“Liquid biopsy” - extracellular vesicles as potential novel players towards precision medicine in asthma
Extracellular vesicles (EVs) have emerged as vital mediators in intracellular communication in the lung microenvironment. Environmental exposure to various triggers (e.g., viruses, allergens) stimulates the EV-mediated cascade of pro-inflammatory responses that play a key role in the asthma pathomec...
Saved in:
| Published in | Frontiers in immunology Vol. 13; p. 1025348 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
17.11.2022
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-3224 1664-3224 |
| DOI | 10.3389/fimmu.2022.1025348 |
Cover
| Abstract | Extracellular vesicles (EVs) have emerged as vital mediators in intracellular communication in the lung microenvironment. Environmental exposure to various triggers (e.g., viruses, allergens) stimulates the EV-mediated cascade of pro-inflammatory responses that play a key role in the asthma pathomechanism. This complex EV-mediated crosstalk in the asthmatic lung microenvironment occurs between different cell types, including airway epithelial cells and immune cells. The cargo composition of EVs mirrors hereby the type and activation status of the parent cell. Therefore, EVs collected in a noninvasive way (e.g., in nasal lavage, serum) could inform on the disease status as a “liquid biopsy”, which is particularly important in the pediatric population. As a heterogeneous disease, asthma with its distinct endotypes and phenotypes requires more investigation to develop novel diagnostics and personalized case management. Filling these knowledge gaps may be facilitated by further EV research. Here, we summarize the contribution of EVs in the lung microenvironment as potential novel players towards precision medicine in the development of asthma. Although rapidly evolving, the EV field is still in its infancy. However, it is expected that a better understanding of the role of EVs in the asthma pathomechanism will open up new horizons for precision medicine diagnostic and therapeutic solutions. |
|---|---|
| AbstractList | Extracellular vesicles (EVs) have emerged as vital mediators in intracellular communication in the lung microenvironment. Environmental exposure to various triggers (e.g., viruses, allergens) stimulates the EV-mediated cascade of pro-inflammatory responses that play a key role in the asthma pathomechanism. This complex EV-mediated crosstalk in the asthmatic lung microenvironment occurs between different cell types, including airway epithelial cells and immune cells. The cargo composition of EVs mirrors hereby the type and activation status of the parent cell. Therefore, EVs collected in a noninvasive way (e.g., in nasal lavage, serum) could inform on the disease status as a “liquid biopsy”, which is particularly important in the pediatric population. As a heterogeneous disease, asthma with its distinct endotypes and phenotypes requires more investigation to develop novel diagnostics and personalized case management. Filling these knowledge gaps may be facilitated by further EV research. Here, we summarize the contribution of EVs in the lung microenvironment as potential novel players towards precision medicine in the development of asthma. Although rapidly evolving, the EV field is still in its infancy. However, it is expected that a better understanding of the role of EVs in the asthma pathomechanism will open up new horizons for precision medicine diagnostic and therapeutic solutions. Extracellular vesicles (EVs) have emerged as vital mediators in intracellular communication in the lung microenvironment. Environmental exposure to various triggers (e.g., viruses, allergens) stimulates the EV-mediated cascade of pro-inflammatory responses that play a key role in the asthma pathomechanism. This complex EV-mediated crosstalk in the asthmatic lung microenvironment occurs between different cell types, including airway epithelial cells and immune cells. The cargo composition of EVs mirrors hereby the type and activation status of the parent cell. Therefore, EVs collected in a noninvasive way (e.g., in nasal lavage, serum) could inform on the disease status as a "liquid biopsy", which is particularly important in the pediatric population. As a heterogeneous disease, asthma with its distinct endotypes and phenotypes requires more investigation to develop novel diagnostics and personalized case management. Filling these knowledge gaps may be facilitated by further EV research. Here, we summarize the contribution of EVs in the lung microenvironment as potential novel players towards precision medicine in the development of asthma. Although rapidly evolving, the EV field is still in its infancy. However, it is expected that a better understanding of the role of EVs in the asthma pathomechanism will open up new horizons for precision medicine diagnostic and therapeutic solutions.Extracellular vesicles (EVs) have emerged as vital mediators in intracellular communication in the lung microenvironment. Environmental exposure to various triggers (e.g., viruses, allergens) stimulates the EV-mediated cascade of pro-inflammatory responses that play a key role in the asthma pathomechanism. This complex EV-mediated crosstalk in the asthmatic lung microenvironment occurs between different cell types, including airway epithelial cells and immune cells. The cargo composition of EVs mirrors hereby the type and activation status of the parent cell. Therefore, EVs collected in a noninvasive way (e.g., in nasal lavage, serum) could inform on the disease status as a "liquid biopsy", which is particularly important in the pediatric population. As a heterogeneous disease, asthma with its distinct endotypes and phenotypes requires more investigation to develop novel diagnostics and personalized case management. Filling these knowledge gaps may be facilitated by further EV research. Here, we summarize the contribution of EVs in the lung microenvironment as potential novel players towards precision medicine in the development of asthma. Although rapidly evolving, the EV field is still in its infancy. However, it is expected that a better understanding of the role of EVs in the asthma pathomechanism will open up new horizons for precision medicine diagnostic and therapeutic solutions. |
| Author | Stelmaszczyk-Emmel, Anna Ambrożej, Dominika Feleszko, Wojciech Czystowska-Kuźmicz, Małgorzata |
| AuthorAffiliation | 2 Doctoral School, Medical University of Warsaw , Warsaw , Poland 1 Department of Pediatric Pneumonology and Allergy, Medical University of Warsaw , Warsaw , Poland 3 Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw , Warsaw , Poland 4 Chair and Department of Biochemistry, Medical University of Warsaw , Warsaw , Poland |
| AuthorAffiliation_xml | – name: 4 Chair and Department of Biochemistry, Medical University of Warsaw , Warsaw , Poland – name: 1 Department of Pediatric Pneumonology and Allergy, Medical University of Warsaw , Warsaw , Poland – name: 3 Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw , Warsaw , Poland – name: 2 Doctoral School, Medical University of Warsaw , Warsaw , Poland |
| Author_xml | – sequence: 1 givenname: Dominika surname: Ambrożej fullname: Ambrożej, Dominika – sequence: 2 givenname: Anna surname: Stelmaszczyk-Emmel fullname: Stelmaszczyk-Emmel, Anna – sequence: 3 givenname: Małgorzata surname: Czystowska-Kuźmicz fullname: Czystowska-Kuźmicz, Małgorzata – sequence: 4 givenname: Wojciech surname: Feleszko fullname: Feleszko, Wojciech |
| BookMark | eNp9kctuFDEQRVsoSISQH2DlJZuZ-NUPb5BQxCPSSGxgbZXd1Ykjd7tjuwdmlw-Bn8uXxJMZIcICS5YtV91jX9_X1ckUJqyqt4yuhejUxeDGcVlzyvmaUV4L2b2oTlnTyJXgXJ78tX9Vnad0S8uQSghRn1b-4f7Xxt0trifGhTntHu5_kxXBnzmCRe8XD5FsMTnrMRFIZA4Zp-zAkyls0ZPZww5jIjn8gNiXekTrkgsTGbF31k1I3FSE-WaEN9XLAXzC8-N6Vn3_9PHb5ZfV5uvnq8sPm5WtGcurmhscms4y1pgaG8VkzzoFDdBOCQOqbRAMYicMByOQMlASZc8HZYGaYuysujpw-wC3eo5uhLjTAZx-OgjxWkPMe0u6LbIyDbYDSmGhQDvatiCFkEhRFdb7A2teTHFki_kI_hn0eWVyN_o6bLVqmaxlVwDvjoAY7hZMWY8u7b8WJgxL0ryVbclDtry08kOrjSGliMOfaxjV-6j1U9R6H7U-Rl1E3T8i6zLkkkB5jvP_kz4CYQm3cQ |
| CitedBy_id | crossref_primary_10_1016_j_jaci_2023_12_030 crossref_primary_10_1016_j_biopha_2024_116463 crossref_primary_10_1002_bit_28612 |
| Cites_doi | 10.1186/s13287-021-02244-6 10.1165/rcmb.2018-0156OC 10.4049/jimmunol.1302593 10.3389/fimmu.2021.626755 10.1038/s41598-017-18672-5 10.1016/j.cell.2018.01.011 10.1002/eji.201242909 10.1096/fj.08-119131 10.1186/s13287-020-02072-0 10.4049/jimmunol.170.6.3037 10.1016/J.CELLSIG.2019.109523 10.1080/20013078.2017.1359478 10.1038/ni.3049 10.1016/j.jaci.2017.07.040 10.1165/rcmb.2014-0255OC 10.3389/fimmu.2022.865973 10.1096/fj.201903089R 10.1038/s12276-022-00748-6 10.1038/s41571-020-00457-x 10.1016/J.INTIMP.2019.105981 10.1016/j.eclinm.2021.101257 10.1016/j.anai.2018.01.003 10.1186/s12931-020-01402-3 10.1080/20013078.2020.1723260 10.1002/clt2.12138 10.3389/fped.2019.00246 10.1016/j.jaci.2010.06.039 10.1016/j.matt.2022.06.012 10.3390/biomedicines10030622 10.3389/fimmu.2019.01987 10.3389/fcimb.2022.850744 10.1186/1465-9921-13-2 10.3389/fimmu.2017.00941 10.1111/jcmm.13479 10.1016/j.mvr.2020.104093 10.1038/s41577-020-00477-9 10.1016/j.immuni.2009.08.008 10.3389/fimmu.2018.02538 10.1080/20013078.2017.1286095 10.1038/s41598-018-24531-8 10.1093/hmg/ddab283 10.3389/fbioe.2022.845042 10.1038/s41565-021-00931-2 10.3389/fimmu.2022.705472 10.1016/j.yexmp.2012.02.002 10.1016/j.jaci.2007.06.040 10.3390/ijms22073651 10.3389/fimmu.2015.00073 10.1016/j.omtn.2019.10.049 10.1016/j.jaci.2014.11.026 10.1371/journal.pone.0015353 10.1080/15384101.2021.2020432 10.1016/J.YEXCR.2017.12.021 10.2147/JAA.S307165 10.1038/s41419-020-2606-x 10.3389/fimmu.2019.01191 10.1159/000053691 10.1146/annurev-cellbio-101512-122326 10.1164/rccm.201802-0373OC 10.1177/0300060520903220 10.3390/ijms22052273 10.1111/all.15480 10.3109/01902140903410757 10.1016/J.ANAI.2018.06.009 