Tolerance to alkaline ambient pH in Aspergillus nidulans depends on the activity of ENA proteins

Tolerance of microorganisms to abiotic stress is enabled by regulatory mechanisms that coordinate the expression and activity of resistance genes. Alkalinity and high salt concentrations are major environmental physicochemical stresses. Here, we analyzed the roles of sodium-extrusion family (ENA) tr...

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Published inScientific reports Vol. 10; no. 1; p. 14325
Main Authors Markina-Iñarrairaegui, Ane, Spielvogel, Anja, Etxebeste, Oier, Ugalde, Unai, Espeso, Eduardo A.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 31.08.2020
Nature Publishing Group
Subjects
631/326/325/1507
631/326/88
Adenosine Triphosphatases - genetics
Adenosine Triphosphatases - metabolism
Algae
Alkalinity
Aspergillus nidulans - genetics
Aspergillus nidulans - metabolism
Cation Transport Proteins - genetics
Cation Transport Proteins - metabolism
Cell division
Flowering
Fungal Proteins - metabolism
Gene Expression Regulation
Humanities and Social Sciences
Hydrogen-Ion Concentration
Isoetes
Lithium - metabolism
Microorganisms
multidisciplinary
Phylogeny
Salt Tolerance
Salts
Science
Science (multidisciplinary)
Sodium - metabolism
Transcription Factors - metabolism
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-020-71297-z

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Abstract Tolerance of microorganisms to abiotic stress is enabled by regulatory mechanisms that coordinate the expression and activity of resistance genes. Alkalinity and high salt concentrations are major environmental physicochemical stresses. Here, we analyzed the roles of sodium-extrusion family (ENA) transporters EnaA, EnaB and EnaC in the response to these stress conditions in the filamentous fungus Aspergillus nidulans . While EnaC has a minor role, EnaB is a key element for tolerance to Na + and Li + toxicity. Adaptation to alkaline pH requires the concerted action of EnaB with EnaA. Accordingly, expression of enaA and enaB was induced by Na + , Li + and pH 8. These expression patterns are altered in a sltA Δ background and completely inhibited in a mutant expressing non-functional PacC protein ( palH72 ). However, a constitutively active PacC form was not sufficient to restore maximum enaA expression. In agreement with their predicted role as membrane ATPases, EnaA localized to the plasma membrane while EnaB accumulated at structures resembling the endoplasmic reticulum. Overall, results suggest different PacC- and SltA-dependent roles for EnaB in pH and salt homeostasis, acting in coordination with EnaA at pH 8 but independently under salt stress.
AbstractList Tolerance of microorganisms to abiotic stress is enabled by regulatory mechanisms that coordinate the expression and activity of resistance genes. Alkalinity and high salt concentrations are major environmental physicochemical stresses. Here, we analyzed the roles of sodium-extrusion family (ENA) transporters EnaA, EnaB and EnaC in the response to these stress conditions in the filamentous fungus Aspergillus nidulans. While EnaC has a minor role, EnaB is a key element for tolerance to Na+ and Li+ toxicity. Adaptation to alkaline pH requires the concerted action of EnaB with EnaA. Accordingly, expression of enaA and enaB was induced by Na+, Li+ and pH 8. These expression patterns are altered in a sltAΔ background and completely inhibited in a mutant expressing non-functional PacC protein (palH72). However, a constitutively active PacC form was not sufficient to restore maximum enaA expression. In agreement with their predicted role as membrane ATPases, EnaA localized to the plasma membrane while EnaB accumulated at structures resembling the endoplasmic reticulum. Overall, results suggest different PacC- and SltA-dependent roles for EnaB in pH and salt homeostasis, acting in coordination with EnaA at pH 8 but independently under salt stress.
Tolerance of microorganisms to abiotic stress is enabled by regulatory mechanisms that coordinate the expression and activity of resistance genes. Alkalinity and high salt concentrations are major environmental physicochemical stresses. Here, we analyzed the roles of sodium-extrusion family (ENA) transporters EnaA, EnaB and EnaC in the response to these stress conditions in the filamentous fungus Aspergillus nidulans. While EnaC has a minor role, EnaB is a key element for tolerance to Na+ and Li+ toxicity. Adaptation to alkaline pH requires the concerted action of EnaB with EnaA. Accordingly, expression of enaA and enaB was induced by Na+, Li+ and pH 8. These expression patterns are altered in a sltAΔ background and completely inhibited in a mutant expressing non-functional PacC protein (palH72). However, a constitutively active PacC form was not sufficient to restore maximum enaA expression. In agreement with their predicted role as membrane ATPases, EnaA localized to the plasma membrane while EnaB accumulated at structures resembling the endoplasmic reticulum. Overall, results suggest different PacC- and SltA-dependent roles for EnaB in pH and salt homeostasis, acting in coordination with EnaA at pH 8 but independently under salt stress.Tolerance of microorganisms to abiotic stress is enabled by regulatory mechanisms that coordinate the expression and activity of resistance genes. Alkalinity and high salt concentrations are major environmental physicochemical stresses. Here, we analyzed the roles of sodium-extrusion family (ENA) transporters EnaA, EnaB and EnaC in the response to these stress conditions in the filamentous fungus Aspergillus nidulans. While EnaC has a minor role, EnaB is a key element for tolerance to Na+ and Li+ toxicity. Adaptation to alkaline pH requires the concerted action of EnaB with EnaA. Accordingly, expression of enaA and enaB was induced by Na+, Li+ and pH 8. These expression patterns are altered in a sltAΔ background and completely inhibited in a mutant expressing non-functional PacC protein (palH72). However, a constitutively active PacC form was not sufficient to restore maximum enaA expression. In agreement with their predicted role as membrane ATPases, EnaA localized to the plasma membrane while EnaB accumulated at structures resembling the endoplasmic reticulum. Overall, results suggest different PacC- and SltA-dependent roles for EnaB in pH and salt homeostasis, acting in coordination with EnaA at pH 8 but independently under salt stress.
