Sports nutrition supplements and adverse events – a meta-epidemiological study of case reports specifically addressing causality assessment
Purpose This meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically addressing the issue of causality assessments. Methods Through a systematic literature search we identified all published case reports of...
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| Published in | European journal of clinical pharmacology Vol. 78; no. 1; pp. 1 - 9 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.01.2022
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0031-6970 1432-1041 1432-1041 |
| DOI | 10.1007/s00228-021-03223-9 |
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| Abstract | Purpose
This meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically addressing the issue of causality assessments.
Methods
Through a systematic literature search we identified all published case reports of AEs associated with sports nutrition supplements between 1 January 2008 and 1 March 2019. Data regarding AEs, suspected supplements, relevant causality assessment factors and the reporting of clinical reasoning and/or systematic causality assessment methods were extracted.
Results
In all, 72 publications were included, reporting 134 supplements and 37 different AEs in 97 patients (85% males; median age: 30 years [range: 14–60]). Information regarding previous health and regular prescription drugs was not presented in 30% (29/97) and 46% (45/97) of cases, respectively. In 23% (22/97) of the cases, no alternative cause was mentioned. Clinical reasoning was identified in 63% (61/97), and in 13% (8/61) of these, a systematic causality assessment method was applied. In cases with clinical reasoning, a theoretic rationale (92% vs 78%, P = 0.05), a description of previous cases (90% vs 72%, P = 0.021) and body fluid analysis (18% vs 3%, P = 0.027) were reported to a greater extent. Among cases with clinical reasoning, the application of a systematic causality assessment method captured additional important aspects: use of medication (100% vs 55%, P = 0.015), alcohol use (88% vs 43%, P = 0.020) and illicit drug use (88% vs 40%, P = 0.011).
Conclusions
In published case reports where sports nutrition supplements were suspected to have caused AEs, essential factors for causality assessment were left out in a non-negligible proportion. Clinical reasoning was identified in most cases whereas a systematic causality assessment method was applied in a minority. Factors of importance for causality assessment were reported to a greater extent in cases including clinical reasoning, and the application of a systematic causality assessment method captured additional aspects of importance. |
|---|---|
| AbstractList | Purpose
This meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically addressing the issue of causality assessments.
Methods
Through a systematic literature search we identified all published case reports of AEs associated with sports nutrition supplements between 1 January 2008 and 1 March 2019. Data regarding AEs, suspected supplements, relevant causality assessment factors and the reporting of clinical reasoning and/or systematic causality assessment methods were extracted.
Results
In all, 72 publications were included, reporting 134 supplements and 37 different AEs in 97 patients (85% males; median age: 30 years [range: 14–60]). Information regarding previous health and regular prescription drugs was not presented in 30% (29/97) and 46% (45/97) of cases, respectively. In 23% (22/97) of the cases, no alternative cause was mentioned. Clinical reasoning was identified in 63% (61/97), and in 13% (8/61) of these, a systematic causality assessment method was applied. In cases with clinical reasoning, a theoretic rationale (92% vs 78%, P = 0.05), a description of previous cases (90% vs 72%, P = 0.021) and body fluid analysis (18% vs 3%, P = 0.027) were reported to a greater extent. Among cases with clinical reasoning, the application of a systematic causality assessment method captured additional important aspects: use of medication (100% vs 55%, P = 0.015), alcohol use (88% vs 43%, P = 0.020) and illicit drug use (88% vs 40%, P = 0.011).
Conclusions
In published case reports where sports nutrition supplements were suspected to have caused AEs, essential factors for causality assessment were left out in a non-negligible proportion. Clinical reasoning was identified in most cases whereas a systematic causality assessment method was applied in a minority. Factors of importance for causality assessment were reported to a greater extent in cases including clinical reasoning, and the application of a systematic causality assessment method captured additional aspects of importance. This meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically addressing the issue of causality assessments. Through a systematic literature search we identified all published case reports of AEs associated with sports nutrition supplements between 1 January 2008 and 1 March 2019. Data regarding AEs, suspected