From tissue mechanics to transcription factors
Changes in tissue stiffness are frequently associated with diseases such as cancer, fibrosis, and atherosclerosis. Several recent studies suggest that, in addition to resulting from pathology, mechanical changes may play a role akin to soluble factors in causing the progression of disease, and simil...
Saved in:
| Published in | Differentiation (London) Vol. 86; no. 3; pp. 112 - 120 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier B.V
01.10.2013
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0301-4681 1432-0436 1432-0436 |
| DOI | 10.1016/j.diff.2013.07.004 |
Cover
| Abstract | Changes in tissue stiffness are frequently associated with diseases such as cancer, fibrosis, and atherosclerosis. Several recent studies suggest that, in addition to resulting from pathology, mechanical changes may play a role akin to soluble factors in causing the progression of disease, and similar mechanical control might be essential for normal tissue development and homeostasis. Many cell types alter their structure and function in response to exogenous forces or as a function of the mechanical properties of the materials to which they adhere. This review summarizes recent progress in identifying intracellular signaling pathways, and especially transcriptional programs, that are differentially activated when cells adhere to materials with different mechanical properties or when they are subject to tension arising from external forces. Several cytoplasmic or cytoskeletal signaling pathways involving small GTPases, focal adhesion kinase and transforming growth factor beta as well as the transcriptional regulators MRTF-A, NFκB, and Yap/Taz have emerged as important mediators of mechanical signaling. |
|---|---|
| AbstractList | Changes in tissue stiffness are frequently associated with diseases such as cancer, fibrosis, and atherosclerosis. Several recent studies suggest that, in addition to resulting from pathology, mechanical changes may play a role akin to soluble factors in causing the progression of disease, and similar mechanical control might be essential for normal tissue development and homeostasis. Many cell types alter their structure and function in response to exogenous forces or as a function of the mechanical properties of the materials to which they adhere. This review summarizes recent progress in identifying intracellular signaling pathways, and especially transcriptional programs, that are differentially activated when cells adhere to materials with different mechanical properties or when they are subject to tension arising from external forces. Several cytoplasmic or cytoskeletal signaling pathways involving small GTPases, focal adhesion kinase and transforming growth factor beta as well as the transcriptional regulators MRTF-A, NFκB, and Yap/Taz have emerged as important mediators of mechanical signaling. Changes in tissue stiffness are frequently associated with diseases such as cancer, fibrosis, and atherosclerosis. Several recent studies suggest that, in addition to resulting from pathology, mechanical changes may play a role akin to soluble factors in causing the progression of disease, and similar mechanical control might be essential for normal tissue development and homeostasis. Many cell types alter their structure and function in response to exogenous forces or as a function of the mechanical properties of the materials to which they adhere. This review summarizes recent progress in identifying intracellular signaling pathways, and especially transcriptional programs, that are differentially activated when cells adhere to materials with different mechanical properties or when they are subject to tension arising from external forces. Several cytoplasmic or cytoskeletal signaling pathways involving small GTPases, focal adhesion kinase and transforming growth factor beta as well as the transcriptional regulators MRTF-A, NFκB, and Yap/Taz have emerged as important mediators of mechanical signaling.Changes in tissue stiffness are frequently associated with diseases such as cancer, fibrosis, and atherosclerosis. Several recent studies suggest that, in addition to resulting from pathology, mechanical changes may play a role akin to soluble factors in causing the progression of disease, and similar mechanical control might be essential for normal tissue development and homeostasis. Many cell types alter their structure and function in response to exogenous forces or as a function of the mechanical properties of the materials to which they adhere. This review summarizes recent progress in identifying intracellular signaling pathways, and especially transcriptional programs, that are differentially activated when cells adhere to materials with different mechanical properties or when they are subject to tension arising from external forces. Several cytoplasmic or cytoskeletal signaling pathways involving small GTPases, focal adhesion kinase and transforming growth factor beta as well as the transcriptional regulators MRTF-A, NFκB, and Yap/Taz have emerged as important mediators of mechanical signaling. |
| Author | McCulloch, Christopher A. Assoian, Richard K. Wells, Rebecca G. Janmey, Paul A. |
| AuthorAffiliation | b Departments of Medicine and Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA c Departments of Pharmacology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA d Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Fitzgerald Building, Toronto, Ontario, Canada M5S 3E2 a Departments of Physiology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA |
| AuthorAffiliation_xml | – name: d Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Fitzgerald Building, Toronto, Ontario, Canada M5S 3E2 – name: c Departments of Pharmacology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA – name: b Departments of Medicine and Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA – name: a Departments of Physiology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA |
| Author_xml | – sequence: 1 givenname: Paul A. surname: Janmey fullname: Janmey, Paul A. email: janmey@mail.med.upenn.edu organization: Departments of Physiology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 2 givenname: Rebecca G. surname: Wells fullname: Wells, Rebecca G. organization: Departments of Medicine and Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 3 givenname: Richard K. surname: Assoian fullname: Assoian, Richard K. organization: Departments of Pharmacology and Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 4 givenname: Christopher A. surname: McCulloch fullname: McCulloch, Christopher A. organization: Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Fitzgerald Building, Toronto, Ontario, Canada M5S 3E2 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23969122$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkUFr3DAQhUVJaDZJ_0APxcde7M5IsmxDCJTQtIVAL8lZyPK40WJLG0kb6L-vzSalzSE9DHOY9x4f807ZkQ-eGHuPUCGg-rStBjeOFQcUFTQVgHzDNigFL0EKdcQ2IABLqVo8YacpbQGgVRzfshMuOtUh5xtWXccwF9mltKdiJntvvLOpyKHI0fhko9tlF3wxGptDTOfseDRTondP-4zdXX-5vfpW3vz4-v3q801pa4Rcdkp2vRyVRKyVVKKnYeDUWGW73gigHpEjjShVU3dUDwIUWRBc0Ng1YFpxxi4Pubt9P9NgyS84k95FN5v4Swfj9L8X7-71z_CoZS1rxfkS8PEpIIaHPaWsZ5csTZPxFPZJYyNEzZdp_i-VUohWSFixPvyN9Yfn-Z-LoD0IbAwpRRq1ddmsH1wo3aQR9Fqd3uq1Or1Wp6HRS3WLlb-wPqe_aro4mGgp49FR1Mk68pYGF8lmPQT3mv03G_exUA |
| CitedBy_id | crossref_primary_10_1152_ajpheart_00095_2018 crossref_primary_10_1016_j_tcb_2015_02_008 crossref_primary_10_1098_rsob_160250 crossref_primary_10_3390_healthcare9020181 crossref_primary_10_1016_j_tem_2015_01_002 crossref_primary_10_1091_mbc_E15_06_0357 crossref_primary_10_1038_s41598_018_27346_9 crossref_primary_10_1111_wrr_12283 crossref_primary_10_1016_j_celrep_2021_109019 crossref_primary_10_1039_C3BM60319A crossref_primary_10_1016_j_exer_2015_03_021 crossref_primary_10_1098_rsob_200360 crossref_primary_10_1016_j_biomaterials_2015_03_027 crossref_primary_10_1161_ATVBAHA_117_310237 crossref_primary_10_3390_ijms22116040 crossref_primary_10_1038_nrdp_2015_2 crossref_primary_10_1007_s12013_019_00888_z crossref_primary_10_1002_jcp_25624 crossref_primary_10_1016_j_actbio_2022_07_042 crossref_primary_10_1186_s13058_017_0860_3 crossref_primary_10_1016_j_eml_2020_101049 crossref_primary_10_3390_bioengineering10050584 crossref_primary_10_1007_s00441_018_2842_x crossref_primary_10_52979_raoa_1111231_1223 crossref_primary_10_1039_c5ib00040h crossref_primary_10_1039_D3CS00396E crossref_primary_10_1016_j_ceb_2016_03_006 crossref_primary_10_1158_1541_7786_MCR_14_0542 crossref_primary_10_1039_C6IB00229C crossref_primary_10_1093_nar_gkab470 crossref_primary_10_1152_ajpgi_00447_2014 crossref_primary_10_3390_ijms25020870 crossref_primary_10_1039_C6SM00300A crossref_primary_10_1146_annurev_bioeng_062117_121224 crossref_primary_10_1073_pnas_1802568115 crossref_primary_10_1063_5_0071648 crossref_primary_10_1016_j_semcdb_2016_09_004 crossref_primary_10_3390_cells10112840 crossref_primary_10_3233_JCB_15024 crossref_primary_10_1038_srep23353 crossref_primary_10_1016_j_jmbbm_2017_05_039 crossref_primary_10_1146_annurev_bioeng_092419_060810 crossref_primary_10_1126_sciadv_abb8471 crossref_primary_10_1016_j_matbio_2015_01_020 crossref_primary_10_1152_ajplung_00300_2014 crossref_primary_10_1016_j_ceb_2018_08_004 crossref_primary_10_1016_j_yjmcc_2016_05_002 crossref_primary_10_1007_s12551_017_0302_6 crossref_primary_10_1038_ncomms5656 crossref_primary_10_1242_jcs_183699 crossref_primary_10_1016_j_bpj_2019_02_018 crossref_primary_10_1080_14728222_2021_1849145 crossref_primary_10_1016_j_bbamcr_2015_05_007 crossref_primary_10_1016_j_biomaterials_2015_10_005 crossref_primary_10_1016_j_pbiomolbio_2018_08_004 crossref_primary_10_1186_s12859_019_3010_3 crossref_primary_10_1115_1_4035350 crossref_primary_10_3390_mi9040187 crossref_primary_10_1016_j_ymeth_2015_08_001 crossref_primary_10_1134_S106236042570002X crossref_primary_10_1002_adma_201504845 crossref_primary_10_1016_j_semcdb_2019_12_005 crossref_primary_10_1172_JCI93561 crossref_primary_10_1371_journal_pone_0126015 crossref_primary_10_3390_ijms24043635 crossref_primary_10_1016_j_ejcb_2014_07_008 crossref_primary_10_1016_j_diff_2013_08_001 crossref_primary_10_1038_s41467_025_57521_2 crossref_primary_10_1242_jcs_260636 crossref_primary_10_1038_ncb3537 crossref_primary_10_1002_adhm_202100821 crossref_primary_10_1016_j_pbi_2015_10_005 crossref_primary_10_1038_s41467_017_01846_0 crossref_primary_10_1080_03008207_2021_1952193 crossref_primary_10_1016_j_matbio_2016_07_001 crossref_primary_10_1038_s41556_018_0270_5 crossref_primary_10_1016_j_cellsig_2016_10_002 crossref_primary_10_1016_j_ocarto_2020_100071 crossref_primary_10_1016_j_ejcb_2015_05_009 crossref_primary_10_1016_j_bbamcr_2015_11_014 crossref_primary_10_1016_j_nano_2016_06_011 crossref_primary_10_1111_wrr_12889 crossref_primary_10_1146_annurev_physiol_021317_121312 crossref_primary_10_1534_genetics_114_166876 crossref_primary_10_7554_eLife_07811 crossref_primary_10_1002_JLB_MR0318_126R crossref_primary_10_1016_j_ceca_2019_03_010 crossref_primary_10_1038_s41467_024_50126_1 crossref_primary_10_1167_iovs_17_23580 crossref_primary_10_3389_fphys_2018_00951 crossref_primary_10_1371_journal_pone_0128974 crossref_primary_10_1016_j_yexcr_2015_10_025 crossref_primary_10_1002_cm_21277 crossref_primary_10_1038_s41598_022_13324_9 crossref_primary_10_1152_physrev_00018_2013 crossref_primary_10_1152_ajpcell_00054_2020 crossref_primary_10_1007_s11011_025_01545_6 crossref_primary_10_1016_j_celrep_2015_02_023 crossref_primary_10_1371_journal_pone_0214385 crossref_primary_10_1186_s12929_015_0167_6 crossref_primary_10_1101_cshperspect_a029157 crossref_primary_10_1186_s13287_021_02356_z crossref_primary_10_1016_j_actbio_2021_11_015 crossref_primary_10_1007_s11926_014_0493_9 crossref_primary_10_1016_j_stemcr_2022_05_002 crossref_primary_10_1167_iovs_18_24258 crossref_primary_10_1097_MNH_0000000000000138 crossref_primary_10_1111_acel_12410 crossref_primary_10_1007_s12265_015_9630_8 crossref_primary_10_1038_ncomms11642 |