Tolerance of microorganisms to abiotic stress is enabled by regulatory mechanisms that coordinate the expression and activity of resistance genes. Alkalinity and high salt concentrations are major environmental physicochemical stresses. Here, we analyzed the roles of sodium-extrusion family (ENA) transporters EnaA, EnaB and EnaC in the response to these stress conditions in the filamentous fungus Aspergillus nidulans. While EnaC has a minor role, EnaB is a key element for tolerance to Na and Li toxicity. Adaptation to alkaline pH requires the concerted action of EnaB with EnaA. Accordingly, expression of enaA and enaB was induced by Na , Li and pH 8. These expression patterns are altered in a sltAΔ background and completely inhibited in a mutant expressing non-functional PacC protein (palH72). However, a constitutively active PacC form was not sufficient to restore maximum enaA expression. In agreement with their predicted role as membrane ATPases, EnaA localized to the plasma membrane while EnaB accumulated at structures resembling the endoplasmic reticulum. Overall, results suggest different PacC- and SltA-dependent roles for EnaB in pH and salt homeostasis, acting in coordination with EnaA at pH 8 but independently under salt stress.
Tolerance of microorganisms to abiotic stress is enabled by regulatory mechanisms that coordinate the expression and activity of resistance genes. Alkalinity and high salt concentrations are major environmental physicochemical stresses. Here, we analyzed the roles of sodium-extrusion family (ENA) transporters EnaA, EnaB and EnaC in the response to these stress conditions in the filamentous fungus Aspergillus nidulans . While EnaC has a minor role, EnaB is a key element for tolerance to Na + and Li + toxicity. Adaptation to alkaline pH requires the concerted action of EnaB with EnaA. Accordingly, expression of enaA and enaB was induced by Na + , Li + and pH 8. These expression patterns are altered in a sltA Δ background and completely inhibited in a mutant expressing non-functional PacC protein ( palH72 ). However, a constitutively active PacC form was not sufficient to restore maximum enaA expression. In agreement with their predicted role as membrane ATPases, EnaA localized to the plasma membrane while EnaB accumulated at structures resembling the endoplasmic reticulum. Overall, results suggest different PacC- and SltA-dependent roles for EnaB in pH and salt homeostasis, acting in coordination with EnaA at pH 8 but independently under salt stress.
ArticleNumber 14325
Author Espeso, Eduardo A.
Etxebeste, Oier
Spielvogel, Anja
Markina-Iñarrairaegui, Ane
Ugalde, Unai
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Cites_doi 10.1111/mmi.13156
10.1099/mgen.0.000415
10.1007/BF00333978
10.1091/mbc.e07-05-0464
10.1016/S0304-4157(99)00011-8
10.1046/j.1365-2958.2000.01776.x
10.1073/pnas.87.23.9348
10.1099/00221287-148-4-933
10.1128/MMBR.00042-09
10.1016/j.bbamem.2010.07.009
10.1101/gad.9.13.1622
10.1016/j.fgb.2008.07.023
10.1007/s00438-010-0513-z
10.1111/mmi.12294
10.1074/jbc.273.3.1640
10.1016/j.tim.2008.03.006
10.1093/emboj/21.6.1350
10.1016/0378-1119(95)00166-4
10.1128/EC.00252-08
10.1128/EC.00207-07
10.1016/j.fgb.2011.03.002
10.1093/nar/gkz239
10.1128/EC.3.5.1359-1362.2004
10.1016/j.fgb.2015.06.002
10.1371/journal.pone.0158424
10.1016/S1087-1845(03)00077-X
10.1042/BJ20080344
10.1093/femsyr/fov017
10.1046/j.1365-2958.1999.01267.x
10.1128/EC.00333-08
10.1074/jbc.M110.114371
10.1128/MCB.19.5.3328
10.1111/j.1365-2958.2007.06102.x