supplements, relevant causality assessment factors and the reporting of clinical reasoning and/or systematic causality assessment methods were extracted. In all, 72 publications were included, reporting 134 supplements and 37 different AEs in 97 patients (85% males; median age: 30 years [range: 14-60]). Information regarding previous health and regular prescription drugs was not presented in 30% (29/97) and 46% (45/97) of cases, respectively. In 23% (22/97) of the cases, no alternative cause was mentioned. Clinical reasoning was identified in 63% (61/97), and in 13% (8/61) of these, a systematic causality assessment method was applied. In cases with clinical reasoning, a theoretic rationale (92% vs 78%, P = 0.05), a description of previous cases (90% vs 72%, P = 0.021) and body fluid analysis (18% vs 3%, P = 0.027) were reported to a greater extent. Among cases with clinical reasoning, the application of a systematic causality assessment method captured additional important aspects: use of medication (100% vs 55%, P = 0.015), alcohol use (88% vs 43%, P = 0.020) and illicit drug use (88% vs 40%, P = 0.011). In published case reports where sports nutrition supplements were suspected to have caused AEs, essential factors for causality assessment were left out in a non-negligible proportion. Clinical reasoning was identified in most cases whereas a systematic causality assessment method was applied in a minority. Factors of importance for causality assessment were reported to a greater extent in cases including clinical reasoning, and the application of a systematic causality assessment method captured additional aspects of importance. This meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically addressing the issue of causality assessments.PURPOSEThis meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically addressing the issue of causality assessments.Through a systematic literature search we identified all published case reports of AEs associated with sports nutrition supplements between 1 January 2008 and 1 March 2019. Data regarding AEs, suspected supplements, relevant causality assessment factors and the reporting of clinical reasoning and/or systematic causality assessment methods were extracted.METHODSThrough a systematic literature search we identified all published case reports of AEs associated with sports nutrition supplements between 1 January 2008 and 1 March 2019. Data regarding AEs, suspected supplements, relevant causality assessment factors and the reporting of clinical reasoning and/or systematic causality assessment methods were extracted.In all, 72 publications were included, reporting 134 supplements and 37 different AEs in 97 patients (85% males; median age: 30 years [range: 14-60]). Information regarding previous health and regular prescription drugs was not presented in 30% (29/97) and 46% (45/97) of cases, respectively. In 23% (22/97) of the cases, no alternative cause was mentioned. Clinical reasoning was identified in 63% (61/97), and in 13% (8/61) of these, a systematic causality assessment method was applied. In cases with clinical reasoning, a theoretic rationale (92% vs 78%, P = 0.05), a description of previous cases (90% vs 72%, P = 0.021) and body fluid analysis (18% vs 3%, P = 0.027) were reported to a greater extent. Among cases with clinical reasoning, the application of a systematic causality assessment method captured additional important aspects: use of medication (100% vs 55%, P = 0.015), alcohol use (88% vs 43%, P = 0.020) and illicit drug use (88% vs 40%, P = 0.011).RESULTSIn all, 72 publications were included, reporting 134 supplements and 37 different AEs in 97 patients (85% males; median age: 30 years [range: 14-60]). Information regarding previous health and regular prescription drugs was not presented in 30% (29/97) and 46% (45/97) of cases, respectively. In 23% (22/97) of the cases, no alternative cause was mentioned. Clinical reasoning was identified in 63% (61/97), and in 13% (8/61) of these, a systematic causality assessment method was applied. In cases with clinical reasoning, a theoretic rationale (92% vs 78%, P = 0.05), a description of previous cases (90% vs 72%, P = 0.021) and body fluid analysis (18% vs 3%, P = 0.027) were reported to a greater extent. Among cases with clinical reasoning, the application of a systematic causality assessment method captured additional important aspects: use of medication (100% vs 55%, P = 0.015), alcohol use (88% vs 43%, P = 0.020) and illicit drug use (88% vs 40%, P = 0.011).In published case reports where sports nutrition supplements were suspected to have caused AEs, essential factors for causality assessment were left out in a non-negligible proportion. Clinical reasoning was identified in most cases whereas a systematic causality assessment method was applied in a minority. Factors of importance for causality assessment were reported to a greater extent in cases including clinical reasoning, and the application of a systematic causality assessment method captured additional aspects of importance.CONCLUSIONSIn published