Subject-Specific Mapping of Excess Manganese Accumulation in the Brain of Welders Using Magnetic Resonance Imaging Relaxometry
Chronic overexposure to manganese (Mn) can occur in occupational settings, such as welding, leading to increased Mn levels in the brain. Excess brain Mn accumulation may result in neurotoxicity, which is characterized by Parkinsonian-like symptoms including motor and cognitive dysfunctions. In this...
Saved in:
| Published in | Toxics (Basel) Vol. 13; no. 3; p. 157 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
25.02.2025
MDPI |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2305-6304 2305-6304 |
| DOI | 10.3390/toxics13030157 |
Cover
| Abstract | Chronic overexposure to manganese (Mn) can occur in occupational settings, such as welding, leading to increased Mn levels in the brain. Excess brain Mn accumulation may result in neurotoxicity, which is characterized by Parkinsonian-like symptoms including motor and cognitive dysfunctions. In this work, we demonstrate a novel methodology for personalized diagnosis and spatial characterization of abnormal Magnetic Resonance Imaging R1 (R1 = 1/T1) relaxation rates arising from excessive Mn accumulation in welders’ brains. Utilizing voxel-wise population-derived norms based on a frequency age-matched non-exposed group (n = 25), we demonstrate the ability to conduct subject-specific assessments and mapping of Mn exposure using MRI relaxometry. Our results show elevated R1 in multiple brain regions in individual welders, but also extreme between-subject variability in Mn accumulation, debasing the concept that high exposures correlate with uniformly high Mn deposition in the brain. Consequently, the presented personalized methodology serves as a counterpart to group-based comparison, which allows for understanding the level of individual exposure and the toxicokinetics of Mn accumulation. This work lays a foundation for improved occupational health assessments and preventive measures against neurotoxic metal exposure. |
|---|---|
| AbstractList | Chronic overexposure to manganese (Mn) can occur in occupational settings, such as welding, leading to increased Mn levels in the brain. Excess brain Mn accumulation may result in neurotoxicity, which is characterized by Parkinsonian-like symptoms including motor and cognitive dysfunctions. In this work, we demonstrate a novel methodology for personalized diagnosis and spatial characterization of abnormal Magnetic Resonance Imaging R1 (R1 = 1/T1) relaxation rates arising from excessive Mn accumulation in welders' brains. Utilizing voxel-wise population-derived norms based on a frequency age-matched non-exposed group (n = 25), we demonstrate the ability to conduct subject-specific assessments and mapping of Mn exposure using MRI relaxometry. Our results show elevated R1 in multiple brain regions in individual welders, but also extreme between-subject variability in Mn accumulation, debasing the concept that high exposures correlate with uniformly high Mn deposition in the brain. Consequently, the presented personalized methodology serves as a counterpart to group-based comparison, which allows for understanding the level of individual exposure and the toxicokinetics of Mn accumulation. This work lays a foundation for improved occupational health assessments and preventive measures against neurotoxic metal exposure. Chronic overexposure to manganese (Mn) can occur in occupational settings, such as welding, leading to increased Mn levels in the brain. Excess brain Mn accumulation may result in neurotoxicity, which is characterized by Parkinsonian-like symptoms including motor and cognitive dysfunctions. In this work, we demonstrate a novel methodology for personalized diagnosis and spatial characterization of abnormal Magnetic