10.1111/j.1365-2958.2008.06520.x
10.1007/s004380100474
10.1038/nprot.2007.112
10.33549/physiolres.930000.53.S91
10.1016/0378-1119(83)90191-9
10.1111/j.1574-6968.2006.00473.x
10.1091/mbc.e09-03-0254
10.1046/j.1365-2958.2002.02774.x
10.3389/fmicb.2017.00516
10.1093/genetics/52.1.217
10.1016/S1389-1723(99)80191-1
10.1016/S0074-7696(08)62219-6
10.1016/S0926-6593(66)80120-0
10.1016/j.fgb.2008.07.013
10.1016/j.fgb.2010.04.002
10.1093/molbev/msw054
10.1146/annurev.biophys.093008.131331
10.1016/j.fgb.2005.09.004
10.1128/EC.00337-07
10.1002/j.1460-2075.1993.tb06072.x
10.1371/journal.pone.0067154
10.1111/j.1574-6968.2011.02214.x
10.1534/genetics.105.052563
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References Markina-Iñarrairaegui, Pantazopoulou, Espeso, Peñalva (CR34) 2013; 8
Herrero-Garcia (CR54) 2015
Kumar, Stecher, Tamura (CR58) 2016; 33
Findon (CR1) 2010; 47
Sychrová (CR43) 2004; 53
Mendizabal, Pascual-Ahuir, Serrano, de Larrinoa (CR24) 2001; 265
Sambrook, Fritsch, Maniatis (CR52) 1989
Etxebeste (CR53) 2008; 7
Balázs (CR38) 2010; 283
Harris (CR26) 2009; 46
Palmgren, Nissen (CR27) 2011; 40
Portillo (CR6) 2000; 1469
Yang (CR49) 2004; 3
Arst, Peñalva (CR21) 2003; 40
Taheri-Talesh (CR33) 2008; 19
Mulet (CR4) 1999; 19
Ariño, Ramos, Sychrová (CR5) 2010; 74
Miskei, Karányi, Pócsi (CR19) 2009; 46
Cove (CR56) 1966; 113
Hernández-Ortiz, Espeso (CR22) 2013; 89
Todd, Davis, Hynes (CR48) 2007; 2
Ruíz, Ariño (CR11) 2007; 6
Espeso, Tilburn, Arst, Penalva (CR45) 1993; 12
Rodríguez-Navarro, Benito (CR15) 2010; 1798
Ramos, Arino, Sychrova (CR14) 2011; 317
Watanabe (CR41) 1999; 88
Caddick, Brownlee, Arst (CR37) 1986; 203
Lopez (CR2) 1999; 31
Bagar, Altenbach, Read, Bencina (CR8) 2009; 8
Nayak (CR51) 2006; 172
Bañuelos (CR39) 1998; 144
Serrano (CR3) 1996; 165
Portillo, Eraso, Serrano, Lee (CR7) 1996
Hervás-Aguilar, Galindo, Peñalva (CR29) 2010; 285
Mendoza-Martinez, Lara-Rojas, Sanchez, Aguirre (CR44) 2017; 8
Bañuelos, Rodríguez-Navarro (CR42) 1998; 273
Tilburn (CR50) 1983; 26
Araújo-Bazán, Peñalva, Espeso (CR31) 2008; 67
Benito, Garciadeblás, Rodríguez-Navarro (CR12) 2000; 35
Benito, Garciadeblás, Fraile-Escanciano, Rodríguez-Navarro (CR17) 2011; 48
Letunic, Bork (CR59) 2019; 47
Garzia (CR55) 2009; 71
Miller, Vogg, Sanders (CR9) 1990; 87
Petrezselyova (CR25) 2016; 11
Peñalva, Tilburn, Bignell, Arst (CR20) 2008; 16
Benito, Garciadeblás, Rodríguez-Navarro (CR13) 2002; 148
Picazo (CR10) 2020
Pantazopoulou, Peñalva (CR32) 2009; 20
Peñalva (CR57) 2005; 42
Spielvogel (CR16) 2008; 414
Díez (CR36) 2002; 21
Punt, Kuyvenhoven, van den Hondel (CR35) 1995; 158
Benito, Garciadeblás, Pérez-Martín, Rodríguez-Navarro (CR40) 2009; 8
Mellado (CR23) 2015; 82
Käfer (CR47) 1965; 52
Orejas (CR30) 1995; 9
Gorjan, Plemenitas (CR28) 2006; 265
Marques (CR46) 2015; 15
Han, Prade (CR18) 2002; 43
MA Peñalva (71297_CR20) 2008; 16
R Serrano (71297_CR3) 1996; 165
RB Todd (71297_CR48) 2007; 2
A Spielvogel (71297_CR16) 2008; 414
L Yang (71297_CR49) 2004; 3
Y Watanabe (71297_CR41) 1999; 88
M Orejas (71297_CR30) 1995; 9
MC Marques (71297_CR46) 2015; 15
EA Espeso (71297_CR45) 1993; 12
AE Mendoza-Martinez (71297_CR44) 2017; 8
JM Mulet (71297_CR4) 1999; 19
B Benito (71297_CR17) 2011; 48
KH Han (71297_CR18) 2002; 43
L Araújo-Bazán (71297_CR31) 2008; 67
DJ Cove (71297_CR56) 1966; 113
J Ramos (71297_CR14) 2011; 317
A Hervás-Aguilar (71297_CR29) 2010; 285
B Benito (71297_CR40) 2009; 8
E Díez (71297_CR36) 2002; 21
M Miskei (71297_CR19) 2009; 46
F Portillo (71297_CR6) 2000; 1469
MX Caddick (71297_CR37) 1986; 203
E Käfer (71297_CR47) 1965; 52
