A new boronic acid based fluorescent reporter for catechol
Catechol skeleton widely exists in natural products and bioactive substances. Fluorescent reporters which could recognize catechol are very promising for the construction of chemosensors to detect catechol and its derivatives in biological environment. Herein, we reported a novel catechol reporter,...
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| Published in | Bioorganic & medicinal chemistry letters Vol. 22; no. 23; pp. 7179 - 7182 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Ltd
01.12.2012
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0960-894X 1464-3405 1464-3405 |
| DOI | 10.1016/j.bmcl.2012.09.060 |
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| Abstract | Catechol skeleton widely exists in natural products and bioactive substances. Fluorescent reporters which could recognize catechol are very promising for the construction of chemosensors to detect catechol and its derivatives in biological environment. Herein, we reported a novel catechol reporter, 2-(4-boronophenyl)quinoline-4-carboxylic acid, which exhibits significant fluorescent property changes upon binding catechol containing molecules in an aqueous solution. |
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| AbstractList | Catechol skeleton widely exists in natural products and bioactive substances. Fluorescent reporters which could recognize catechol are very promising for the construction of chemosensors to detect catechol and its derivatives in biological environment. Herein, we reported a novel catechol reporter, 2-(4-boronophenyl)quinoline-4-carboxylic acid, which exhibits significant fluorescent property changes upon binding catechol containing molecules in an aqueous solution. Catechol skeleton widely exists in natural products and bioactive substances. Fluorescent reporters which could recognize catechol are very promising for the construction of chemosensors to detect catechol and its derivatives in biological environment. Herein, we reported a novel catechol reporter, 2-(4-boronophenyl)quinoline-4-carboxylic acid, which exhibits significant fluorescent property changes upon binding catechol containing molecules in an aqueous solution.Catechol skeleton widely exists in natural products and bioactive substances. Fluorescent reporters which could recognize catechol are very promising for the construction of chemosensors to detect catechol and its derivatives in biological environment. Herein, we reported a novel catechol reporter, 2-(4-boronophenyl)quinoline-4-carboxylic acid, which exhibits significant fluorescent property changes upon binding catechol containing molecules in an aqueous solution. |
| Author | Li, Minyong Wang, Binghe Fang, Hao Wu, Zhongyu |
| Author_xml | – sequence: 1 givenname: Zhongyu surname: Wu fullname: Wu, Zhongyu organization: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University,44 West Wenhua Rd., Ji’nan 250012, China – sequence: 2 givenname: Minyong surname: Li fullname: Li, Minyong organization: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University,44 West Wenhua Rd., Ji’nan 250012, China – sequence: 3 givenname: Hao surname: Fang fullname: Fang, Hao email: haofangcn@sdu.edu.cn organization: Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmacy, Shandong University,44 West Wenhua Rd., Ji’nan 250012, China – sequence: 4 givenname: Binghe surname: Wang fullname: Wang, Binghe organization: Department of Chemistry, Gerogia State University, Atlanta 30303, USA |
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| Cites_doi | 10.1016/j.jpba.2009.09.045 10.1166/sl.2010.1343 10.1039/c1an15021a 10.4236/ajac.2011.22036 10.1212/WNL.63.1.2 10.1016/S0049-0172(85)80009-3 10.1016/j.bioelechem.2010.03.004 10.1039/c1ay00003a 10.1016/j.bios.2004.04.018 10.1039/c39940000477 10.1093/oxfordjournals.alcalc.a008218 10.1212/01.wnl.0000191304.55196.4d 10.1515/HC.2004.10.6.383 10.1016/j.bios.2011.05.025 10.1149/1.3456629 10.1186/cc2879 10.1016/S0968-0896(00)82131-8 10.3346/jkms.2010.25.3.399 10.1016/j.snb.2006.06.004 10.1021/ol048625f 10.4236/ajac.2011.22032 |
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| Keywords | Chemosensor Boronic acid Catechol detection BWFFCJJLMPLDBV-UHFFFAOYSA-N KXZJHVJKXJLBKO-UHFFFAOYSA-N Fluorescent reporter Boron Organic compounds Pyrocatechol Chemical sensor Fluorescent compound Detection |
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| Snippet | Catechol skeleton widely exists in natural products and bioactive substances. Fluorescent reporters which could recognize catechol are very promising for the... |
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| SubjectTerms | aqueous solutions bioactive properties Biological and medical sciences Boronic acid Boronic Acids - chemistry Catechol Catechol detection Catechols - chemistry Chemosensor Electron Transport fluorescence Fluorescent Dyes - chemistry Fluorescent reporter Kinetics Medical sciences natural products Pharmacology. Drug treatments Spectrometry, Fluorescence |
| Title | A new boronic acid based fluorescent reporter for catechol |
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