Resonance Imaging R1 (R1 = 1/T1) relaxation rates arising from excessive Mn accumulation in welders' brains. Utilizing voxel-wise population-derived norms based on a frequency age-matched non-exposed group (n = 25), we demonstrate the ability to conduct subject-specific assessments and mapping of Mn exposure using MRI relaxometry. Our results show elevated R1 in multiple brain regions in individual welders, but also extreme between-subject variability in Mn accumulation, debasing the concept that high exposures correlate with uniformly high Mn deposition in the brain. Consequently, the presented personalized methodology serves as a counterpart to group-based comparison, which allows for understanding the level of individual exposure and the toxicokinetics of Mn accumulation. This work lays a foundation for improved occupational health assessments and preventive measures against neurotoxic metal exposure.Chronic overexposure to manganese (Mn) can occur in occupational settings, such as welding, leading to increased Mn levels in the brain. Excess brain Mn accumulation may result in neurotoxicity, which is characterized by Parkinsonian-like symptoms including motor and cognitive dysfunctions. In this work, we demonstrate a novel methodology for personalized diagnosis and spatial characterization of abnormal Magnetic Resonance Imaging R1 (R1 = 1/T1) relaxation rates arising from excessive Mn accumulation in welders' brains. Utilizing voxel-wise population-derived norms based on a frequency age-matched non-exposed group (n = 25), we demonstrate the ability to conduct subject-specific assessments and mapping of Mn exposure using MRI relaxometry. Our results show elevated R1 in multiple brain regions in individual welders, but also extreme between-subject variability in Mn accumulation, debasing the concept that high exposures correlate with uniformly high Mn deposition in the brain. Consequently, the presented personalized methodology serves as a counterpart to group-based comparison, which allows for understanding the level of individual exposure and the toxicokinetics of Mn accumulation. This work lays a foundation for improved occupational health assessments and preventive measures against neurotoxic metal exposure. |
| Audience | Academic |
| Author | Monsivais, Humberto Dydak, Ulrike |
| AuthorAffiliation | 1 School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA; hmonsiva@purdue.edu 2 Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA |
| AuthorAffiliation_xml | – name: 1 School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA; hmonsiva@purdue.edu – name: 2 Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA |
| Author_xml | – sequence: 1 givenname: Humberto orcidid: 0000-0001-7503-7738 surname: Monsivais fullname: Monsivais, Humberto – sequence: 2 givenname: Ulrike orcidid: 0000-0003-1852-7110 surname: Dydak fullname: Dydak, Ulrike |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40137484$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkk1v1DAQhiNURD_olSOKxIXLFjt27OSElqqFlVohtVQcrbEzSb1K7MVO0PbCb8ehpe0i7IOtmXcee-z3MNtz3mGWvaHkhLGafBj91ppIGWGElvJFdlAwUi4EI3zv2X4_O45xTdKoKauEeJXtc0KZ5BU_yH5dT3qNZlxcb9DY1pr8EjYb67rct_nZ1mCMKeI6cBgxXxozDVMPo_Uuty4fbzH_FCDtkvo79g2GmN_EufwSOodj4l1h9A6cwXw1QDenrrCHrR9wDHevs5ct9BGPH9aj7Ob87Nvpl8XF18-r0-XFwpSkHhfQaE5aU7RNJWUDRNJKNxxEQXTN5lRdaYpSM86RtcJoiQWt0LRQcM1rYEfZ6p7beFirTbADhDvlwao_AR86BSHdtkclNRBsmGwkFZzCzOK10ASEYKJuysT6eM_aTHrAxqAbA_Q70N2Ms7eq8z8VpTUvueCJ8P6BEPyPCeOoBhsN9n16ZT9FxWhVcMloPR_27h_p2k_BpbeaVVSKsuLiSdVB6sC61qeDzQxVyyr9OafJIkl18h9Vmg0O1iRrtTbFdwrePu_0scW_9nkimuBjDNg-SihRs0XVrkXZb0nd2bg |