MA Peñalva (71297_CR57) 2005; 42
MA Bañuelos (71297_CR39) 1998; 144
N Taheri-Talesh (71297_CR33) 2008; 19
T Bagar (71297_CR8) 2009; 8
A Garzia (71297_CR55) 2009; 71
A Rodríguez-Navarro (71297_CR15) 2010; 1798
I Letunic (71297_CR59) 2019; 47
PJ Punt (71297_CR35) 1995; 158
J Sambrook (71297_CR52) 1989
L Mellado (71297_CR23) 2015; 82
A Markina-Iñarrairaegui (71297_CR34) 2013; 8
MA Bañuelos (71297_CR42) 1998; 273
H Sychrová (71297_CR43) 2004; 53
S Kumar (71297_CR58) 2016; 33
I Picazo (71297_CR10) 2020
SD Harris (71297_CR26) 2009; 46
E Herrero-Garcia (71297_CR54) 2015
F Portillo (71297_CR7) 1996
P Hernández-Ortiz (71297_CR22) 2013; 89
A Ruíz (71297_CR11) 2007; 6
J Ariño (71297_CR5) 2010; 74
J Tilburn (71297_CR50) 1983; 26
F Lopez (71297_CR2) 1999; 31
B Benito (71297_CR12) 2000; 35
B Benito (71297_CR13) 2002; 148
AJ Miller (71297_CR9) 1990; 87
T Nayak (71297_CR51) 2006; 172
H Findon (71297_CR1) 2010; 47
I Mendizabal (71297_CR24) 2001; 265
S Petrezselyova (71297_CR25) 2016; 11
O Etxebeste (71297_CR53) 2008; 7
A Gorjan (71297_CR28) 2006; 265
A Balázs (71297_CR38) 2010; 283
HN Arst Jr (71297_CR21) 2003; 40
MG Palmgren (71297_CR27) 2011; 40
A Pantazopoulou (71297_CR32) 2009; 20
References_xml – volume: 317
  start-page: 1
  year: 2011
  end-page: 8
  ident: CR14
  article-title: Alkali-metal-cation influx and efflux systems in nonconventional yeast species
  publication-title: FEMS Microbiol. Lett.
– volume: 43
  start-page: 1065
  year: 2002
  end-page: 1078
  ident: CR18
  article-title: Osmotic stress-coupled maintenance of polar growth in
  publication-title: Mol. Microbiol.
– volume: 8
  start-page: 703
  year: 2009
  end-page: 712
  ident: CR8
  article-title: Live-cell imaging and measurement of intracellular pH in filamentous fungi using a genetically encoded ratiometric probe
  publication-title: Eukaryot. Cell
– volume: 6
  start-page: 2175
  year: 2007
  end-page: 2183
  ident: CR11
  article-title: Function and regulation of the ENA sodium ATPase system
  publication-title: Eukaryot. Cell
– volume: 15
  start-page: fov017
  year: 2015
  ident: CR46
  article-title: A functional Rim101 complex is required for proper accumulation of the Ena1 Na+-ATPase protein in response to salt stress in
  publication-title: FEMS Yeast Res.
– year: 2015
  ident: CR54
  article-title: Tip-to-nucleus migration dynamics of the asexual development regulator FlbB in vegetative cells
  publication-title: Mol. Microbiol.
  doi: 10.1111/mmi.13156
– volume: 414
  start-page: 419
  year: 2008
  end-page: 429
  ident: CR16
  article-title: Two zinc finger transcription factors, CrzA and SltA, are involved in cation homoeostasis and detoxification in
  publication-title: Biochem. J.
– volume: 285
  start-page: 18095
  year: 2010
  end-page: 18102
  ident: CR29
  article-title: Receptor-independent ambient pH signaling by ubiquitin attachment to fungal arrestin-like PalF
  publication-title: J. Biol. Chem.
– volume: 148
  start-page: 933
  year: 2002
  end-page: 941
  ident: CR13
  article-title: Potassium- or sodium-efflux ATPase, a key enzyme in the evolution of fungi
  publication-title: Microbiology
– volume: 82
  start-page: 116
  year: 2015
  end-page: 128
  ident: CR23
  article-title: A second component of the SltA-dependent cation tolerance pathway in
  publication-title: Fungal Genet. Biol.
– volume: 2
  start-page: 811
  year: 2007
  end-page: 821
  ident: CR48
  article-title: Genetic manipulation of : meiotic progeny for genetic analysis and strain construction
  publication-title: Nat. Protoc.