| Cites_doi | 10.1039/c2ib00149g 10.1073/pnas.1005998107 10.1002/cm.20041 10.1038/ncpcardio1397 10.1016/S0008-6363(00)00030-4 10.1152/ajpgi.00222.2012 10.1007/BF00210512 10.1097/00075198-200502000-00013 10.1016/j.celrep.2012.09.018 10.1529/biophysj.107.116863 10.2174/1381612043383755 10.1016/j.cell.2005.09.021 10.1016/j.devcel.2004.05.013 10.1242/jcs.112.17.2971 10.1016/j.ejcb.2005.09.004 10.1242/jcs.00360 10.1016/j.conb.2009.07.008 10.1016/j.mvr.2011.06.007 10.1007/s12013-009-9067-2 10.1097/00001756-200212200-00007 10.1038/18884 10.1042/BC20060039 10.1152/physrev.00043.2003 10.1128/MCB.00465-09 10.1007/s11883-007-0010-y 10.1002/hep.21802 10.1016/j.cld.2008.07.008 10.1016/S0002-9440(10)62353-X 10.1074/jbc.M109.075218 10.1164/rccm.201204-0754OC 10.1126/stke.110pe13 10.1074/jbc.R300038200 10.1002/hep.21792 10.3109/00016357309004617 10.1152/ajpheart.00515.2010 10.1097/MCC.0b013e3282f3a166 10.1038/jid.2011.219 10.1091/mbc.12.9.2730 10.2741/2681 10.1016/j.carpath.2010.10.001 10.1242/jcs.01232 10.1016/j.febslet.2010.08.033 10.1073/pnas.1106145108 10.1016/j.biomaterials.2009.09.002 10.1002/bit.24880 10.1074/jbc.M101898200 10.1074/jbc.272.16.10948 10.1016/j.joca.2010.11.004 10.1038/nature10137 10.1016/S1471-4914(03)00164-3 10.1016/j.bone.2010.03.014 10.1016/j.actbio.2012.10.012 10.1186/1423-0127-16-12 10.1161/CIRCRESAHA.108.177782 10.1016/j.ccr.2011.05.008 10.1152/japplphysiol.01121.2004 10.1074/jbc.M207681200 10.1152/ajpcell.00270.2007 10.1016/j.exer.2013.05.014 10.1152/ajpcell.1997.272.5.C1654 10.1038/nrm809 10.1038/ncb2074 10.1242/jcs.001586 10.1074/jbc.C110.212621 10.1016/j.jbiomech.2011.11.023 10.1371/journal.pone.0005262 10.1083/jcb.200704042 10.2741/3230 10.1016/j.bpj.2009.07.033 10.1016/S0092-8674(03)00278-2 10.1038/nrm1433 10.1016/j.cub.2012.08.050 10.1161/CIRCRESAHA.110.222588 10.1165/rcmb.2012-0050OC 10.1073/pnas.71.4.1286 10.1074/jbc.M203130200 10.1073/pnas.94.25.13661 10.1002/cbf.1077 10.1017/S1431927605050440 10.1038/ncb2055 10.1016/j.biomaterials.2009.05.050 10.1038/nrm3416 10.1002/hep.24108 10.1128/MCB.00154-10 10.1177/0022034509338914 10.1038/nm.2574 10.1161/ATVBAHA.110.220061 10.1529/biophysj.105.073114 10.1016/j.bpj.2009.03.046 10.1016/j.cub.2009.07.069 10.1161/01.RES.0000069031.55281.7C 10.1016/j.cell.2005.09.020 10.1074/jbc.M602308200 10.1016/j.bbamcr.2009.01.012 10.1016/S0021-9258(18)48383-4 10.1128/MCB.25.8.3173-3181.2005 10.1242/jcs.009852 10.1073/pnas.1103345108 10.1016/S0896-6273(03)00505-1 10.1038/ncomms1668 10.1167/iovs.12-11007 10.1083/jcb.201004082 10.1016/S0092-8674(01)00404-4 10.1074/jbc.M104106200 10.1186/1476-4598-9-35 10.1074/jbc.275.5.3088 10.1038/nature07765 10.1073/pnas.222561499 10.1111/j.1600-0765.2004.00782.x |
| ContentType | Journal Article |
| Copyright | 2013 International Society of Differentiation 2013 International Society of Differentiation. Published by Elsevier B.V. All rights reserved. |
| Copyright_xml | – notice: 2013 International Society of Differentiation – notice: 2013 International Society of Differentiation. Published by Elsevier B.V. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 5PM |
| DOI | 10.1016/j.diff.2013.07.004 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE AGRICOLA MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1432-0436 |
| EndPage | 120 |
| ExternalDocumentID | PMC4545622 23969122 10_1016_j_diff_2013_07_004 S0301468113000613 |
| Genre | Journal Article Review |
| GeographicLocations | Yap |
| GeographicLocations_xml | – name: Yap |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: R01 CA072639 |
| GroupedDBID | --- --K --M -~X .3N .GJ .~1 0R~ 1B1 1OC 1RT 1VV 1~. 29G 31~ 36B 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 8-1 8P~ 9JM 9M8 AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABFNM ABFRF ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIWK ACPRK ACRLP ACXQS ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFBPY AFEBI AFKWA AFTJW AFXIZ AFZJQ AGHFR AGRDE AGUBO AGYEJ AHEFC AHHHB AI. AIEXJ AIKHN AITUG AJAOE AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BFHJK BKOJK BLXMC CAG CO8 COF CS3 DCZOG DOVZS DU5 EBS EFJIC EFLBG EJD EMB EMOBN F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 GBLVA HLW HVGLF HZ~ H~9 IH2 IHE KOM LAS LH4 LW6 M41 MO0 O-L O9- OAUVE OBS OVD P-8 P-9 P2P PC. Q38 R2- RIG ROL SBG SDF SDH SES SPCBC SSU SSZ SV3 T5K TEORI TN5 UNMZH VH1 W99 WH7 WUQ YFH YUY ZGI ZXP ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD AGCQF AGRNS BNPGV CGR CUY CVF ECM EIF NPM SSH 7X8 7S9 L.6 5PM |
| ID | FETCH-LOGICAL-c510t-9649b4f641156463bedd2e7c6c9ba30eb1121ef146759e5d306ec0323ef970a83 |
| IEDL.DBID | .~1 |
| ISSN | 0301-4681 1432-0436 |
| IngestDate | Tue Sep 30 15:25:20 EDT 2025 Sun Sep 28 01:45:36 EDT 2025 Fri Sep 05 12:00:46 EDT 2025 Mon Jul 21 05:48:57 EDT 2025 Thu Apr 24 23:01:18 EDT 2025 Wed Oct 01 04:58:12 EDT 2025 Fri Feb 23 02:29:36 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Substrate stiffness Mechanotransduction Mechanosensing Mechanical stress |
| Language | English |
| License | 2013 International Society of Differentiation. Published by Elsevier B.V. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c510t-9649b4f641156463bedd2e7c6c9ba30eb1121ef146759e5d306ec0323ef970a83 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 23969122 |
| PQID | 1443383408 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4545622 proquest_miscellaneous_1733523357 proquest_miscellaneous_1443383408 pubmed_primary_23969122 crossref_citationtrail_10_1016_j_diff_2013_07_004 crossref_primary_10_1016_j_diff_2013_07_004 elsevier_sciencedirect_doi_10_1016_j_diff_2013_07_004 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-10-01 |
| PublicationDateYYYYMMDD | 2013-10-01 |
| PublicationDate_xml | – month: 10 year: 2013 text: 2013-10-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Differentiation (London) |
| PublicationTitleAlternate | Differentiation |
| PublicationYear | 2013 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Perepelyuk, M., Terajima, M., Wang, A.Y., Georges, P.C., Janmey, P.A., Yamauchi, M., Wells, R.G., 2013. Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury. American Journal of Physiology—Gastrointestinal and Liver Physiology 304, G605-614. Banerjee, Arha, Choudhary, Ashton, Bhatia, Schaffer, Kane (bib2) 2009; 30 Huang, Yang, Fiore, Barker, Sun, Morris, Ding, Thannickal, Zhou (bib45) 2012; 47 Wang, Su, Fan, Seth, McCulloch (bib108) 2002; 277 Georges, Miller, Meaney, Sawyer, Janmey (bib34) 2006; 90 D′Addario, Arora, Ellen, McCulloch (bib19) 2002; 277 Roca-Cusachs, Alcaraz, Sunyer, Samitier, Farre, Navajas (bib87) 2008; 94 Her, Wu, Chen, Chen, Chang, Wang (bib41) 2013; 9 Mammoto, Connor, Mammoto, Yung, Huh, Aderman, Mostoslavsky, Smith, Ingber (bib70) 2009; 457 Byfield, Wen, Levental, Nordstrom, Arratia, Miller, Janmey (bib6) 2009; 96 Georges, Janmey (bib33) 2005; 98 Zebda, Dubrovskyi, Birukov (bib119) 2012; 83 Wozniak, Cheng, Shen, Gao, Olarerin-George, Won, Hogenesch, Chen (bib113) 2012; 22 Crider, Risinger, Haaksma, Howard, Tomasek (bib18) 2011; 131 Raghunathan, Morgan, Dreier, Reilly, Thomasy, Wood, Ly, Tuyen, Hughbanks, Murphy, Russell (bib85) 2013; 54 Kumar, Hendrix, Johnson, Owens (bib58) 2003; 92 Kuwahara, Kinoshita, Kuwabara, Nakagawa, Usami, Minami, Yamada, Fujiwara, Nakao (bib60) 2010; 30 Kobielak, Fuchs (bib53) 2004; 5 Levental, Levental, Klein, Assoian, Miller, Wells, Janmey (bib63) 2010; 22 Duprez, Cohn (bib24) 2007; 9 Li, Dranoff, Chan, Uemura, Sevigny, Wells (bib65) 2007; 46 Potard, Butler, Wang (bib84) 1997; 272 MacKenna, Summerour, Villarreal (bib69) 2000; 46 Wang, Li, Hockemeyer, Sutherland, Wang, Schratt, Richardson, Nordheim, Olson (bib107) 2002; 99 Ozaki, Kaneko, Podyma-Inoue, Yanagishita, Soma (bib79) 2005; 40 Wells (bib109) 2008; 12 Demicheva, Hecker, Korff (bib21) 2008; 103 Pardo, Lopez, Boriek (bib81) 2008; 294 Hinz (bib42) 2006; 85 Schrader, Gordon-Walker, Aucott, van Deemter, Quaas, Walsh, Benten, Forbes, Wells, Iredale (bib92) 2011; 53 Robinson, Chatterjee-Kishore, Yaworsky, Cullen, Zhao, Li, Kharode, Sauter, Babij, Brown, Hill, Akhter, Johnson, Recker, Komm, Bex (bib86) 2006; 281 Wang, Chang, Wang, Sutherland, Richardson, Small, Krieg, Olson (bib106) 2001; 105 Cheng, Wang, Ma, Chan, Yang, Liang, Zhang, Li, Du (bib12) 2010; 107 Elsharkawy, Mann (bib26) 2007; 46 Olsen, Bloomer, Chan, Gaca, Georges, Sackey, Uemura, Janmey, Wells (bib78) 2011; 301 Chen, Tan, Tien (bib10) 2004; 6 Li, Hata, Kosugi, Kataoka, Funaki (bib64) 2010; 584 Syntichaki, Tavernarakis (bib96) 2004; 84 Tarone, Lembo (bib97) 2003; 9 Stenqvist, Odenstedt, Lundin (bib95) 2008; 14 Leipzig, Shoichet (bib62) 2009; 30 Sandbo, Lau, Kach, Ngam, Yau, Dulin (bib91) 2011; 301 Martins, Finan, Guilak, Lee (bib73) 2012; 14 Yeung, Georges, Flanagan, Marg, Ortiz, Funaki, Zahir, Ming, Weaver, Janmey (bib115) 2005; 60 Dupont, Morsut, Aragona, Enzo, Giulitti, Cordenonsi, Zanconato, Le Digabel, Forcato, Bicciato, Elvassore, Piccolo (bib23) 2011; 474 Georges, Hui, Gombos, McCormick, Wang, Uemura, Mick, Janmey, Furth, Wells (bib32) 2007; 293 Liu, Mih, Shea, Kho, Sharif, Tager, Tschumperlin (bib68) 2010; 190 Krishnan, Davidovitch (bib56) 2009; 88 Young, Gerard-O′Riley, Harrington, Pavalko (bib118) 2010; 47 Hinz, Celetta, Tomasek, Gabbiani, Chaponnier (bib43) 2001; 12 Halder, Dupont, Piccolo (bib36) 2012; 13 Booth, Hadley, Cornett, Dreffs, Matthes, Tsui, Weiss, Horowitz, Fiore, Barker, Moore, Martinez, Niklason, White (bib5) 2012; 186 Hansen, Albrecht (bib37) 1999; 112 Zhao, Laschinger, Arora, Szaszi, Kapus, McCulloch (bib120) 2007; 120 Franze, Gerdelmann, Weick, Betz, Pawlizak, Lakadamyali, Bayer, Rillich, Gogler, Lu, Reichenbach, Janmey, Kas (bib28) 2009; 97 Yin, Kuebler (bib116) 2010; 56 Fringer, Grinnell (bib29) 2001; 276 Martinac (bib72) 2004; 117 Tetsunaga, Nishida, Furumatsu, Naruse, Hirohata, Yoshida, Saito, Ozaki (bib99) 2011; 19 Thomasy, Morgan, Wood, Murphy, Russell (bib100) 2013; 113C Kim, Koh, Chen, Gumbiner (bib49) 2011; 108 Hsieh, Hsiao, Wu, Liu, Tsai, Chao, Wang, Hsieh (bib44) 2009; 16 Hautmann, Madsen, Owens (bib38) 1997; 272 Ingber (bib46) 2003; 116 Rygh (bib89) 1973; 31 Linask, Manisastry, Han (bib66) 2005; 11 Hellman, Liu, Merkel, Austin, Le Corre, Beier, Sun, Sharma, Yoder, Drummond (bib39) 2011; 107 Klein, Yin, Kothapalli, Castagnino, Byfield, Xu, Levental, Hawthorne, Janmey, Assoian (bib51) 2009; 19 Skerry, Suva (bib93) 2003; 21 Kothapalli, Liu, Bae, Monslow, Xu, Hawthorne, Byfield, Castagnino, Rao, Rader, Pure, Phillips, Lund-Katz, Janmey, Assoian (bib55) 2012; 2 Tomasek, Gabbiani, Hinz, Chaponnier, Brown (bib101) 2002; 3 Helmke, Schwartz (bib40) 2004; 6 Galie, Westfall, Stegemann (bib30) 2011; 20 Kostic, Sap, Sheetz (bib54) 2007; 120 Lionetti, Recchia, Ranieri (bib67) 2005; 11 Corey (bib17) 2003; 39 Migliorini, Ban, Grenci, Andolfi, Pozzato, Tormen, Torre, Lazzarino (bib74) 2013; 110 Mitchell, Hwang, Vasan, Larson, Pencina, Hamburg, Vita, Levy, Benjamin (bib76) 2010; 121 Betz, Koch, Lu, Franze, Kas (bib3) 2011; 108 Katsumi, Orr, Tzima, Schwartz (bib48) 2004; 279 Wipff, Rifkin, Meister, Hinz (bib111) 2007; 179 Samuel, Lopez, McGhee, Croft, Strachan, Timpson, Munro, Schroder, Zhou, Brunton, Barker, Clevers, Sansom, Anderson, Weaver, Olson (bib90) 2011; 19 Versaevel, Grevesse, Gabriele (bib105) 2012; 3 Kuwahara, Barrientos, Pipes, Li, Olson (bib59) 2005; 25 Martin (bib71) 2007; 7 Yonemura, Wada, Watanabe, Nagafuchi, Shibata (bib117) 2010; 12 Pelham, Wang (bib82) 1997; 94 Turner, Robling (bib104) 2004; 10 Miralles, Posern, Zaromytidou, Treisman (bib75) 2003; 113 Tsunozaki, Bautista (bib103) 2009; 19 Catalucci, Latronico, Ellingsen, Condorelli (bib7) 2008; 13 Davies (bib20) 2009; 6 Gottlieb, Suchyna, Ostrow, Sachs (bib35) 2004; 3 Jiang, Austin, Niederhoff, Manson, Riehm, Cook, Pengue, Chitaley, Nakayama, Nakayama, Weintraub (bib47) 2009; 29 Ko, Arora, McCulloch (bib52) 2001; 276 Pardee (bib80) 1974; 71 Chan, Chaudary, Lee, Copeland, McCulloch (bib8) 2010; 285 Chopra, Tabdanov, Patel, Janmey, Kresh (bib15) 2011; 300 Connelly, Gautrot, Trappmann, Tan, Donati, Huck, Watt (bib16) 2010; 12 Lam, Cao, Umesh, Keung, Sen, Kumar (bib61) 2010; 9 Nam, Aguda, Rath, Agarwal (bib77) 2009; 4 Squier (bib94) 1981; 220 Blank, McQuinn, Yin, Thompson, Takeyasu, Schwartz, Owens (bib4) 1992; 267 Kshitiz, Hubbi, Ahn, Downey, Afzal, Kim, Rey, Chang, Kundu, Semenza, Abraham, Levchenko (bib57) 2012; 5, ra41 Chopra, Lin, McCollough, Atzet, Prestwich, Wechsler, Murray, Oake, Kresh, Janmey (bib14) 2012; 45 Kiselyov, Patterson (bib50) 2009; 14 Chiquet, Gelman, Lutz, Maier (bib13) 2009; 1793 Drees, Pokutta, Yamada, Nelson, Weis (bib22) 2005; 123 Ganz, Lambert, Saez, Silberzan, Buguin, Mege, Ladoux (bib31) 2006; 98 Wells, Discher (bib110) 2008; 1 Rosenfeldt, Grinnell (bib88) 2000; 275 Tomasek, McRae, Owens, Haaksma (bib102) 2005; 166 Tetsu, McCormick (bib98) 1999; 398 Balestrini, Chaudhry, Sarrazy, Koehler, Hinz (bib1) 2012; 4 Chan, Lim, Chong, Pobbati, Huang, Hong (bib9) 2011; 286 Flanagan, Ju, Marg, Osterfield, Janmey (bib27) 2002; 13 Chen, Chen, Sider, Yip, Simmons (bib11) 2011; 31 Elberg, Chen, Elberg, Chan, Logan, Turman (bib25) 2008; 294 Wong, Rustad, Akaishi, Sorkin, Glotzbach, Januszyk, Nelson, Levi, Paterno, Vial, Kuang, Longaker, Gurtner (bib112) 2012; 18 Yamada, Pokutta, Drees, Weis, Nelson (bib114) 2005; 123 Pelham (10.1016/j.diff.2013.07.004_bib82) 1997; 94 Jiang (10.1016/j.diff.2013.07.004_bib47) 2009; 29 Blank (10.1016/j.diff.2013.07.004_bib4) 1992; 267 Elsharkawy (10.1016/j.diff.2013.07.004_bib26) 2007; 46 Stenqvist (10.1016/j.diff.2013.07.004_bib95) 2008; 14 Pardee (10.1016/j.diff.2013.07.004_bib80) 1974; 71 Squier (10.1016/j.diff.2013.07.004_bib94) 1981; 220 Tomasek (10.1016/j.diff.2013.07.004_bib102) 2005; 166 Georges (10.1016/j.diff.2013.07.004_bib33) 2005; 98 Hsieh (10.1016/j.diff.2013.07.004_bib44) 2009; 16 Leipzig (10.1016/j.diff.2013.07.004_bib62) 2009; 30 Drees (10.1016/j.diff.2013.07.004_bib22) 2005; 123 Elberg (10.1016/j.diff.2013.07.004_bib25) 2008; 294 Ganz (10.1016/j.diff.2013.07.004_bib31) 2006; 98 Mitchell (10.1016/j.diff.2013.07.004_bib76) 2010; 121 Martinac (10.1016/j.diff.2013.07.004_bib72) 2004; 117 Tetsu (10.1016/j.diff.2013.07.004_bib98) 1999; 398 Yamada (10.1016/j.diff.2013.07.004_bib114) 2005; 123 Banerjee (10.1016/j.diff.2013.07.004_bib2) 2009; 30 Chan (10.1016/j.diff.2013.07.004_bib8) 2010; 285 Gottlieb (10.1016/j.diff.2013.07.004_bib35) 2004; 3 Young (10.1016/j.diff.2013.07.004_bib118) 2010; 47 Tomasek (10.1016/j.diff.2013.07.004_bib101) 2002; 3 Wang (10.1016/j.diff.2013.07.004_bib106) 2001; 105 Flanagan (10.1016/j.diff.2013.07.004_bib27) 2002; 13 Zhao (10.1016/j.diff.2013.07.004_bib120) 2007; 120 Rosenfeldt (10.1016/j.diff.2013.07.004_bib88) 2000; 275 Wang (10.1016/j.diff.2013.07.004_bib107) 2002; 99 Hinz (10.1016/j.diff.2013.07.004_bib42) 2006; 85 Georges (10.1016/j.diff.2013.07.004_bib32) 2007; 293 Kostic (10.1016/j.diff.2013.07.004_bib54) 2007; 120 Davies (10.1016/j.diff.2013.07.004_bib20) 2009; 6 Martins (10.1016/j.diff.2013.07.004_bib73) 2012; 14 Krishnan (10.1016/j.diff.2013.07.004_bib56) 2009; 88 Levental (10.1016/j.diff.2013.07.004_bib63) 2010; 22 Miralles (10.1016/j.diff.2013.07.004_bib75) 2003; 113 Ozaki (10.1016/j.diff.2013.07.004_bib79) 2005; 40 Samuel (10.1016/j.diff.2013.07.004_bib90) 2011; 19 Connelly (10.1016/j.diff.2013.07.004_bib16) 2010; 12 Ko (10.1016/j.diff.2013.07.004_bib52) 2001; 276 Roca-Cusachs (10.1016/j.diff.2013.07.004_bib87) 2008; 94 Martin (10.1016/j.diff.2013.07.004_bib71) 2007; 7 Wang (10.1016/j.diff.2013.07.004_bib108) 2002; 277 Lam (10.1016/j.diff.2013.07.004_bib61) 2010; 9 Dupont (10.1016/j.diff.2013.07.004_bib23) 2011; 474 Huang (10.1016/j.diff.2013.07.004_bib45) 2012; 47 Balestrini (10.1016/j.diff.2013.07.004_bib1) 2012; 4 Syntichaki (10.1016/j.diff.2013.07.004_bib96) 2004; 84 Catalucci (10.1016/j.diff.2013.07.004_bib7) 2008; 13 Helmke (10.1016/j.diff.2013.07.004_bib40) 2004; 6 Fringer (10.1016/j.diff.2013.07.004_bib29) 2001; 276 Yonemura (10.1016/j.diff.2013.07.004_bib117) 2010; 12 Halder (10.1016/j.diff.2013.07.004_bib36) 2012; 13 Wozniak (10.1016/j.diff.2013.07.004_bib113) 2012; 22 Crider (10.1016/j.diff.2013.07.004_bib18) 2011; 131 MacKenna (10.1016/j.diff.2013.07.004_bib69) 2000; 46 Tsunozaki (10.1016/j.diff.2013.07.004_bib103) 2009; 19 Kiselyov (10.1016/j.diff.2013.07.004_bib50) 2009; 14 Robinson (10.1016/j.diff.2013.07.004_bib86) 2006; 281 Rygh (10.1016/j.diff.2013.07.004_bib89) 1973; 31 Schrader (10.1016/j.diff.2013.07.004_bib92) 2011; 53 Linask (10.1016/j.diff.2013.07.004_bib66) 2005; 11 Hinz (10.1016/j.diff.2013.07.004_bib43) 2001; 12 Cheng (10.1016/j.diff.2013.07.004_bib12) 2010; 107 Chiquet (10.1016/j.diff.2013.07.004_bib13) 2009; 1793 Olsen (10.1016/j.diff.2013.07.004_bib78) 2011; 301 Liu (10.1016/j.diff.2013.07.004_bib68) 2010; 190 Galie (10.1016/j.diff.2013.07.004_bib30) 2011; 20 Yin (10.1016/j.diff.2013.07.004_bib116) 2010; 56 Booth (10.1016/j.diff.2013.07.004_bib5) 2012; 186 Chen (10.1016/j.diff.2013.07.004_bib10) 2004; 6 Hellman (10.1016/j.diff.2013.07.004_bib39) 2011; 107 Li (10.1016/j.diff.2013.07.004_bib64) 2010; 584 Nam (10.1016/j.diff.2013.07.004_bib77) 2009; 4 Kobielak (10.1016/j.diff.2013.07.004_bib53) 2004; 5 Chan (10.1016/j.diff.2013.07.004_bib9) 2011; 286 Hautmann (10.1016/j.diff.2013.07.004_bib38) 1997; 272 Demicheva (10.1016/j.diff.2013.07.004_bib21) 2008; 103 Klein (10.1016/j.diff.2013.07.004_bib51) 2009; 19 Katsumi (10.1016/j.diff.2013.07.004_bib48) 2004; 279 10.1016/j.diff.2013.07.004_bib83 Raghunathan (10.1016/j.diff.2013.07.004_bib85) 2013; 54 Thomasy (10.1016/j.diff.2013.07.004_bib100) 2013; 113C Kshitiz (10.1016/j.diff.2013.07.004_bib57) 2012; 5, ra41 Wells (10.1016/j.diff.2013.07.004_bib109) 2008; 12 Duprez (10.1016/j.diff.2013.07.004_bib24) 2007; 9 Chopra (10.1016/j.diff.2013.07.004_bib15) 2011; 300 Georges (10.1016/j.diff.2013.07.004_bib34) 2006; 90 Lionetti (10.1016/j.diff.2013.07.004_bib67) 2005; 11 Ingber (10.1016/j.diff.2013.07.004_bib46) 2003; 116 Turner (10.1016/j.diff.2013.07.004_bib104) 2004; 10 Pardo (10.1016/j.diff.2013.07.004_bib81) 2008; 294 Migliorini (10.1016/j.diff.2013.07.004_bib74) 2013; 110 Tarone (10.1016/j.diff.2013.07.004_bib97) 2003; 9 Franze (10.1016/j.diff.2013.07.004_bib28) 2009; 97 Kim (10.1016/j.diff.2013.07.004_bib49) 2011; 108 Byfield (10.1016/j.diff.2013.07.004_bib6) 2009; 96 Tetsunaga (10.1016/j.diff.2013.07.004_bib99) 2011; 19 Wong (10.1016/j.diff.2013.07.004_bib112) 2012; 18 Kothapalli (10.1016/j.diff.2013.07.004_bib55) 2012; 2 Li (10.1016/j.diff.2013.07.004_bib65) 2007; 46 Kuwahara (10.1016/j.diff.2013.07.004_bib60) 2010; 30 Wipff (10.1016/j.diff.2013.07.004_bib111) 2007; 179 Chen (10.1016/j.diff.2013.07.004_bib11) 2011; 31 Chopra (10.1016/j.diff.2013.07.004_bib14) 2012; 45 D′Addario (10.1016/j.diff.2013.07.004_bib19) 2002; 277 Mammoto (10.1016/j.diff.2013.07.004_bib70) 2009; 457 Yeung (10.1016/j.diff.2013.07.004_bib115) 2005; 60 Betz (10.1016/j.diff.2013.07.004_bib3) 2011; 108 Zebda (10.1016/j.diff.2013.07.004_bib119) 2012; 83 Her (10.1016/j.diff.2013.07.004_bib41) 2013; 9 Wells (10.1016/j.diff.2013.07.004_bib110) 2008; 1 Kumar (10.1016/j.diff.2013.07.004_bib58) 2003; 92 Hansen (10.1016/j.diff.2013.07.004_bib37) 1999; 112 Kuwahara (10.1016/j.diff.2013.07.004_bib59) 2005; 25 Potard (10.1016/j.diff.2013.07.004_bib84) 1997; 272 Corey (10.1016/j.diff.2013.07.004_bib17) 2003; 39 Versaevel (10.1016/j.diff.2013.07.004_bib105) 2012; 3 Sandbo (10.1016/j.diff.2013.07.004_bib91) 2011; 301 Skerry (10.1016/j.diff.2013.07.004_bib93) 2003; 21 |
| References_xml | – volume: 5, ra41 year: 2012 ident: bib57 article-title: Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors publication-title: Science Signaling – volume: 46 start-page: 257 year: 2000 end-page: 263 ident: bib69 article-title: Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis publication-title: Cardiovascular Research – volume: 60 start-page: 24 year: 2005 end-page: 34 ident: bib115 article-title: Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion publication-title: Cell Motility and the Cytoskeleton – volume: 12 start-page: 533 year: 2010 end-page: 542 ident: bib117 article-title: alpha-Catenin as a tension transducer that induces adherens junction development publication-title: Nature Cell Biology – volume: 276 start-page: 35967 year: 2001 end-page: 35977 ident: bib52 article-title: Cadherins mediate intercellular mechanical signaling in fibroblasts by activation of stretch-sensitive calcium-permeable channels publication-title: Journal of Biological Chemistry – volume: 9 start-page: 376 year: 2003 end-page: 382 ident: bib97 article-title: Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy publication-title: Trends in Molecular Medicine – volume: 117 start-page: 2449 year: 2004 end-page: 2460 ident: bib72 article-title: Mechanosensitive ion channels: molecules of mechanotransduction publication-title: Journal of Cell Science – volume: 108 start-page: 13420 year: 2011 end-page: 13425 ident: bib3 article-title: Growth cones as soft and weak force generators publication-title: Proceedings of the National Academy of Sciences of United States America – volume: 103 start-page: 477 year: 2008 end-page: 484 ident: bib21 article-title: Stretch-induced activation of the transcription factor activator protein-1 controls monocyte chemoattractant protein-1 expression during arteriogenesis publication-title: Circulation Research – volume: 16 start-page: 12 year: 2009 ident: bib44 article-title: Regulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells publication-title: Journal of Biomedical Science – volume: 279 start-page: 12001 year: 2004 end-page: 12004 ident: bib48 article-title: Integrins in mechanotransduction publication-title: Journal of Biological Chemistry – volume: 14 start-page: 431 year: 2012 end-page: 455 ident: bib73 article-title: Mechanical regulation of nuclear structure and function publication-title: Proceedings of the National Academy of Sciences of United States of America – volume: 9 start-page: 139 year: 2007 end-page: 144 ident: bib24 article-title: Arterial stiffness as a risk factor for coronary atherosclerosis publication-title: Current Atherosclerosis Reports – volume: 220 start-page: 325 year: 1981 end-page: 335 ident: bib94 article-title: The effect of stretching on formation of myofibroblasts in mouse skin publication-title: Cell and Tissue Research – volume: 131 start-page: 2378 year: 2011 end-page: 2385 ident: bib18 article-title: Myocardin-related transcription factors A and B are key regulators of TGF-beta1-induced fibroblast to myofibroblast differentiation publication-title: Journal of Investigative Dermatology – volume: 105 start-page: 851 year: 2001 end-page: 862 ident: bib106 article-title: Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor publication-title: Cell – volume: 267 start-page: 984 year: 1992 end-page: 989 ident: bib4 article-title: Elements of the smooth muscle alpha-actin promoter required in cis for transcriptional activation in smooth muscle. Evidence for cell type-specific regulation publication-title: Journal of Biological Chemistry – volume: 13 start-page: 591 year: 2012 end-page: 600 ident: bib36 article-title: Transduction of mechanical and cytoskeletal cues by YAP and TAZ publication-title: Nature Reviews Molecular Cell Biology – volume: 71 start-page: 1286 year: 1974 end-page: 1290 ident: bib80 article-title: A restriction point for control of normal animal cell proliferation publication-title: Proceedings of the National Academy of Sciences of United States of America – volume: 47 start-page: 340 year: 2012 end-page: 348 ident: bib45 article-title: Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction publication-title: American Journal of Respiratory Cell and Molecular Biology – volume: 30 start-page: 6867 year: 2009 end-page: 6878 ident: bib62 article-title: The effect of substrate stiffness on adult neural stem cell behavior publication-title: Biomaterials – volume: 94 start-page: 4984 year: 2008 end-page: 4995 ident: bib87 article-title: Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation publication-title: Biophysical Journal – volume: 120 start-page: 1801 year: 2007 end-page: 1809 ident: bib120 article-title: Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathway publication-title: Journal of Cell Science – volume: 7 start-page: 48 year: 2007 end-page: 53 ident: bib71 article-title: The importance of mechanical loading in bone biology and medicine publication-title: Journal of Musculoskeletal and Neuronal Interactions – volume: 301 start-page: L656 year: 2011 end-page: 666 ident: bib91 article-title: Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-beta publication-title: American Journal of Physiology – volume: 46 start-page: 590 year: 2007 end-page: 597 ident: bib26 article-title: Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis publication-title: Hepatology – volume: 30 start-page: 4134 year: 2010 end-page: 4148 ident: bib60 article-title: Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression publication-title: Molecular and Cellular Biology – volume: 12 start-page: 759 year: 2008 end-page: 768 ident: bib109 article-title: Cellular sources of extracellular matrix in hepatic fibrosis publication-title: Clinics In Liver Disease – volume: 12 start-page: 2730 year: 2001 end-page: 2741 ident: bib43 article-title: Alpha-smooth muscle actin expression upregulates fibroblast contractile activity publication-title: Molecular Biology of the Cell – volume: 121 start-page: 505 year: 2010 end-page: 511 ident: bib76 article-title: Arterial stiffness and cardiovascular events: the Framingham heart study publication-title: Circulation – volume: 39 start-page: 585 year: 2003 end-page: 588 ident: bib17 article-title: New TRP channels in hearing and mechanosensation publication-title: Neuron – volume: 99 start-page: 14855 year: 2002 end-page: 14860 ident: bib107 article-title: Potentiation of serum response factor activity by a family of myocardin-related transcription factors publication-title: Proceedings of the National Academy of Sciences of United States of America – volume: 474 start-page: 179 year: 2011 end-page: 183 ident: bib23 article-title: Role of YAP/TAZ in mechanotransduction publication-title: Nature – volume: 54 start-page: 378 year: 2013 end-page: 386 ident: bib85 article-title: Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ publication-title: Investigative Ophthalmology and Visual Science – reference: Perepelyuk, M., Terajima, M., Wang, A.Y., Georges, P.C., Janmey, P.A., Yamauchi, M., Wells, R.G., 2013. Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury. American Journal of Physiology—Gastrointestinal and Liver Physiology 304, G605-614. – volume: 18 start-page: 148 year: 2012 end-page: 152 ident: bib112 article-title: Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling publication-title: Nature Medicine – volume: 277 start-page: 47541 year: 2002 end-page: 47550 ident: bib19 article-title: Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A publication-title: Journal of Biological Chemistry – volume: 179 start-page: 1311 year: 2007 end-page: 1323 ident: bib111 article-title: Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix publication-title: Journal of Cell Biology – volume: 56 start-page: 1 year: 2010 end-page: 18 ident: bib116 article-title: Mechanotransduction by TRP channels: general concepts and specific role in the vasculature publication-title: Cell Biochemistry and Biophysics – volume: 47 start-page: 74 year: 2010 end-page: 82 ident: bib118 article-title: Activation of NF-kappaB by fluid shear stress, but not TNF-alpha, requires focal adhesion kinase in osteoblasts publication-title: Bone – volume: 3 start-page: 287 year: 2004 end-page: 295 ident: bib35 article-title: Mechanosensitive ion channels as drug targets publication-title: Current Drug Targets – volume: 116 start-page: 1397 year: 2003 end-page: 1408 ident: bib46 article-title: Tensegrity II. How structural networks influence cellular information processing networks publication-title: Journal of Cell Science – volume: 19 start-page: 362 year: 2009 end-page: 369 ident: bib103 article-title: Mammalian somatosensory mechanotransduction publication-title: Current Opinion in Neurobiology – volume: 22 start-page: 194120 year: 2010 ident: bib63 article-title: A simple indentation device for measuring micrometer-scale tissue stiffness publication-title: Journal of Physics – volume: 29 start-page: 5104 year: 2009 end-page: 5114 ident: bib47 article-title: Mechanoregulation of proliferation publication-title: Molecular and Cellular Biology – volume: 5 start-page: 614 year: 2004 end-page: 625 ident: bib53 article-title: Alpha-catenin: at the junction of intercellular adhesion and actin dynamics publication-title: Nature Reviews Molecular Cell Biology – volume: 6 start-page: 275 year: 2004 end-page: 302 ident: bib10 article-title: Mechanotransduction at cell-matrix and cell-cell contacts publication-title: Proceedings of the National Academy of Sciences of United States of America – volume: 19 start-page: 222 year: 2011 end-page: 232 ident: bib99 article-title: Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells publication-title: Osteoarthritis and Cartilage – volume: 123 start-page: 903 year: 2005 end-page: 915 ident: bib22 article-title: Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly publication-title: Cell – volume: 13 start-page: 2411 year: 2002 end-page: 2415 ident: bib27 article-title: Neurite branching on deformable substrates publication-title: Neuroreport – volume: 14 start-page: 87 year: 2008 end-page: 93 ident: bib95 article-title: Dynamic respiratory mechanics in acute lung injury/acute respiratory distress syndrome: research or clinical tool? publication-title: Current Opinion in Critical Care – volume: 108 start-page: 11930 year: 2011 end-page: 11935 ident: bib49 article-title: E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components publication-title: Proceedings of the National Academy of Sciences of United States of America – volume: 53 start-page: 1192 year: 2011 end-page: 1205 ident: bib92 article-title: Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells publication-title: Hepatology – volume: 584 start-page: 4145 year: 2010 end-page: 4150 ident: bib64 article-title: The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes publication-title: FEBS Letters – volume: 30 start-page: 4695 year: 2009 end-page: 4699 ident: bib2 article-title: The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells publication-title: Biomaterials – volume: 20 start-page: 325 year: 2011 end-page: 333 ident: bib30 article-title: Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matrices publication-title: Cardiovascular Pathology – volume: 92 start-page: 840 year: 2003 end-page: 847 ident: bib58 article-title: Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins publication-title: Circulation Research – volume: 1 start-page: pe13 year: 2008 ident: bib110 article-title: Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet publication-title: Science Signaling – volume: 13 start-page: 312 year: 2008 end-page: 324 ident: bib7 article-title: Physiological myocardial hypertrophy: how and why? publication-title: Frontiers in Bioscience – volume: 286 start-page: 7018 year: 2011 end-page: 7026 ident: bib9 article-title: Hippo pathway-independent restriction of TAZ and YAP by angiomotin publication-title: Journal of Biological Chemistry – volume: 31 start-page: 590 year: 2011 end-page: 597 ident: bib11 article-title: beta-catenin mediates mechanically regulated, transforming growth factor-beta1-induced myofibroblast differentiation of aortic valve interstitial cells publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology – volume: 94 start-page: 13661 year: 1997 end-page: 13665 ident: bib82 article-title: Cell locomotion and focal adhesions are regulated by substrate flexibility publication-title: Proceedings of the National Academy of Sciences of United States of America – volume: 84 start-page: 1097 year: 2004 end-page: 1153 ident: bib96 article-title: Genetic models of mechanotransduction: the nematode publication-title: Physiological Reviews – volume: 45 start-page: 824 year: 2012 end-page: 831 ident: bib14 article-title: Reprogramming cardiomyocyte mechanosensing by crosstalk between integrins and hyaluronic acid receptors publication-title: Journal of Biomechanics – volume: 6 start-page: 16 year: 2009 end-page: 26 ident: bib20 