case reports where sports nutrition supplements were suspected to have caused AEs, essential factors for causality assessment were left out in a non-negligible proportion. Clinical reasoning was identified in most cases whereas a systematic causality assessment method was applied in a minority. Factors of importance for causality assessment were reported to a greater extent in cases including clinical reasoning, and the application of a systematic causality assessment method captured additional aspects of importance. Purpose This meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically addressing the issue of causality assessments. Methods Through a systematic literature search we identified all published case reports of AEs associated with sports nutrition supplements between 1 January 2008 and 1 March 2019. Data regarding AEs, suspected supplements, relevant causality assessment factors and the reporting of clinical reasoning and/or systematic causality assessment methods were extracted. Results In all, 72 publications were included, reporting 134 supplements and 37 different AEs in 97 patients (85% males; median age: 30 years [range: 14-60]). Information regarding previous health and regular prescription drugs was not presented in 30% (29/97) and 46% (45/97) of cases, respectively. In 23% (22/97) of the cases, no alternative cause was mentioned. Clinical reasoning was identified in 63% (61/97), and in 13% (8/61) of these, a systematic causality assessment method was applied. In cases with clinical reasoning, a theoretic rationale (92% vs 78%, P = 0.05), a description of previous cases (90% vs 72%, P = 0.021) and body fluid analysis (18% vs 3%, P = 0.027) were reported to a greater extent. Among cases with clinical reasoning, the application of a systematic causality assessment method captured additional important aspects: use of medication (100% vs 55%, P = 0.015), alcohol use (88% vs 43%, P = 0.020) and illicit drug use (88% vs 40%, P = 0.011). Conclusions In published case reports where sports nutrition supplements were suspected to have caused AEs, essential factors for causality assessment were left out in a non-negligible proportion. Clinical reasoning was identified in most cases whereas a systematic causality assessment method was applied in a minority. Factors of importance for causality assessment were reported to a greater extent in cases including clinical reasoning, and the application of a systematic causality assessment method captured additional aspects of importance. PurposeThis meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically addressing the issue of causality assessments.MethodsThrough a systematic literature search we identified all published case reports of AEs associated with sports nutrition supplements between 1 January 2008 and 1 March 2019. Data regarding AEs, suspected supplements, relevant causality assessment factors and the reporting of clinical reasoning and/or systematic causality assessment methods were extracted.ResultsIn all, 72 publications were included, reporting 134 supplements and 37 different AEs in 97 patients (85% males; median age: 30 years [range: 14–60]). Information regarding previous health and regular prescription drugs was not presented in 30% (29/97) and 46% (45/97) of cases, respectively. In 23% (22/97) of the cases, no alternative cause was mentioned. Clinical reasoning was identified in 63% (61/97), and in 13% (8/61) of these, a systematic causality assessment method was applied. In cases with clinical reasoning, a theoretic rationale (92% vs 78%, P = 0.05), a description of previous cases (90% vs 72%, P = 0.021) and body fluid analysis (18% vs 3%, P = 0.027) were reported to a greater extent. Among cases with clinical reasoning, the application of a systematic causality assessment method captured additional important aspects: use of medication (100% vs 55%, P = 0.015), alcohol use (88% vs 43%, P = 0.020) and illicit drug use (88% vs 40%, P = 0.011).ConclusionsIn published case reports where sports nutrition supplements were suspected to have caused AEs, essential factors for causality assessment were left out in a non-negligible proportion. Clinical reasoning was identified in most cases whereas a systematic causality assessment method was applied in a minority. Factors of importance for causality assessment were reported to a greater extent in cases including clinical reasoning, and the application of a systematic causality assessment method captured additional aspects of importance. |
| Author | Hantelius, Victor Zeijlon, Rickard Holmqvist, Lina Wallerstedt, Susanna M. |
