Fibrosis quantification in Hypertensive Heart Disease with LVH and Non-LVH: Findings from T1 mapping and Contrast-free Cardiac Diffusion-weighted imaging

This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH) and hypertensive patients without LVH (HTN non-LVH) using cardiac diffusion-weighted imaging and T1 mapping. T1 mapping was p...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 7; no. 1; pp. 559 - 9
Main Authors Wu, Lian-Ming, Wu, Rui, Ou, Yang-Rongzheng, Chen, Bing-Hua, Yao, Qiu-Ying, Lu, Qing, Hu, Jiani, Jiang, Meng, An, Dong-Aolei, Xu, Jian-Rong
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 03.04.2017
Nature Portfolio
Subjects
59/36
59/57
692/4019/592/75/243
692/420
Blood Pressure
Diffusion Magnetic Resonance Imaging - methods
Female
Fibrosis
Heart Function Tests
Humanities and Social Sciences
Humans
Hypertension - diagnostic imaging
Hypertension - pathology
Hypertension - physiopathology
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - pathology
Male
Middle Aged
multidisciplinary
Science
Science (multidisciplinary)
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-017-00627-5

Cover

Abstract This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH) and hypertensive patients without LVH (HTN non-LVH) using cardiac diffusion-weighted imaging and T1 mapping. T1 mapping was performed in 13 HTN LVH (mean age, 56.23 ± 3.30 years), 17 HTN non-LVH (mean age, 56.41 ± 2.78 years), and 12 normal control subjects (mean age, 55.67 ± 3.08 years) with 3.0 T MRI using cardiac diffusion-weighted imaging and T1 mapping. HTN LVH subjects had higher native T1 (1233.12 ± 79.01) compared with controls (1133.88 ± 27.40) (p < 0.05). HTN LVH subjects had higher ECV (0.28 ± 0.03) compared with HTN non-LVH subjects (0.26 ± 0.02) or controls (0.24 ± 0.03) (p < 0.05). HTN LVH subjects had higher ADC (2.23 ± 0.34) compared with HTN non-LVH subjects (1.88 ± 0.27) or controls (1.61 ± 0.38), (p < 0.05). Positive associations were noted between LVMI and ADC (Spearman = 0.450, p < 0.05) and between LVMI and ECV (Spearman = 0.181, p < 0.05). ADC was also related to an increase in ECV (R 2  = 0.210). Increased levels of ADC were associated with reduced peak systolic and early diastolic circumferential strain rates across all subjects. Contrast-free DW-CMR is an alternative sequence to ECV for the evaluation of fibrosis extent in HTN LVH and HTN non-LVH, while native T1 has limited value.
AbstractList Abstract This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH) and hypertensive patients without LVH (HTN non-LVH) using cardiac diffusion-weighted imaging and T1 mapping. T1 mapping was performed in 13 HTN LVH (mean age, 56.23 ± 3.30 years), 17 HTN non-LVH (mean age, 56.41 ± 2.78 years), and 12 normal control subjects (mean age, 55.67 ± 3.08 years) with 3.0 T MRI using cardiac diffusion-weighted imaging and T1 mapping. HTN LVH subjects had higher native T1 (1233.12 ± 79.01) compared with controls (1133.88 ± 27.40) (p < 0.05). HTN LVH subjects had higher ECV (0.28 ± 0.03) compared with HTN non-LVH subjects (0.26 ± 0.02) or controls (0.24 ± 0.03) (p < 0.05). HTN LVH subjects had higher ADC (2.23 ± 0.34) compared with HTN non-LVH subjects (1.88 ± 0.27) or controls (1.61 ± 0.38), (p < 0.05). Positive associations were noted between LVMI and ADC (Spearman = 0.450, p < 0.05) and between LVMI and ECV (Spearman = 0.181, p < 0.05). ADC was also related to an increase in ECV (R2 = 0.210). Increased levels of ADC were associated with reduced peak systolic and early diastolic circumferential strain rates across all subjects. Contrast-free DW-CMR is an alternative sequence to ECV for the evaluation of fibrosis extent in HTN LVH and HTN non-LVH, while native T1 has limited value.
This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH) and hypertensive patients without LVH (HTN non-LVH) using cardiac diffusion-weighted imaging and T1 mapping. T1 mapping was performed in 13 HTN LVH (mean age, 56.23 ± 3.30 years), 17 HTN non-LVH (mean age, 56.41 ± 2.78 years), and 12 normal control subjects (mean age, 55.67 ± 3.08 years) with 3.0 T MRI using cardiac diffusion-weighted imaging and T1 mapping. HTN LVH subjects had higher native T1 (1233.12 ± 79.01) compared with controls (1133.88 ± 27.40) (p < 0.05). HTN LVH subjects had higher ECV (0.28 ± 0.03) compared with HTN non-LVH subjects (0.26 ± 0.02) or controls (0.24 ± 0.03) (p < 0.05). HTN LVH subjects had higher ADC (2.23 ± 0.34) compared with HTN non-LVH subjects (1.88 ± 0.27) or controls (1.61 ± 0.38), (p < 0.05). Positive associations were noted between LVMI and ADC (Spearman = 0.450, p < 0.05) and between LVMI and ECV (Spearman = 0.181, p < 0.05). ADC was also related to an increase in ECV (R 2  = 0.210). Increased levels of ADC were associated with reduced peak systolic and early diastolic circumferential strain rates across all subjects. Contrast-free DW-CMR is an alternative sequence to ECV for the evaluation of fibrosis extent in HTN LVH and HTN non-LVH, while native T1 has limited value.
This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH) and hypertensive patients without LVH (HTN non-LVH) using cardiac diffusion-weighted imaging and T1 mapping. T1 mapping was performed in 13 HTN LVH (mean age, 56.23 ± 3.30 years), 17 HTN non-LVH (mean age, 56.41 ± 2.78 years), and 12 normal control subjects (mean age, 55.67 ± 3.08 years) with 3.0 T MRI using cardiac diffusion-weighted imaging and T1 mapping. HTN LVH subjects had higher native T1 (1233.12 ± 79.01) compared with controls (1133.88 ± 27.40) (p < 0.05). HTN LVH subjects had higher ECV (0.28 ± 0.03) compared with HTN non-LVH subjects (0.26 ± 0.02) or controls (0.24 ± 0.03) (p < 0.05). HTN LVH subjects had higher ADC (2.23 ± 0.34) compared with HTN non-LVH subjects (1.88 ± 0.27) or controls (1.61 ± 0.38), (p < 0.05). Positive associations were noted between LVMI and ADC (Spearman = 0.450, p < 0.05) and between LVMI and ECV (Spearman = 0.181, p < 0.05). ADC was also related to an increase in ECV (R2 = 0.210). Increased levels of ADC were associated with reduced peak systolic and early diastolic circumferential strain rates across all subjects. Contrast-free DW-CMR is an alternative sequence to ECV for the evaluation of fibrosis extent in HTN LVH and HTN non-LVH, while native T1 has limited value.This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH) and hypertensive patients without LVH (HTN non-LVH) using cardiac diffusion-weighted imaging and T1 mapping. T1 mapping was performed in 13 HTN LVH (mean age, 56.23 ± 3.30 years), 17 HTN non-LVH (mean age, 56.41 ± 2.78 years), and 12 normal control subjects (mean age, 55.67 ± 3.08 years) with 3.0 T MRI using cardiac diffusion-weighted imaging and T1 mapping. HTN LVH subjects had higher native T1 (1233.12 ± 79.01) compared with controls (1133.88 ± 27.40) (p < 0.05). HTN LVH subjects had higher ECV (0.28 ± 0.03) compared with HTN non-LVH subjects (0.26 ± 0.02) or controls (0.24 ± 0.03) (p < 0.05). HTN LVH subjects had higher ADC (2.23 ± 0.34) compared with HTN non-LVH subjects (1.88 ± 0.27) or controls (1.61 ± 0.38), (p < 0.05). Positive associations were noted between LVMI and ADC (Spearman = 0.450, p < 0.05) and between LVMI and ECV (Spearman = 0.181, p < 0.05). ADC was also related to an increase in ECV (R2 = 0.210). Increased levels of ADC were associated with reduced peak systolic and early diastolic circumferential strain rates across all subjects. Contrast-free DW-CMR is an alternative sequence to ECV for the evaluation of fibrosis extent in HTN LVH and HTN non-LVH, while native T1 has limited value.
