Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration
Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the ro...
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| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 9; pp. 3817 - 3826 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
26.02.2019
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| Series | PNAS Plus |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0027-8424 1091-6490 1091-6490 |
| DOI | 10.1073/pnas.1806820116 |
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| Abstract | Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the role of neuronally derived IGF-1 remains largely unexplored. We discovered that dopamine neurons secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopamine in the ventral midbrain. In addition, conditional deletion of dopamine neuron-derived IGF-1 in adult mice leads to decrease of dopamine content in the striatum and deficits in dopamine neuron firing and causes reduced spontaneous locomotion and impairments in explorative and learning behaviors. These data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors. |
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| AbstractList | Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the role of neuronally derived IGF-1 remains largely unexplored. We discovered that dopamine neurons secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopamine in the ventral midbrain. In addition, conditional deletion of dopamine neuron-derived IGF-1 in adult mice leads to decrease of dopamine content in the striatum and deficits in dopamine neuron firing and causes reduced spontaneous locomotion and impairments in explorative and learning behaviors. These data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors. Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the role of neuronally derived IGF-1 remains largely unexplored. We discovered that dopamine neurons secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopamine in the ventral midbrain. In addition, conditional deletion of dopamine neuron-derived IGF-1 in adult mice leads to decrease of dopamine content in the striatum and deficits in dopamine neuron firing and causes reduced spontaneous locomotion and impairments in explorative and learning behaviors. These data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors.Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the role of neuronally derived IGF-1 remains largely unexplored. We discovered that dopamine neurons secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopamine in the ventral midbrain. In addition, conditional deletion of dopamine neuron-derived IGF-1 in adult mice leads to decrease of dopamine content in the striatum and deficits in dopamine neuron firing and causes reduced spontaneous locomotion and impairments in explorative and learning behaviors. These data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors. Midbrain dopamine neurons play a role in motivational and cognitive control of behavior. In addition, they regulate motor functions. Dysregulation of dopamine neurons has been linked to depression, schizophrenia, and addiction and their degeneration is causal to