– volume: 172
  start-page: 1557
  year: 2006
  end-page: 1566
  ident: CR51
  article-title: A versatile and efficient gene-targeting system for
  publication-title: Genetics
– volume: 113
  start-page: 51
  year: 1966
  end-page: 56
  ident: CR56
  article-title: The induction and repression of nitrate reductase in the fungus
  publication-title: Biochim. Biophys. Acta
– volume: 19
  start-page: 1439
  year: 2008
  end-page: 1449
  ident: CR33
  article-title: The tip growth apparatus of
  publication-title: Mol. Biol. Cell
– volume: 87
  start-page: 9348
  year: 1990
  end-page: 9352
  ident: CR9
  article-title: Cytosolic calcium homeostasis in fungi: roles of plasma membrane transport and intracellular sequestration of calcium
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
– volume: 40
  start-page: 243
  year: 2011
  end-page: 266
  ident: CR27
  article-title: P-type ATPases
  publication-title: Annu. Rev. Biophys.
– volume: 9
  start-page: 1622
  year: 1995
  end-page: 1632
  ident: CR30
  article-title: Activation of the PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety
  publication-title: Genes Dev.
– volume: 8
  start-page: 516
  year: 2017
  ident: CR44
  article-title: NapA mediates a redox regulation of the antioxidant response, carbon utilization and development in
  publication-title: Front. Microbiol.
– volume: 31
  start-page: 1255
  year: 1999
  end-page: 1264
  ident: CR2
  article-title: The yeast inositol monophosphatase is a lithium- and sodium-sensitive enzyme encoded by a non-essential gene pair
  publication-title: Mol. Microbiol.
– volume: 203
  start-page: 346
  year: 1986
  end-page: 353
  ident: CR37
  article-title: Regulation of gene expression by pH of the growth medium in
  publication-title: Mol. Gen. Genet.
– volume: 3
  start-page: 1359
  year: 2004
  end-page: 1362
  ident: CR49
  article-title: Rapid production of gene replacement constructs and generation of a green fluorescent protein-tagged centromeric marker in
  publication-title: Eukaryot. Cell
– volume: 47
  start-page: 647
  year: 2010
  end-page: 655
  ident: CR1
  article-title: Analysis of a novel calcium auxotrophy in
  publication-title: Fungal Genet. Biol.
– volume: 16
  start-page: 291
  year: 2008
  end-page: 300
  ident: CR20
  article-title: Ambient pH gene regulation in fungi: making connections
  publication-title: Trends Microbiol.
– year: 1989
  ident: CR52
  publication-title: Molecular Cloning: A Laboratory Manual
– volume: 20
  start-page: 4335
  year: 2009
  end-page: 4347
  ident: CR32
  article-title: Organization and dynamics of the Golgi during apical extension and mitosis
  publication-title: Mol. Biol. Cell
– volume: 21
  start-page: 1350
  year: 2002
  end-page: 1359
  ident: CR36
  article-title: Activation of the PacC zinc finger transcription factor requires two proteolytic steps
  publication-title: EMBO J.
– volume: 1798
  start-page: 1841
  year: 2010
  end-page: 1853
  ident: CR15
  article-title: Sodium or potassium efflux ATPase a fungal, bryophyte, and protozoal ATPase
  publication-title: Biochim. Biophys. Acta
– volume: 7
  start-page: 38
  year: 2008
  end-page: 48
  ident: CR53
  article-title: Basic-zipper-type transcription factor FlbB controls asexual development in
  publication-title: Eukaryot. Cell
– volume: 74
  start-page: 95
  year: 2010
  end-page: 120
  ident: CR5
  article-title: Alkali metal cation transport and homeostasis in yeasts
  publication-title: Microbiol. Mol. Biol. Rev.
– volume: 1469
  start-page: 31
  year: 2000
  end-page: 42
  ident: CR6
  article-title: Regulation of plasma membrane H(+)-ATPase in fungi and plants
  publication-title: Biochim. Biophys. Acta
– year: 2020
  ident: CR10
  article-title: Defining the transcriptional responses of to cation/alkaline pH stress and the role of the transcription factor SltA
  publication-title: Microb. Genomics
  doi: 10.1099/mgen.0.000415
– volume: 48
  start-page: 812
  year: 2011
  end-page: 822
  ident: CR17
  article-title: Potassium and sodium uptake systems in fungi. The transporter diversity of
  publication-title: Fungal Genet. Biol.
– volume: 67
  start-page: 891
  year: 2008
  end-page: 905
  ident: CR31
  article-title: Preferential localization of the endocytic internalization machinery to hyphal tips underlies polarization of the actin cytoskeleton in
  publication-title: Mol. Microbiol.
– start-page: 225
  year: 1996
  end-page: 240
  ident: CR7
  article-title: The plasma membrane H -ATPase of fungi and plants
  publication-title: Biomembranes: A Multi-Volume Treatise ATPases
– volume: 33
  start-page: 1870
  year: 2016
  end-page: 1874
  ident: CR58
  article-title: MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets
  publication-title: Mol. Biol. Evol.