This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH) and hypertensive patients without LVH (HTN non-LVH) using cardiac diffusion-weighted imaging and T1 mapping. T1 mapping was performed in 13 HTN LVH (mean age, 56.23 ± 3.30 years), 17 HTN non-LVH (mean age, 56.41 ± 2.78 years), and 12 normal control subjects (mean age, 55.67 ± 3.08 years) with 3.0 T MRI using cardiac diffusion-weighted imaging and T1 mapping. HTN LVH subjects had higher native T1 (1233.12 ± 79.01) compared with controls (1133.88 ± 27.40) (p < 0.05). HTN LVH subjects had higher ECV (0.28 ± 0.03) compared with HTN non-LVH subjects (0.26 ± 0.02) or controls (0.24 ± 0.03) (p < 0.05). HTN LVH subjects had higher ADC (2.23 ± 0.34) compared with HTN non-LVH subjects (1.88 ± 0.27) or controls (1.61 ± 0.38), (p < 0.05). Positive associations were noted between LVMI and ADC (Spearman = 0.450, p < 0.05) and between LVMI and ECV (Spearman = 0.181, p < 0.05). ADC was also related to an increase in ECV (R  = 0.210). Increased levels of ADC were associated with reduced peak systolic and early diastolic circumferential strain rates across all subjects. Contrast-free DW-CMR is an alternative sequence to ECV for the evaluation of fibrosis extent in HTN LVH and HTN non-LVH, while native T1 has limited value.
ArticleNumber 559
Author Wu, Rui
Hu, Jiani
An, Dong-Aolei
Wu, Lian-Ming
Ou, Yang-Rongzheng
Yao, Qiu-Ying
Jiang, Meng
Chen, Bing-Hua
Xu, Jian-Rong
Lu, Qing
Author_xml – sequence: 1
  givenname: Lian-Ming
  surname: Wu
  fullname: Wu, Lian-Ming
  organization: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
– sequence: 2
  givenname: Rui
  surname: Wu
  fullname: Wu, Rui
  organization: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
– sequence: 3
  givenname: Yang-Rongzheng
  surname: Ou
  fullname: Ou, Yang-Rongzheng
  organization: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
– sequence: 4
  givenname: Bing-Hua
  surname: Chen
  fullname: Chen, Bing-Hua
  organization: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
– sequence: 5
  givenname: Qiu-Ying
  surname: Yao
  fullname: Yao, Qiu-Ying
  organization: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
– sequence: 6
  givenname: Qing
  surname: Lu
  fullname: Lu, Qing
  organization: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
– sequence: 7
  givenname: Jiani
  surname: Hu
  fullname: Hu, Jiani
  organization: Department of Radiology, wayne state university
– sequence: 8
  givenname: Meng
  surname: Jiang
  fullname: Jiang, Meng
  organization: Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
– sequence: 9
  givenname: Dong-Aolei
  surname: An
  fullname: An, Dong-Aolei
  email: andongaolei@yeah.net
  organization: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
– sequence: 10
  givenname: Jian-Rong
  surname: Xu
  fullname: Xu, Jian-Rong
  email: xujianr@yeah.net
  organization: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28373647$$D View this record in MEDLINE/PubMed
BookMark eNp9ks1uEzEUhUeoiJbSF2CBvGQz1L9jDwskFEhTKYJNYWs5njsTRxM7tT2t-ii8LW7SopZFvbFln_MdXd_7tjrywUNVvSf4E8FMnSdORKtqTGSNcUNlLV5VJxRzUVNG6dGT83F1ltIGlyVoy0n7pjqmiknWcHlS_Zm7VQzJJXQ9GZ9d76zJLnjkPFrc7SBm8MndAFqAiRl9cwlMAnTr8hotfy-Q8R36EXxdzp_R3PnO-SGhPoYtuiJoa3a7crFXzYLP0aRc9xEAzUzsnLEF2PdTKoH1LbhhnaFDbmuGYnpXve7NmODsYT-tfs2_X80W9fLnxeXs67K2gtBcWwwC2vIXbEWpJStGmW3aXlloDOecAqWy7xqiuCCiU5xIA8D6lRTCNphZdlpdHrhdMBu9iyU-3ulgnN5fhDjoUrmzI2jMOskbhqUk5SNNb5TkXLYWlJSm421hfTmwdtNqC52F-5LHZ9DnL96t9RButOC0MHABfHwAxHA9Qcp665KFcTQewpQ0UaWChqmGFemHp1n_Qh57WwTqILClwSlCr63L--aWaDdqgvX9JOnDJOkySXo_SVoUK_3P-kh_0cQOplTEfoCoN2GKvvTuJddfXk3b1w
CitedBy_id crossref_primary_10_1093_ehjci_jeaa164
crossref_primary_10_1002_jmri_26016
crossref_primary_10_1016_j_pcad_2019_03_003
crossref_primary_10_1007_s11547_022_01571_9
crossref_primary_10_1371_journal_pone_0278308
crossref_primary_10_1016_j_crad_2020_11_001
crossref_primary_10_1002_jmri_29261
crossref_primary_10_1530_EC_18_0553
crossref_primary_10_1016_j_diabres_2017_08_018
crossref_primary_10_1161_CIRCIMAGING_122_014158
crossref_primary_10_1016_j_ejrad_2018_10_013
crossref_primary_10_1007_s11906_021_01135_8
crossref_primary_10_31393_bba42_2021_08
crossref_primary_10_1186_s12872_020_01361_z
crossref_primary_10_3390_diagnostics13010137
crossref_primary_10_1007_s00117_022_01068_6
crossref_primary_10_5005_jp_journals_10050_10091
crossref_primary_10_3348_kjr_2021_0815
Cites_doi 10.1097/00004872-199816070-00018
10.1002/mrm.21350
10.1186/1532-429X-12-69
10.1161/01.CIR.88.3.993