10.3402/jev.v4.29260 10.3389/fmed.2020.00326 10.3389/fped.2022.823399 10.1016/J.JCONREL.2021.08.024 10.1165/rcmb.2016-0033OC 10.1016/j.coi.2019.02.003 10.1183/13993003.03024-2020 10.1111/all.14008 10.1159/000493013 10.1111/pai.13418 10.3389/fmolb.2022.805570 10.1084/jem.20141675 10.1016/j.it.2017.07.003 10.1080/20013078.2018.1535750 10.1111/pai.13741 10.3389/fmed.2017.00093 10.1186/s12967-016-0927-4 10.1080/20013078.2017.1400370 10.1189/jlb.3AB0516-233RR 10.1155/2021/6696525 10.1016/S0140-6736(20)30925-9 10.1002/eji.201847655 10.1016/j.jaci.2021.04.025 10.1111/jcmm.16843 10.20517/evcna.2020.09 10.4168/aair.2017.9.2.101 10.1111/cea.13122 10.1111/all.14103 10.1155/2021/6686625 10.1371/journal.pone.0162244 10.3389/fgene.2022.872499 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 Ambrożej, Stelmaszczyk-Emmel, Czystowska-Kuźmicz and Feleszko. Copyright © 2022 Ambrożej, Stelmaszczyk-Emmel, Czystowska-Kuźmicz and Feleszko 2022 Ambrożej, Stelmaszczyk-Emmel, Czystowska-Kuźmicz and Feleszko |
| Copyright_xml | – notice: Copyright © 2022 Ambrożej, Stelmaszczyk-Emmel, Czystowska-Kuźmicz and Feleszko. – notice: Copyright © 2022 Ambrożej, Stelmaszczyk-Emmel, Czystowska-Kuźmicz and Feleszko 2022 Ambrożej, Stelmaszczyk-Emmel, Czystowska-Kuźmicz and Feleszko |
| DBID | AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.3389/fimmu.2022.1025348 |
| DatabaseName | CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1664-3224 |
| ExternalDocumentID | oai_doaj_org_article_7d2f7d2be7fe43ca83b8077a4334e0e9 PMC9714548 10_3389_fimmu_2022_1025348 |
| GrantInformation_xml | – fundername: ; |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EBS EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM 7X8 5PM |
| ID | FETCH-LOGICAL-c511t-52bef68c116b5e6914d189a6a0893ba976eabee83b2ab3e01a94e4d2f9ca0b933 |
| IEDL.DBID | M48 |
| ISSN | 1664-3224 |
| IngestDate | Wed Aug 27 01:05:58 EDT 2025 Thu Aug 21 18:38:46 EDT 2025 Thu Sep 04 18:54:27 EDT 2025 Tue Jul 01 02:11:40 EDT 2025 Thu Apr 24 22:51:31 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c511t-52bef68c116b5e6914d189a6a0893ba976eabee83b2ab3e01a94e4d2f9ca0b933 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 This article was submitted to Mucosal Immunity, a section of the journal Frontiers in Immunology Edited by: Hideaki Morita, National Center for Child Health and Development (NCCHD), Japan Reviewed by: Hae-Sim Park, Ajou University Hospital, South Korea |
| OpenAccessLink | https://doaj.org/article/7d2f7d2be7fe43ca83b8077a4334e0e9 |
| PQID | 2747004472 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7d2f7d2be7fe43ca83b8077a4334e0e9 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9714548 proquest_miscellaneous_2747004472 crossref_primary_10_3389_fimmu_2022_1025348 crossref_citationtrail_10_3389_fimmu_2022_1025348 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2022-11-17 |
| PublicationDateYYYYMMDD | 2022-11-17 |
| PublicationDate_xml | – month: 11 year: 2022 text: 2022-11-17 day: 17 |
| PublicationDecade | 2020 |
| PublicationTitle | Frontiers in immunology |
| PublicationYear | 2022 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Tang (B46) 2022; 13 Maroto (B97) 2017; 6 Scherzer (B13) 2018; 121 Zhuansun (B69) 2019; 77 McBrien (B50) 2017; 4 Zou (B37) 2021; 13 Mion (B33) 2014; 193 Nakagome (B80) 2022; 13 Cañas (B53) 2017; 101 Wen (B2) 2017; 6 Hewitt (B24) 2021; 21 Mills (B83) 2019; 10 Zhou (B92) 2021; 2021 Fujiogi (B95) 2022; 43 Azoulay-Alfaguter (B58) 2018; 48 Mazzeo (B51) 2015; 135 Xie (B34) 2018; 141 Oh (B84) 2022; 12 Huang (B41) 2019; 86 Lucchetti (B76) 2021; 58 Draijer (B48) 2020; 34 Skokos (B30) 2001; 124 Demkow (B9) 2021; 22 Esser (B42) 2010; 126 Makrinioti (B79) 2022; 33 Dharmage (B14) 2019; 7 Choi (B85) 2017; 9 Fang (B74) 2020; 11 Zhang (B12) 2022; 10 Vargas (B56) 2016; 55 Beit-Yannai (B96) 2018; 22 Liang (B35) 2018; 10 Schindler (B19) 2022; 10 Li (B49) 2021; 14 Bartel (B8) 2020; 7 Chen (B55) 2022; 9 Molfetta (B32) 2020; 75 Ma (B63) 2022; 10 Vázquez-Mera (B89) 2022 (B11) 2020; 396 Ax (B20) 2020; 21 Tung (B59) 2018; 8 Kesimer (B17) 2009; 23 Ray (B54) 2017; 38 Du (B68) 2018; 363 Patente (B40) 2019; 58 Herrmann (B90) 2021; 16 Vroman (B43) 2017; 8 Tang (B26) 2020; 133 Aye (B36) 2012; 92 Gutierrez (B82) 2016; 11 Lambrecht (B15) 2015; 16 Dong (B72) 2021; 12 Chahar (B81) 2018; 8 Shang (B66) 2020; 19 Huang (B10) 2020; 48 Jia (B25) 2019; 199 Elenius (B78) 2021; 32 Comfort (B75) 2021; 2 Colombo (B3) 2014; 30 Szefler (B77) 2018; 120 Zareba (B7) 2021; 22 Lässer (B22) 2016; 14 D’Incà (B29) 2015; 6 Planat-Benard (B64) 2021; 12 Reis (B70) 2018; 9 Zhang (B27) 2021; 148 Mateescu (B4) 2017; 6 Wang (B88) 2022; 13 Popowski (B94) 2022; 5 Yang (B86) 2022; 54 Dong (B71) 2021; 12 Skokos (B31) 2003; 170 Yu (B28) 2021; 25 Bourdonnay (B47) 2015; 212 Kvarnhammar (B21) 2012; 13 Ignatiadis (B5) 2021; 18 Gupta (B16) 2019; 60 Admyre (B61) 2007; 120 Fang (B73) 2020; 9 Eldh (B38) 2010; 5 Shan (B67) 2022; 21 Careau (B44) 2010; 36 Lee (B93) 2022; 12 Kopp (B87) 2018; 172 Cañas (B52) 2018; 48 Pei (B91) 2021; 338 Potaczek (B23) 2020; 69 Weiss (B62) 2019; 10 Mun (B65) 2021; 2021 Yuana (B6) 2015; 4 Lee (B45) 2015; 52 Zhang (B57) 2022; 31 Lambrecht (B39) 2009; 31 Bartel (B18) 2020; 75 Smyth (B60) 2013; 43 Théry (B1) 2018; 7 |