article-title: Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology publication-title: Nature Clinical Practice Cardiovascular Medicine – volume: 10 start-page: 2629 year: 2004 end-page: 2641 ident: bib104 article-title: Exercise as an anabolic stimulus for bone publication-title: Current Pharmaceutical Design – volume: 294 start-page: C1056 year: 2008 end-page: 1066 ident: bib81 article-title: FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump publication-title: American Journal of Physiology—Cell Physiology – volume: 97 start-page: 1883 year: 2009 end-page: 1890 ident: bib28 article-title: Neurite branch retraction is caused by a threshold-dependent mechanical impact publication-title: Biophysical Journal – volume: 457 start-page: 1103 year: 2009 end-page: 1108 ident: bib70 article-title: A mechanosensitive transcriptional mechanism that controls angiogenesis publication-title: Nature – volume: 293 start-page: G1147 year: 2007 end-page: 1154 ident: bib32 article-title: Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis publication-title: American Journal of Physiology – volume: 285 start-page: 9273 year: 2010 end-page: 9281 ident: bib8 article-title: Force-induced myofibroblast differentiation through collagen receptors is dependent on mammalian diaphanous (mDia) publication-title: Journal of Biological Chemistry – volume: 88 start-page: 597 year: 2009 end-page: 608 ident: bib56 article-title: On a path to unfolding the biological mechanisms of orthodontic tooth movement publication-title: Journal of Dental Research – volume: 294 start-page: F1116 year: 2008 end-page: 1128 ident: bib25 article-title: MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells publication-title: American Journal of Physiology – volume: 22 start-page: 2017 year: 2012 end-page: 2026 ident: bib113 article-title: Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch publication-title: Current Biology – volume: 11 start-page: 200 year: 2005 end-page: 208 ident: bib66 article-title: Cross talk between cell-cell and cell-matrix adhesion signaling pathways during heart organogenesis: implications for cardiac birth defects publication-title: Microscopy and Microanalysis – volume: 40 start-page: 110 year: 2005 end-page: 117 ident: bib79 article-title: Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress publication-title: Journal of Periodontal Research – volume: 398 start-page: 422 year: 1999 end-page: 426 ident: bib98 article-title: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells publication-title: Nature – volume: 98 start-page: 1547 year: 2005 end-page: 1553 ident: bib33 article-title: Cell type-specific response to growth on soft materials publication-title: Journal of Applied Physiology – volume: 272 start-page: C1654 year: 1997 end-page: 1663 ident: bib84 article-title: Cytoskeletal mechanics in confluent epithelial cells probed through integrins and E-cadherins publication-title: American Journal of Physiology – volume: 166 start-page: 1343 year: 2005 end-page: 1351 ident: bib102 article-title: Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element publication-title: American Journal of Pathology – volume: 19 start-page: 1511 year: 2009 end-page: 1518 ident: bib51 article-title: Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening publication-title: Current Biology – volume: 98 start-page: 721 year: 2006 end-page: 730 ident: bib31 article-title: Traction forces exerted through N-cadherin contacts publication-title: Biology of the Cell – volume: 46 start-page: 1246 year: 2007 end-page: 1256 ident: bib65 article-title: Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture publication-title: Hepatology – volume: 11 start-page: 82 year: 2005 end-page: 86 ident: bib67 article-title: Overview of ventilator-induced lung injury mechanisms publication-title: Current Opinion in Critical Care – volume: 2 start-page: 1259 year: 2012 end-page: 1271 ident: bib55 article-title: Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening publication-title: Cell Reports – volume: 120 start-page: 3895 year: 2007 end-page: 3904 ident: bib54 article-title: RPTPalpha is required for rigidity-dependent inhibition of extension and differentiation of hippocampal neurons publication-title: Journal of Cell Science – volume: 281 start-page: 31720 year: 2006 end-page: 31728 ident: bib86 article-title: Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone publication-title: Journal of Biological Chemistry – volume: 12 start-page: 711 year: 2010 end-page: 718 ident: bib16 article-title: Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions publication-title: Nature Cell Biology – volume: 275 start-page: 3088 year: 2000 end-page: 3092 ident: bib88 article-title: Fibroblast quiescence and the disruption of ERK signaling in mechanically unloaded collagen matrices publication-title: Journal of Biological Chemistry – volume: 112 start-page: 2971 year: 1999 end-page: 2981 ident: bib37 article-title: Regulation of the hepatocyte cell cycle by type I collagen matrix: role of cyclin D1 publication-title: Journal of Cell Science – volume: 25 start-page: 3173 year: 2005 end-page: 3181 ident: bib59 article-title: Muscle-specific signaling mechanism that links actin dynamics to serum response factor publication-title: Molecular and Cellular Biology – volume: 21 start-page: 223 year: 2003 end-page: 229 ident: bib93 article-title: Investigation of the regulation of bone mass by mechanical loading: from quantitative cytochemistry to gene array publication-title: Cell Biochemistry and Function – volume: 113C start-page: 66 year: 2013 end-page: 73 ident: bib100 article-title: Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells publication-title: Experimental Eye Research – volume: 277 start-page: 22889 year: 2002 end-page: 22895 ident: bib108 article-title: Transcriptional regulation of a contractile gene by mechanical forces applied through integrins in osteoblasts publication-title: Journal of Biological Chemistry – volume: 19 start-page: 776 year: 2011 end-page: 791 ident: bib90 article-title: Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth publication-title: Cancer Cell – volume: 300 start-page: H1252 year: 2011 end-page: 1266 ident: bib15 article-title: Cardiac myocyte remodeling mediated by N-cadherin-dependent mechanosensing publication-title: American Journal of Physiology—Heart and Circulatory Physiology – volume: 190 start-page: 693 year: 2010 end-page: 706 ident: bib68 article-title: Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression publication-title: Journal of Cell Biology – volume: 31 start-page: 109 year: 1973 end-page: 122 ident: bib89 article-title: Ultrastructural changes in pressure zones of human periodontium incident to orthodontic tooth movement publication-title: Acta Odontologica Scandinavica – volume: 272 start-page: 10948 year: 1997 end-page: 10956 ident: bib38 article-title: A transforming growth factor beta (TGFbeta) control element drives TGFbeta-induced stimulation of smooth muscle alpha-actin gene expression in concert with two CArG elements publication-title: Journal of Biological Chemistry – volume: 113 start-page: 329 year: 2003 end-page: 342 ident: bib75 article-title: Actin dynamics control SRF activity by regulation of its coactivator MAL publication-title: Cell – volume: 123 start-page: 889 year: 2005 end-page: 901 ident: bib114 article-title: Deconstructing the cadherin-catenin-actin complex publication-title: Cell – volume: 107 start-page: 1265 year: 2010 end-page: 1274 ident: bib12 article-title: The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts publication-title: Circulation Research – volume: 186 start-page: 866 year: 2012 end-page: 876 ident: bib5 article-title: Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation publication-title: American Journal of Respiratory and Critical Care Medicine – volume: 90 start-page: 3012 year: 2006 end-page: 3018 ident: bib34 article-title: Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures publication-title: Biophysical Journal – volume: 9 start-page: 5170 year: 2013 end-page: 5180 ident: bib41 article-title: Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages publication-title: Acta Biomaterialia – volume: 6 start-page: 745 year: 2004 end-page: 746 ident: bib40 article-title: Putting the squeeze on mechanotransduction publication-title: Developmental Cell – volume: 4 start-page: 410 year: 2012 end-page: 421 ident: bib1 article-title: The mechanical memory of lung myofibroblasts publication-title: Integrative Biology – volume: 107 start-page: 18499 year: 2011 end-page: 18504 ident: bib39 article-title: The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch publication-title: Proceedings of the National Academy of Sciences of United States of America – volume: 1793 start-page: 911 year: 2009 end-page: 920 ident: bib13 article-title: From mechanotransduction to extracellular matrix gene expression in fibroblasts publication-title: Biochimica et Biophysica Acta – volume: 276 start-page: 31047 year: 2001 end-page: 31052 ident: bib29 article-title: Fibroblast quiescence in floating or released collagen matrices: contribution of the ERK signaling pathway and actin cytoskeletal organization publication-title: Journal of Biological Chemistry – volume: 301 start-page: G110 year: 2011 end-page: 118 ident: bib78 article-title: Hepatic stellate cells require a stiff environment for myofibroblastic differentiation publication-title: American Journal of Physiology – volume: 96 start-page: 5095 year: 2009 end-page: 5102 ident: bib6 article-title: Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectin publication-title: Biophysical Journal – volume: 85 start-page: 175 year: 2006 end-page: 181 ident: bib42 article-title: Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission publication-title: European Journal of Cell Biology – volume: 4 start-page: e5262 year: 2009 ident: bib77 article-title: Biomechanical thresholds regulate inflammation through the NF-kappaB pathway: experiments and modeling publication-title: PloS One – volume: 3 start-page: 671 year: 2012 ident: bib105 article-title: Spatial coordination between cell and nuclear shape within micropatterned endothelial cells publication-title: Nature Communications – volume: 14 start-page: 45 year: 2009 end-page: 58 ident: bib50 article-title: The integrative function of TRPC channels publication-title: Frontiers in Bioscience – volume: 9 start-page: 35 year: 2010 ident: bib61 article-title: Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression publication-title: Molecular Cancer – volume: 110 start-page: 2301 year: 2013 end-page: 2310 ident: bib74 article-title: Nanomechanics controls neuronal precursors adhesion and differentiation publication-title: Biotechnology and Bioengineering – volume: 3 start-page: 349 year: 2002 end-page: 363 ident: bib101 article-title: Myofibroblasts and mechano-regulation of connective tissue remodelling publication-title: Nature Reviews Molecular Cell Biology – volume: 83 start-page: 71 year: 2012 end-page: 81 ident: bib119 article-title: Focal adhesion