Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration - Pristerà, Alessandro; Blomeley, Craig; Lopes, Emanuel; Threlfell, Sarah; Merlini, Elisa; Burdakov, Denis; Cragg, Stephanie; Guillemot, François; Ang, Siew-Lan (Proceedings of the National Academy of Sciences - PNAS, 2019)
Keywords: Animals; Biological Sciences; Clonal deletion; Cognition - physiology; Cognitive ability; Corpus Striatum - metabolism; Corpus Striatum - physiology; Depolarization; Dopamine; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - pathology; Dopaminergic Neurons - physiology; Exploration; Exploratory Behavior - physiology; Growth factors; Hormones; Hormones - metabolism; Insulin; Insulin-like growth factor I; Insulin-Like Growth Factor I - biosynthesis; Insulin-Like Growth Factor I - genetics; Insulin-like growth factors; Learning - physiology; Learning behavior; Liver; Locomotion; Locomotion - genetics; Locomotion - physiology; Mesencephalon; Mesencephalon - metabolism; Mesencephalon - physiology; Mice; Neostriatum; Neurons; Neuropeptides; Neuropeptides - genetics; PNAS Plus; Reinforcement; firing; IGF-1; behavior; somatodendritic; dopamine