| Cites_doi | 10.1371/journal.pone.0163774 10.2174/1574887117666220617104539 10.1016/j.ncl.2020.07.008 10.1002/ajim.20518 10.1016/j.neuro.2011.12.010 10.1016/j.neuro.2006.03.014 10.1016/j.neuroimage.2010.03.005 10.1016/j.cgh.2020.07.039 10.1093/annweh/wxx091 10.1016/j.neuroimage.2007.07.007 10.1016/j.neuroimage.2012.12.045 10.1016/j.neuro.2017.05.010 10.1016/j.compbiomed.2020.103708 10.1093/toxsci/kfv099 10.1007/s00204-021-03166-1 10.1002/hbm.24522 10.1109/TMI.2019.2897538 10.1016/j.neuroimage.2019.01.029 10.1002/mrm.10407 10.1016/j.neuroimage.2011.09.015 10.1016/j.neuroimage.2024.120523 10.1016/j.neuro.2017.08.013 10.1136/oemed-2011-100119 10.1111/add.13373 10.2741/4665 10.1152/physrev.1987.67.3.858 10.1002/mrm.27927 10.1016/j.neuro.2006.08.005 10.1039/C7MT00079K 10.1093/toxsci/kfz174 10.1093/toxsci/kfv088 10.1002/jmri.22104 10.1016/j.neuro.2006.05.020 10.1097/WCO.0000000000000222 10.18383/j.tom.2015.00166 10.1039/9781782622383-00477 10.3945/an.117.015305 10.1016/S0140-6736(95)92164-8 10.1007/s00204-020-02839-7 10.1006/enrs.2000.4068 10.1016/B978-0-444-62627-1.00003-2 10.1016/j.ntt.2013.11.004 10.1016/S1353-8020(08)70005-1 10.1148/radiol.2015142690 10.1016/j.nicl.2018.11.017 10.1007/s11548-021-02511-0 10.1111/j.1471-4159.1993.tb02153.x 10.1148/radiol.15150025 10.1016/j.neuroimage.2011.01.052 10.1016/j.neuro.2006.11.001 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2025 MDPI AG 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2025 by the authors. 2025 |
| Copyright_xml | – notice: COPYRIGHT 2025 MDPI AG – notice: 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2025 by the authors. 2025 |
| DBID | AAYXX CITATION NPM 3V. 7U7 7XB 8FE 8FH 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO GNUQQ GUQSH HCIFZ LK8 M2O M7P MBDVC PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.3390/toxics13030157 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Toxicology Abstracts ProQuest Central (purchase pre-March 2016) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central ProQuest Central Student ProQuest Research Library SciTech Premium Collection Biological Sciences Research Library Biological Science Database Research Library (Corporate) ProQuest Central Premium ProQuest One Academic ProQuest Publicly Available Content ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Research Library ProQuest Central (New) ProQuest Biological Science Collection ProQuest Central Basic Toxicology Abstracts ProQuest One Academic Eastern Edition Biological Science Database ProQuest SciTech Collection ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed CrossRef MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health |
| EISSN | 2305-6304 |
| ExternalDocumentID | oai_doaj_org_article_7ba0ed37d71641acb7e496b0a66369d5 PMC11945464 A838641030 40137484 10_3390_toxics13030157 |
| Genre | Journal Article |
| GeographicLocations | Massachusetts Minnesota |
| GeographicLocations_xml | – name: Minnesota – name: Massachusetts |
| GrantInformation_xml | – fundername: International Manganese Institute grantid: N/A – fundername: NIH HHS grantid: 1F31ES035299-01A1 – fundername: NIEHS NIH HHS grantid: R01ES020529 – fundername: NIEHS NIH HHS grantid: R01ES032478 – fundername: NIH/NIEHS grantid: F31ES035299; R01ES020529; R01ES032478 – fundername: International Manganese Institute |
| GroupedDBID | 53G 5VS 8FE 8FH 8G5 AADQD AAFWJ AAHBH AAYXX ABUWG ADBBV AEUYN AFKRA AFPKN AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BBNVY BCNDV BENPR BHPHI BPHCQ CCPQU CITATION DWQXO GNUQQ GROUPED_DOAJ GUQSH HCIFZ HYE IAO IHR ITC KQ8 LK8 M2O M7P MODMG M~E OK1 PGMZT PHGZM PHGZT PIMPY PQQKQ PROAC RPM NPM PMFND 3V. 7U7 7XB 8FK C1K MBDVC PKEHL PQEST PQGLB PQUKI PRINS Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c509t-adb40fc2fd877da0718bd4a620b93b40f98b1e7b344e3f6cb7e218ecfa24b49a3 |
| IEDL.DBID | BENPR |
| ISSN | 2305-6304 |