| Author_xml | – sequence: 1 givenname: Rickard surname: Zeijlon fullname: Zeijlon, Rickard email: rickard.zeijlon@gu.se organization: Department of Internal Medicine, Sahlgrenska University Hospital, Department of Medicine, Sahlgrenska Academy, University of Gothenburg – sequence: 2 givenname: Victor surname: Hantelius fullname: Hantelius, Victor organization: Department of Internal Medicine, Sahlgrenska University Hospital – sequence: 3 givenname: Susanna M. surname: Wallerstedt fullname: Wallerstedt, Susanna M. organization: Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, HTA-Centrum, Sahlgrenska University Hospital – sequence: 4 givenname: Lina surname: Holmqvist fullname: Holmqvist, Lina organization: Department of Internal Medicine, Sahlgrenska University Hospital, Department of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg Emergency Medicine Research Group, GEMREG, Sahlgrenska University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34599661$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/310180$$DView record from Swedish Publication Index |
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| CitedBy_id | crossref_primary_10_56016_dahudermj_1184388 crossref_primary_10_1080_19390211_2022_2140740 crossref_primary_10_3390_ijerph191912477 crossref_primary_10_3390_nu16111567 crossref_primary_10_20960_nh_05197 |
| Cites_doi | 10.1007/s11096-018-0694-9 10.1111/j.1365-2036.2008.03655.x 10.7205/MILMED-D-12-00265 10.2165/00002018-200831010-00003 10.1007/s10637-010-9456-9 10.1097/PAF.0000000000000058 10.1038/clpt.1981.154 10.1542/peds.2009-3352 10.1056/NEJMsa1504267 10.1177/8755122513503790 10.1016/j.ajem.2009.07.016 10.1016/S1665-2681(19)31764-8 10.1016/j.jada.2006.09.002 10.2146/ajhp070640 10.1016/S1665-2681(19)31474-7 10.1007/s40261-017-0601-5 10.1046/j.1365-2125.1999.00000.x 10.4103/0976-500X.120955 10.1016/0895-4356(93)90101-6 10.1210/jc.2013-2310 10.1111/1541-4337.12173 10.1016/j.gastrohep.2013.09.009 10.1007/s40264-017-0515-4 10.1007/s40800-016-0042-8 10.1002/dta.1764 10.1136/ebmed-2015-110362 10.12659/AJCR.904375 10.1002/phar.1572 10.2165/00002018-200730050-00001 10.7326/L15-0106 10.1345/aph.1R405 10.7205/MILMED-D-11-00342 10.1007/s00228-017-2223-5 10.1136/bmjopen-2015-009038 |
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| Keywords | Clinical reasoning Adverse event Dietary supplement Causality assessment |
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| References | TimboBBRossMPMcCarthyPVLinCTDietary supplements in a national survey: Prevalence of use and reports of adverse eventsJ Am Diet Assoc200610612196619741:CAS:528:DC%2BD2sXhvVymsg%3D%3D10.1016/j.jada.2006.09.002 YoungCOladipoOFrasierSPutkoRChronisterSMarovichMHemorrhagic stroke in young healthy male following use of sports supplement Jack3dMil Med2012177121450145410.7205/MILMED-D-11-00342 MukherjeeSDCoombesMELevineMCosbyJKowaleskiBArnoldAA qualitative study evaluating causality attribution for serious adverse events during early phase oncology clinical trialsInvest New Drugs2011295101310201:CAS:528:DC%2BC3MXhtVOrtLrF10.1007/s10637-010-9456-920512397 AgbabiakaTSavovićJErnstEMethods for Causality Assessment of Adverse Drug ReactionsDrug Saf2008311213710.2165/00002018-200831010-00003 National Institutes of Health. Dietary Supplements for Exercise and Athletic Performance (2020) https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/. Accessed 31 Jan 2020 RochaTAmaralJSOliveiraMBPPAdulteration of Dietary Supplements by the Illegal Addition of Synthetic Drugs: A ReviewCompr Rev Food Sci Food Saf2016151436210.1111/1541-4337.12173 SaidiHManiMSevere metabolic acidosis secondary to coadministration of creatine and metformin, a case reportAm J Emerg Med2010283388.e5610.1016/j.ajem.2009.07.016 EdwardsIRSpontaneous reporting–of what? Clinical concerns about drugsBr J Clin Pharmacol19994821381411:STN:280:DyaK1MzkvVSltw%3D%3D10.1046/j.1365-2125.1999.00000.x Ide K, Yamada H, Kitagawa M, Kawasaki Y, Buno Y, Matsushita K et al (2015) Methods for estimating causal relationships of adverse events with dietary supplements. BMJ Open. 5(11) U.S. Food and Drug Administration (FDA) (2009) Guidance for Industry: Questions and Answers Regarding Adverse Event Reporting and Recordkeeping for Dietary Supplements as Required by the Dietary Supplement and Nonprescription Drug Consumer Protection Act. USA. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/guidance-industry-questions-and-answers-regarding-adverse-event-reporting-and-recordkeeping-dietary. Accessed 3 Feb 2020 EliasonMJEichnerACancioABesterveltLAdamsBDDeusterPACase reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA)Mil Med2012177121455145910.7205/MILMED-D-12-00265 Avelar-EscobarGMéndez-NavarroJOrtiz-OlveraNXCastellanosGRamosRGallardo-CabreraVEHepatotoxicity associated with dietary energy supplements: use and abuse by young athletesAnn Hepatol201211456456910.1016/S1665-2681(19)31474-7 AmpueroJGarcíaESLorenzoMMCalleRFerreroPGómezMRStanozolol-induced bland cholestasisGastroenterol Hepatol2014372717210.1016/j.gastrohep.2013.09.009 Vilella AL, Limsuwat C, Williams DR, Seifert CF (2013) Cholestatic jaundice as a result of combination designer supplement ingestion. Ann Pharmacother. 