10.1093/ajh/3.10.735
10.1161/CIRCIMAGING.112.979815
10.1038/nm.3436
10.1002/mrm.20110
10.1001/jama.2013.905
10.7326/0003-4819-72-6-813
10.1186/s12968-015-0214-1
10.1002/jmri.24947
10.1161/CIRCULATIONAHA.105.545863
10.1016/j.jacc.2008.04.047
10.1088/0031-9155/58/15/5009
10.1002/nbm.3200
10.1016/j.jacc.2008.06.049
10.1056/NEJMra072139
10.1161/01.CIR.0000017264.66561.3D
10.1093/eurheartj/14.suppl_G.12
10.1056/NEJM199005313222203
10.1186/1532-429X-14-37
10.1007/s004280050098
10.1016/j.jcmg.2014.09.020
10.1038/ncpcardio0158
10.1161/hc3901.096700
10.1001/jama.292.19.2350
10.1002/jmri.24962
10.1186/1532-429X-14-64
10.1186/1532-429X-14-63
10.1186/s12968-014-0068-y
10.1161/CIRCHEARTFAILURE.112.969071
10.1161/01.CIR.0000154900.76284.F6
10.1258/ar.2011.100351
10.1097/RCT.0000000000000296
10.1161/CIRCHEARTFAILURE.109.854026
10.1002/mrm.25038
10.1002/mrm.21127
10.1161/CIRCIMAGING.115.003285
10.1007/s12265-009-9136-3
10.1002/mrm.25998
10.1097/RCT.0000000000000521
10.1186/1532-429X-11-47
ContentType Journal Article
Copyright The Author(s) 2017
Copyright_xml – notice: The Author(s) 2017
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOA
DOI 10.1038/s41598-017-00627-5
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList

CrossRef

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 9
ExternalDocumentID oai_doaj_org_article_03d74630771941afa874479ce877ad49
PMC5428770
28373647
10_1038_s41598_017_00627_5
Genre Journal Article
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
EJD
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFPKN
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7X8
PJZUB
PPXIY
PQGLB
PUEGO
5PM
ID FETCH-LOGICAL-c512t-c0e5e91593b22c1b323c69f8ce6a4442e227fd6184515d8417aee3fb755c603c3
IEDL.DBID M48
ISSN 2045-2322
IngestDate Wed Aug 27 01:29:20 EDT 2025
Thu Aug 21 17:50:41 EDT 2025
Thu Sep 04 15:25:45 EDT 2025
Wed Feb 19 02:43:29 EST 2025
Tue Jul 01 01:32:39 EDT 2025
Thu Apr 24 22:51:38 EDT 2025
Fri Feb 21 02:40:36 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c512t-c0e5e91593b22c1b323c69f8ce6a4442e227fd6184515d8417aee3fb755c603c3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.nature.com/articles/s41598-017-00627-5
PMID 28373647
PQID 1884163863
PQPubID 23479
PageCount 9
ParticipantIDs doaj_primary_oai_doaj_org_article_03d74630771941afa874479ce877ad49
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5428770
proquest_miscellaneous_1884163863
pubmed_primary_28373647
crossref_citationtrail_10_1038_s41598_017_00627_5
crossref_primary_10_1038_s41598_017_00627_5
springer_journals_10_1038_s41598_017_00627_5
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2017-04-03
PublicationDateYYYYMMDD 2017-04-03
PublicationDate_xml – month: 04
  year: 2017
  text: 2017-04-03
  day: 03
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2017
Publisher Nature Publishing Group UK
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Portfolio
References Nguyen (CR31) 2014; 72
Nguyen (CR20) 2014; 16
Amano (CR39) 2015; 39
Kannel, Gordon, Castelli, Margolis (CR5) 1970; 72
Redfield (CR7) 2012; 5
Kachenoura (CR14) 2015; 42
Iles (CR13) 2008; 52
Díez, González, López, Querejeta (CR33) 2005; 2
Rossi (CR1) 1998; 16
Kellman, Wilson, Hui, Ugander, Arai (CR17) 2012; 14
Gamper, Boesiger, Kozerke (CR40) 2007; 57
Abdullah (CR26) 2014; 27
CR38
Pardo Mindán, Panizo (CR2) 1993; 14
Wu (CR19) 2007; 58
Edelmann (CR8) 2013; 309
Kuruvilla (CR37) 2015; 8
Rubinshtein (CR11) 2010; 3
Díez (CR36) 2002; 105
Sosnovik (CR42) 2009; 13
Levy, Garrison, Savage, Kannel, Castelli (CR6) 1990; 322
van Ooij (CR16) 2016; 43
Nguyen (CR43) 2015; 17
Mclenachan, Dargie (CR35) 1990; 3
Hill, Olson (CR34) 2008; 358
Mathew (CR9) 2001; 104
Pickering (CR27) 2005; 111
Amano, Takayama, Fukushima, Kitamura, Kumita (CR15) 2011; 52
Haris (CR23) 2014; 20
Piechnik (CR30) 2010; 12
Mundhenke, Schwartzkopff, Strauer (CR4) 1997; 431
Hinojar (CR24) 2015; 8
Pop (CR25) 2013; 58
Devereux (CR10) 2005; 292
Wu (CR21) 2006; 114
Olivotto (CR28) 2008; 52
CR41
Kellman (CR18) 2012; 14
Coelho-Filho (CR32) 2013; 6
Witschey (CR22) 2012; 14
Schwartzkopff (CR3) 1993; 88
Maron (CR12) 2009; 2
Messroghli (CR29) 2004; 52
I Olivotto (627_CR28) 2008; 52
J Mathew (627_CR9) 2001; 104
WR Witschey (627_CR22) 2012; 14
JM Mclenachan (627_CR35) 1990; 3
P Kellman (627_CR17) 2012; 14
M Haris (627_CR23) 2014; 20
M Pop (627_CR25) 2013; 58
B Schwartzkopff (627_CR3) 1993; 88
U Gamper (627_CR40) 2007; 57
Y Amano (627_CR39) 2015; 39
R Hinojar (627_CR24) 2015; 8
DR Messroghli (627_CR29) 2004; 52
J Díez (627_CR36) 2002; 105
