Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells
Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in mel...
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| Published in | Archives of pharmacal research Vol. 41; no. 3; pp. 324 - 332 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Seoul
Pharmaceutical Society of Korea
01.03.2018
대한약학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-6269 1976-3786 1976-3786 |
| DOI | 10.1007/s12272-018-1002-x |
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| Abstract | Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in melanocyte melan-a cells and B16F10 melanoma cells without inducing cytotoxicity. MC1R (melanocortin 1 receptor) protein expression was also inhibited by finasteride thereby decreasing the expression of adenylate cyclase, MITF (Melanogenesis associated transcription factor), tyrosinases, TRP (tyrosinase-related protein) -1 and -2. Thus our study suggest that finasteride inhibits melanogenesis in melanocyte and melanoma cells by inhibiting MC1R. |
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| AbstractList | Finasteride is a well-known 5a-reductase inhibitorused for treatment of alopecia and prostate cancer. But theeffect of finasteride in regulating melanogenesis is stillunclear. In the present study the role of finasteride onmelanogenesis was investigated. Finasteride decrease melaninlevel in melanocyte melan-a cells and B16F10 melanomacells without inducing cytotoxicity. MC1R (melanocortin 1receptor) protein expression was also inhibited by finasteridethereby decreasing the expression of adenylate cyclase, MITF(Melanogenesis associated transcription factor), tyrosinases,TRP (tyrosinase-related protein) -1 and -2. Thus our studysuggest that finasteride inhibits melanogenesis in melanocyteand melanoma cells by inhibiting MC1R. KCI Citation Count: 10 Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in melanocyte melan-a cells and B16F10 melanoma cells without inducing cytotoxicity. MC1R (melanocortin 1 receptor) protein expression was also inhibited by finasteride thereby decreasing the expression of adenylate cyclase, MITF (Melanogenesis associated transcription factor), tyrosinases, TRP (tyrosinase-related protein) -1 and -2. Thus our study suggest that finasteride inhibits melanogenesis in melanocyte and melanoma cells by inhibiting MC1R. Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in melanocyte melan-a cells and B16F10 melanoma cells without inducing cytotoxicity. MC1R (melanocortin 1 receptor) protein expression was also inhibited by finasteride thereby decreasing the expression of adenylate cyclase, MITF (Melanogenesis associated transcription factor), tyrosinases, TRP (tyrosinase-related protein) -1 and -2. Thus our study suggest that finasteride inhibits melanogenesis in melanocyte and melanoma cells by inhibiting MC1R.Finasteride is a well-known 5α-reductase inhibitor used for treatment of alopecia and prostate cancer. But the effect of finasteride in regulating melanogenesis is still unclear. In the present study the role of finasteride on melanogenesis was investigated. Finasteride decrease melanin level in melanocyte melan-a cells and B16F10 melanoma cells without inducing cytotoxicity. MC1R (melanocortin 1 receptor) protein expression was also inhibited by finasteride thereby decreasing the expression of adenylate cyclase, MITF (Melanogenesis associated transcription factor), tyrosinases, TRP (tyrosinase-related protein) -1 and -2. Thus our study suggest that finasteride inhibits melanogenesis in melanocyte and melanoma cells by inhibiting MC1R. |
| Author | Kim, Sun Yeou Yumnam, Silvia Seo, Jae Ok Jeong, Kwang Won |
| Author_xml | – sequence: 1 givenname: Jae Ok surname: Seo fullname: Seo, Jae Ok organization: College of Pharmacy, Gachon University – sequence: 2 givenname: Silvia surname: Yumnam fullname: Yumnam, Silvia organization: College of Pharmacy, Gachon University – sequence: 3 givenname: Kwang Won surname: Jeong fullname: Jeong, Kwang Won organization: College of Pharmacy, Gachon University, Gachon Institute of Pharmaceutical Science, Gachon University – sequence: 4 givenname: Sun Yeou orcidid: 0000-0001-8044-5613 surname: Kim fullname: Kim, Sun Yeou email: sunnykim@gachon.ac.kr organization: College of Pharmacy, Gachon University, Gachon Medical Research Institute, Gil Medical Center, Gachon Institute of Pharmaceutical Science, Gachon University |
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| Keywords | Finasteride MC1R Melanogenesis B16F10 Melan-a |
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| SubjectTerms | adenylate cyclase alopecia alpha-melanocyte-stimulating hormone cytotoxicity enzyme inhibitors Medicine melanin melanocytes melanogenesis melanoma Pharmacology/Toxicology Pharmacy prostatic neoplasms protein synthesis Research Article transcription factors 약학 |
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| Title | Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells |
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