47(7–8):e33 TeschkeRHepatotoxicity by drugs and dietary supplements: safety perspectives on clinical and regulatory issuesAnn Hepatol20098318419510.1016/S1665-2681(19)31764-8 CohenPAEmergency department visits and hospitalisations for adverse events related to dietary supplements are commonEvid Based Med20162127910.1136/ebmed-2015-110362 Grand View Research (2018) Sports Nutrition Market Size, Share & Trends Analysis Report By Product (Drinks, Supplements, Foods), By Distribution Channel (E-Commerce, Brick & Mortar), By Region, and Segment Forecasts, 2018 - 2025. https://www.grandviewresearch.com/industry-analysis/sports-nutrition-market. Accessed 31 Jan 2020 European Union (2002) Regulation (EC) No 178/2002 of the European Parliament and of the Council of 28 January 2002 laying down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety. Official Journal of the European Union. L31/1. Accessed 1 Feb 2002 Venes D (2017) Taber’s cyclopedic medical dictionary. 23 ed. United States. FA Davis Company. 492 p El RahiCThompson-MooreNMejiaPDe HoyosPSuccessful use of N-acetylcysteine to treat severe hepatic injury caused by a dietary fitness supplementPharmacotherapy2015356e96e10110.1002/phar.1572 PlessisLGómezAGarcíaNCerezaGFiguerasALack of essential information in spontaneous reports of adverse drug reactions in Catalonia—a restraint to the potentiality for signal detectionEur J Clin Pharmacol20177367517581:CAS:528:DC%2BC2sXjs1Sitb0%3D10.1007/s00228-017-2223-5 BenichouCDananGA new method for drug causality assessment: RUCAM1994Adverse Drug Reactions A Practical guide to Diagnosis and Management ChistesterJohn Wily & Sons Ltd.277283 KellyWNArellanoFMBarnesJBergmanUEdwardsRIFernandezAMGuidelines for submitting adverse event reports for publicationDrug Saf200730536737310.2165/00002018-200730050-00001 CohenPAZeijlonRNardinRKeizersPHJVenhuisBHemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenyl-ethylamine (BMPEA): A Case ReportAnn Intern Med20151621287988010.7326/L15-0106 PalleriaCLeporiniCChimirriSMarrazzoGSacchettaSBrunoLLimitations and obstacles of the spontaneous adverse drugs reactions reporting: Two "challenging" case reportsJ Pharmacol Pharmacother20134Suppl 16672 Danan G, Benichou C (1993) Causality assessment of adverse reactions to drugs—I. A novel method based on the conclusions of international consensus meetings: Application to drug-induced liver injuries. J Clin Epidemiol. 46(11):1323–30 ArcherJRDarganPILostiaAMvan der WaltJHendersonKDrakeNRunning an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA)Drug Test Anal2015754334381:CAS:528:DC%2BC2MXmslOjtw%3D%3D10.1002/dta.1764 PatelYAMarzellaNDietary Supplement-Drug Interaction-Induced Serotonin Syndrome Progressing to Acute Compartment SyndromeAm J Case Rep20171892693010.12659/AJCR.904375 National Institutes of Health (2020) Dietary Supplement Health and Education Act of 1994 (§3 Definitions; §6 Statements of Nutritional Support). National Institutes of Health - Office of Dietary Supplements, USA. https://ods.od.nih.gov/About/DSHEA_Wording.aspx#sec3. Accessed 30 Jan 2020 BeheraSKDasSXavierASVelupulaSSandhiyaSComparison of different methods for causality assessment of adverse drug reactionsInt J Clin Pharm20184049039101:CAS:528:DC%2BC1cXhtl2lsbbL10.1007/s11096-018-0694-930051231 NaranjoCABustoUSellersEMSandorPRuizIRobertsEAA method for estimating the probability of adverse drug reactionsClin Pharmacol Ther19813022392451:CAS:528:DyaL3MXltVygsLk%3D10.1038/clpt.1981.154 LavonasEJReynoldsKMDartRCTherapeutic acetaminophen is not associated with liver injury in children: a systematic reviewPediatrics20101266e1430e144410.1542/peds.2009-3352 JabbarSBHanlyMGFatal caffeine overdose: a case report and review of literatureAm J Forensic Med Pathol201334432132410.1097/PAF.0000000000000058 ShahRImportance of Publishing Adverse Drug Reaction Case Reports: Promoting Public Health and Advancing Pharmacology and TherapeuticsDrug Saf - Case Reports20174111010.1007/s40800-016-0042-8 DehoneySWelleinMRhabdomyolysis associated with the nutritional supplement HydroxycutAm J Health Syst Pharm20096621421481:CAS:528:DC%2BD1MXitF2jt78%3D10.2146/ajhp070640 García-CortésMLucenaMIPachkoriaKBorrazYHidalgoRAndradeRJEvaluation of naranjo adverse drug reactions probability scale in causality assessment of drug-induced liver injuryAliment Pharmacol Ther200827978078910.1111/j.1365-2036.2008.03655.x DasSBeheraSKXavierASVelupulaSDkharSASelvarajanSAgreement Among Different Scales for Causality Assessment in Drug-Induced Liver InjuryClin Drug Investig20183832112181:CAS:528:DC%2BC2sXhvFekt7bF10.1007/s40261-017-0601-5 OnakpoyaIJHeneghanCJAronsonJKPost-marketing regulation of medicines withdrawn from the market because of drug-attributed deaths: an analysis of justificationDrug Saf201740543110.1007/s40264-017-0515-4 PereraNJSteinbeckKSShackelNThe adverse health consequences of the use of multiple performance-enhancing substances–a deadly cocktailJ Clin Endocrinol Metab20139812461346181:CAS:528:DC%2BC3sXhvF2ksr7F10.1210/jc.2013-2310 Wah ChanLYangBASachdevaVChongHSBalancing Pre and Post-Market Control of Health SupplementsPharm Eng201636594100 GellerAIShehabNWeidleNJLovegroveMCWolpertBJTimboBBEmergency Department Visits for Adverse Events Related to Dietary SupplementsN Engl J Med201537316153115401:CAS:528:DC%2BC28Xot1ajs7g%3D10.1056/NEJMsa1504267 The Uppsala monitoring centre (2020) The use of WHO-UMC system for standardised case causality assessment. http://www.who-umc.org/. Accessed 