J Díez (627_CR33) 2005; 2
R Rubinshtein (627_CR11) 2010; 3
627_CR41
TG Pickering (627_CR27) 2005; 111
M Mundhenke (627_CR4) 1997; 431
F Edelmann (627_CR8) 2013; 309
MA Rossi (627_CR1) 1998; 16
MS Maron (627_CR12) 2009; 2
JA Hill (627_CR34) 2008; 358
SK Piechnik (627_CR30) 2010; 12
RB Devereux (627_CR10) 2005; 292
WB Kannel (627_CR5) 1970; 72
C Nguyen (627_CR20) 2014; 16
N Kachenoura (627_CR14) 2015; 42
EX Wu (627_CR19) 2007; 58
MT Wu (627_CR21) 2006; 114
Y Amano (627_CR15) 2011; 52
DE Sosnovik (627_CR42) 2009; 13
627_CR38
MM Redfield (627_CR7) 2012; 5
OM Abdullah (627_CR26) 2014; 27
C Nguyen (627_CR43) 2015; 17
OR Coelho-Filho (627_CR32) 2013; 6
L Iles (627_CR13) 2008; 52
FJ Pardo Mindán (627_CR2) 1993; 14
P van Ooij (627_CR16) 2016; 43
D Levy (627_CR6) 1990; 322
S Kuruvilla (627_CR37) 2015; 8
P Kellman (627_CR18) 2012; 14
C Nguyen (627_CR31) 2014; 72
26659373 - Circ Cardiovasc Imaging. 2015 Dec;8(12):null
17260376 - Magn Reson Med. 2007 Feb;57(2):331-7
9794745 - J Hypertens. 1998 Jul;16(7):1031-41
16940196 - Circulation. 2006 Sep 5;114(10):1036-45
19007595 - J Am Coll Cardiol. 2008 Nov 4;52(19):1574-80
18367740 - N Engl J Med. 2008 Mar 27;358(13):1370-80
15236377 - Magn Reson Med. 2004 Jul;52(1):141-6
23443441 - JAMA. 2013 Feb 27;309(8):781-91
15547162 - JAMA. 2004 Nov 17;292(19):2350-6
26466104 - J Comput Assist Tomogr. 2015 Nov-Dec;39(6):951-5
25980519 - J Magn Reson Imaging. 2015 Dec;42(6):1713-22
16265485 - Nat Clin Pract Cardiovasc Med. 2005 Apr;2(4):209-16
19912654 - J Cardiovasc Magn Reson. 2009 Nov 13;11:47
12034658 - Circulation. 2002 May 28;105(21):2512-7
26227419 - J Magn Reson Imaging. 2016 Jan;43(1):107-14
19850699 - Circ Heart Fail. 2010 Jan;3(1):51-8
24259113 - Magn Reson Med. 2014 Nov;72(5):1257-67
18687251 - J Am Coll Cardiol. 2008 Aug 12;52(7):559-66
22967246 - J Cardiovasc Magn Reson. 2012 Sep 11;14:64
23159497 - Circ Cardiovasc Imaging. 2013 Jan 1;6(1):134-41
27763940 - J Comput Assist Tomogr. 2017 May/Jun;41(3):344-348
23833042 - Phys Med Biol. 2013 Aug 7;58(15):5009-28
11581138 - Circulation. 2001 Oct 2;104(14):1615-21
9368664 - Virchows Arch. 1997 Oct;431(4):265-73
22704222 - J Cardiovasc Magn Reson. 2012 Jun 15;14:37
2139921 - N Engl J Med. 1990 May 31;322(22):1561-6
22963517 - J Cardiovasc Magn Reson. 2012 Sep 10;14:63
8353927 - Circulation. 1993 Sep;88(3):993-1003
26631061 - J Cardiovasc Magn Reson. 2015 Dec 02;17:107
21498307 - Acta Radiol. 2011 Jul 1;52(6):613-8
25577446 - JACC Cardiovasc Imaging. 2015 Feb;8(2):172-80
25230598 - J Cardiovasc Magn Reson. 2014 Sep 17;16:68
26445426 - Magn Reson Med. 2016 Sep;76(3):862-72
20560000 - J Cardiovasc Transl Res. 2009 Dec;2(4):415-25
21092095 - J Cardiovasc Magn Reson. 2010 Nov 19;12:69
2145865 - Am J Hypertens. 1990 Oct;3(10):735-40
8281955 - Eur Heart J. 1993 Nov;14 Suppl J:12-4
24412924 - Nat Med. 2014 Feb;20(2):209-14
15699287 - Circulation. 2005 Feb 8;111(5):697-716
4247338 - Ann Intern Med. 1970 Jun;72(6):813-22
17899595 - Magn Reson Med. 2007 Oct;58(4):687-95
22991405 - Circ Heart Fail. 2012 Sep 1;5(5):653-9
25200106 - NMR Biomed. 2014 Nov;27(11):1378-86
References_xml – volume: 16
  start-page: 1031
  year: 1998
  end-page: 1041
  ident: CR1
  article-title: Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans
  publication-title: J Hypertens
  doi: 10.1097/00004872-199816070-00018
– volume: 58
  start-page: 687
  year: 2007
  end-page: 695
  ident: CR19
  article-title: Mr diffusion tensor imaging study of postinfarct myocardium structural remodeling in a porcine model
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.21350
– volume: 12
  start-page: 69
  year: 2010
  ident: CR30
  article-title: Shortened Modied Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/1532-429X-12-69
– volume: 88
  start-page: 993
  year: 1993
  end-page: 1003
  ident: CR3
  article-title: Structural and functional alterations of the intramyocardial coronary arterioles in patients with arterial hypertension
  publication-title: Circulation
  doi: 10.1161/01.CIR.88.3.993
– volume: 3
  start-page: 735
  year: 1990
  end-page: 740
  ident: CR35
  article-title: Ventricular arrhythmias in hypertensive left ventricular hypertrophy. relationship to coronary artery disease, left ventricular dysfunction, and myocardial fibrosis
  publication-title: Am J Hypertens
  doi: 10.1093/ajh/3.10.735
– volume: 13
  start-page: 11
  year: 2009
  end-page: 47
  ident: CR42
  article-title: Diffusion MR tractography of the heart
  publication-title: J Cardiovasc Magn Reson.