kinase regulation of mechanotransduction and its impact on endothelial cell functions publication-title: Microvascular Research – volume: 4 start-page: 410 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib1 article-title: The mechanical memory of lung myofibroblasts publication-title: Integrative Biology doi: 10.1039/c2ib00149g – volume: 107 start-page: 18499 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib39 article-title: The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch publication-title: Proceedings of the National Academy of Sciences of United States of America doi: 10.1073/pnas.1005998107 – volume: 60 start-page: 24 year: 2005 ident: 10.1016/j.diff.2013.07.004_bib115 article-title: Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion publication-title: Cell Motility and the Cytoskeleton doi: 10.1002/cm.20041 – volume: 6 start-page: 16 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib20 article-title: Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology publication-title: Nature Clinical Practice Cardiovascular Medicine doi: 10.1038/ncpcardio1397 – volume: 46 start-page: 257 year: 2000 ident: 10.1016/j.diff.2013.07.004_bib69 article-title: Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis publication-title: Cardiovascular Research doi: 10.1016/S0008-6363(00)00030-4 – ident: 10.1016/j.diff.2013.07.004_bib83 doi: 10.1152/ajpgi.00222.2012 – volume: 22 start-page: 194120 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib63 article-title: A simple indentation device for measuring micrometer-scale tissue stiffness publication-title: Journal of Physics – volume: 220 start-page: 325 year: 1981 ident: 10.1016/j.diff.2013.07.004_bib94 article-title: The effect of stretching on formation of myofibroblasts in mouse skin publication-title: Cell and Tissue Research doi: 10.1007/BF00210512 – volume: 11 start-page: 82 year: 2005 ident: 10.1016/j.diff.2013.07.004_bib67 article-title: Overview of ventilator-induced lung injury mechanisms publication-title: Current Opinion in Critical Care doi: 10.1097/00075198-200502000-00013 – volume: 6 start-page: 275 year: 2004 ident: 10.1016/j.diff.2013.07.004_bib10 article-title: Mechanotransduction at cell-matrix and cell-cell contacts publication-title: Proceedings of the National Academy of Sciences of United States of America – volume: 2 start-page: 1259 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib55 article-title: Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening publication-title: Cell Reports doi: 10.1016/j.celrep.2012.09.018 – volume: 94 start-page: 4984 year: 2008 ident: 10.1016/j.diff.2013.07.004_bib87 article-title: Micropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation publication-title: Biophysical Journal doi: 10.1529/biophysj.107.116863 – volume: 10 start-page: 2629 year: 2004 ident: 10.1016/j.diff.2013.07.004_bib104 article-title: Exercise as an anabolic stimulus for bone publication-title: Current Pharmaceutical Design doi: 10.2174/1381612043383755 – volume: 123 start-page: 903 year: 2005 ident: 10.1016/j.diff.2013.07.004_bib22 article-title: Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly publication-title: Cell doi: 10.1016/j.cell.2005.09.021 – volume: 6 start-page: 745 year: 2004 ident: 10.1016/j.diff.2013.07.004_bib40 article-title: Putting the squeeze on mechanotransduction publication-title: Developmental Cell doi: 10.1016/j.devcel.2004.05.013 – volume: 121 start-page: 505 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib76 article-title: Arterial stiffness and cardiovascular events: the Framingham heart study – volume: 112 start-page: 2971 year: 1999 ident: 10.1016/j.diff.2013.07.004_bib37 article-title: Regulation of the hepatocyte cell cycle by type I collagen matrix: role of cyclin D1 publication-title: Journal of Cell Science doi: 10.1242/jcs.112.17.2971 – volume: 85 start-page: 175 year: 2006 ident: 10.1016/j.diff.2013.07.004_bib42 article-title: Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission publication-title: European Journal of Cell Biology doi: 10.1016/j.ejcb.2005.09.004 – volume: 116 start-page: 1397 year: 2003 ident: 10.1016/j.diff.2013.07.004_bib46 article-title: Tensegrity II. How structural networks influence cellular information processing networks publication-title: Journal of Cell Science doi: 10.1242/jcs.00360 – volume: 19 start-page: 362 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib103 article-title: Mammalian somatosensory mechanotransduction publication-title: Current Opinion in Neurobiology doi: 10.1016/j.conb.2009.07.008 – volume: 83 start-page: 71 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib119 article-title: Focal adhesion kinase regulation of mechanotransduction and its impact on endothelial cell functions publication-title: Microvascular Research doi: 10.1016/j.mvr.2011.06.007 – volume: 56 start-page: 1 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib116 article-title: Mechanotransduction by TRP channels: general concepts and specific role in the vasculature publication-title: Cell Biochemistry and Biophysics doi: 10.1007/s12013-009-9067-2 – volume: 13 start-page: 2411 year: 2002 ident: 10.1016/j.diff.2013.07.004_bib27 article-title: Neurite branching on deformable substrates publication-title: Neuroreport doi: 10.1097/00001756-200212200-00007 – volume: 398 start-page: 422 year: 1999 ident: 10.1016/j.diff.2013.07.004_bib98 article-title: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells publication-title: Nature doi: 10.1038/18884 – volume: 98 start-page: 721 year: 2006 ident: 10.1016/j.diff.2013.07.004_bib31 article-title: Traction forces exerted through N-cadherin contacts publication-title: Biology of the Cell doi: 10.1042/BC20060039 – volume: 293 start-page: G1147 year: 2007 ident: 10.1016/j.diff.2013.07.004_bib32 article-title: Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis publication-title: American Journal of Physiology – volume: 84 start-page: 1097 year: 2004 ident: 10.1016/j.diff.2013.07.004_bib96 article-title: Genetic models of mechanotransduction: the nematode Caenorhabditis elegans publication-title: Physiological Reviews doi: 10.1152/physrev.00043.2003 – volume: 5, ra41 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib57 article-title: Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors publication-title: Science Signaling – volume: 29 start-page: 5104 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib47 article-title: Mechanoregulation of proliferation publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.00465-09 – volume: 9 start-page: 139 year: 2007 ident: 10.1016/j.diff.2013.07.004_bib24 article-title: Arterial stiffness as a risk factor for coronary atherosclerosis publication-title: Current Atherosclerosis Reports doi: 10.1007/s11883-007-0010-y – volume: 46 start-page: 590 year: 2007 ident: 10.1016/j.diff.2013.07.004_bib26 article-title: Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis publication-title: Hepatology doi: 10.1002/hep.21802 – volume: 12 start-page: 759 year: 2008 ident: 10.1016/j.diff.2013.07.004_bib109 article-title: Cellular sources of extracellular matrix in hepatic fibrosis publication-title: Clinics In Liver Disease doi: 10.1016/j.cld.2008.07.008 – volume: 166 start-page: 1343 year: 2005 ident: 10.1016/j.diff.2013.07.004_bib102 article-title: Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element publication-title: American Journal of Pathology doi: 10.1016/S0002-9440(10)62353-X – volume: 285 start-page: 9273 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib8 article-title: Force-induced myofibroblast differentiation through collagen receptors is dependent on mammalian diaphanous (mDia) publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M109.075218 – volume: 186 start-page: 866 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib5 article-title: Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation publication-title: American Journal of Respiratory and Critical Care Medicine doi: 10.1164/rccm.201204-0754OC – volume: 1 start-page: pe13 year: 2008 ident: 10.1016/j.diff.2013.07.004_bib110 article-title: Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet publication-title: Science Signaling doi: 10.1126/stke.110pe13 – volume: 279 start-page: 12001 year: 2004 ident: 10.1016/j.diff.2013.07.004_bib48 article-title: Integrins in mechanotransduction publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.R300038200 – volume: 46 start-page: 1246 year: 2007 ident: 10.1016/j.diff.2013.07.004_bib65 article-title: Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture publication-title: Hepatology doi: 10.1002/hep.21792 – volume: 31 start-page: 109 year: 1973 ident: 10.1016/j.diff.2013.07.004_bib89 article-title: Ultrastructural changes in pressure zones of human periodontium incident to orthodontic tooth movement publication-title: Acta Odontologica Scandinavica doi: 10.3109/00016357309004617 – volume: 300 start-page: H1252 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib15 article-title: Cardiac myocyte remodeling mediated by N-cadherin-dependent mechanosensing publication-title: American Journal of Physiology—Heart and Circulatory Physiology doi: 10.1152/ajpheart.00515.2010 – volume: 14 start-page: 87 year: 2008 ident: 10.1016/j.diff.2013.07.004_bib95 article-title: Dynamic respiratory mechanics in acute lung injury/acute respiratory distress syndrome: research or clinical tool? publication-title: Current Opinion in Critical Care doi: 10.1097/MCC.0b013e3282f3a166 – volume: 131 start-page: 2378 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib18 article-title: Myocardin-related transcription factors A and B are key regulators of TGF-beta1-induced fibroblast to myofibroblast differentiation publication-title: Journal of Investigative Dermatology doi: 10.1038/jid.2011.219 – volume: 12 start-page: 2730 year: 2001 ident: 10.1016/j.diff.2013.07.004_bib43 article-title: Alpha-smooth muscle actin expression upregulates fibroblast contractile activity publication-title: Molecular Biology of the Cell doi: 10.1091/mbc.12.9.2730 – volume: 13 start-page: 312 year: 2008 ident: 10.1016/j.diff.2013.07.004_bib7 article-title: Physiological myocardial hypertrophy: how and why? publication-title: Frontiers in Bioscience doi: 10.2741/2681 – volume: 20 start-page: 325 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib30 article-title: Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matrices publication-title: Cardiovascular Pathology doi: 10.1016/j.carpath.2010.10.001 – volume: 117 start-page: 2449 year: 2004 ident: 10.1016/j.diff.2013.07.004_bib72 article-title: Mechanosensitive ion channels: molecules of mechanotransduction publication-title: Journal of Cell Science doi: 10.1242/jcs.01232 – volume: 584 start-page: 4145 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib64 article-title: The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes publication-title: FEBS Letters doi: 10.1016/j.febslet.2010.08.033 – volume: 108 start-page: 13420 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib3 article-title: Growth cones