11 Dec 2020 MiltonRMKelly-RehmMBrahmNFoxMDHypertension in an Adolescent Secondary to Performance-Enhancement Supplement UseJ Pharm Technol201430381861:CAS:528:DC%2BC28XhsVWgtLfM10.1177/8755122513503790 EJ Lavonas (3223_CR32) 2010; 126 C Palleria (3223_CR13) 2013; 4 3223_CR26 BB Timbo (3223_CR8) 2006; 106 L Plessis (3223_CR14) 2017; 73 J Ampuero (3223_CR24) 2014; 37 SB Jabbar (3223_CR42) 2013; 34 3223_CR25 JR Archer (3223_CR43) 2015; 7 G Avelar-Escobar (3223_CR28) 2012; 11 C El Rahi (3223_CR29) 2015; 35 T Rocha (3223_CR34) 2016; 15 PA Cohen (3223_CR6) 2016; 21 S Dehoney (3223_CR19) 2009; 66 MJ Eliason (3223_CR40) 2012; 177 H Saidi (3223_CR39) 2010; 28 3223_CR22 CA Naranjo (3223_CR18) 1981; 30 T Agbabiaka (3223_CR15) 2008; 31 C Benichou (3223_CR23) 1994 L Wah Chan (3223_CR11) 2016; 36 IJ Onakpoya (3223_CR38) 2017; 40 3223_CR17 3223_CR1 3223_CR2 C Young (3223_CR3) 2012; 177 R Shah (3223_CR35) 2017; 4 S Das (3223_CR33) 2018; 38 SK Behera (3223_CR37) 2018; 40 IR Edwards (3223_CR12) 1999; 48 3223_CR7 R Teschke (3223_CR27) 2009; 8 3223_CR9 NJ Perera (3223_CR41) 2013; 98 YA Patel (3223_CR21) 2017; 18 M García-Cortés (3223_CR31) 2008; 27 PA Cohen (3223_CR4) 2015; 162 WN Kelly (3223_CR36) 2007; 30 RM Milton (3223_CR20) 2014; 30 SD Mukherjee (3223_CR16) 2011; 29 3223_CR10 AI Geller (3223_CR5) 2015; 373 3223_CR30 |
| References_xml | – reference: Grand View Research (2018) Sports Nutrition Market Size, Share & Trends Analysis Report By Product (Drinks, Supplements, Foods), By Distribution Channel (E-Commerce, Brick & Mortar), By Region, and Segment Forecasts, 2018 - 2025. https://www.grandviewresearch.com/industry-analysis/sports-nutrition-market. Accessed 31 Jan 2020 – reference: European Union (2002) Regulation (EC) No 178/2002 of the European Parliament and of the Council of 28 January 2002 laying down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety. Official Journal of the European Union. L31/1. Accessed 1 Feb 2002 – reference: TeschkeRHepatotoxicity by drugs and dietary supplements: safety perspectives on clinical and regulatory issuesAnn Hepatol20098318419510.1016/S1665-2681(19)31764-8 – reference: SaidiHManiMSevere metabolic acidosis secondary to coadministration of creatine and metformin, a case reportAm J Emerg Med2010283388.e5610.1016/j.ajem.2009.07.016 – reference: Danan G, Benichou C (1993) Causality assessment of adverse reactions to drugs—I. A novel method based on the conclusions of international consensus meetings: Application to drug-induced liver injuries. J Clin Epidemiol. 46(11):1323–30 – reference: BenichouCDananGA new method for drug causality assessment: RUCAM1994Adverse Drug Reactions A Practical guide to Diagnosis and Management ChistesterJohn Wily & Sons Ltd.277283 – reference: García-CortésMLucenaMIPachkoriaKBorrazYHidalgoRAndradeRJEvaluation of naranjo adverse drug reactions probability scale in causality assessment of drug-induced liver injuryAliment Pharmacol Ther200827978078910.1111/j.1365-2036.2008.03655.x – reference: DasSBeheraSKXavierASVelupulaSDkharSASelvarajanSAgreement Among Different Scales for Causality Assessment in Drug-Induced Liver InjuryClin Drug Investig20183832112181:CAS:528:DC%2BC2sXhvFekt7bF10.1007/s40261-017-0601-5 – reference: DehoneySWelleinMRhabdomyolysis associated with the nutritional supplement HydroxycutAm J Health Syst Pharm20096621421481:CAS:528:DC%2BD1MXitF2jt78%3D10.2146/ajhp070640 – reference: ArcherJRDarganPILostiaAMvan der WaltJHendersonKDrakeNRunning an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA)Drug Test Anal2015754334381:CAS:528:DC%2BC2MXmslOjtw%3D%3D10.1002/dta.1764 – reference: El RahiCThompson-MooreNMejiaPDe HoyosPSuccessful use of N-acetylcysteine to treat severe hepatic injury caused by a dietary fitness supplementPharmacotherapy2015356e96e10110.1002/phar.1572 – reference: The Uppsala monitoring centre (2020) The use of WHO-UMC system for standardised case causality assessment. http://www.who-umc.org/. Accessed 11 Dec 2020 – reference: TimboBBRossMPMcCarthyPVLinCTDietary supplements in a national survey: Prevalence of use and reports of adverse eventsJ Am Diet Assoc200610612196619741:CAS:528:DC%2BD2sXhvVymsg%3D%3D10.1016/j.jada.2006.09.002 – reference: EdwardsIRSpontaneous reporting–of what? Clinical concerns about drugsBr J Clin Pharmacol19994821381411:STN:280:DyaK1MzkvVSltw%3D%3D10.1046/j.1365-2125.1999.00000.x – reference: MukherjeeSDCoombesMELevineMCosbyJKowaleskiBArnoldAA qualitative study evaluating causality attribution for serious adverse events during early phase oncology clinical trialsInvest New Drugs2011295101310201:CAS:528:DC%2BC3MXhtVOrtLrF10.1007/s10637-010-9456-920512397 – reference: PalleriaCLeporiniCChimirriSMarrazzoGSacchettaSBrunoLLimitations and obstacles of the spontaneous adverse drugs reactions reporting: Two "challenging" case reportsJ Pharmacol Pharmacother20134Suppl 16672 – reference: National Institutes of Health (2020) Dietary Supplement Health and Education Act of 1994 (§3 Definitions; §6 Statements of Nutritional Support). National Institutes of Health - Office of Dietary Supplements, USA. https://ods.od.nih.gov/About/DSHEA_Wording.aspx#sec3. Accessed 30 Jan 2020 – reference: Vilella AL, Limsuwat C, Williams DR, Seifert CF (2013) Cholestatic jaundice as a result of combination designer supplement ingestion. Ann Pharmacother. 47(7–8):e33 – reference: KellyWNArellanoFMBarnesJBergmanUEdwardsRIFernandezAMGuidelines for submitting adverse event reports for publicationDrug Saf200730536737310.2165/00002018-200730050-00001 – reference: U.S. Food and Drug Administration (FDA) (2009) Guidance for Industry: Questions and Answers Regarding Adverse Event Reporting and Recordkeeping for Dietary Supplements as Required by the Dietary Supplement and Nonprescription Drug Consumer Protection Act. USA. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/guidance-industry-questions-and-answers-regarding-adverse-event-reporting-and-recordkeeping-dietary. Accessed 3 Feb 2020 – reference: Ide K, Yamada H, Kitagawa M, Kawasaki Y, Buno Y, Matsushita K et al (2015) Methods for estimating causal relationships of adverse events with dietary supplements. BMJ Open. 5(11) – reference: GellerAIShehabNWeidleNJLovegroveMCWolpertBJTimboBBEmergency Department Visits for Adverse Events Related to Dietary SupplementsN Engl J Med201537316153115401:CAS:528:DC%2BC28Xot1ajs7g%3D10.1056/NEJMsa1504267 – reference: YoungCOladipoOFrasierSPutkoRChronisterSMarovichMHemorrhagic stroke in young healthy male following use of sports supplement Jack3dMil Med2012177121450145410.7205/MILMED-D-11-00342 – reference: PereraNJSteinbeckKSShackelNThe adverse health consequences of the use of multiple performance-enhancing substances–a deadly cocktailJ Clin Endocrinol Metab20139812461346181:CAS:528:DC%2BC3sXhvF2ksr7F10.1210/jc.2013-2310 – reference: PatelYAMarzellaNDietary Supplement-Drug Interaction-Induced Serotonin Syndrome Progressing to Acute Compartment SyndromeAm J Case Rep20171892693010.12659/AJCR.904375 – reference: EliasonMJEichnerACancioABesterveltLAdamsBDDeusterPACase reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA)Mil Med2012177121455145910.7205/MILMED-D-12-00265 – reference: RochaTAmaralJSOliveiraMBPPAdulteration of Dietary Supplements by the Illegal Addition of Synthetic Drugs: A ReviewCompr Rev Food Sci Food Saf2016151436210.1111/1541-4337.12173 – reference: AmpueroJGarcíaESLorenzoMMCalleRFerreroPGómezMRStanozolol-induced bland cholestasisGastroenterol Hepatol2014372717210.1016/j.gastrohep.2013.09.009 – reference: Avelar-EscobarGMéndez-NavarroJOrtiz-OlveraNXCastellanosGRamosRGallardo-CabreraVEHepatotoxicity associated with dietary energy supplements: use and abuse by young athletesAnn Hepatol201211456456910.1016/S1665-2681(19)31474-7 – reference: LavonasEJReynoldsKMDartRCTherapeutic acetaminophen is not associated with liver injury in children: a systematic reviewPediatrics20101266e1430e144410.1542/peds.2009-3352 – reference: MiltonRMKelly-RehmMBrahmNFoxMDHypertension in an Adolescent Secondary to Performance-Enhancement Supplement UseJ Pharm Technol201430381861:CAS:528:DC%2BC28XhsVWgtLfM10.1177/8755122513503790 – reference: JabbarSBHanlyMGFatal caffeine overdose: a case report and review of literatureAm J Forensic Med Pathol201334432132410.1097/PAF.0000000000000058 – reference: Wah ChanLYangBASachdevaVChongHSBalancing Pre and Post-Market Control of Health SupplementsPharm Eng201636594100 – reference: CohenPAZeijlonRNardinRKeizersPHJVenhuisBHemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenyl-ethylamine (BMPEA): A Case ReportAnn Intern Med20151621287988010.7326/L15-0106 – reference: BeheraSKDasSXavierASVelupulaSSandhiyaSComparison of different methods for causality assessment of adverse drug reactionsInt J Clin Pharm20184049039101:CAS:528:DC%2BC1cXhtl2lsbbL10.1007/s11096-018-0694-930051231 – reference: CohenPAEmergency department visits and hospitalisations for adverse events related to dietary supplements are commonEvid Based Med20162127910.1136/ebmed-2015-110362 – reference: PlessisLGómezAGarcíaNCerezaGFiguerasALack of essential information in spontaneous reports of adverse drug reactions in Catalonia—a restraint to the potentiality for signal detectionEur J Clin Pharmacol20177367517581:CAS:528:DC%2BC2sXjs1Sitb0%3D10.1007/s00228-017-2223-5 – reference: ShahRImportance of Publishing Adverse Drug Reaction Case Reports: Promoting Public Health and Advancing Pharmacology and TherapeuticsDrug Saf - Case Reports20174111010.1007/s40800-016-0042-8 – reference: National Institutes of Health. Dietary Supplements for Exercise and Athletic Performance (2020) https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/. Accessed 31 Jan 2020 – reference: Venes D (2017) Taber’s cyclopedic medical dictionary. 23 ed. United States. FA Davis Company. 