– volume: 6
  start-page: 134
  year: 2013
  end-page: 141
  ident: CR32
  article-title: Role of transcytolemmal water-exchange in magnetic resonance measurements of diffuse myocardial fibrosis in hypertensive heart disease
  publication-title: Circ Cardiovasc Imaging
  doi: 10.1161/CIRCIMAGING.112.979815
– volume: 20
  start-page: 209
  year: 2014
  end-page: 214
  ident: CR23
  article-title: A technique for mapping of myocardial creatine kinase metabolism
  publication-title: Nat Med
  doi: 10.1038/nm.3436
– volume: 52
  start-page: 141
  year: 2004
  end-page: 146
  ident: CR29
  article-title: Modified Look-Locker inversion recovery (MOLLI) for high- resolution T1 mapping of the heart
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.20110
– volume: 309
  start-page: 781
  year: 2013
  end-page: 791
  ident: CR8
  article-title: Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the aldo-dhf randomized controlled trial
  publication-title: JAMA
  doi: 10.1001/jama.2013.905
– volume: 72
  start-page: 813
  year: 1970
  end-page: 822
  ident: CR5
  article-title: Electrocardiographic left ventricular hypertrophy and risk of coronary heart disease. The framingham study
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-72-6-813
– volume: 17
  start-page: 107
  year: 2015
  ident: CR43
  article-title: Contrast-free detection of myocardial fibrosis in hypertrophic cardiomyopathy patients with diffusion-weighted cardiovascular magnetic resonance
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/s12968-015-0214-1
– volume: 42
  start-page: 1713
  year: 2015
  end-page: 1722
  ident: CR14
  article-title: Kinetic index combining native and postcontrast myocardial t1 in hypertrophic cardiomyopathy
  publication-title: J Magn Reson Imaging
  doi: 10.1002/jmri.24947
– volume: 114
  start-page: 1036
  year: 2006
  end-page: 1045
  ident: CR21
  article-title: Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction: correlation with viability and wall motion
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.545863
– volume: 52
  start-page: 559
  year: 2008
  end-page: 566
  ident: CR28
  article-title: Assessment and significance of left ventricular mass by cardiovascular magnetic resonance in hypertrophic cardiomyopathy
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2008.04.047
– volume: 58
  start-page: 5009
  year: 2013
  end-page: 5028
  ident: CR25
  article-title: Quantification of fibrosis in infarcted swine hearts by late gadolinium-enhancement and diffusion-weighted mri methods
  publication-title: Phys Med Biol
  doi: 10.1088/0031-9155/58/15/5009
– volume: 27
  start-page: 1378
  year: 2014
  end-page: 1386
  ident: CR26
  article-title: Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quantitative histological validation
  publication-title: NMR Biomed
  doi: 10.1002/nbm.3200
– volume: 52
  start-page: 1574
  year: 2008
  end-page: 1580
  ident: CR13
  article-title: Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced t1 mapping
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2008.06.049
– volume: 358
  start-page: 1370
  year: 2008
  end-page: 1380
  ident: CR34
  article-title: Cardiac plasticity
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra072139
– volume: 105
  start-page: 2512
  year: 2002
  end-page: 2517
  ident: CR36
  article-title: Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000017264.66561.3D
– volume: 14
  start-page: 12
  year: 1993
  end-page: 14
  ident: CR2
  article-title: Alterations in the extracellular matrix of the myocardium in essential hypertension
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/14.suppl_G.12
– volume: 322
  start-page: 1706
  year: 1990
  end-page: 1707
  ident: CR6
  article-title: Prognostic implications of echocardiographically determined left ventricular mass in the framingham heart study
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199005313222203
– volume: 14
  start-page: 37
  year: 2012
  ident: CR22
  article-title: chronic myocardial infarction characterization by spin locked cardiovascular magnetic resonance
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/1532-429X-14-37
– volume: 431
  start-page: 265
  year: 1997
  end-page: 73
  ident: CR4
  article-title: Structural analysis of arteriolar and myocardial remodelling in the subendocardial region of patients with hypertensive heart disease and hypertrophic cardiomyopathy
  publication-title: Virchows Arch
  doi: 10.1007/s004280050098
– volume: 8
  start-page: 172
  year: 2015
  end-page: 180
  ident: CR37
  article-title: Increased extracellular volume and altered mechanics are associated with lvh inhypertensive heart disease, nothypertension alone
  publication-title: Jacc Cardiovasc Imaging
  doi: 10.1016/j.jcmg.2014.09.020
– volume: 2
  start-page: 209
  year: 2005
  end-page: 216
  ident: CR33
  article-title: Mechanisms of disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease
  publication-title: Nat Clin Pract Cardiovasc Med
  doi: 10.1038/ncpcardio0158
– ident: CR38
– volume: 104
  start-page: 1615
  year: 2001
  end-page: 1621
  ident: CR9
  article-title: Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril
  publication-title: Circulation
  doi: 10.1161/hc3901.096700
– volume: 292
  start-page: 2350
  year: 2005
  end-page: 2356
  ident: CR10
  article-title: Prognostic significance of left ventricular mass change during treatment of hypertension
  publication-title: JAMA
  doi: 10.1001/jama.292.19.2350
– volume: 43
  start-page: 107
  year: 2016
  end-page: 114
  ident: CR16
  article-title: 4D flow MRI and T1 -Mapping: Assessment of altered cardiac hemodynamics and extracellular volume fraction in hypertrophic cardiomyopathy
  publication-title: J Magn Reson Imaging
  doi: 10.1002/jmri.24962
– volume: 14
  start-page: 64
  year: 2012
  ident: CR18
  article-title: Extracellular volume fraction mapping in the myocardium, part 2: initial clinical experience
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/1532-429X-14-64
– volume: 14
  start-page: 63
  year: 2012
  ident: CR17
  article-title: Extracellular volume fraction mapping in the myocardium, part 1: evaluation of an automated method
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/1532-429X-14-63
– volume: 16
  start-page: 1770
  year: 2014
  ident: CR20
  article-title: contrast free chronic myocardial infarction characterization using diffusion-weighted cardiovascular magnetic resonance
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/s12968-014-0068-y
– volume: 5
  start-page: 653
  year: 2012
  end-page: 659
  ident: CR7
  article-title: Phosphdiesterase-5 inhibition to improve clinical status and exercise capacity in diastolic heart failure (relax) trial: rationale and design
  publication-title: Circ Heart Fail
  doi: 10.1161/CIRCHEARTFAILURE.112.969071
– volume: 111
  start-page: 697
  year: 2005
  end-page: 716
  ident: CR27
  article-title: Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000154900.76284.F6
– volume: 52
  start-page: 613
  year: 2011
  end-page: 618