as soft and weak force generators publication-title: Proceedings of the National Academy of Sciences of United States America doi: 10.1073/pnas.1106145108 – volume: 30 start-page: 6867 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib62 article-title: The effect of substrate stiffness on adult neural stem cell behavior publication-title: Biomaterials doi: 10.1016/j.biomaterials.2009.09.002 – volume: 110 start-page: 2301 year: 2013 ident: 10.1016/j.diff.2013.07.004_bib74 article-title: Nanomechanics controls neuronal precursors adhesion and differentiation publication-title: Biotechnology and Bioengineering doi: 10.1002/bit.24880 – volume: 276 start-page: 31047 year: 2001 ident: 10.1016/j.diff.2013.07.004_bib29 article-title: Fibroblast quiescence in floating or released collagen matrices: contribution of the ERK signaling pathway and actin cytoskeletal organization publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M101898200 – volume: 272 start-page: 10948 year: 1997 ident: 10.1016/j.diff.2013.07.004_bib38 article-title: A transforming growth factor beta (TGFbeta) control element drives TGFbeta-induced stimulation of smooth muscle alpha-actin gene expression in concert with two CArG elements publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.272.16.10948 – volume: 19 start-page: 222 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib99 article-title: Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells publication-title: Osteoarthritis and Cartilage doi: 10.1016/j.joca.2010.11.004 – volume: 474 start-page: 179 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib23 article-title: Role of YAP/TAZ in mechanotransduction publication-title: Nature doi: 10.1038/nature10137 – volume: 9 start-page: 376 year: 2003 ident: 10.1016/j.diff.2013.07.004_bib97 article-title: Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy publication-title: Trends in Molecular Medicine doi: 10.1016/S1471-4914(03)00164-3 – volume: 47 start-page: 74 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib118 article-title: Activation of NF-kappaB by fluid shear stress, but not TNF-alpha, requires focal adhesion kinase in osteoblasts publication-title: Bone doi: 10.1016/j.bone.2010.03.014 – volume: 9 start-page: 5170 year: 2013 ident: 10.1016/j.diff.2013.07.004_bib41 article-title: Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages publication-title: Acta Biomaterialia doi: 10.1016/j.actbio.2012.10.012 – volume: 16 start-page: 12 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib44 article-title: Regulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells publication-title: Journal of Biomedical Science doi: 10.1186/1423-0127-16-12 – volume: 103 start-page: 477 year: 2008 ident: 10.1016/j.diff.2013.07.004_bib21 article-title: Stretch-induced activation of the transcription factor activator protein-1 controls monocyte chemoattractant protein-1 expression during arteriogenesis publication-title: Circulation Research doi: 10.1161/CIRCRESAHA.108.177782 – volume: 19 start-page: 776 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib90 article-title: Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.05.008 – volume: 98 start-page: 1547 year: 2005 ident: 10.1016/j.diff.2013.07.004_bib33 article-title: Cell type-specific response to growth on soft materials publication-title: Journal of Applied Physiology doi: 10.1152/japplphysiol.01121.2004 – volume: 277 start-page: 47541 year: 2002 ident: 10.1016/j.diff.2013.07.004_bib19 article-title: Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M207681200 – volume: 294 start-page: C1056 year: 2008 ident: 10.1016/j.diff.2013.07.004_bib81 article-title: FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump publication-title: American Journal of Physiology—Cell Physiology doi: 10.1152/ajpcell.00270.2007 – volume: 113C start-page: 66 year: 2013 ident: 10.1016/j.diff.2013.07.004_bib100 article-title: Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells publication-title: Experimental Eye Research doi: 10.1016/j.exer.2013.05.014 – volume: 272 start-page: C1654 year: 1997 ident: 10.1016/j.diff.2013.07.004_bib84 article-title: Cytoskeletal mechanics in confluent epithelial cells probed through integrins and E-cadherins publication-title: American Journal of Physiology doi: 10.1152/ajpcell.1997.272.5.C1654 – volume: 3 start-page: 349 year: 2002 ident: 10.1016/j.diff.2013.07.004_bib101 article-title: Myofibroblasts and mechano-regulation of connective tissue remodelling publication-title: Nature Reviews Molecular Cell Biology doi: 10.1038/nrm809 – volume: 12 start-page: 711 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib16 article-title: Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions publication-title: Nature Cell Biology doi: 10.1038/ncb2074 – volume: 120 start-page: 1801 year: 2007 ident: 10.1016/j.diff.2013.07.004_bib120 article-title: Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathway publication-title: Journal of Cell Science doi: 10.1242/jcs.001586 – volume: 286 start-page: 7018 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib9 article-title: Hippo pathway-independent restriction of TAZ and YAP by angiomotin publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.C110.212621 – volume: 45 start-page: 824 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib14 article-title: Reprogramming cardiomyocyte mechanosensing by crosstalk between integrins and hyaluronic acid receptors publication-title: Journal of Biomechanics doi: 10.1016/j.jbiomech.2011.11.023 – volume: 4 start-page: e5262 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib77 article-title: Biomechanical thresholds regulate inflammation through the NF-kappaB pathway: experiments and modeling publication-title: PloS One doi: 10.1371/journal.pone.0005262 – volume: 179 start-page: 1311 year: 2007 ident: 10.1016/j.diff.2013.07.004_bib111 article-title: Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix publication-title: Journal of Cell Biology doi: 10.1083/jcb.200704042 – volume: 14 start-page: 45 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib50 article-title: The integrative function of TRPC channels publication-title: Frontiers in Bioscience doi: 10.2741/3230 – volume: 97 start-page: 1883 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib28 article-title: Neurite branch retraction is caused by a threshold-dependent mechanical impact publication-title: Biophysical Journal doi: 10.1016/j.bpj.2009.07.033 – volume: 3 start-page: 287 year: 2004 ident: 10.1016/j.diff.2013.07.004_bib35 article-title: Mechanosensitive ion channels as drug targets publication-title: Current Drug Targets – volume: 113 start-page: 329 year: 2003 ident: 10.1016/j.diff.2013.07.004_bib75 article-title: Actin dynamics control SRF activity by regulation of its coactivator MAL publication-title: Cell doi: 10.1016/S0092-8674(03)00278-2 – volume: 5 start-page: 614 year: 2004 ident: 10.1016/j.diff.2013.07.004_bib53 article-title: Alpha-catenin: at the junction of intercellular adhesion and actin dynamics publication-title: Nature Reviews Molecular Cell Biology doi: 10.1038/nrm1433 – volume: 22 start-page: 2017 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib113 article-title: Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch publication-title: Current Biology doi: 10.1016/j.cub.2012.08.050 – volume: 301 start-page: L656 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib91 article-title: Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-beta publication-title: American Journal of Physiology – volume: 107 start-page: 1265 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib12 article-title: The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts publication-title: Circulation Research doi: 10.1161/CIRCRESAHA.110.222588 – volume: 301 start-page: G110 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib78 article-title: Hepatic stellate cells require a stiff environment for myofibroblastic differentiation publication-title: American Journal of Physiology – volume: 47 start-page: 340 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib45 article-title: Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction publication-title: American Journal of Respiratory Cell and Molecular Biology doi: 10.1165/rcmb.2012-0050OC – volume: 71 start-page: 1286 year: 1974 ident: 10.1016/j.diff.2013.07.004_bib80 article-title: A restriction point for control of normal animal cell proliferation publication-title: Proceedings of the National Academy of Sciences of United States of America doi: 10.1073/pnas.71.4.1286 – volume: 277 start-page: 22889 year: 2002 ident: 10.1016/j.diff.2013.07.004_bib108 article-title: Transcriptional regulation of a contractile gene by mechanical forces applied through integrins in osteoblasts publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M203130200 – volume: 94 start-page: 13661 year: 1997 ident: 10.1016/j.diff.2013.07.004_bib82 article-title: Cell locomotion and focal adhesions are regulated by substrate flexibility publication-title: Proceedings of the National Academy of Sciences of United States of America doi: 10.1073/pnas.94.25.13661 – volume: 21 start-page: 223 year: 2003 ident: 10.1016/j.diff.2013.07.004_bib93 article-title: Investigation of the regulation of bone mass by mechanical loading: from quantitative cytochemistry to gene array publication-title: Cell Biochemistry and Function doi: 10.1002/cbf.1077 – volume: 11 start-page: 200 year: 2005 ident: 10.1016/j.diff.2013.07.004_bib66 article-title: Cross talk between cell-cell and cell-matrix adhesion signaling pathways during heart organogenesis: implications for cardiac birth defects publication-title: Microscopy and Microanalysis doi: 10.1017/S1431927605050440 – volume: 12 start-page: 533 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib117 article-title: alpha-Catenin as a tension transducer that induces adherens junction development publication-title: Nature Cell Biology doi: 10.1038/ncb2055 – volume: 30 start-page: 4695 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib2 article-title: The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells publication-title: Biomaterials doi: 10.1016/j.biomaterials.2009.05.050 – volume: 13 start-page: 591 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib36 article-title: Transduction of mechanical and cytoskeletal cues by YAP and TAZ publication-title: Nature Reviews Molecular Cell Biology doi: 10.1038/nrm3416 – volume: 53 start-page: 1192 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib92 article-title: Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells publication-title: Hepatology doi: 10.1002/hep.24108 – volume: 30 start-page: 4134 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib60 article-title: Myocardin-related transcription factor A is a common mediator of mechanical stress- and neurohumoral stimulation-induced cardiac hypertrophic signaling leading to activation of brain natriuretic peptide gene expression publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.00154-10 – volume: 88 start-page: 