_bb0445 article-title: Coupling between endocytosis and sphingosine kinase 1 recruitment publication-title: Nat. Cell Biol. doi: 10.1038/ncb2987 – volume: 53 start-page: 484 year: 2019 ident: 10.1016/j.nbd.2024.106682_bb0140 article-title: Ceramides and sphingosine-1-phosphate as potential markers in diagnosis of ischaemic stroke publication-title: Neurol. Neurochir. Pol. doi: 10.5603/PJNNS.a2019.0063 – volume: 264 start-page: 743 year: 1999 ident: 10.1016/j.nbd.2024.106682_bb0285 article-title: Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1999.1586 – volume: 28 start-page: 9741 year: 2008 ident: 10.1016/j.nbd.2024.106682_bb0575 article-title: Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0458-08.2008 – volume: 14 start-page: 18 year: 2017 ident: 10.1016/j.nbd.2024.106682_bb0430 article-title: Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke publication-title: J. Neuroinflammation doi: 10.1186/s12974-017-0792-y |
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| SubjectTerms | Animals Brain - metabolism Brain Ischemia - metabolism Ceramide Humans Ischemic stroke Signal Transduction - physiology Sphingolipids - metabolism Sphingomyelin Sphingosine-1-phosphate |
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| Title | Signaling roles of sphingolipids in the ischemic brain and their potential utility as therapeutic targets |
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