| References_xml | – volume: 12 start-page: 204 year: 2021 ident: B72 article-title: Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization publication-title: Stem Cell Res Ther doi: 10.1186/s13287-021-02244-6 – volume: 60 year: 2019 ident: B16 article-title: Intercellular communication between airway epithelial cells is mediated by exosome-like vesicles publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2018-0156OC – volume: 193 year: 2014 ident: B33 article-title: Mast cells control the expansion and differentiation of IL-10-competent b cells publication-title: J Immunol doi: 10.4049/jimmunol.1302593 – volume: 12 year: 2021 ident: B64 article-title: MSCs and inflammatory cells crosstalk in regenerative medicine: Concerted actions for optimized resolution driven by energy metabolism publication-title: Front Immunol doi: 10.3389/fimmu.2021.626755 – volume: 8 start-page: 387 year: 2018 ident: B81 article-title: Respiratory syncytial virus infection changes cargo composition of exosome released from airway epithelial cells publication-title: Sci Rep doi: 10.1038/s41598-017-18672-5 – volume: 172 start-page: 393 year: 2018 ident: B87 article-title: Functional classification and experimental dissection of long noncoding RNAs publication-title: Cell doi: 10.1016/j.cell.2018.01.011 – volume: 43 year: 2013 ident: B60 article-title: CD73 expression on extracellular vesicles derived from CD4+ CD25+ Foxp3+ T cells contributes to their regulatory function publication-title: Eur J Immunol doi: 10.1002/eji.201242909 – volume: 23 year: 2009 ident: B17 article-title: Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: A possible role in innate defense publication-title: FASEB J doi: 10.1096/fj.08-119131 – volume: 12 start-page: 4 year: 2021 ident: B71 article-title: Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice publication-title: Stem Cell Res Ther doi: 10.1186/s13287-020-02072-0 – volume: 170 year: 2003 ident: B31 article-title: Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo publication-title: J Immunol doi: 10.4049/jimmunol.170.6.3037 – volume: 69 year: 2020 ident: B23 article-title: Role of airway epithelial cells in the development of different asthma phenotypes publication-title: Cell Signal doi: 10.1016/J.CELLSIG.2019.109523 – volume: 6 year: 2017 ident: B97 article-title: Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses publication-title: J Extracell vesicles doi: 10.1080/20013078.2017.1359478 – volume: 16 start-page: 45 year: 2015 ident: B15 article-title: The immunology of asthma publication-title: Nat Immunol doi: 10.1038/ni.3049 – volume: 141 year: 2018 ident: B34 article-title: Mast cell exosomes can suppress allergic reactions by binding to IgE publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2017.07.040 – volume: 52 year: 2015 ident: B45 article-title: Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/CCl2, regulate airway inflammation and remodeling in allergic asthma publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2014-0255OC – volume: 13 year: 2022 ident: B80 article-title: Innate immune responses by respiratory viruses, including rhinovirus, during asthma exacerbation publication-title: Front Immunol doi: 10.3389/fimmu.2022.865973 – volume: 34 year: 2020 ident: B48 article-title: Resident alveolar macrophage-derived vesicular SOCS3 dampens allergic airway inflammation publication-title: FASEB J doi: 10.1096/fj.201903089R – volume: 54 year: 2022 ident: B86 article-title: A new horizon of precision medicine: Combination of the microbiome and extracellular vesicles publication-title: Exp Mol Med doi: 10.1038/s12276-022-00748-6 – volume: 18 start-page: 297 year: 2021 ident: B5 article-title: Liquid biopsy enters the clinic — implementation issues and future challenges publication-title: Nat Rev Clin Oncol doi: 10.1038/s41571-020-00457-x – volume: 77 year: 2019 ident: B69 article-title: MSCs exosomal miR-1470 promotes the differentiation of CD4+CD25+FOXP3+ tregs in asthmatic patients by inducing the expression of P27KIP1 publication-title: Int Immunopharmacol doi: 10.1016/J.INTIMP.2019.105981 – volume: 43 year: 2022 ident: B95 article-title: Identifying and predicting severe bronchiolitis profiles at high risk for developing asthma: Analysis of three prospective cohorts publication-title: eClinicalMedicine doi: 10.1016/j.eclinm.2021.101257 – volume: 120 year: 2018 ident: B77 article-title: Challenges in the treatment of asthma in children and adolescents publication-title: Ann Allergy Asthma Immunol doi: 10.1016/j.anai.2018.01.003 – volume: 21 start-page: 155 year: 2020 ident: B20 article-title: T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles publication-title: Respir Res doi: 10.1186/s12931-020-01402-3 – volume: 9 year: 2020 ident: B73 article-title: Small extracellular vesicles derived from human mesenchymal stromal cells prevent group 2 innate lymphoid cell-dominant allergic airway inflammation through delivery of miR-146a-5p publication-title: J Extracell vesicles doi: 10.1080/20013078.2020.1723260 – volume: 12 year: 2022 ident: B93 article-title: Immunoregulatory effects of lactococcus lactis-derived extracellular vesicles in allergic asthma publication-title: Clin Transl Allergy doi: 10.1002/clt2.12138 – volume: 7 year: 2019 ident: B14 article-title: Epidemiology of asthma in children and adults publication-title: Front Pediatr doi: 10.3389/fped.2019.00246 – volume: 126 year: 2010 ident: B42 article-title: Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.06.039 – volume: 5 year: 2022 ident: B94 article-title: Inhalable dry powder mRNA vaccines based on extracellular vesicles publication-title: Matter doi: 10.1016/j.matt.2022.06.012 – volume: 10 start-page: 622 year: 2022 ident: B19 article-title: Side-directed release of differential extracellular vesicle-associated microRNA profiles from bronchial epithelial cells of healthy and asthmatic subjects publication-title: Biomedicines doi: 10.3390/biomedicines10030622 – volume: 10 year: 2019 ident: B83 article-title: Airway epithelial cells generate pro-inflammatory tenascin-c and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection publication-title: Front Immunol doi: 10.3389/fimmu.2019.01987 – volume: 12 year: 2022 ident: B84 article-title: Anti-viral activities of umbilical cord mesenchymal stem cell-derived small extracellular vesicles against human respiratory viruses publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2022.850744 – volume: 13 year: 2012 ident: B21 article-title: Diminished levels of nasal S100A7 (psoriasin) in seasonal allergic rhinitis: An effect mediated by Th2 cytokines publication-title: Respir Res doi: 10.1186/1465-9921-13-2 – volume: 8 year: 2017 ident: B43 article-title: Dendritic cell subsets in asthma: Impaired tolerance or exaggerated inflammation publication-title: Front Immunol doi: 10.3389/fimmu.2017.00941 – volume: 22 year: 2018 ident: B96 article-title: Physical exosome: Exosome interactions publication-title: J Cell Mol Med doi: 10.1111/jcmm.13479 – volume: 133 start-page: 104093 year: 2020 ident: B26 article-title: Tumor necrosis factor-α requires ezrin to regulate the cytoskeleton and cause pulmonary microvascular endothelial barrier damage publication-title: Microvasc Res doi: 10.1016/j.mvr.2020.104093 – volume: 21 year: 2021 ident: B24 article-title: Regulation of immune responses by the airway epithelial cell landscape publication-title: Nat Rev Immunol doi: 10.1038/s41577-020-00477-9 – volume: 31 year: 2009 ident: B39 article-title: Biology of lung dendritic cells at the origin of asthma publication-title: Immunity doi: 10.1016/j.immuni.2009.08.008 – volume: 9 year: 2018 ident: B70 article-title: Mesenchymal stromal cell-derived extracellular vesicles attenuate dendritic cell maturation and function publication-title: Front Immunol doi: 10.3389/fimmu.2018.02538 – volume: 6 year: 2017 ident: B4 article-title: Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper publication-title: J Extracell Vesicles doi: 10.1080/20013078.2017.1286095 – volume: 8 start-page: 6065 year: 2018 ident: B59 article-title: Regulatory T cell-derived extracellular vesicles modify dendritic cell function publication-title: Sci Rep doi: 10.1038/s41598-018-24531-8 – volume: 31 year: 2022 ident: B57 article-title: Exosomal transfer of activated neutrophil-derived lncRNA CRNDE promotes proliferation and migration of airway smooth muscle cells in asthma publication-title: Hum Mol Genet doi: 10.1093/hmg/ddab283 – volume: 10 year: 2022 ident: B63 article-title: Emerging therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in chronic respiratory diseases: An overview of recent progress publication-title: Front Bioeng Biotechnol doi: 10.3389/fbioe.2022.845042 – volume: 16 year: 2021 ident: B90 article-title: Extracellular vesicles as a next-generation drug delivery platform publication-title: Nat Nanotechnol doi: 10.1038/s41565-021-00931-2 – volume: 13 year: 2022 ident: B46 article-title: Extracellular Vesicle/Macrophage axis: Potential targets for inflammatory disease intervention publication-title: Front Immunol doi: 10.3389/fimmu.2022.705472 – volume: 92 year: 2012 ident: B36 article-title: Identification of genes and proteins specifically regulated by costimulation of mast cell fcϵ receptor I and chemokine receptor 1 publication-title: Exp Mol Pathol doi: 10.1016/j.yexmp.2012.02.002 – volume: 120 year: 2007 ident: B61 article-title: B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2007.06.040 – volume: 22 start-page: 3651 year: 2021 ident: B7 article-title: EVs