Quantification of urinary 5-aminolevulinic acid by gas chromatography–mass spectrometry
In this report, we describe a method for the specific quantification of urinary 5-aminolevulinic acid. It is based on gas chromatographic mass spectrometric measurement of the trimethylsilyl ester of the ethylacetoacetate pyrrole derivative of 5-aminolevulinic acid. Selected ion monitoring (SIM) was...
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| Published in | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 806; no. 1; pp. 19 - 23 |
|---|---|
| Main Authors | , |
| Format | Journal Article Conference Proceeding |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
25.06.2004
Elsevier Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1570-0232 1873-376X |
| DOI | 10.1016/j.jchromb.2004.02.026 |
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| Abstract | In this report, we describe a method for the specific quantification of urinary 5-aminolevulinic acid. It is based on gas chromatographic mass spectrometric measurement of the trimethylsilyl ester of the ethylacetoacetate pyrrole derivative of 5-aminolevulinic acid. Selected ion monitoring (SIM) was used for quantification using 3-hydroxymyristic acid as an internal standard. The detection limit of this method was 0.1
nmol/ml. This method was applied to the determination of urinary 5-aminolevulinic acid from a tyrosinemia type I patient and normal subjects, and 21.4
mmol/mol creatinine and 0.54±0.49
mmol/mol creatinine (
n=7), respectively, were detected. Less than 0.2
ml urine was sufficient for the determination of 5-aminolevulinic acid in healthy subjects. |
|---|---|
| AbstractList | In this report, we describe a method for the specific quantification of urinary 5-aminolevulinic acid. It is based on gas chromatographic mass spectrometric measurement of the trimethylsilyl ester of the ethylacetoacetate pyrrole derivative of 5-aminolevulinic acid. Selected ion monitoring (SIM) was used for quantification using 3-hydroxymyristic acid as an internal standard. The detection limit of this method was 0.1 nmol/ml. This method was applied to the determination of urinary 5-aminolevulinic acid from a tyrosinemia type I patient and normal subjects, and 21.4 mmol/mol creatinine and 0.54+/- 0.49 mmol/mol creatinine (n = 7), respectively, were detected. Less than 0.2 ml urine was sufficient for the determination of 5-aminolevulinic acid in healthy subjects.In this report, we describe a method for the specific quantification of urinary 5-aminolevulinic acid. It is based on gas chromatographic mass spectrometric measurement of the trimethylsilyl ester of the ethylacetoacetate pyrrole derivative of 5-aminolevulinic acid. Selected ion monitoring (SIM) was used for quantification using 3-hydroxymyristic acid as an internal standard. The detection limit of this method was 0.1 nmol/ml. This method was applied to the determination of urinary 5-aminolevulinic acid from a tyrosinemia type I patient and normal subjects, and 21.4 mmol/mol creatinine and 0.54+/- 0.49 mmol/mol creatinine (n = 7), respectively, were detected. Less than 0.2 ml urine was sufficient for the determination of 5-aminolevulinic acid in healthy subjects. In this report, we describe a method for the specific quantification of urinary 5-aminolevulinic acid. It is based on gas chromatographic mass spectrometric measurement of the trimethylsilyl ester of the ethylacetoacetate pyrrole derivative of 5-aminolevulinic acid. Selected ion monitoring (SIM) was used for quantification using 3-hydroxymyristic acid as an internal standard. The detection limit of this method was 0.1 nmol/ml. This method was applied to the determination of urinary 5-aminolevulinic acid from a tyrosinemia type I patient and normal subjects, and 21.4 mmol/mol creatinine and 0.54±0.49 mmol/mol creatinine ( n=7), respectively, were detected. Less than 0.2 ml urine was sufficient for the determination of 5-aminolevulinic acid in healthy subjects. In this report, we describe a method for the specific quantification of urinary 5-aminolevulinic acid. It is based on gas chromatographic mass spectrometric measurement of the trimethylsilyl ester of the ethylacetoacetate pyrrole derivative of 5-aminolevulinic acid. Selected ion monitoring (SIM) was used for quantification using 3-hydroxymyristic acid as an internal standard. The detection limit of this method was 0.1 nmol/ml. This method was applied to the determination of urinary 5-aminolevulinic acid from a tyrosinemia type I patient and normal subjects, and 21.4 mmol/mol creatinine and 0.54+/- 0.49 mmol/mol creatinine (n = 7), respectively, were detected. Less than 0.2 ml urine was sufficient for the determination of 5-aminolevulinic acid in healthy subjects. |
| Author | Kuhara, Tomiko Shinka, Toshihiro |
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| Cites_doi | 10.1016/0006-2944(74)90109-4 10.1007/BF02034752 10.1016/0009-8981(86)90258-5 10.1111/j.1651-2227.2003.tb02518.x 10.1042/bj2190883 10.1016/0140-6736(92)92685-9 10.1056/NEJM199002153220704 10.1007/BF01797926 10.1016/S0021-9258(18)65809-0 10.1002/(SICI)1098-2787(1996)15:1<43::AID-MAS3>3.0.CO;2-B 10.1016/S0022-3476(77)80701-4 10.1016/S0378-4347(01)00138-4 10.1093/clinchem/36.8.1494 10.1007/BF01811440 10.1073/pnas.74.10.4641 10.1016/0009-8981(69)90040-0 10.1084/jem.162.3.1060 |
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| Keywords | 5-Aminolevulinic acid Creatinine Human Urine Gas chromatography Biological fluid Spectrometry Tyrosinemia Investigation method Quantitative analysis |
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| SubjectTerms | 5-Aminolevulinic acid Aminolevulinic Acid - urine Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Fundamental and applied biological sciences. Psychology Gas Chromatography-Mass Spectrometry - methods General pharmacology Humans Medical sciences Pharmacology. Drug treatments Reference Standards Tyrosinemias - urine |
| Title | Quantification of urinary 5-aminolevulinic acid by gas chromatography–mass spectrometry |
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