| IngestDate | Wed Aug 27 01:26:02 EDT 2025 Thu Aug 21 18:39:07 EDT 2025 Fri Sep 05 17:51:43 EDT 2025 Fri Jul 25 12:04:07 EDT 2025 Tue Jun 17 21:57:05 EDT 2025 Tue Jun 10 20:53:01 EDT 2025 Sun Mar 30 01:29:59 EDT 2025 Tue Jul 01 05:39:54 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | neurotoxicity welding R1 mapping MRI manganese |
| Language | English |
| License | https://creativecommons.org/licenses/by/4.0 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c509t-adb40fc2fd877da0718bd4a620b93b40f98b1e7b344e3f6cb7e218ecfa24b49a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Current address: Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. |
| ORCID | 0000-0001-7503-7738 0000-0003-1852-7110 |
| OpenAccessLink | https://www.proquest.com/docview/3181765846?pq-origsite=%requestingapplication%&accountid=15518 |
| PMID | 40137484 |
| PQID | 3181765846 |
| PQPubID | 2032322 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7ba0ed37d71641acb7e496b0a66369d5 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11945464 proquest_miscellaneous_3182473195 proquest_journals_3181765846 gale_infotracmisc_A838641030 gale_infotracacademiconefile_A838641030 pubmed_primary_40137484 crossref_primary_10_3390_toxics13030157 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2025-02-25 |
| PublicationDateYYYYMMDD | 2025-02-25 |
| PublicationDate_xml | – month: 02 year: 2025 text: 2025-02-25 day: 25 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Toxics (Basel) |
| PublicationTitleAlternate | Toxics |
| PublicationYear | 2025 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Abenavoli (ref_38) 2022; 17 Kim (ref_14) 1999; 20 Ma (ref_27) 2018; 64 Ye (ref_41) 2017; 9 Bonnier (ref_3) 2018; 21 Lee (ref_25) 2015; 146 Criswell (ref_15) 2012; 69 Choi (ref_26) 2007; 28 ref_16 Ward (ref_28) 2018; 62 Stockwell (ref_49) 2016; 111 Krieger (ref_17) 1995; 346 Scarpazza (ref_43) 2013; 70 Racette (ref_7) 2012; 33 Jenkinson (ref_33) 2012; 62 Bowler (ref_11) 2018; 64 Slater (ref_37) 2019; 40 Jiang (ref_19) 2007; 28 Weiskopf (ref_4) 2015; 28 Han (ref_42) 2021; 95 Jenkinson (ref_32) 2005; 17 McDonald (ref_51) 2015; 275 Bowler (ref_10) 2015; Volume 131 Martin (ref_13) 2020; 38 Ellingsen (ref_50) 2014; 41 Piredda (ref_34) 2020; 83 Bowler (ref_9) 2007; 28 Dietz (ref_20) 2001; 85 Aschner (ref_5) 2017; 8 Tsuboi (ref_8) 2007; 13 Edmondson (ref_22) 2019; 172 Deoni (ref_29) 2003; 49 Chen (ref_40) 2018; 23 Zoni (ref_12) 2007; 50 Kanda (ref_52) 2015; 276 Balakrishnan (ref_45) 2019; 38 Ashburner (ref_31) 2007; 38 Prohaska (ref_48) 1987; 67 Monsivais (ref_24) 2024; 288 Chang (ref_18) 2010; 31 Tabelow (ref_30) 2019; 194 Draganski (ref_36) 2011; 55 ref_44 Kano (ref_39) 2021; 19 Shao (ref_46) 2022; 17 Shin (ref_21) 2007; 28 Badve (ref_35) 2015; 1 ref_1 Edmondson (ref_23) 2020; 94 Baudrexel (ref_2) 2010; 51 Rabin (ref_47) 1993; 61 Guilarte (ref_6) 2015; 146 |
| References_xml | – ident: ref_1 doi: 10.1371/journal.pone.0163774 – volume: 17 start-page: 216 year: 2022 ident: ref_38 article-title: Hepatic Encephalopathy by Manganese Deposition: A Case Report and a Review of Literature publication-title: Rev. Recent Clin. Trials doi: 10.2174/1574887117666220617104539 – volume: 38 start-page: 913 year: 2020 ident: ref_13 article-title: Manganese Exposure and Neurologic Outcomes in Adult Populations publication-title: Neurol. Clin. doi: 10.1016/j.ncl.2020.07.008 – volume: 50 start-page: 812 year: 2007 ident: ref_12 article-title: Neuropsychological Testing for the Assessment of Manganese Neurotoxicity: A Review and a Proposal publication-title: Am. J. Ind. Med. doi: 10.1002/ajim.20518 – volume: 33 start-page: 881 year: 2012 ident: ref_7 article-title: Pathophysiology of Manganese-Associated Neurotoxicity publication-title: NeuroToxicology doi: 10.1016/j.neuro.2011.12.010 – volume: 28 start-page: 257 year: 2007 ident: ref_21 article-title: High Signal Intensity on Magnetic Resonance Imaging as a