Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients - Li, Xingnan; Hawkins, Gregory A.; Ampleford, Elizabeth J.; Moore, Wendy C.; Li, Huashi; Hastie, Annette T.; Howard, Timothy D.; Boushey, Homer A.; Busse, William W.; Calhoun, William J.; Castro, Mario; Erzurum, Serpil C.; et al. (Journal of allergy and clinical immunology, 2013)
Keywords: Asthma; Asthma - genetics; Asthma - metabolism; Asthma - physiopathology; Biological and medical sciences; Female; FEV1; Forced Expiratory Volume - genetics; Fundamental and applied biological sciences. Psychology; Fundamental immunology; genes; Genome-Wide Association Study; Genomes; Humans; IL12A; IL12RB1; inflammation; Interferon Regulatory Factor-2 - genetics; Interferon Regulatory Factor-2 - metabolism; interleukin-12; Interleukin-12 - genetics; Interleukin-12 - metabolism; IRF2; loci; Lung - metabolism; Lung - physiopathology; Lung function; Male; Medical sciences; meta-analysis; patients; Polymorphism, Single Nucleotide; Quality control; Respiratory Function Tests; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; single nucleotide polymorphism; STAT4; STAT4 Transcription Factor - genetics; STAT4 Transcription Factor - metabolism; Studies; TH1; Th1 Cells - immunology; Th1 Cells - metabolism; variance; Vital Capacity - genetics; Whites; ACRN; ATS; TENOR; GWAS; TALC; asthma; SARP; ppFVC; BASALT; FVC; Lung function; ppFEV1; NHLBI; SNP; CSGA; IRF2; STAT4; LD; FEV1; IL12A; TH1; IL12RB1; Human; Lung disease; Immunopathology; Respiratory disease; Th1 lymphocyte; Interferon regulatory factor 2; Asthma; 1; Association; Immunology; Gene; T; Transcription factor STAT4; FEV; T-Lymphocyte; Bronchus disease; Genetics; Obstructive pulmonary disease; Genome; Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroids; Forced vital capacity; Linkage disequilibrium; National Heart, Lung, and Blood Institute; Asthma Clinical Research Network; Percent predicted forced vital capacity; Genome-wide association study; Percent predicted FEV; Collaborative Studies on the Genetics of Asthma; ppFEV; T(H)1; American Thoracic Society; Severe Asthma Research Program