– volume: 26
  start-page: 205
  year: 1983
  end-page: 221
  ident: CR50
  article-title: Transformation by integration in
  publication-title: Gene
– volume: 8
  start-page: 821
  year: 2009
  end-page: 829
  ident: CR40
  article-title: Growth at high pH and sodium and potassium tolerance in media above the cytoplasmic pH depend on ENA ATPases in
  publication-title: Eukaryot. Cell
– volume: 89
  start-page: 532
  year: 2013
  end-page: 551
  ident: CR22
  article-title: Phospho-regulation and nucleocytoplasmic trafficking of CrzA in response to calcium and alkaline-pH stress in
  publication-title: Mol. Microbiol.
– volume: 35
  start-page: 1079
  year: 2000
  end-page: 1088
  ident: CR12
  article-title: Molecular cloning of the calcium and sodium ATPases in
  publication-title: Mol. Microbiol.
– volume: 53
  start-page: S91
  issue: Suppl 1
  year: 2004
  end-page: S98
  ident: CR43
  article-title: Yeast as a model organism to study transport and homeostasis of alkali metal cations
  publication-title: Physiol. Res.
– volume: 46
  start-page: S82
  issue: Suppl 1
  year: 2009
  end-page: S92
  ident: CR26
  article-title: Morphology and development in : a complex puzzle
  publication-title: Fungal Genet. Biol.
– volume: 158
  start-page: 119
  year: 1995
  end-page: 123
  ident: CR35
  article-title: A mini-promoter lacZ gene fusion for the analysis of fungal transcription control sequences
  publication-title: Gene
– volume: 47
  start-page: W256
  year: 2019
  end-page: W259
  ident: CR59
  article-title: Interactive Tree Of Life (iTOL) v4: recent updates and new developments
  publication-title: Nucleic Acids Res.
– volume: 165
  start-page: 1
  year: 1996
  end-page: 52
  ident: CR3
  article-title: Salt tolerance in plants and microorganisms: toxicity targets and defense responses
  publication-title: Int. Rev. Cytol.
– volume: 46
  start-page: S105
  issue: Suppl 1
  year: 2009
  end-page: S120
  ident: CR19
  article-title: Annotation of stress-response proteins in the aspergilli
  publication-title: Fungal Genet. Biol.
– volume: 265
  start-page: 41
  year: 2006
  end-page: 50
  ident: CR28
  article-title: Identification and characterization of ENA ATPases HwENA1 and HwENA2 from the halophilic black yeast
  publication-title: FEMS Microbiol. Lett.
– volume: 12
  start-page: 3947
  year: 1993
  end-page: 3956
  ident: CR45
  article-title: pH regulation is a major determinant in expression of a fungal penicillin biosynthetic gene
  publication-title: EMBO J.
– volume: 265
  start-page: 801
  year: 2001
  end-page: 811
  ident: CR24
  article-title: Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene
  publication-title: Mol. Genet. Genomics
– volume: 52
  start-page: 217
  year: 1965
  end-page: 232
  ident: CR47
  article-title: Origins of translocations in
  publication-title: Genetics
– volume: 42
  start-page: 963
  year: 2005
  end-page: 975
  ident: CR57
  article-title: Tracing the endocytic pathway of with FM4-64
  publication-title: Fungal Genet. Biol.
– volume: 283
  start-page: 289
  year: 2010
  end-page: 303
  ident: CR38
  article-title: AtfA bZIP-type transcription factor regulates oxidative and osmotic stress responses in
  publication-title: Mol. Genet. Genomics
– volume: 19
  start-page: 3328
  year: 1999
  end-page: 3337
  ident: CR4
  article-title: A novel mechanism of ion homeostasis and salt tolerance in yeast: the Hal4 and Hal5 protein kinases modulate the Trk1–Trk2 potassium transporter
  publication-title: Mol. Cell Biol.
– volume: 40
  start-page: 1
  year: 2003
  end-page: 3
  ident: CR21
  article-title: Recognizing gene regulation by ambient pH
  publication-title: Fungal Genet. Biol.
– volume: 8
  start-page: e67154
  year: 2013
  ident: CR34
  article-title: The peripheral ER: disorganization by ER stress and persistence during mitosis
  publication-title: PLoS ONE
– volume: 71
  start-page: 172
  year: 2009
  end-page: 184
  ident: CR55
  article-title: FlbE is an upstream developmental activator of conidiation functionally associated with the putative transcription factor FlbB
  publication-title: Mol. Microbiol.
– volume: 11
  start-page: e0158424
  year: 2016
  ident: CR25
  article-title: Regulation of the Na /K -ATPase Ena1 expression by calcineurin/Crz1 under High pH stress: a quantitative study
  publication-title: PLoS ONE
– volume: 88
  start-page: 136
  year: 1999
  end-page: 142
  ident: CR41
  article-title: Characterization of the Na+-ATPase gene (ZENA1) from the salt-tolerant yeast
  publication-title: J. Biosci. Bioeng.
– volume: 273
  start-page: 1640
  year: 1998
  end-page: 1646
  ident: CR42
  article-title: P-type ATPases mediate sodium and potassium effluxes in
  publication-title: J. Biol. Chem.