Predictor of Neurobehavioral Performance of Workers Exposed to Manganese publication-title: NeuroToxicology doi: 10.1016/j.neuro.2006.03.014 – volume: 51 start-page: 512 year: 2010 ident: ref_2 article-title: Quantitative Mapping of T1 and T2* Discloses Nigral and Brainstem Pathology in Early Parkinson’s Disease publication-title: NeuroImage doi: 10.1016/j.neuroimage.2010.03.005 – volume: 19 start-page: e114 year: 2021 ident: ref_39 article-title: Pallidal Manganese Concentration in Hepatic Encephalopathy publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/j.cgh.2020.07.039 – volume: 17 start-page: 167 year: 2005 ident: ref_32 article-title: BET2—MR-Based Estimation of Brain, Skull and Scalp Surfaces publication-title: Elev. Annu. Meet. Organ. Hum. Brain Mapp. – volume: 62 start-page: 101 year: 2018 ident: ref_28 article-title: Toenail Manganese: A Sensitive and Specific Biomarker of Exposure to Manganese in Career Welders publication-title: Ann. Work Expo. Health doi: 10.1093/annweh/wxx091 – volume: 38 start-page: 95 year: 2007 ident: ref_31 article-title: A Fast Diffeomorphic Image Registration Algorithm publication-title: NeuroImage doi: 10.1016/j.neuroimage.2007.07.007 – volume: 70 start-page: 175 year: 2013 ident: ref_43 article-title: When the Single Matters More than the Group: Very High False Positive Rates in Single Case Voxel Based Morphometry publication-title: NeuroImage doi: 10.1016/j.neuroimage.2012.12.045 – volume: 64 start-page: 19 year: 2018 ident: ref_11 article-title: Association of MRI T1 Relaxation Time with Neuropsychological Test Performance in Manganese-Exposed Welders publication-title: NeuroToxicology doi: 10.1016/j.neuro.2017.05.010 – ident: ref_44 doi: 10.1016/j.compbiomed.2020.103708 – volume: 146 start-page: 204 year: 2015 ident: ref_6 article-title: Manganese-Induced Parkinsonism Is Not Idiopathic Parkinson’s Disease: Environmental and Genetic Evidence publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfv099 – volume: 95 start-page: 3665 year: 2021 ident: ref_42 article-title: Alcohol Exposure Increases Manganese Accumulation in the Brain and Exacerbates Manganese-Induced Neurotoxicity in Mice publication-title: Arch. Toxicol. doi: 10.1007/s00204-021-03166-1 – volume: 40 start-page: 2252 year: 2019 ident: ref_37 article-title: Evolution of White Matter Tract Microstructure across the Life Span publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.24522 – volume: 38 start-page: 1788 year: 2019 ident: ref_45 article-title: VoxelMorph: A Learning Framework for Deformable Medical Image Registration publication-title: IEEE Trans. Med. Imag. doi: 10.1109/TMI.2019.2897538 – volume: 20 start-page: 901 year: 1999 ident: ref_14 article-title: Increase in Signal Intensities on T1-Weighted Magnetic Resonance Images in Asymptomatic Manganese-Exposed Workers publication-title: Neurotoxicology – volume: 194 start-page: 191 year: 2019 ident: ref_30 article-title: hMRI—A Toolbox for Quantitative MRI in Neuroscience and Clinical Research publication-title: NeuroImage doi: 10.1016/j.neuroimage.2019.01.029 – volume: 49 start-page: 515 year: 2003 ident: ref_29 article-title: Rapid Combined T1 and T2 Mapping Using Gradient Recalled Acquisition in the Steady State publication-title: Magn. Reson. Med. doi: 10.1002/mrm.10407 – volume: 62 start-page: 782 year: 2012 ident: ref_33 article-title: FSL publication-title: NeuroImage doi: 10.1016/j.neuroimage.2011.09.015 – volume: 288 start-page: 120523 year: 2024 ident: ref_24 article-title: Whole-Brain Mapping of Increased Manganese Levels in Welders and Its Association with Exposure and Motor Function publication-title: NeuroImage doi: 10.1016/j.neuroimage.2024.120523 – volume: 64 start-page: 30 year: 2018 ident: ref_27 article-title: Thalamic GABA Levels and Occupational