  ident: CR15
  article-title: Delayed-enhancement mri of apical hypertrophic cardiomyopathy: assessment of the intramural distribution and comparison with clinical symptoms, ventricular arrhythmias, and cine mri
  publication-title: Acta Radiol
  doi: 10.1258/ar.2011.100351
– volume: 39
  start-page: 951
  year: 2015
  end-page: 5
  ident: CR39
  article-title: Distribution and clinical significance of high signal intensity of the myocardium on T2-weighted images in 2 phenotypes of hypertrophic cardiomyopathy
  publication-title: J Comput Assist Tomogr
  doi: 10.1097/RCT.0000000000000296
– volume: 3
  start-page: 51
  year: 2010
  end-page: 58
  ident: CR11
  article-title: Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance imaging in patients with hypertrophic cardiomyopathy
  publication-title: Circ Heart Fail
  doi: 10.1161/CIRCHEARTFAILURE.109.854026
– volume: 72
  start-page: 1257
  year: 2014
  end-page: 67
  ident: CR31
  article-title: three-dimensional high resolution cardiac diffusion-weighted MRI: a motion compensated diffusion-prepared balanced steady-state free precession approach
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.25038
– ident: CR41
– volume: 57
  start-page: 331
  year: 2007
  end-page: 7
  ident: CR40
  article-title: Diffusion imaging of the heart using spin echoes–considerations on bulk motion sensitivity
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.21127
– volume: 8
  start-page: e003285
  year: 2015
  ident: CR24
  article-title: T1 mapping in discrimination of hypertrophic phenotypes: hypertensive heart disease and hypertrophic cardiomyopathy: findings from the international t1 multicenter cardiovascular magnetic resonance study
  publication-title: Circ Cardiovasc Imaging
  doi: 10.1161/CIRCIMAGING.115.003285
– volume: 2
  start-page: 415
  year: 2009
  end-page: 425
  ident: CR12
  article-title: The current and emerging role of cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy
  publication-title: J Cardiovasc Transl Res
  doi: 10.1007/s12265-009-9136-3
– volume: 52
  start-page: 1574
  year: 2008
  ident: 627_CR13
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2008.06.049
– volume: 58
  start-page: 5009
  year: 2013
  ident: 627_CR25
  publication-title: Phys Med Biol
  doi: 10.1088/0031-9155/58/15/5009
– volume: 322
  start-page: 1706
  year: 1990
  ident: 627_CR6
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199005313222203
– volume: 358
  start-page: 1370
  year: 2008
  ident: 627_CR34
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra072139
– volume: 14
  start-page: 64
  year: 2012
  ident: 627_CR18
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/1532-429X-14-64
– volume: 114
  start-page: 1036
  year: 2006
  ident: 627_CR21
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.545863
– volume: 8
  start-page: 172
  year: 2015
  ident: 627_CR37
  publication-title: Jacc Cardiovasc Imaging
  doi: 10.1016/j.jcmg.2014.09.020
– volume: 14
  start-page: 12
  year: 1993
  ident: 627_CR2
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/14.suppl_G.12
– volume: 5
  start-page: 653
  year: 2012
  ident: 627_CR7
  publication-title: Circ Heart Fail
  doi: 10.1161/CIRCHEARTFAILURE.112.969071
– volume: 88
  start-page: 993
  year: 1993
  ident: 627_CR3
  publication-title: Circulation
  doi: 10.1161/01.CIR.88.3.993
– volume: 14
  start-page: 63
  year: 2012
  ident: 627_CR17
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/1532-429X-14-63
– volume: 292
  start-page: 2350
  year: 2005
  ident: 627_CR10
  publication-title: JAMA
  doi: 10.1001/jama.292.19.2350
– volume: 57
  start-page: 331
  year: 2007
  ident: 627_CR40
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.21127
– volume: 431
  start-page: 265
  year: 1997
  ident: 627_CR4
  publication-title: Virchows Arch
  doi: 10.1007/s004280050098
– volume: 72
  start-page: 1257
  year: 2014
  ident: 627_CR31
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.25038
– volume: 3
  start-page: 735
  year: 1990
  ident: 627_CR35
  publication-title: Am J Hypertens
  doi: 10.1093/ajh/3.10.735
– volume: 309
  start-page: 781
  year: 2013
  ident: 627_CR8
  publication-title: JAMA
  doi: 10.1001/jama.2013.905
– volume: 8
  start-page: e003285
  year: 2015
  ident: 627_CR24
  publication-title: Circ Cardiovasc Imaging
  doi: 10.1161/CIRCIMAGING.115.003285
– volume: 52
  start-page: 559
  year: 2008
  ident: 627_CR28
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2008.04.047
– volume: 52
  start-page: 613
  year: 2011
  ident: 627_CR15
  publication-title: Acta Radiol
  doi: 10.1258/ar.2011.100351
– volume: 58
  start-page: 687
  year: 2007
  ident: 627_CR19
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.21350
– volume: 3
  start-page: 51
  year: 2010
  ident: 627_CR11
  publication-title: Circ Heart Fail
  doi: 10.1161/CIRCHEARTFAILURE.109.854026
– volume: 43
  start-page: 107
  year: 2016
  ident: 627_CR16
  publication-title: J Magn Reson Imaging
  doi: 10.1002/jmri.24962
– volume: 12
  start-page: 69
  year: 2010
  ident: 627_CR30
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/1532-429X-12-69
– volume: 17
  start-page: 107
  year: 2015
  ident: 627_CR43
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/s12968-015-0214-1
– volume: 14
  start-page: 37
  year: 2012
  ident: 627_CR22
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/1532-429X-14-37
– volume: 16
  start-page: 1031
  year: 1998
  ident: 627_CR1
  publication-title: J Hypertens
  doi: 10.1097/00004872-199816070-00018
– volume: 2
  start-page: 415
  year: 2009
  ident: 627_CR12
  publication-title: J Cardiovasc Transl Res
  doi: 10.1007/s12265-009-9136-3
– volume: 39
  start-page: 951
  year: 2015
  ident: 627_CR39
  publication-title: J Comput Assist Tomogr
  doi: 10.1097/RCT.0000000000000296
– volume: 111
  start-page: 697
  year: 2005
  ident: 627_CR27
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000154900.76284.F6
– volume: 6
  start-page: 134
  year: 2013
  ident: 627_CR32
  publication-title: Circ Cardiovasc Imaging
  doi: 10.1161/CIRCIMAGING.112.979815
– volume: 2
  start-page: 209
  year: 2005
  ident: 627_CR33
  publication-title: Nat Clin Pract Cardiovasc Med
  doi: 10.1038/ncpcardio0158
– volume: 105
  start-page: 2512
  year: 2002
  ident: 627_CR36
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000017264.66561.3D
– ident: 627_CR41
  doi: 10.1002/mrm.25998
– volume: 20
  start-page: 209
  year: 2014
  ident: 627_CR23
  publication-title: Nat Med
  doi: 10.1038/nm.3436
– volume: 27
  start-page: 1378
  year: 2014
  ident: 627_CR26
  publication-title: NMR Biomed
  doi: 10.1002/nbm.3200
– ident: 627_CR38
  doi: 10.1097/RCT.0000000000000521
– volume: 42
  start-page: 1713
  year: 2015
  ident: 627_CR14
  publication-title: J Magn Reson Imaging
  doi: 10.1002/jmri.24947
– volume: 16
  start-page: 1770
  year: 2014
  ident: 627_CR20
  publication-title: J Cardiovasc Magn Reson
  doi: 10.1186/s12968-014-0068-y
– volume: 13
  start-page: 11
  year: 2009
  ident: 627_CR42
  publication-title: J Cardiovasc Magn Reson.