Parkinson’s disease. Peripheral hormones have been shown to regulate dopamine neurons functions. Insulin-like growth factor 1 (IGF-1) is a hormone mainly produced in the liver. With this study we discovered that midbrain dopamine neurons synthesize and release IGF-1 in an activity dependent manner. In addition, dopamine neuron-derived IGF-1 modulates dopamine synthesis and dopamine neuron firing and ultimately it controls dopamine-dependent behaviors. This study highlights the neuromodulatory role of neuron-derived IGF-1 and its role in shaping dopamine transmission in the brain. Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the role of neuronally derived IGF-1 remains largely unexplored. We discovered that dopamine neurons secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopamine in the ventral midbrain. In addition, conditional deletion of dopamine neuron-derived IGF-1 in adult mice leads to decrease of dopamine content in the striatum and deficits in dopamine neuron firing and causes reduced spontaneous locomotion and impairments in explorative and learning behaviors. These data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors. |
| Author | Pristerà, Alessandro Lopes, Emanuel Cragg, Stephanie Ang, Siew-Lan Blomeley, Craig Merlini, Elisa Threlfell, Sarah Burdakov, Denis Guillemot, François |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30808767$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.neuron.2014.09.034 10.2174/1874473710902020195 10.1016/S1353-8020(09)70781-3 10.1196/annals.1417.003 10.1038/ncomms9543 10.1038/nn.3185 10.1242/jcs.061119 10.1038/nature17187 10.1016/j.neuroscience.2014.07.032 10.1016/j.neuron.2011.08.027 10.1016/j.tins.2007.03.003 10.1523/JNEUROSCI.2961-09.2009 10.1038/nrn3209 10.1016/j.expneurol.2007.01.029 10.1056/NEJM199610313351805 10.1126/scisignal.2005283 10.1016/j.celrep.2017.01.030 10.1038/ncomms2439 10.1186/1479-5876-10-224 10.1002/syn.890110405 10.1038/sj.emboj.7601608 10.7554/eLife.03772 10.1523/JNEUROSCI.4087-12.2013 10.1111/j.1471-4159.1991.tb08214.x 10.1371/journal.pbio.0060254 10.1038/nrn1406 10.1038/nn.4068 10.1016/j.febslet.2015.09.016 10.1016/0006-8993(92)91709-N 10.1002/jnr.10634 10.1523/JNEUROSCI.4742-09.2009 10.1523/JNEUROSCI.1163-05.2005 10.1016/j.celrep.2014.10.008 10.1016/0896-6273(95)90216-3 10.1073/pnas.1213569110 10.1038/aps.2010.105 10.1073/pnas.0813415106 10.1007/s00221-016-4572-1 10.1371/journal.pone.0109636 10.1016/j.neuron.2012.09.014 10.1016/S0896-6273(00)80950-2 10.1016/j.neuron.2015.12.034 10.1038/celldisc.2015.23 10.1093/brain/124.11.2131 10.1152/jn.00768.2004 10.1016/j.neuron.2004.05.019 10.1016/j.tins.2007.03.009 10.1046/j.1471-4159.1998.71041670.x 10.1038/nn.3321 10.1111/j.1471-4159.1991.tb08300.x 10.1371/journal.pone.0031728 10.1038/nrn.2016.57 10.1111/j.1471-4159.2004.02797.x 10.1210/mend.12.9.0162 10.1152/ajpendo.00425.2004 10.1152/jn.00077.2012 10.1016/j.neuron.2017.06.015 10.1042/BJ20110892 10.1093/hmg/ddi178 10.1523/JNEUROSCI.0590-10.2011 10.1098/rstb.2014.0185 10.1016/0092-8674(95)90145-0 10.1016/j.jchemneu.2011.02.001 10.1523/JNEUROSCI.4341-06.2007 10.1523/JNEUROSCI.0481-06.2006 10.1016/j.neuron.2009.04.015 10.1073/pnas.0631766100 10.1016/j.cell.2011.03.034 10.1016/j.neures.2004.12.006 10.1016/j.neuroscience.2014.01.025 10.1074/jbc.M506544200 |