Manganese Neurotoxicity: Association with Exposure Levels and Brain MRI publication-title: NeuroToxicology doi: 10.1016/j.neuro.2017.08.013 – volume: 69 start-page: 437 year: 2012 ident: ref_15 article-title: Basal Ganglia Intensity Indices and Diffusion Weighted Imaging in Manganese-Exposed Welders publication-title: Occup. Environ. Med. doi: 10.1136/oemed-2011-100119 – volume: 111 start-page: 1203 year: 2016 ident: ref_49 article-title: Estimating Under- and over-Reporting of Drinking in National Surveys of Alcohol Consumption: Identification of Consistent Biases across Four English-Speaking Countries publication-title: Addict. Abingdon Engl. doi: 10.1111/add.13373 – volume: 23 start-page: 1655 year: 2018 ident: ref_40 article-title: Manganese Metabolism in Humans publication-title: Front. Biosci. Landmark doi: 10.2741/4665 – volume: 67 start-page: 858 year: 1987 ident: ref_48 article-title: Functions of Trace Elements in Brain Metabolism publication-title: Physiol. Rev. doi: 10.1152/physrev.1987.67.3.858 – volume: 83 start-page: 337 year: 2020 ident: ref_34 article-title: Quantitative Brain Relaxation Atlases for Personalized Detection and Characterization of Brain Pathology publication-title: Magn. Reson. Med. doi: 10.1002/mrm.27927 – volume: 28 start-page: 126 year: 2007 ident: ref_19 article-title: Brain Magnetic Resonance Imaging and Manganese Concentrations in Red Blood Cells of Smelting Workers: Search for Biomarkers of Manganese Exposure publication-title: NeuroToxicology doi: 10.1016/j.neuro.2006.08.005 – volume: 9 start-page: 1028 year: 2017 ident: ref_41 article-title: Influence of Iron Metabolism on Manganese Transport and Toxicity publication-title: Metallomics doi: 10.1039/C7MT00079K – volume: 172 start-page: 181 year: 2019 ident: ref_22 article-title: Reversibility of Neuroimaging Markers Influenced by Lifetime Occupational Manganese Exposure publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfz174 – volume: 146 start-page: 281 year: 2015 ident: ref_25 article-title: T1 Relaxation Rate (R1) Indicates Nonlinear Mn Accumulation in Brain Tissue of Welders with Low-Level Exposure publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfv088 – volume: 31 start-page: 1020 year: 2010 ident: ref_18 article-title: Pallidal Index Measured with Three-Dimensional T1-Weighted Gradient Echo Sequence Is a Good Predictor of Manganese Exposure in Welders publication-title: J. Magn. Reson. Imaging doi: 10.1002/jmri.22104 – volume: 28 start-page: 284 year: 2007 ident: ref_26 article-title: Evaluation of MR Signal Index for the Assessment of Occupational Manganese Exposure of Welders by Measurement of Local Proton T1 Relaxation Time publication-title: NeuroToxicology doi: 10.1016/j.neuro.2006.05.020 – volume: 28 start-page: 313 year: 2015 ident: ref_4 article-title: Advances in MRI-Based Computational Neuroanatomy: From Morphometry to in-Vivo Histology publication-title: Curr. Opin. Neurol. doi: 10.1097/WCO.0000000000000222 – volume: 1 start-page: 136 year: 2015 ident: ref_35 article-title: Simultaneous T1 and T2 Brain Relaxometry in Asymptomatic Volunteers Using Magnetic Resonance Fingerprinting publication-title: Tomography doi: 10.18383/j.tom.2015.00166 – ident: ref_16 doi: 10.1039/9781782622383-00477 – volume: 8 start-page: 520 year: 2017 ident: ref_5 article-title: Manganese publication-title: Adv. Nutr. doi: 10.3945/an.117.015305 – volume: 346 start-page: 270 year: 1995 ident: ref_17 article-title: Manganese and Chronic Hepatic Encephalopathy Departments of Neurology publication-title: The Lancet doi: 10.1016/S0140-6736(95)92164-8 – volume: 94 start-page: 3409 year: 2020 ident: ref_23 article-title: Whole-Brain R1 Predicts Manganese Exposure and Biological Effects in Welders publication-title: Arch. Toxicol. doi: 10.1007/s00204-020-02839-7 – volume: 85 start-page: 37 year: 2001 ident: ref_20 article-title: Results of Magnetic Resonance Imaging in Long-Term Manganese Dioxide-Exposed Workers publication-title: Environ. Res. doi: 10.1006/enrs.2000.4068 – volume: Volume 131 start-page: 23 year: 2015 ident: ref_10 article-title: Neuropsychologic Evaluation and Exposure to Neurotoxicants publication-title: Handbook of Clinical Neurology doi: 10.1016/B978-0-444-62627-1.00003-2 – volume: 41 start-page: 8 year: 2014 ident: ref_50 article-title: The Interaction between Manganese Exposure and Alcohol on Neurobehavioral Outcomes in Welders publication-title: Neurotoxicol. Teratol. doi: 10.1016/j.ntt.2013.11.004 – volume: 13 start-page: S221 year: 2007 ident: ref_8 article-title: Neuropathology of Parkinson’s Disease Dementia and Dementia with Lewy Bodies with Reference to Striatal Pathology publication-title: Park. Relat. Disord. doi: 10.1016/S1353-8020(08)70005-1 – volume: 276 start-page: 228 year: 2015 ident: ref_52 article-title: Gadolinium-Based Contrast Agent Accumulates in the Brain Even in Subjects without Severe Renal Dysfunction: Evaluation of Autopsy Brain Specimens with Inductively Coupled Plasma Mass Spectroscopy publication-title: Radiology doi: 10.1148/radiol.2015142690 – volume: 21 start-page: 101607 year: 2018 ident: ref_3 article-title: Personalized Pathology Maps to Quantify Diffuse and Focal Brain Damage publication-title: NeuroImage Clin. doi: 10.1016/j.nicl.2018.11.017 – volume: 17 start-page: 157 year: 2022 ident: ref_46 article-title: A Multi-Scale Unsupervised Learning for Deformable Image Registration publication-title: Int. J. Comput. Assist. Radiol. Surg. doi: 10.1007/s11548-021-02511-0 – volume: 61 start-page: 509 year: 1993 ident: ref_47 article-title: Rapid Brain Uptake of Manganese (II) Across the Blood-Brain Barrier publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.1993.tb02153.x – volume: 275 start-page: 772 year: 2015 ident: ref_51 article-title: Intracranial Gadolinium Deposition after Contrast-Enhanced MR Imaging publication-title: Radiology doi: 10.1148/radiol.15150025 – volume: 55 start-page: 1423 year: 2011 ident: ref_36 article-title: Regional Specificity of MRI Contrast Parameter Changes in Normal Ageing Revealed by Voxel-Based Quantification (VBQ) publication-title: Neuroimage doi: 10.1016/j.neuroimage.2011.01.052 – volume: 28 start-page: 298 year: 2007 ident: ref_9 article-title: Sequelae of Fume Exposure in Confined Space Welding: A Neurological and Neuropsychological Case Series publication-title: NeuroToxicology doi: 10.1016/j.neuro.2006.11.001 |
| SSID | ssj0000913866 |
| Score | 2.2875123 |
| Snippet | Chronic overexposure to manganese (Mn) can occur in occupational settings, such as welding, leading to increased Mn levels in the brain. Excess brain Mn... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | 157 |
| SubjectTerms | Accumulation Age Assessments Basal ganglia Brain Brain research Central nervous system diseases Customization Exposure Magnetic resonance imaging Manganese Mapping Medical imaging Metal workers Movement disorders MRI Neuroimaging Neurotoxicity Occupational exposure Occupational health R1 mapping Welding Welding machines |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT0gIUZ6BgoyExClqEk8c-7hFrQpSOVHRW-TnsodNqm5WWi789s446WojDly4ZpxdxzOehzX-PsY-CVd4iEXMQ1RYoNR1zK2CKtfORi-VLEzCmb36Li-v4dtNfXNA9UU9YSM88Lhwp401RfCi8ZTYl8bZJoCWtjAYKqX2Cb200MVBMZV8sC6FknJEaRRY158O_W7lNuSxMQA2syiUwPr_dskHMWneL3kQgC6esadT5sgX44yP2aPQPWdPxmM3Pt4mesH-oCOgk5U88cpHlFwZQmBY8j7y8x3dCcAn3dIQ8SRfOLddT_xdfNVxTAb5GXFG0OifgQi8Nzw1FeBLy47uO3I67yeQjsC_rhPDEad-ul2_DsPd75fs-uL8x5fLfKJYyB1mCkNuvIUiuip61TTeYL6hrAcjq8JqQSKtbBkaKwCCiJJWH3OC4KKpwII24hU76vouvGHcWltjsulL_EkIBqyIlRE6QNS2VBIy9vlhydvbEUmjxQqElNPOlZOxM9LIfhQhYKcHaBftZBftv-wC_4702dI-RaU5M103wMkS4lW7UGggQCRrGTuZjcT95ebiB4top_29adETlk1K3jL2cS-mN6lnrQv9No2poEEXh3N5PRrQ_pOoqiUU14ypmWnNvnku6Va_Evp3WWqoQcLb_7FK79jjigiN6Y5-fcKOhrtteI9Z1mA_pA11D-eOKG4 priority: 102 providerName: Directory of Open Access Journals |