  doi: 10.1186/1532-429X-11-47
– volume: 104
  start-page: 1615
  year: 2001
  ident: 627_CR9
  publication-title: Circulation
  doi: 10.1161/hc3901.096700
– volume: 52
  start-page: 141
  year: 2004
  ident: 627_CR29
  publication-title: Magn Reson Med
  doi: 10.1002/mrm.20110
– volume: 72
  start-page: 813
  year: 1970
  ident: 627_CR5
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-72-6-813
– reference: 24412924 - Nat Med. 2014 Feb;20(2):209-14
– reference: 22963517 - J Cardiovasc Magn Reson. 2012 Sep 10;14:63
– reference: 12034658 - Circulation. 2002 May 28;105(21):2512-7
– reference: 18687251 - J Am Coll Cardiol. 2008 Aug 12;52(7):559-66
– reference: 25230598 - J Cardiovasc Magn Reson. 2014 Sep 17;16:68
– reference: 4247338 - Ann Intern Med. 1970 Jun;72(6):813-22
– reference: 19912654 - J Cardiovasc Magn Reson. 2009 Nov 13;11:47
– reference: 16265485 - Nat Clin Pract Cardiovasc Med. 2005 Apr;2(4):209-16
– reference: 23159497 - Circ Cardiovasc Imaging. 2013 Jan 1;6(1):134-41
– reference: 2145865 - Am J Hypertens. 1990 Oct;3(10):735-40
– reference: 22967246 - J Cardiovasc Magn Reson. 2012 Sep 11;14:64
– reference: 23833042 - Phys Med Biol. 2013 Aug 7;58(15):5009-28
– reference: 25980519 - J Magn Reson Imaging. 2015 Dec;42(6):1713-22
– reference: 19007595 - J Am Coll Cardiol. 2008 Nov 4;52(19):1574-80
– reference: 19850699 - Circ Heart Fail. 2010 Jan;3(1):51-8
– reference: 25200106 - NMR Biomed. 2014 Nov;27(11):1378-86
– reference: 26227419 - J Magn Reson Imaging. 2016 Jan;43(1):107-14
– reference: 9368664 - Virchows Arch. 1997 Oct;431(4):265-73
– reference: 22704222 - J Cardiovasc Magn Reson. 2012 Jun 15;14:37
– reference: 26466104 - J Comput Assist Tomogr. 2015 Nov-Dec;39(6):951-5
– reference: 17260376 - Magn Reson Med. 2007 Feb;57(2):331-7
– reference: 8353927 - Circulation. 1993 Sep;88(3):993-1003
– reference: 26631061 - J Cardiovasc Magn Reson. 2015 Dec 02;17:107
– reference: 15547162 - JAMA. 2004 Nov 17;292(19):2350-6
– reference: 21498307 - Acta Radiol. 2011 Jul 1;52(6):613-8
– reference: 16940196 - Circulation. 2006 Sep 5;114(10):1036-45
– reference: 17899595 - Magn Reson Med. 2007 Oct;58(4):687-95
– reference: 26659373 - Circ Cardiovasc Imaging. 2015 Dec;8(12):null
– reference: 24259113 - Magn Reson Med. 2014 Nov;72(5):1257-67
– reference: 2139921 - N Engl J Med. 1990 May 31;322(22):1561-6
– reference: 23443441 - JAMA. 2013 Feb 27;309(8):781-91
– reference: 21092095 - J Cardiovasc Magn Reson. 2010 Nov 19;12:69
– reference: 11581138 - Circulation. 2001 Oct 2;104(14):1615-21
– reference: 25577446 - JACC Cardiovasc Imaging. 2015 Feb;8(2):172-80
– reference: 18367740 - N Engl J Med. 2008 Mar 27;358(13):1370-80
– reference: 26445426 - Magn Reson Med. 2016 Sep;76(3):862-72
– reference: 15699287 - Circulation. 2005 Feb 8;111(5):697-716
– reference: 20560000 - J Cardiovasc Transl Res. 2009 Dec;2(4):415-25
– reference: 27763940 - J Comput Assist Tomogr. 2017 May/Jun;41(3):344-348
– reference: 15236377 - Magn Reson Med. 2004 Jul;52(1):141-6
– reference: 22991405 - Circ Heart Fail. 2012 Sep 1;5(5):653-9
– reference: 8281955 - Eur Heart J. 1993 Nov;14 Suppl J:12-4
– reference: 9794745 - J Hypertens. 1998 Jul;16(7):1031-41
SSID ssj0000529419
Score 2.284631
Snippet This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left ventricular...
Abstract This study assessed the extent of fibrosis and the relationship between the ADC value and systolic strain in hypertensive patients with left...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 559
SubjectTerms 59/36
59/57
692/4019/592/75/243
692/420
Blood Pressure
Diffusion Magnetic Resonance Imaging - methods
Female
Fibrosis
Heart Function Tests
Humanities and Social Sciences
Humans
Hypertension - diagnostic imaging
Hypertension - pathology
Hypertension - physiopathology
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - pathology
Male
Middle Aged
multidisciplinary
Science
Science (multidisciplinary)
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJSQuiDcBiozEDawm8TO9lcIqQtBTi3qzHD8gEs3CJivET-HfdmxnV11A5cItSpzE9ny2ZzyebxB6ySqvJGsccYZTwiSzpOmcJ8I5HkJnlHcxGvnjiWjP2Ptzfn4l1Vc8E5bpgXPHHZTUSSYAiRLM7coEE_naZWPhF9I4lkL3yqa8YkxlVu8aSjdzlExJ1cEIK1WMJoNJOcYNSsJ3VqJE2P83LfPPw5K_eUzTQrS4g27PGiQ-yjW_i2744R66mXNK_ryPfi3AAF6O_Yi_r00-CZQ6H_cDbsHoXM1H1nELGJ_w2-ygwXE_Fn_41GIzOHyyHAhcH-JFn4JeRhyjUPBphS9M5HP4nEpFYquVGScSVt7j4wQ1Cx8MYR234MiPtOvqHe4vUiqkB-hs8e70uCVz_gViQQ2YiC099w10G-3q2lYdrakVTVDWC8MYq31dy-BixhhQipxilTTe09BJzq0oqaUP0d6wHPxjhJsOpOGcNMkz60BrbMoAuqSTwgolVYGqjSy0ncnJY46Mrzo5yanSWX4a5KeT_DQv0KvtO98yNce1pd9EEW9LRlrtdAPApmew6X-BrUAvNgDRMAyjb8UMfrkedaVUUm0FLdCjDJjtryLBUKTpL5DcgdJOXXafDP2XRPXNo0UrywK93oBOz3PMeE1bn_yPtj5Ft-o0Whgp6TO0N63Wfh8UsKl7nsbaJaizKoE