– volume: 144
  start-page: 2749
  issue: Pt 10
  year: 1998
  end-page: 2758
  ident: CR39
  article-title: The Nha1 antiporter of mediates sodium and potassium efflux
  publication-title: Microbiology
– volume: 203
  start-page: 346
  year: 1986
  ident: 71297_CR37
  publication-title: Mol. Gen. Genet.
  doi: 10.1007/BF00333978
– volume: 19
  start-page: 1439
  year: 2008
  ident: 71297_CR33
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e07-05-0464
– volume: 1469
  start-page: 31
  year: 2000
  ident: 71297_CR6
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/S0304-4157(99)00011-8
– volume: 35
  start-page: 1079
  year: 2000
  ident: 71297_CR12
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2000.01776.x
– volume: 87
  start-page: 9348
  year: 1990
  ident: 71297_CR9
  publication-title: Proc. Natl. Acad. Sci. U.S.A.
  doi: 10.1073/pnas.87.23.9348
– volume: 148
  start-page: 933
  year: 2002
  ident: 71297_CR13
  publication-title: Microbiology
  doi: 10.1099/00221287-148-4-933
– volume: 74
  start-page: 95
  year: 2010
  ident: 71297_CR5
  publication-title: Microbiol. Mol. Biol. Rev.
  doi: 10.1128/MMBR.00042-09
– volume: 1798
  start-page: 1841
  year: 2010
  ident: 71297_CR15
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamem.2010.07.009
– volume: 9
  start-page: 1622
  year: 1995
  ident: 71297_CR30
  publication-title: Genes Dev.
  doi: 10.1101/gad.9.13.1622
– year: 2015
  ident: 71297_CR54
  publication-title: Mol. Microbiol.
  doi: 10.1111/mmi.13156
– volume: 46
  start-page: S82
  issue: Suppl 1
  year: 2009
  ident: 71297_CR26
  publication-title: Fungal Genet. Biol.
  doi: 10.1016/j.fgb.2008.07.023
– volume: 144
  start-page: 2749
  issue: Pt 10
  year: 1998
  ident: 71297_CR39
  publication-title: Microbiology
– volume: 283
  start-page: 289
  year: 2010
  ident: 71297_CR38
  publication-title: Mol. Genet. Genomics
  doi: 10.1007/s00438-010-0513-z
– volume: 89
  start-page: 532
  year: 2013
  ident: 71297_CR22
  publication-title: Mol. Microbiol.
  doi: 10.1111/mmi.12294
– volume-title: Molecular Cloning: A Laboratory Manual
  year: 1989
  ident: 71297_CR52
– volume: 273
  start-page: 1640
  year: 1998
  ident: 71297_CR42
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.3.1640
– volume: 16
  start-page: 291
  year: 2008
  ident: 71297_CR20
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2008.03.006
– volume: 21
  start-page: 1350
  year: 2002
  ident: 71297_CR36
  publication-title: EMBO J.
  doi: 10.1093/emboj/21.6.1350
– volume: 158
  start-page: 119
  year: 1995
  ident: 71297_CR35
  publication-title: Gene
  doi: 10.1016/0378-1119(95)00166-4
– volume: 8
  start-page: 821
  year: 2009
  ident: 71297_CR40
  publication-title: Eukaryot. Cell
  doi: 10.1128/EC.00252-08
– volume: 7
  start-page: 38
  year: 2008
  ident: 71297_CR53
  publication-title: Eukaryot. Cell
  doi: 10.1128/EC.00207-07
– volume: 48
  start-page: 812
  year: 2011
  ident: 71297_CR17
  publication-title: Fungal Genet. Biol.
  doi: 10.1016/j.fgb.2011.03.002
– volume: 47
  start-page: W256
  year: 2019
  ident: 71297_CR59
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz239
– volume: 3
  start-page: 1359
  year: 2004
  ident: 71297_CR49
  publication-title: Eukaryot. Cell
  doi: 10.1128/EC.3.5.1359-1362.2004
– volume: 82
  start-page: 116
  year: 2015
  ident: 71297_CR23
  publication-title: Fungal Genet. Biol.
  doi: 10.1016/j.fgb.2015.06.002
– volume: 11
  start-page: e0158424
  year: 2016
  ident: 71297_CR25
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0158424
– volume: 40
  start-page: 1
  year: 2003
  ident: 71297_CR21
  publication-title: Fungal Genet. Biol.
  doi: 10.1016/S1087-1845(03)00077-X
– volume: 414
  start-page: 419
  year: 2008
  ident: 71297_CR16
  publication-title: Biochem. J.
  doi: 10.1042/BJ20080344
– volume: 15
  start-page: fov017
  year: 2015
  ident: 71297_CR46
  publication-title: FEMS Yeast Res.