597 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib56 article-title: On a path to unfolding the biological mechanisms of orthodontic tooth movement publication-title: Journal of Dental Research doi: 10.1177/0022034509338914 – volume: 18 start-page: 148 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib112 article-title: Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling publication-title: Nature Medicine doi: 10.1038/nm.2574 – volume: 31 start-page: 590 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib11 article-title: beta-catenin mediates mechanically regulated, transforming growth factor-beta1-induced myofibroblast differentiation of aortic valve interstitial cells publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.110.220061 – volume: 90 start-page: 3012 year: 2006 ident: 10.1016/j.diff.2013.07.004_bib34 article-title: Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures publication-title: Biophysical Journal doi: 10.1529/biophysj.105.073114 – volume: 96 start-page: 5095 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib6 article-title: Absence of filamin A prevents cells from responding to stiffness gradients on gels coated with collagen but not fibronectin publication-title: Biophysical Journal doi: 10.1016/j.bpj.2009.03.046 – volume: 19 start-page: 1511 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib51 article-title: Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening publication-title: Current Biology doi: 10.1016/j.cub.2009.07.069 – volume: 92 start-page: 840 year: 2003 ident: 10.1016/j.diff.2013.07.004_bib58 article-title: Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins publication-title: Circulation Research doi: 10.1161/01.RES.0000069031.55281.7C – volume: 123 start-page: 889 year: 2005 ident: 10.1016/j.diff.2013.07.004_bib114 article-title: Deconstructing the cadherin-catenin-actin complex publication-title: Cell doi: 10.1016/j.cell.2005.09.020 – volume: 281 start-page: 31720 year: 2006 ident: 10.1016/j.diff.2013.07.004_bib86 article-title: Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M602308200 – volume: 1793 start-page: 911 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib13 article-title: From mechanotransduction to extracellular matrix gene expression in fibroblasts publication-title: Biochimica et Biophysica Acta doi: 10.1016/j.bbamcr.2009.01.012 – volume: 14 start-page: 431 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib73 article-title: Mechanical regulation of nuclear structure and function publication-title: Proceedings of the National Academy of Sciences of United States of America – volume: 267 start-page: 984 year: 1992 ident: 10.1016/j.diff.2013.07.004_bib4 article-title: Elements of the smooth muscle alpha-actin promoter required in cis for transcriptional activation in smooth muscle. Evidence for cell type-specific regulation publication-title: Journal of Biological Chemistry doi: 10.1016/S0021-9258(18)48383-4 – volume: 25 start-page: 3173 year: 2005 ident: 10.1016/j.diff.2013.07.004_bib59 article-title: Muscle-specific signaling mechanism that links actin dynamics to serum response factor publication-title: Molecular and Cellular Biology doi: 10.1128/MCB.25.8.3173-3181.2005 – volume: 120 start-page: 3895 year: 2007 ident: 10.1016/j.diff.2013.07.004_bib54 article-title: RPTPalpha is required for rigidity-dependent inhibition of extension and differentiation of hippocampal neurons publication-title: Journal of Cell Science doi: 10.1242/jcs.009852 – volume: 108 start-page: 11930 year: 2011 ident: 10.1016/j.diff.2013.07.004_bib49 article-title: E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components publication-title: Proceedings of the National Academy of Sciences of United States of America doi: 10.1073/pnas.1103345108 – volume: 39 start-page: 585 year: 2003 ident: 10.1016/j.diff.2013.07.004_bib17 article-title: New TRP channels in hearing and mechanosensation publication-title: Neuron doi: 10.1016/S0896-6273(03)00505-1 – volume: 3 start-page: 671 year: 2012 ident: 10.1016/j.diff.2013.07.004_bib105 article-title: Spatial coordination between cell and nuclear shape within micropatterned endothelial cells publication-title: Nature Communications doi: 10.1038/ncomms1668 – volume: 54 start-page: 378 year: 2013 ident: 10.1016/j.diff.2013.07.004_bib85 article-title: Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ publication-title: Investigative Ophthalmology and Visual Science doi: 10.1167/iovs.12-11007 – volume: 294 start-page: F1116 year: 2008 ident: 10.1016/j.diff.2013.07.004_bib25 article-title: MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells publication-title: American Journal of Physiology – volume: 190 start-page: 693 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib68 article-title: Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression publication-title: Journal of Cell Biology doi: 10.1083/jcb.201004082 – volume: 105 start-page: 851 year: 2001 ident: 10.1016/j.diff.2013.07.004_bib106 article-title: Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor publication-title: Cell doi: 10.1016/S0092-8674(01)00404-4 – volume: 276 start-page: 35967 year: 2001 ident: 10.1016/j.diff.2013.07.004_bib52 article-title: Cadherins mediate intercellular mechanical signaling in fibroblasts by activation of stretch-sensitive calcium-permeable channels publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M104106200 – volume: 9 start-page: 35 year: 2010 ident: 10.1016/j.diff.2013.07.004_bib61 article-title: Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression publication-title: Molecular Cancer doi: 10.1186/1476-4598-9-35 – volume: 275 start-page: 3088 year: 2000 ident: 10.1016/j.diff.2013.07.004_bib88 article-title: Fibroblast quiescence and the disruption of ERK signaling in mechanically unloaded collagen matrices publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.275.5.3088 – volume: 457 start-page: 1103 year: 2009 ident: 10.1016/j.diff.2013.07.004_bib70 article-title: A mechanosensitive transcriptional mechanism that controls angiogenesis publication-title: Nature doi: 10.1038/nature07765 – volume: 99 start-page: 14855 year: 2002 ident: 10.1016/j.diff.2013.07.004_bib107 article-title: Potentiation of serum response factor activity by a family of myocardin-related transcription factors publication-title: Proceedings of the National Academy of Sciences of United States of America doi: 10.1073/pnas.222561499 – volume: 7 start-page: 48 year: 2007 ident: 10.1016/j.diff.2013.07.004_bib71 article-title: The importance of mechanical loading in bone biology and medicine publication-title: Journal of Musculoskeletal and Neuronal Interactions – volume: 40 start-page: 110 year: 2005 ident: 10.1016/j.diff.2013.07.004_bib79 article-title: Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress publication-title: Journal of Periodontal Research doi: 10.1111/j.1600-0765.2004.00782.x |
| SSID | ssj0008621 |
| Score | 2.431862 |
| SecondaryResourceType | review_article |
| Snippet | Changes in tissue stiffness are frequently associated with diseases such as cancer, fibrosis, and atherosclerosis. Several recent studies suggest that, in... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 112 |
| SubjectTerms | Animals atherosclerosis cytoskeleton Cytoskeleton - metabolism disease course Fibroblasts - metabolism fibrosis Focal Adhesions - metabolism guanosinetriphosphatase homeostasis Humans mechanical properties Mechanical stress Mechanosensing Mechanotransduction Mechanotransduction, Cellular non-specific protein-tyrosine kinase signal transduction Stress, Mechanical Substrate stiffness transcription (genetics) transcription factor NF-kappa B Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic transforming growth factor beta Yap |
| Title | From tissue mechanics to transcription factors |
| URI | https://dx.doi.org/10.1016/j.diff.2013.07.004 https://www.ncbi.nlm.nih.gov/pubmed/23969122 https://www.proquest.com/docview/1443383408 https://www.proquest.com/docview/1733523357 https://pubmed.ncbi.nlm.nih.gov/PMC4545622 |
| Volume | 86 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Baden-Württemberg Complete Freedom Collection (Elsevier) customDbUrl: eissn: 1432-0436 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0008621 issn: 0301-4681 databaseCode: GBLVA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier ScienceDirect customDbUrl: eissn: 1432-0436 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0008621 issn: 0301-4681 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals [SCFCJ] customDbUrl: eissn: 1432-0436 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0008621 issn: 0301-4681 databaseCode: AIKHN dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Freedom Collection customDbUrl: eissn: 1432-0436 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0008621 issn: 0301-4681 databaseCode: ACRLP dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1432-0436 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0008621 issn: 0301-4681 databaseCode: AKRWK dateStart: 19730201 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07T8MwED5VRUgsiDflUQWJDYU6tuPEI0JUBSQWQGKL7MQRRTSt2jCw8NvxJU6hgDowZEhyjpyzfQ_dd3cApySninEjfSNS5VsNEfgxVblPch2KjKQkNhXK904MHvnNU_jUgssmFwZhlU721zK9ktbuSc9xszcZDnv3lTcg4gADMqiVMIOdC4T1nX98wTysxR7UkQTrK1lqlzhTY7ywCQnCu1hVwNM1a_tDOf02Pn9iKL8ppf4GrDtr0ruoJ7wJLVNswWrdX_J9G8770_HIKyveeiODSb7DdOaVY69EFdUIDM813dmBx_7Vw-XAdw0S_NQepdKXgkvNc8EDLPkimDZZRk2UilRqxYgVwwENTI7CMJQmzKx7YFLCKDO5jIiK2S60i3Fh9sELq-Os40hRwrXOpKJKWOOKaWY_wU0HgoYzSeqqh2MTi9ekgYm9JMjNBLmZEAxq8w6czcdM6toZS6nDhuHJwg5IrHBfOu6kWZ3EHg2Md6jCjN9m1qvh6IBzEi-hiTDpzF5RB_bqFZ3PlTIpZEBpB6KFtZ4TYGnuxTfF8Lkq0c3RMKX04J__dAhreFeDBo-gXU7fzLE1fkrdrXZ3F1Yurm8Hd5-QrAKO |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NT9swFH8qRRNcJmBsK2NbkLhNWR3bceJjhagKZb3QStwsO3FEEaQI0gP_PX6JU60b6oFDLvFz5Dzbv_ee3hfAKSmoZtzK0IpMh05CRGFKdRGSwsQiJxlJbR3lOxGjGb-8iW86cNbmwmBYpcf-BtNrtPZv-p6b_cf5vH9dWwMijdAhg1JpC7Z57DC5C9uDi_FosgJkp7RHjTPBmUtugs-dacK8sA8JRnixuoan79f2hnz6X__8N4zyL7k03IOPXqEMBs2a96FjywP40LSYfPkEv4dPi4egqtkbPFjM851nz0G1CCqUUi1mBL7vziHMhufTs1HoeySEmbtNVSgFl4YXgkdY9UUwY_Oc2iQTmTSaEYfEEY1sgXgYSxvnzkKwGWGU2UImRKfsM3TLRWm_QhDXN9qkiaaEG5NLTbVw-hUzzH2C2x5ELWdU5guIYx-Le9VGit0p5KZCbiqCfm3eg1-rOY9N-YyN1HHLcLV2CJTD943zTtrdUe52oMtDl3axfHaGDUcbnJN0A02CeWfuSXrwpdnR1Vopk0JGlPYgWdvrFQFW514fKee3dZVujroppUfv_KefsDOa_rlSVxeT8TfYxZEmhvAYutXT0n53ulBlfviz_gpXzQU5 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=From+tissue+mechanics+to+transcription+factors&rft.jtitle=Differentiation+%28London%29&rft.au=Janmey%2C+Paul+A.&rft.au=Wells%2C+Rebecca+G.&rft.au=Assoian%2C+Richard+K.&rft.au=McCulloch%2C+Christopher+A.&rft.date=2013-10-01&rft.pub=Elsevier+B.V&rft.issn=0301-4681&rft.eissn=1432-0436&rft.volume=86&rft.issue=3&rft.spage=112&rft.epage=120&rft_id=info:doi/10.1016%2Fj.diff.2013.07.004&rft.externalDocID=S0301468113000613 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0301-4681&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0301-4681&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0301-4681&client=summon |