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dj5QwEJ-cezHxxfgtfqUmvmkj0EKLb-vphmz0Xrwz99aUttyReKDAxvin-N86Lewmq5dLfCNQoDC_Tqedmd8AvOKJk4IXllqdMcoFN7SorKO5tVldV1o667ORPx_n5Slfn2VnB5Buc2FC0H6gtAxqehsd9nbAicYng6FO9Wl_gmY34FAKVL8LOFwu11_Wu50V77viSTFnyMRMXnHz3iwUyPqvsjD_DZT8y1saJqHVHbg9W49kOfX3Lhy49h7cnOpJ_roPv1e4-O2GZiA_NnqKAgo_njQtKXHB2c_h6qREfI_kw-ScIX4vlnz6WhLdWnLctRSP35FVExJeBuIzUMhJQi6153I4D608qVWvh5HWvXPkKMDM4APreuO33-jPsOPqLGkuQxmkB3C6-nhyVNK59gI1aAKM1MQucwX-NlalqUkqljKTF7U0Ltec89SlqaitrxaDBpGVPBHaOVZXIstMHjPDHsKi7Vr3GEhRoTSsFTp4ZS1ajEVcox1pRW5yKWQEyVYWyszE5L4-xjcVHORMqkl-CuWngvxUFsHr3T3fJ1qOa1u_9yLetfSU2uFE15-rGWIqZlbwHFWeSBA-uta-MIAoDGJZaMuLCF5uAaJwCHq_im5dtxlUImUwa3MWwaMJMLtXeXIhT9EfgdiD0l5f9q-0zUWg-c78albEEbzZgk7N-mW45luf_F_zp3ArDeOC05g9g8XYb9xzNLPG6sU8rv4AsysibA
  priority: 102
  providerName: Springer Nature
Title Fibrosis quantification in Hypertensive Heart Disease with LVH and Non-LVH: Findings from T1 mapping and Contrast-free Cardiac Diffusion-weighted imaging
URI https://link.springer.com/article/10.1038/s41598-017-00627-5
https://www.ncbi.nlm.nih.gov/pubmed/28373647
https://www.proquest.com/docview/1884163863
https://pubmed.ncbi.nlm.nih.gov/PMC5428770
https://doaj.org/article/03d74630771941afa874479ce877ad49
Volume 7
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3bjtMwEB3tRUi8IO6ES2Uk3sCQxE6cICHULVtVFVQItmjfLMd2lkq7KZu0gv0U_paxk1QqlH1qlTptmjkTn_F4zgC84JHNBM8NNSphlAuuaV4YS1NjkrIsVGaNq0b-NEsncz49TU73oG931N3AZmdo5_pJzevz178ur96jw79rS8azNw1OQq5QDJ-3riRQ0GQfDn2-yG3l6-h-q_Ud5zzKu9qZ3ac6dWAM2pys-tZU5RX9d9HQf3dT_pVS9TPV-Dbc6igmGbaYuAN7troLN9qmk1f34PcYI-Rls2jI5Vq1W4W8dciiIhOMSutuTzuZoBOsyIc2g0Pcgi35-G1CVGXIbFlRfP-WjBe-KqYhrkyFnETkQjnBhzM_yilf1apZ0bK2low8FjV-YVmu3Rod_emXZa0hiwvfK-k-zMfHJ6MJ7Ro0UI08YUV1aBOb4x1kRRzrqGAx02leZtqminMe2zgWpXEtZZA1mYxHQlnLykIkiU5DptkDOKiWlX0EJC_QMMYI5VO3BmllHpZINo1IdZqJLICot4XUnXq5a6JxLn0WnWWyNaVEU0pvSpkE8HJzzo9Wu-Pa0UfOxJuRTnfbH1jWZ7JzYxkyI3iKz0URIZJUqVz3AJFrBLxQhucBPO8BItFPXfJFVXa5bmSUZZ77piyAhy1gNj_VAy4AsQWlrWvZ_qRafPda4IkLeUUYwKsedLL3oWv-6-P_XsITuBl7b-A0ZE_hYFWv7TOkXatiAPviVAzgcDicfp3i69Hx7PMXPDpKRwO_lDHw3vYHGGYsLQ
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dj5QwEG_OM0ZfjJ8nftbEN20EWtrim65uUPf2ac_cW1PacpJ4oMDG-Kf439opsMnq5RLfCLRQOr-2087MbxB6wRInBcstsTqjhAlmSF5aR7i1WVWVWjoL0cjHa16csE-n2ekBSudYmOC0HygtwzQ9e4e97v1CA8Fgfk6FsD9BsivoqgTydzDQ8sXuXAUsVyzJp_iYmMoLqu6tQYGq_yL98l83yb9spWEJWt5CNyfdEb8dW3sbHbjmDro2ZpP8dRf9Xvqtb9vXPf6x1aMPUOh2XDe48NvNbnJWx4VH94Dfj6YZDCexePWlwLqxeN02xF-_wcs6hLv0GOJP8CbB5xqYHM5CKaC06nQ_kKpzDi8CyIx_YVVt4fCN_Aznrc7i-jwkQbqHTpYfNouCTJkXiPEKwEBM7DKX-26jZZqapKQpNTyvpHFcM8ZSl6aispArxqtDVrJEaOdoVYosMzymht5Hh03buAcI56WXhrVCB5us9fpiHldei7SCGy6FjFAyy0KZiZYcsmN8U8E8TqUa5ae8_FSQn8oi9HJX5_tIynFp6Xcg4l1JINQON9ruTE0AUzG1gnE_4YnEw0dXGtICiNx4JAttWR6h5zNAlB-AYFXRjWu3vUqkDEotpxE6GgGz-xRQCwFBf4TEHpT22rL_pKm_BpLvDPayIo7Qqxl0appd-kv-9eH_FX-Grheb45VafVx_foRupGGMMBLTx-hw6LbuiVe4hvJpGGF_ALDrJAA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZKEagXxJvwNBI3MCSxYyfcYMsqQFlxaFFvluNHidQmJckK8VP4t4ydZKWFqhK3KLETx_PZHntmvkHoBUtsLlhhiFEZJUwwTYrKWMKNyZyrVG6Nj0b-suLlEft0nB3vID7HwgSn_UBpGabp2TvsTQ8LjQ8GgznVh_0Jkr0-N-4KugpfSvyma8EXm7MVb71iSTHFyMQ0v6D61joU6Pov0jH_dZX8y14alqHlTXRj0h_xu7HFt9CObW6ja2NGyV930O8lbH_bvu7xj7Ua_YBC1-O6wSVsObvJYR2XgPAB74_mGexPY_HBtxKrxuBV2xC4fouXdQh56bGPQcGHCT5Tns3hJJTytFad6gfiOmvxIgBNwwudW_sDOPIznLlag-uzkAjpLjpafjhclGTKvkA0KAED0bHNbAHdRqs01UlFU6p54XJtuWKMpTZNhTM-XwyoRCYHKShrqatElmkeU03vod2mbewDhIsKpGGMUMEua0BnLGIHmqQRXPNc5BFKZllIPVGT-wwZpzKYyGkuR_lJkJ8M8pNZhF5u6pyPxByXln7vRbwp6Um1w422O5ETyGRMjWAcJj2RAHyUUz41gCg0oFkow4oIPZ8BImEQesuKamy77mWS50Gx5TRC90fAbD7l6YU8SX-ExBaUttqy_aSpvwei78zvZ0UcoVcz6OQ0w_SX_OvD_yv-DF3_ur-UBx9Xnx-hvTQMEUZi-hjtDt3aPgGda6iehgH2B8vQJQk
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fibrosis+quantification+in+Hypertensive+Heart+Disease+with+LVH+and+Non-LVH%3A+Findings+from+T1+mapping+and+Contrast-free+Cardiac+Diffusion-weighted+imaging&rft.jtitle=Scientific+reports&rft.au=Wu%2C+Lian-Ming&rft.au=Wu%2C+Rui&rft.au=Ou%2C+Yang-Rongzheng&rft.au=Chen%2C+Bing-Hua&rft.date=2017-04-03&rft.eissn=2045-2322&rft.volume=7&rft.issue=1&rft.spage=559&rft_id=info:doi/10.1038%2Fs41598-017-00627-5&rft_id=info%3Apmid%2F28373647&rft.externalDocID=28373647
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon