Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients - Potje, Simone R.; Costa, Tiago J.; Fraga-Silva, Thais F.C.; Martins, Ronaldo B.; Benatti, Maira N.; Almado, Carlos E.L.; de Sá, Keyla S.G.; Bonato, Vânia L.D.; Arruda, Eurico; Louzada-Junior, Paulo; Oliveira, Rene D.R.; Zamboni, Dario S.; et al. (Life sciences (1973), 2021)
Keywords: ACE2; adhesion; Aged; Alveoli; Angiotensin; Angiotensin-converting enzyme 2; Blood Coagulation Disorders - blood; Blood Coagulation Disorders - virology; C-reactive protein; Capillaries; Cardiovascular diseases; Case-Control Studies; Cell Adhesion - physiology; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - metabolism; COVID-19 - pathology; COVID-19 infection; COVID-19 Testing; Cytokines; Degradation; Dimers; disease severity; Endothelial cells; Endothelium, Vascular - metabolism; Female; Ferritin; Glycocalyx; Glycocalyx - metabolism; Glycocalyx - pathology; Glycocalyx - virology; Glycoproteins; Health services; Heparan sulfate proteoglycans; Heparin; Heparin - pharmacology; Homeostasis; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Inflammation; Inflammatory response; Interleukin 1; Interleukin 6; Interleukin-1beta - blood; Interleukin-6 - blood; Leukocytes; Lipid peroxidation; Lipids; Low molecular weight heparin; Low molecular weights; Lymphopenia; Male; Middle Aged; Molecular weight; Neutrophilia; Oxidation-Reduction; Peptidyl-dipeptidase A; Permeability; Peroxidation; Perturbation; Plasma; Proteoglycans; Reactive oxygen species; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Shedding; Thromboembolism; Thrombosis; Thrombosis - metabolism; Umbilical vein; Vascular dysfunction; Viral diseases; COVID-19; Heparan sulfate proteoglycans; Low molecular weight heparin; Glycocalyx; Vascular dysfunction; Endothelial cells