from BALF-mediators of inflammation and potential biomarkers in lung diseases publication-title: Int J Mol Sci doi: 10.3390/ijms22073651 – volume: 6 year: 2015 ident: B29 article-title: Exosomes: Tiny clues for mast cell communication publication-title: Front Immunol doi: 10.3389/fimmu.2015.00073 – volume: 19 year: 2020 ident: B66 article-title: Exosomes from mmu_circ_0001359-modified ADSCs attenuate airway remodeling by enhancing FoxO1 signaling-mediated M2-like macrophage activation publication-title: Mol Ther Nucleic Acids doi: 10.1016/j.omtn.2019.10.049 – volume: 135 year: 2015 ident: B51 article-title: Exosome secretion by eosinophils: A possible role in asthma pathogenesis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2014.11.026 – volume: 5 year: 2010 ident: B38 article-title: Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA publication-title: PloS One doi: 10.1371/journal.pone.0015353 – volume: 21 year: 2022 ident: B67 article-title: Human bone marrow-mesenchymal stem cell-derived exosomal microRNA-188 reduces bronchial smooth muscle cell proliferation in asthma through suppressing the JARID2/Wnt/β-catenin axis publication-title: Cell Cycle doi: 10.1080/15384101.2021.2020432 – volume: 363 year: 2018 ident: B68 article-title: Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma publication-title: Exp Cell Res doi: 10.1016/J.YEXCR.2017.12.021 – volume: 14 year: 2021 ident: B49 article-title: MiR-21-5p in macrophage-derived exosomes targets Smad7 to promote epithelial mesenchymal transition of airway epithelial cells publication-title: J Asthma Allergy doi: 10.2147/JAA.S307165 – volume: 11 start-page: 409 year: 2020 ident: B74 article-title: Small extracellular vesicles derived from human MSCs prevent allergic airway inflammation via immunomodulation on pulmonary macrophages publication-title: Cell Death Dis doi: 10.1038/s41419-020-2606-x – volume: 10 year: 2019 ident: B62 article-title: Immunomodulation by mesenchymal stem cells (MSCs): Mechanisms of action of living, apoptotic, and dead MSCs publication-title: Front Immunol doi: 10.3389/fimmu.2019.01191 – volume: 124 year: 2001 ident: B30 article-title: Nonspecific b and T cell-stimulatory activity mediated by mast cells is associated with exosomes publication-title: Int Arch Allergy Immunol doi: 10.1159/000053691 – volume: 30 year: 2014 ident: B3 article-title: Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles publication-title: Annu Rev Cell Dev Biol doi: 10.1146/annurev-cellbio-101512-122326 – volume: 199 start-page: 496 year: 2019 ident: B25 article-title: Ezrin, a membrane cytoskeleton cross-linker protein, as a marker of epithelial damage in asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201802-0373OC – volume: 48 year: 2020 ident: B10 article-title: Exosomes: An important messenger in the asthma inflammatory microenvironment publication-title: J Int Med Res doi: 10.1177/0300060520903220 – volume: 22 year: 2021 ident: B9 article-title: Extracellular vesicles in allergic rhinitis and asthma and laboratory possibilities for their assessment publication-title: Int J Mol Sci doi: 10.3390/ijms22052273 – year: 2022 ident: B89 article-title: Serum exosome inflamma-miRs are surrogate biomarkers for asthma phenotype and severity publication-title: Allergy doi: 10.1111/all.15480 – volume: 36 year: 2010 ident: B44 article-title: Alveolar macrophages reduce airway hyperresponsiveness and modulate cytokine levels publication-title: Exp Lung Res doi: 10.3109/01902140903410757 – volume: 121 year: 2018 ident: B13 article-title: Heterogeneity and the origins of asthma publication-title: Ann Allergy Asthma Immunol doi: 10.1016/J.ANAI.2018.06.009 – volume: 4 year: 2015 ident: B6 article-title: Handling and storage of human body fluids for analysis of extracellular vesicles publication-title: J Extracell Vesicles doi: 10.3402/jev.v4.29260 – volume: 7 year: 2020 ident: B8 article-title: Extracellular vesicles as mediators of cellular cross talk in the lung microenvironment publication-title: Front Med doi: 10.3389/fmed.2020.00326 – volume: 10 year: 2022 ident: B12 article-title: The burden of childhood asthma by age group, 1990-2019: A systematic analysis of global burden of disease 2019 data publication-title: Front Pediatr doi: 10.3389/fped.2022.823399 – volume: 338 year: 2021 ident: B91 article-title: Exosome membrane-modified M2 macrophages targeted nanomedicine: Treatment for allergic asthma publication-title: J Control Release doi: 10.1016/J.JCONREL.2021.08.024 – volume: 55 year: 2016 ident: B56 article-title: Neutrophil-derived exosomes: A new mechanism contributing to airway smooth muscle remodeling publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2016-0033OC – volume: 58 start-page: 16 year: 2019 ident: B40 article-title: Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2019.02.003 – volume: 58 start-page: 2003024 year: 2021 ident: B76 article-title: Detection and