  doi: 10.1093/femsyr/fov017
– volume: 31
  start-page: 1255
  year: 1999
  ident: 71297_CR2
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.1999.01267.x
– volume: 8
  start-page: 703
  year: 2009
  ident: 71297_CR8
  publication-title: Eukaryot. Cell
  doi: 10.1128/EC.00333-08
– volume: 285
  start-page: 18095
  year: 2010
  ident: 71297_CR29
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.114371
– volume: 19
  start-page: 3328
  year: 1999
  ident: 71297_CR4
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.19.5.3328
– volume: 67
  start-page: 891
  year: 2008
  ident: 71297_CR31
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.2007.06102.x
– volume: 71
  start-page: 172
  year: 2009
  ident: 71297_CR55
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.2008.06520.x
– volume: 265
  start-page: 801
  year: 2001
  ident: 71297_CR24
  publication-title: Mol. Genet. Genomics
  doi: 10.1007/s004380100474
– volume: 2
  start-page: 811
  year: 2007
  ident: 71297_CR48
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2007.112
– volume: 53
  start-page: S91
  issue: Suppl 1
  year: 2004
  ident: 71297_CR43
  publication-title: Physiol. Res.
  doi: 10.33549/physiolres.930000.53.S91
– volume: 26
  start-page: 205
  year: 1983
  ident: 71297_CR50
  publication-title: Gene
  doi: 10.1016/0378-1119(83)90191-9
– volume: 265
  start-page: 41
  year: 2006
  ident: 71297_CR28
  publication-title: FEMS Microbiol. Lett.
  doi: 10.1111/j.1574-6968.2006.00473.x
– volume: 20
  start-page: 4335
  year: 2009
  ident: 71297_CR32
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e09-03-0254
– volume: 43
  start-page: 1065
  year: 2002
  ident: 71297_CR18
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2002.02774.x
– start-page: 225
  volume-title: Biomembranes: A Multi-Volume Treatise ATPases
  year: 1996
  ident: 71297_CR7
– volume: 8
  start-page: 516
  year: 2017
  ident: 71297_CR44
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2017.00516
– volume: 52
  start-page: 217
  year: 1965
  ident: 71297_CR47
  publication-title: Genetics
  doi: 10.1093/genetics/52.1.217
– volume: 88
  start-page: 136
  year: 1999
  ident: 71297_CR41
  publication-title: J. Biosci. Bioeng.
  doi: 10.1016/S1389-1723(99)80191-1
– volume: 165
  start-page: 1
  year: 1996
  ident: 71297_CR3
  publication-title: Int. Rev. Cytol.
  doi: 10.1016/S0074-7696(08)62219-6
– volume: 113
  start-page: 51
  year: 1966
  ident: 71297_CR56
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/S0926-6593(66)80120-0
– volume: 46
  start-page: S105
  issue: Suppl 1
  year: 2009
  ident: 71297_CR19
  publication-title: Fungal Genet. Biol.
  doi: 10.1016/j.fgb.2008.07.013
– volume: 47
  start-page: 647
  year: 2010
  ident: 71297_CR1
  publication-title: Fungal Genet. Biol.
  doi: 10.1016/j.fgb.2010.04.002
– volume: 33
  start-page: 1870
  year: 2016
  ident: 71297_CR58
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msw054
– volume: 40
  start-page: 243
  year: 2011
  ident: 71297_CR27
  publication-title: Annu. Rev. Biophys.
  doi: 10.1146/annurev.biophys.093008.131331
– volume: 42
  start-page: 963
  year: 2005
  ident: 71297_CR57
  publication-title: Fungal Genet. Biol.
  doi: 10.1016/j.fgb.2005.09.004
– volume: 6
  start-page: 2175
  year: 2007
  ident: 71297_CR11
  publication-title: Eukaryot. Cell
  doi: 10.1128/EC.00337-07
– volume: 12
  start-page: 3947
  year: 1993
  ident: 71297_CR45
  publication-title: EMBO J.
  doi: 10.1002/j.1460-2075.1993.tb06072.x
– volume: 8
  start-page: e67154
  year: 2013
  ident: 71297_CR34
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0067154
– volume: 317
  start-page: 1
  year: 2011
  ident: 71297_CR14
  publication-title: FEMS Microbiol. Lett.
  doi: 10.1111/j.1574-6968.2011.02214.x
– year: 2020
  ident: 71297_CR10
  publication-title: Microb. Genomics
  doi: 10.1099/mgen.0.000415
– volume: 172
  start-page: 1557
  year: 2006
  ident: 71297_CR51
  publication-title: Genetics
  doi: 10.1534/genetics.105.052563
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SubjectTerms 631/326/325/1507
631/326/88
Adenosine Triphosphatases - genetics
Adenosine Triphosphatases - metabolism
Algae
Alkalinity
Aspergillus nidulans - genetics
Aspergillus nidulans - metabolism
Cation Transport Proteins - genetics
Cation Transport Proteins - metabolism
Cell division
Flowering
Fungal Proteins - metabolism
Gene Expression Regulation
Humanities and Social Sciences
Hydrogen-Ion Concentration
Isoetes
Lithium - metabolism
Microorganisms
multidisciplinary
Phylogeny
Salt Tolerance
Salts
Science
Science (multidisciplinary)
Sodium - metabolism
Transcription Factors - metabolism
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Title Tolerance to alkaline ambient pH in Aspergillus nidulans depends on the activity of ENA proteins
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