A new boronic acid based fluorescent reporter for catechol

• Published in: Bioorganic & medicinal chemistry letters Vol. 22; no. 23; pp. 7179 - 7182
• Main Authors: Wu, Zhongyu, Li, Minyong, Fang, Hao, Wang, Binghe
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.12.2012; Elsevier
• Subjects: aqueous solutions; bioactive properties; Biological and medical sciences; Boronic acid; Boronic Acids - chemistry; Catechol; Catechol detection; Catechols - chemistry; Chemosensor; Electron Transport; fluorescence; Fluorescent Dyes - chemistry; Fluorescent reporter; Kinetics; Medical sciences; natural products; Pharmacology. Drug treatments; Spectrometry, Fluorescence; Chemosensor; Boronic acid; Catechol detection; BWFFCJJLMPLDBV-UHFFFAOYSA-N; KXZJHVJKXJLBKO-UHFFFAOYSA-N; Fluorescent reporter; Boron Organic compounds; Pyrocatechol; Chemical sensor; Fluorescent compound; Detection
• ISSN: 0960-894X; 1464-3405; 1464-3405
• DOI: 10.1016/j.bmcl.2012.09.060

Catechol skeleton widely exists in natural products and bioactive substances. Fluorescent reporters which could recognize catechol are very promising for the construction of chemosensors to detect catechol and its derivatives in biological environment. Herein, we reported a novel catechol reporter, 2-(4-boronophenyl)quinoline-4-carboxylic acid, which exhibits significant fluorescent property changes upon binding catechol containing molecules in an aqueous solution.