characterization of extracellular vesicles in exhaled breath condensate and sputum of COPD and severe asthma patients publication-title: Eur Respir J doi: 10.1183/13993003.03024-2020 – volume: 75 year: 2020 ident: B18 article-title: Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development publication-title: Allergy doi: 10.1111/all.14008 – volume: 86 year: 2019 ident: B41 article-title: Exosomes from thymic stromal lymphopoietin-activated dendritic cells promote Th2 differentiation through the OX40 ligand publication-title: Pathobiology doi: 10.1159/000493013 – volume: 32 year: 2021 ident: B78 article-title: Lung function testing and inflammation markers for wheezing preschool children: A systematic review for the EAACI clinical practice recommendations on diagnostics of preschool wheeze publication-title: Pediatr Allergy Immunol doi: 10.1111/pai.13418 – volume: 10 year: 2018 ident: B35 article-title: The chemokine receptor CCR1 is identified in mast cell-derived exosomes publication-title: Am J Transl Res – volume: 9 year: 2022 ident: B55 article-title: Identification of key signaling pathways and genes in eosinophilic asthma and neutrophilic asthma by weighted gene Co-expression network analysis publication-title: Front Mol Biosci doi: 10.3389/fmolb.2022.805570 – volume: 212 year: 2015 ident: B47 article-title: Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling publication-title: J Exp Med doi: 10.1084/jem.20141675 – volume: 38 year: 2017 ident: B54 article-title: Neutrophilic inflammation in asthma and association with disease severity publication-title: Trends Immunol doi: 10.1016/j.it.2017.07.003 – volume: 7 year: 2018 ident: B1 article-title: Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines publication-title: J Extracell vesicles doi: 10.1080/20013078.2018.1535750 – volume: 33 year: 2022 ident: B79 article-title: The role of respiratory syncytial virus- and rhinovirus-induced bronchiolitis in recurrent wheeze and asthma–a systematic review and meta-analysis publication-title: Pediatr Allergy Immunol doi: 10.1111/pai.13741 – volume: 13 year: 2021 ident: B37 article-title: MicroRNA-21 released from mast cells-derived extracellular vesicles drives asthma in mice by potentiating airway inflammation and oxidative stress publication-title: Am J Transl Res – volume: 4 year: 2017 ident: B50 article-title: The biology of eosinophils and their role in asthma publication-title: Front Med doi: 10.3389/fmed.2017.00093 – volume: 14 start-page: 181 year: 2016 ident: B22 article-title: Exosomes in the nose induce immune cell trafficking and harbour an altered protein cargo in chronic airway inflammation publication-title: J Transl Med doi: 10.1186/s12967-016-0927-4 – volume: 6 year: 2017 ident: B2 article-title: Biological roles and potential applications of immune cell-derived extracellular vesicles publication-title: J Extracell vesicles doi: 10.1080/20013078.2017.1400370 – volume: 101 year: 2017 ident: B53 article-title: Exosomes from eosinophils autoregulate and promote eosinophil functions publication-title: J Leukoc Biol doi: 10.1189/jlb.3AB0516-233RR – volume: 2021 year: 2021 ident: B92 article-title: HMSC-derived exosome inhibited Th2 cell differentiation via regulating miR-146a-5p/SERPINB2 pathway publication-title: J Immunol Res doi: 10.1155/2021/6696525 – volume: 396 year: 2020 ident: B11 article-title: Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019 publication-title: Lancet doi: 10.1016/S0140-6736(20)30925-9 – volume: 48 year: 2018 ident: B58 article-title: Proteomic analysis of human T cell-derived exosomes reveals differential RAS/MAPK signaling publication-title: Eur J Immunol doi: 10.1002/eji.201847655 – volume: 148 year: 2021 ident: B27 article-title: Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cells-dominant T cell responses in asthma publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2021.04.025 – volume: 25 year: 2021 ident: B28 article-title: Increased airway epithelial cell–derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding publication-title: J Cell Mol Med doi: 10.1111/jcmm.16843 – volume: 2 start-page: 29 year: 2021 ident: B75 article-title: Isolation and characterization of extracellular vesicles in saliva of children with asthma publication-title: Extracell vesicles Circ Nucleic Acids doi: 10.20517/evcna.2020.09 – volume: 9 year: 2017 ident: B85 article-title: Extracellular vesicles, a key mediator to link environmental microbiota to airway immunity publication-title: Allergy Asthma Immunol Res doi: 10.4168/aair.2017.9.2.101 – volume: 48 year: 2018 ident: B52 article-title: Eosinophil-derived exosomes contribute to asthma remodelling by activating structural lung cells publication-title: Clin Exp Allergy doi: 10.1111/cea.13122 – volume: 75 year: 2020 ident: B32 article-title: Immune complexes exposed on mast cell-derived nanovesicles amplify allergic inflammation publication-title: Allergy doi: 10.1111/all.14103 – volume: 2021 year: 2021 ident: B65 article-title: Intranasally administered extracellular vesicles from adipose stem cells have immunomodulatory effects in a mouse model of asthma publication-title: Stem Cells Int doi: 10.1155/2021/6686625 – volume: 11 year: 2016 ident: B82 article-title: Airway secretory microRNAome changes during rhinovirus infection in early childhood publication-title: PLoS One doi: 10.1371/journal.pone.0162244 – volume: 13 year: 2022 ident: B88 article-title: Construction of lncRNA-mediated competing endogenous RNA networks correlated with T2 asthma publication-title: Front Genet doi: 10.3389/fgene.2022.872499 |
