Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells - Li, Yun; Fu, Jianxin; Ling, Yun; Yago, Tadayuki; McDaniel, J. Michael; Song, Jianhua; Bai, Xia; Kondo, Yuji; Qin, Yannan; Hoover, Christopher; McGee, Samuel; Shao, Bojing; et al. (Proceedings of the National Academy of Sciences - PNAS, 2017)
Keywords: Accumulation; Animals; Asialoglycoprotein Receptor - metabolism; Biological Sciences; Blood platelets; Blood Platelets - metabolism; Cells; Galactosyltransferases - genetics; Glycosylation; Hepatocytes; Hepatocytes - metabolism; Homeostasis - physiology; Kupffer cells; Kupffer Cells - metabolism; Lectins, C-Type - metabolism; Liver; Liver - metabolism; Membrane proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucin; N-Acetylneuraminic Acid - metabolism; Phagocytosis; Platelets; Polysaccharides; Polysaccharides - metabolism; Proteins; Rodents; Sialic acids; Thrombocytopenia - pathology; O-glycan; Kupffer cell; clearance; platelet