The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans - Holth, Jerrah K.; Fritschi, Sarah K.; Wang, Chanung; Pedersen, Nigel P.; Cirrito, John R.; Mahan, Thomas E.; Finn, Mary Beth; Manis, Melissa; Geerling, Joel C.; Fuller, Patrick M.; Lucey, Brendan P.; Holtzman, David M. (Science (American Association for the Advancement of Science), 2019)
Keywords: Alzheimer's disease; Amyloid beta-Peptides - analysis; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - metabolism; Animals; Brain; Brain - metabolism; Brain damage; Brain injury; Cerebrospinal fluid; Circadian Rhythm; Cognitive ability; Extracellular Fluid - chemistry; Extracellular Fluid - metabolism; Female; Male; Mice; Mice, Transgenic; Neurodegeneration; Neurodegenerative diseases; Neurological Impairments; Pathology; Proteins; Senile plaques; Sleep; Sleep - physiology; Sleep and wakefulness; Sleep deprivation; Sleep Deprivation - cerebrospinal fluid; Sleep Deprivation - metabolism; Spires; Spreading; Tau protein; tau Proteins - analysis; tau Proteins - cerebrospinal fluid; tau Proteins - metabolism; Wakefulness; Wakefulness - genetics; Wakefulness - physiology; β-Amyloid