| SSID | ssj0000493335 |
| Score | 2.350379 |
| SecondaryResourceType | review_article |
| Snippet | Extracellular vesicles (EVs) have emerged as vital mediators in intracellular communication in the lung microenvironment. Environmental exposure to various... |
| SourceID | doaj pubmedcentral proquest crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
| StartPage | 1025348 |
| SubjectTerms | asthma exosome extracellular vesicle Immunology intercellular communication microRNA precision medicine |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NatwwEBYlUOil9Jdu2xQFeismtiVL1rEpDaGkPTWQmxhpx8Rl197uegO55UHal8uTdMb2hvWlvfRgDJZky9-MNTPW_AjxXjlaGW2pEsxzl2hQ8wRI8CSoVOTK29rmHI389Zs5u9BfLovLvVJf7BM2pAcegDu287yiI6CtUKsIpQplai1opTSm2IfukRjbM6Z-DHqvUqoYomTICnPHVb1cbskezHPOVlAoLvizJ4n6hP0TLXPqI7kndE6fiMejtig_DrN8Kh5g80w8HOpH3jwXi7vbX-f1z209l6FuV5ubu9vfMpG03q6B_8izi6m8xk3v-iZhI1dtx95BdMumvcaFXC2AVW7Z9c6z1L4eS-7I3Z67rBsa2F0t4YW4OP38_dNZMpZPSCJpUR2ZmAErU8YsM6FA4zI9z0oHBlLSUQKQHoIQEAnQHILCNAOnURPcLkIaCL-X4qBpG3wlpIlo0mh1QWcdTAi2qjRkJkZnCyjsTGQ7KH0cc4tziYuFJxuD4fc9_J7h9yP8M_HhfsxqyKzx194nTKH7npwVu79AvOJHXvH_4pWZONrR19NXxISABtvtxrNtznvbNp8JOyH85InTlqa-6vNxO5tpMvxe_48pvhGP-LU52jGzb8VBt97iIak9XXjXc_gfxKQGKg priority: 102 providerName: Directory of Open Access Journals |
| Title | “Liquid biopsy” - extracellular vesicles as potential novel players towards precision medicine in asthma |
| URI | https://www.proquest.com/docview/2747004472 https://pubmed.ncbi.nlm.nih.gov/PMC9714548 https://doaj.org/article/7d2f7d2be7fe43ca83b8077a4334e0e9 |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1664-3224 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000493335 issn: 1664-3224 databaseCode: KQ8 dateStart: 20100101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1664-3224 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000493335 issn: 1664-3224 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVBFR databaseName: Free Medical Journals - Free Access to All customDbUrl: eissn: 1664-3224 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000493335 issn: 1664-3224 databaseCode: DIK dateStart: 20100101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1664-3224 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000493335 issn: 1664-3224 databaseCode: GX1 dateStart: 20100101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1664-3224 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000493335 issn: 1664-3224 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1664-3224 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0000493335 issn: 1664-3224 databaseCode: RPM dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVFZP databaseName: Scholars Portal Open Access Journals customDbUrl: eissn: 1664-3224 dateEnd: 20250131 omitProxy: true ssIdentifier: ssj0000493335 issn: 1664-3224 databaseCode: M48 dateStart: 20101001 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3di9QwEA_nieCL-InrxxEP8UWqTZMm7YOIiuchnk8u7FtJslO3stt22-7h_vfOtN3DgooPbaH5aDOTZGaSyfwYey5TnBlNIgOIojRQVi4Di4InACk9IW8rE9Fp5Iuv-nyuPi_ixRE7uNuOBGz_aNoRntS8Wb_6ud2_xQH_hixOlLev82Kz2aGpF0UUiCCWKnlRbwMClqIN2BFl4xq7jsIqoo5_MVoAPwYFWcoehlNorQLs3mo4WvOXmifiq4_yP1FNp46Vv0mqs9vs1qhi8ndDn7jDjqC8y24MoJP7e2x1-qXY7oold0VVt_tTHnCcoBtLS_jkk8ovoe195bhteV115E6E1ZXVJax5vbako_Ou97bF9GbE6OGHTXpelFiwW23sfTY_-_jtw3kw4i0EHtWuDm1SB7lOvBDaxaBToZYiSa22ISo1zqLiAtYBJNJF1kkIhU0VqGWUp96GDun4gB2XVQkPGdcedOiNivGpnHbO5LmyQnufmtjGZsbEgYyZH4OREybGOkOjhEif9aTPiPTZSPoZe3lVph5Ccfwz93vizlVOCqPdv6ia79k4KjODP4-XA5ODkt5i05LQGKukVBBCOmPPDrzNcNgRI2wJ1a7NyJinzXATzZiZMH3yxWlKWaz6AN6pEQotxUf_UftjdpNaRacfhXnCjrtmB09RDercSb98gPdPC3HSd-pfmcsKyA |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%22Liquid+biopsy%22+-+extracellular+vesicles+as+potential+novel+players+towards+precision+medicine+in+asthma&rft.jtitle=Frontiers+in+immunology&rft.au=Ambro%C5%BCej%2C+Dominika&rft.au=Stelmaszczyk-Emmel%2C+Anna&rft.au=Czystowska-Ku%C5%BAmicz%2C+Ma%C5%82gorzata&rft.au=Feleszko%2C+Wojciech&rft.date=2022-11-17&rft.issn=1664-3224&rft.eissn=1664-3224&rft.volume=13&rft.spage=1025348&rft_id=info:doi/10.3389%2Ffimmu.2022.1025348&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-3224&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-3224&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-3224&client=summon |