| Title | Subject-Specific Mapping of Excess Manganese Accumulation in the Brain of Welders Using Magnetic Resonance Imaging Relaxometry |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/40137484 https://www.proquest.com/docview/3181765846 https://www.proquest.com/docview/3182473195 https://pubmed.ncbi.nlm.nih.gov/PMC11945464 https://doaj.org/article/7ba0ed37d71641acb7e496b0a66369d5 |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bi9NAFB7W7osg4t3ouowg-BQ2l8nM5EGklS6rsEXExX0Lc-32ocnaplBf_O2eM0nqBsHXzKSdZM5tTs75PkLe5SaxzCc-dl7CAaUofKwly-LSaG-55IkKOLOXC35xxb5cF9dHZDH0wmBZ5WATg6G2jcEc-RnIXiqCu_x4-zNG1ij8ujpQaKieWsF-CBBj98gxmOQimZDj2Xzx9dsh64IomJLzDr0xh_P-WdvsV2aLlhwcoxh5pwDi_6-pvuOrxnWUdxzT-SPysI8o6bQTgcfkyNVPyIMuHUe7LqOn5DcYCMy4xIFv3sPIpUJkhiVtPJ3vsVcArtRLhYSUdGrMbt3zetFVTSFIpDPkksDZPxwSe29pKDaAm5Y19kFS_A6A4B2Ofl4H5iOKdXb7Zu3aza9n5Op8_v3TRdxTL8QGIog2VlazxJvMWymEVRCHSG2Z4lmiyxyHSqlTJ3TOmMs9N1o4iBWc8SpjmpUqf04mdVO7l4RqrQsIQm0KP8mcYjr3mcpLx3ypU8lZRN4Pr7y67RA2KjiZ4OZU482JyAx35DALkbHDhWazrHpFq4RWibO5sHgQTBWujJVcJwpCK17aAv4O97NC_YVNM6pvQ4DFIhJWNZUgIAzJ1yJyMpoJemfGw4NEVL3eb6u_UhqRt4dhvBNr2WrX7MKcjAkwfbCWF50AHR4JT7uI7hoRORKt0TOPR-rVTUAFT9OSFYyzV_9f12tyP0MKY-zKL07IpN3s3BuIq1p92ivLachL_AFCmCdk |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6V9AASQrxJKbBIIE5W_Viv7UOFEkiV0CZCqBW9ufsMOcRu8xDphZ_Gb2NmbYdaSNx69ayddea1s975PkLeRcrXzPrWMzaFAiWOrSdTFnqZklbzlPvC4cyOJ3x4xr6cx-c75HfTC4PHKpuY6AK1LhXukR-A7QWJS5cfL688ZI3Cr6sNhYaoqRX0oYMYqxs7js31Tyjhloejz6Dv92F4NDj9NPRqlgFPQbJceUJL5lsVWp0miRaQclOpmeChL7MIRVkqA5PIiDETWa5kYiAtGmVFyCTLRATPvUN2GW6gdMhufzD5-m27y4OomynnFVpkFGX-warczNQSMwck4qSVDR1pwL-p4UZubJ_bvJEIjx6SB_UKlvYqk3tEdkzxmNyvtv9o1dX0hPyCgIQ7PJ7jt7cgGQtEgpjS0tLBBnsT4EoxFUiASXtKrec1jxidFRQWpbSP3BU4-rtBIvEldYcb4KZpgX2XFL87IFiIoaO5Y1qieK5vU87NanH9lJzdihKekU5RFuYFoVLKGBa9OoBHMiOYjGwooswwm8kg5axLPjR_eX5ZIXrkUAmhcvK2crqkjxrZjkIkbnehXEzz2rHzRArf6CjRWHgGAmfGMi59AUs5nukYfg71mWO8AKUpUbc9wGQReSvvpWAgDMneumS_NRL8XLXFjUXkdZxZ5n-9okvebsV4J56dK0y5dmNClkCohbk8rwxo-0pYXSOabJekLdNqvXNbUsx-OBTyIMhYzDjb-_-83pC7w9PxSX4ymhy_JPdCpE9GRIB4n3RWi7V5BWu6lXxdOw4lF7ftq38AejBk7A |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VVkJICPHGUGCRQJys-LFe24cKJTRRQ2lUISp6c_cZcohd8hDphR_Ir2JmbYdaSNx69a6ddea1s575PkLexirQzAbWNzaDBCVJrC8zFvm5klbzjAfC4cyeTPjRGft0npzvkN9tLwyWVbY-0TlqXSk8I--B7oWpC5c925RFnB6OPlz-8JFBCr-0tnQaoqFZ0AcObqxp8jg2Vz8hnVsejA9B9u-iaDT8-vHIbxgHfAWBc-ULLVlgVWR1lqZaQPjNpGaCR4HMYxzKMxmaVMaMmdhyJVMDIdIoKyImWS5ieO4tspdC1IdEcG8wnJx-2Z74IAJnxnmNHBnHedBbVZuZWmIUgaCcdiKjIxD4N0xci5PdGs5rQXF0n9xrdrO0X6vfA7Jjyofkbn0USOsOp0fkFzgnPO3xHde9hZETgagQU1pZOtxgnwJcKacCyTBpX6n1vOEUo7OSwgaVDpDHAmd_M0gqvqSu0AFumpbYg0nxGwQChxg6njvWJYo1fptqblaLq8fk7EaE8ITsllVpnhEqpUxgA6xDeCQzgsnYRiLODbO5DDPOPPK-_cuLyxrdo4CsCIVTdIXjkQFKZDsLUbndhWoxLRojL1IpAqPjVGMSGgpcGcu5DARs63iuE_g5lGeBvgOEpkTTAgGLRRSuop-BgjAkfvPIfmcm2LzqDrcaUTQ-Z1n8tRCPvNkO451YR1eaau3mRCwFtwtreVor0PaVMNNGZFmPZB3V6rxzd6ScfXeI5GGYs4Rx9vz_63pNboPNFp_Hk-MX5E6ETMoIDpDsk93VYm1ewvZuJV81dkPJxU2b6h8NIGkw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Subject-Specific+Mapping+of+Excess+Manganese+Accumulation+in+the+Brain+of+Welders+Using+Magnetic+Resonance+Imaging+Relaxometry&rft.jtitle=Toxics+%28Basel%29&rft.au=Monsivais%2C+Humberto&rft.au=Dydak%2C+Ulrike&rft.date=2025-02-25&rft.pub=MDPI+AG&rft.issn=2305-6304&rft.eissn=2305-6304&rft.volume=13&rft.issue=3&rft_id=info:doi/10.3390%2Ftoxics13030157&rft.externalDocID=A838641030 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2305-6304&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2305-6304&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2305-6304&client=summon |