492 p – reference: AgbabiakaTSavovićJErnstEMethods for Causality Assessment of Adverse Drug ReactionsDrug Saf2008311213710.2165/00002018-200831010-00003 – reference: NaranjoCABustoUSellersEMSandorPRuizIRobertsEAA method for estimating the probability of adverse drug reactionsClin Pharmacol Ther19813022392451:CAS:528:DyaL3MXltVygsLk%3D10.1038/clpt.1981.154 – reference: OnakpoyaIJHeneghanCJAronsonJKPost-marketing regulation of medicines withdrawn from the market because of drug-attributed deaths: an analysis of justificationDrug Saf201740543110.1007/s40264-017-0515-4 – ident: 3223_CR1 – start-page: 277 volume-title: A new method for drug causality assessment: RUCAM year: 1994 ident: 3223_CR23 – volume: 40 start-page: 903 issue: 4 year: 2018 ident: 3223_CR37 publication-title: Int J Clin Pharm doi: 10.1007/s11096-018-0694-9 – volume: 27 start-page: 780 issue: 9 year: 2008 ident: 3223_CR31 publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2008.03655.x – volume: 177 start-page: 1455 issue: 12 year: 2012 ident: 3223_CR40 publication-title: Mil Med doi: 10.7205/MILMED-D-12-00265 – volume: 31 start-page: 21 issue: 1 year: 2008 ident: 3223_CR15 publication-title: Drug Saf doi: 10.2165/00002018-200831010-00003 – volume: 29 start-page: 1013 issue: 5 year: 2011 ident: 3223_CR16 publication-title: Invest New Drugs doi: 10.1007/s10637-010-9456-9 – volume: 34 start-page: 321 issue: 4 year: 2013 ident: 3223_CR42 publication-title: Am J Forensic Med Pathol doi: 10.1097/PAF.0000000000000058 – volume: 30 start-page: 239 issue: 2 year: 1981 ident: 3223_CR18 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.1981.154 – volume: 126 start-page: e1430 issue: 6 year: 2010 ident: 3223_CR32 publication-title: Pediatrics doi: 10.1542/peds.2009-3352 – ident: 3223_CR7 – volume: 373 start-page: 1531 issue: 16 year: 2015 ident: 3223_CR5 publication-title: N Engl J Med doi: 10.1056/NEJMsa1504267 – volume: 30 start-page: 81 issue: 3 year: 2014 ident: 3223_CR20 publication-title: J Pharm Technol doi: 10.1177/8755122513503790 – volume: 28 start-page: 388.e5 issue: 3 year: 2010 ident: 3223_CR39 publication-title: Am J Emerg Med doi: 10.1016/j.ajem.2009.07.016 – ident: 3223_CR9 – volume: 8 start-page: 184 issue: 3 year: 2009 ident: 3223_CR27 publication-title: Ann Hepatol doi: 10.1016/S1665-2681(19)31764-8 – volume: 106 start-page: 1966 issue: 12 year: 2006 ident: 3223_CR8 publication-title: J Am Diet Assoc doi: 10.1016/j.jada.2006.09.002 – volume: 66 start-page: 142 issue: 2 year: 2009 ident: 3223_CR19 publication-title: Am J Health Syst Pharm doi: 10.2146/ajhp070640 – volume: 11 start-page: 564 issue: 4 year: 2012 ident: 3223_CR28 publication-title: Ann Hepatol doi: 10.1016/S1665-2681(19)31474-7 – volume: 38 start-page: 211 issue: 3 year: 2018 ident: 3223_CR33 publication-title: Clin Drug Investig doi: 10.1007/s40261-017-0601-5 – volume: 48 start-page: 138 issue: 2 year: 1999 ident: 3223_CR12 publication-title: Br J Clin Pharmacol doi: 10.1046/j.1365-2125.1999.00000.x – volume: 4 start-page: 66 issue: Suppl 1 year: 2013 ident: 3223_CR13 publication-title: J Pharmacol Pharmacother doi: 10.4103/0976-500X.120955 – ident: 3223_CR22 doi: 10.1016/0895-4356(93)90101-6 – volume: 98 start-page: 4613 issue: 12 year: 2013 ident: 3223_CR41 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-2310 – volume: 15 start-page: 43 issue: 1 year: 2016 ident: 3223_CR34 publication-title: Compr Rev Food Sci Food Saf doi: 10.1111/1541-4337.12173 – ident: 3223_CR10 – volume: 36 start-page: 94 issue: 5 year: 2016 ident: 3223_CR11 publication-title: Pharm Eng – volume: 37 start-page: 71 issue: 2 year: 2014 ident: 3223_CR24 publication-title: Gastroenterol Hepatol doi: 10.1016/j.gastrohep.2013.09.009 – ident: 3223_CR2 – volume: 40 start-page: 431 issue: 5 year: 2017 ident: 3223_CR38 publication-title: Drug Saf doi: 10.1007/s40264-017-0515-4 – ident: 3223_CR26 – volume: 4 start-page: 1 issue: 1 year: 2017 ident: 3223_CR35 publication-title: Drug Saf - 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This meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs),... This meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs), specifically... PurposeThis meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs),... Purpose This meta-epidemiological study aimed to systematically review case reports regarding sports nutrition supplements and adverse events (AEs),... |
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| SubjectTerms | Adolescent Adult Adverse Adverse events Biomedical and Life Sciences Biomedicine Case reports Causality Causality assessment Clinical reasoning death Dietary supplement Dietary supplements Dietary Supplements - adverse effects drug-reactions Epidemiologic Studies Epidemiology event Farmakologi och toxikologi Female hemorrhagic stroke hepatotoxicity Humans Male Middle Aged Nutrition Pharmacology & Pharmacy Pharmacology and Toxicology Pharmacology/Toxicology probability Review Sports Nutritional Sciences Young Adult |
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| Title | Sports nutrition supplements and adverse events – a meta-epidemiological study of case reports specifically addressing causality assessment |
| URI | https://link.springer.com/article/10.1007/s00228-021-03223-9 https://www.ncbi.nlm.nih.gov/pubmed/34599661 https://www.proquest.com/docview/2616135035 https://www.proquest.com/docview/2578766960 https://pubmed.ncbi.nlm.nih.gov/PMC8724217 https://gup.ub.gu.se/publication/310180 |
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