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| Keywords | firing IGF-1 behavior somatodendritic dopamine |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Edited by Richard D. Palmiter, University of Washington, Seattle, WA, and approved December 27, 2018 (received for review April 23, 2018) Author contributions: A.P., C.B., E.L., S.T., S.C., and S.-L.A. designed research; A.P., C.B., E.L., S.T., and E.M. performed research; A.P., C.B., E.L., S.T., E.M., D.B., S.C., and S.-L.A. analyzed data; and A.P., F.G., and S.-L.A. wrote the paper. |
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| References | e_1_3_3_50_2 Weinert M (e_1_3_3_21_2) 2015 e_1_3_3_71_2 Threlfell S (e_1_3_3_30_2) 2006 e_1_3_3_16_2 e_1_3_3_18_2 e_1_3_3_39_2 e_1_3_3_12_2 e_1_3_3_37_2 e_1_3_3_58_2 e_1_3_3_14_2 e_1_3_3_35_2 e_1_3_3_56_2 e_1_3_3_33_2 e_1_3_3_54_2 e_1_3_3_10_2 e_1_3_3_31_2 e_1_3_3_52_2 e_1_3_3_73_2 e_1_3_3_40_2 e_1_3_3_61_2 e_1_3_3_5_2 e_1_3_3_7_2 e_1_3_3_9_2 e_1_3_3_27_2 e_1_3_3_29_2 e_1_3_3_23_2 e_1_3_3_48_2 e_1_3_3_69_2 e_1_3_3_25_2 e_1_3_3_46_2 e_1_3_3_67_2 Yee AG (e_1_3_3_32_2) 2018 e_1_3_3_1_2 e_1_3_3_44_2 e_1_3_3_65_2 e_1_3_3_3_2 e_1_3_3_42_2 e_1_3_3_63_2 e_1_3_3_51_2 e_1_3_3_74_2 e_1_3_3_70_2 e_1_3_3_17_2 e_1_3_3_19_2 e_1_3_3_38_2 e_1_3_3_13_2 e_1_3_3_36_2 e_1_3_3_59_2 e_1_3_3_15_2 e_1_3_3_34_2 e_1_3_3_57_2 e_1_3_3_55_2 e_1_3_3_11_2 e_1_3_3_53_2 e_1_3_3_72_2 e_1_3_3_62_2 e_1_3_3_60_2 e_1_3_3_6_2 e_1_3_3_8_2 e_1_3_3_28_2 e_1_3_3_49_2 e_1_3_3_24_2 e_1_3_3_47_2 e_1_3_3_26_2 e_1_3_3_45_2 e_1_3_3_68_2 e_1_3_3_2_2 e_1_3_3_20_2 e_1_3_3_43_2 e_1_3_3_66_2 e_1_3_3_4_2 e_1_3_3_22_2 e_1_3_3_41_2 e_1_3_3_64_2 |
| References_xml | – ident: e_1_3_3_37_2 doi: 10.1016/j.neuron.2014.09.034 – ident: e_1_3_3_44_2 doi: 10.2174/1874473710902020195 – ident: e_1_3_3_68_2 doi: 10.1016/S1353-8020(09)70781-3 – ident: e_1_3_3_2_2 doi: 10.1196/annals.1417.003 – ident: e_1_3_3_52_2 doi: 10.1038/ncomms9543 – ident: e_1_3_3_50_2 doi: 10.1038/nn.3185 – ident: e_1_3_3_36_2 doi: 10.1242/jcs.061119 – ident: e_1_3_3_12_2 doi: 10.1038/nature17187 – ident: e_1_3_3_63_2 doi: 10.1016/j.neuroscience.2014.07.032 – ident: e_1_3_3_72_2 doi: 10.1016/j.neuron.2011.08.027 – ident: e_1_3_3_49_2 doi: 10.1016/j.tins.2007.03.003 – ident: e_1_3_3_43_2 doi: 10.1523/JNEUROSCI.2961-09.2009 – ident: e_1_3_3_8_2 doi: 10.1038/nrn3209 – ident: e_1_3_3_42_2 doi: 10.1016/j.expneurol.2007.01.029 – ident: e_1_3_3_9_2 doi: 10.1056/NEJM199610313351805 – ident: e_1_3_3_41_2 doi: 10.1126/scisignal.2005283 – ident: e_1_3_3_15_2 doi: 10.1016/j.celrep.2017.01.030 – ident: e_1_3_3_17_2 doi: 10.1038/ncomms2439 – ident: e_1_3_3_5_2 doi: 10.1186/1479-5876-10-224 – ident: e_1_3_3_25_2 doi: 10.1002/syn.890110405 – ident: e_1_3_3_64_2 doi: 10.1038/sj.emboj.7601608 – ident: e_1_3_3_34_2 doi: 10.7554/eLife.03772 – ident: e_1_3_3_53_2 doi: 10.1523/JNEUROSCI.4087-12.2013 – ident: e_1_3_3_56_2 doi: 10.1111/j.1471-4159.1991.tb08214.x – ident: e_1_3_3_7_2 doi: 10.1371/journal.pbio.0060254 – ident: e_1_3_3_1_2 doi: 10.1038/nrn1406 – ident: e_1_3_3_74_2 doi: 10.1038/nn.4068 – volume-title: Electrochemical Methods for Neuroscience year: 2006 ident: e_1_3_3_30_2 – ident: e_1_3_3_51_2 doi: 10.1016/j.febslet.2015.09.016 – ident: e_1_3_3_54_2 doi: 10.1016/0006-8993(92)91709-N – ident: e_1_3_3_38_2 doi: 10.1002/jnr.10634 – ident: e_1_3_3_60_2 doi: 10.1523/JNEUROSCI.4742-09.2009 – ident: e_1_3_3_73_2 doi: 10.1523/JNEUROSCI.1163-05.2005 – ident: e_1_3_3_14_2 doi: 10.1016/j.celrep.2014.10.008 – ident: e_1_3_3_6_2 doi: 10.1016/0896-6273(95)90216-3 – ident: e_1_3_3_31_2 doi: 10.1073/pnas.1213569110 – ident: e_1_3_3_61_2 doi: 10.1038/aps.2010.105 – ident: e_1_3_3_62_2 doi: 10.1073/pnas.0813415106 – ident: e_1_3_3_18_2 doi: 10.1007/s00221-016-4572-1 – ident: e_1_3_3_33_2 doi: 10.1371/journal.pone.0109636 – ident: e_1_3_3_19_2 doi: 10.1016/j.neuron.2012.09.014 – ident: e_1_3_3_57_2 doi: 10.1016/S0896-6273(00)80950-2 – ident: e_1_3_3_28_2 doi: 10.1016/j.neuron.2015.12.034 – ident: e_1_3_3_58_2 doi: 10.1038/celldisc.2015.23 – ident: e_1_3_3_46_2 doi: 10.1093/brain/124.11.2131 – ident: e_1_3_3_27_2 doi: 10.1152/jn.00768.2004 – ident: e_1_3_3_22_2 doi: 10.1016/j.neuron.2004.05.019 – ident: e_1_3_3_4_2 doi: 10.1016/j.tins.2007.03.009 – ident: e_1_3_3_55_2 doi: 10.1046/j.1471-4159.1998.71041670.x – ident: e_1_3_3_16_2 doi: 10.1038/nn.3321 – ident: e_1_3_3_39_2 doi: 10.1111/j.1471-4159.1991.tb08300.x – ident: e_1_3_3_47_2 doi: 10.1371/journal.pone.0031728 – ident: e_1_3_3_3_2 doi: 10.1038/nrn.2016.57 – ident: e_1_3_3_40_2 doi: 10.1111/j.1471-4159.2004.02797.x – ident: e_1_3_3_71_2 doi: 10.1210/mend.12.9.0162 – ident: e_1_3_3_69_2 doi: 10.1152/ajpendo.00425.2004 – ident: e_1_3_3_24_2 doi: 10.1152/jn.00077.2012 – year: 2018 ident: e_1_3_3_32_2 article-title: Action potential and calcium dependence of tonic somatodendritic dopamine release in the Substantia Nigra pars compacta publication-title: J Neurochem – ident: e_1_3_3_11_2 doi: 10.1016/j.neuron.2017.06.015 – start-page: e52475 year: 2015 ident: e_1_3_3_21_2 article-title: Isolation, culture and long-term maintenance of primary mesencephalic dopaminergic neurons from embryonic rodent brains publication-title: J Vis Exp – ident: e_1_3_3_35_2 doi: 10.1042/BJ20110892 – ident: e_1_3_3_13_2 doi: 10.1093/hmg/ddi178 – ident: e_1_3_3_70_2 doi: 10.1523/JNEUROSCI.0590-10.2011 – ident: e_1_3_3_29_2 doi: 10.1098/rstb.2014.0185 – ident: e_1_3_3_45_2 doi: 10.1016/0092-8674(95)90145-0 – ident: e_1_3_3_20_2 doi: 10.1016/j.jchemneu.2011.02.001 – ident: e_1_3_3_59_2 doi: 10.1523/JNEUROSCI.4341-06.2007 – ident: e_1_3_3_66_2 doi: 10.1523/JNEUROSCI.0481-06.2006 – ident: e_1_3_3_67_2 doi: 10.1016/j.neuron.2009.04.015 – ident: e_1_3_3_26_2 doi: 10.1073/pnas.0631766100 – ident: e_1_3_3_10_2 doi: 10.1016/j.cell.2011.03.034 – ident: e_1_3_3_48_2 doi: 10.1016/j.neures.2004.12.006 – ident: e_1_3_3_23_2 doi: 10.1016/j.neuroscience.2014.01.025 – ident: e_1_3_3_65_2 doi: 10.1074/jbc.M506544200 |
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| Snippet | Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms,... Midbrain dopamine neurons play a role in motivational and cognitive control of behavior. In addition, they regulate motor functions. Dysregulation of dopamine... |
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| Title | Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration |
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