Prognostic impact of RUNX1 mutations and deletions in pediatric acute myeloid leukemia: results from the French ELAM02 study group
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| Published in | Leukemia Vol. 37; no. 8; pp. 1723 - 1726 |
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| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.08.2023
Nature Publishing Group Springer Nature |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0887-6924 1476-5551 1476-5551 |
| DOI | 10.1038/s41375-023-01931-y |
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| Author | Leverger, Guy Lapillonne, Hélène Fenwarth, Laurène Rialland, Fanny Guilmatre, Audrey Michel, Gérard Ballerini, Paola Gandemer, Virginie Schneider, Pascale Lew-Derivry, Lucille Ferreboeuf, Maxime Baruchel, Andre Preudhomme, Claude Cuccuini, Wendy Bertrand, Yves Petit, Arnaud Marceau-Renaut, Alice |
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| Cites_doi | 10.1182/bloodadvances.2019000901 10.1007/s40272-016-0200-6 10.1182/bloodadvances.2021004556 10.1182/blood-2016-08-733196 10.1182/blood-2017-11-814442 10.3322/caac.21654 10.1182/bloodadvances.2019000644 10.1038/nm.4439 10.1182/blood.2019000937 10.1097/HS9.0000000000000031 10.1182/blood-2016-10-687830 10.1038/leu.2016.126 10.1182/blood-2008-07-168260 10.3390/ijms18081618 |
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| Copyright | The Author(s) 2023 The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Attribution |
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| Keywords | risk assessment cytology Humans major clinical study Article transcription factor RUNX1 Leukemia, Myeloid, Acute cytogenetics missense mutation gene deletion genetics leukemia remission acute myeloid leukemia event free survival Core Binding Factor Alpha 2 Subunit overall survival female France Child frameshift mutation human nonsense mutation gene mutation risk factor prognosis cancer prognosis gene frequency mutation pediatric patient controlled study cancer mortality RUNX1 protein, human adolescent RUNX1 gene male |
| Language | English |
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reveals recurrent structural alterations and age-specific mutational interactions publication-title: Nat Med doi: 10.1038/nm.4439 – volume: 136 start-page: 24 year: 2020 end-page: 35 ident: CR13 article-title: Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA) publication-title: Blood. doi: 10.1182/blood.2019000937 – volume: 2 start-page: e31 year: 2018 ident: CR4 article-title: Molecular Profiling Defines Distinct Prognostic Subgroups in Childhood AML: A Report From the French ELAM02 Study Group publication-title: HemaSphere doi: 10.1097/HS9.0000000000000031 – volume: 129 start-page: 2070 year: 2017 end-page: 82 ident: CR5 article-title: Role of RUNX1 in hematological malignancies publication-title: Blood. doi: 10.1182/blood-2016-10-687830 – volume: 30 start-page: 2160 year: 2016 end-page: 8 ident: CR8 article-title: RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features publication-title: Leukemia. doi: 10.1038/leu.2016.126 – volume: 113 start-page: 5583 year: 2009 end-page: 7 ident: CR14 article-title: High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder publication-title: Blood. doi: 10.1182/blood-2008-07-168260 – volume: 18 start-page: 1618 year: 2017 ident: CR6 article-title: Clinical Outcomes and Co-Occurring Mutations in Patients with RUNX1-Mutated Acute Myeloid Leukemia publication-title: Int J Mol Sci doi: 10.3390/ijms18081618 – volume: 3 start-page: 2962 year: 2019 ident: 1931_CR11 publication-title: Blood Adv doi: 10.1182/bloodadvances.2019000644 – volume: 2 start-page: e31 year: 2018 ident: 1931_CR4 publication-title: HemaSphere doi: 10.1097/HS9.0000000000000031 – volume: 5 start-page: 3254 year: 2021 ident: 1931_CR12 publication-title: Blood Adv doi: 10.1182/bloodadvances.2021004556 – volume: 71 start-page: 7 year: 2021 ident: 1931_CR1 publication-title: CA Cancer J Clin doi: 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| SubjectTerms | 38/23 38/47 38/77 45 631/67/2324 692/699/67/69 692/700/1720 Acute myeloid leukemia Blood diseases Cancer Cancer Research Critical Care Medicine Cytogenetics Hematology Intensive Internal Medicine Kinases Letter Leukemia Life Sciences Medical prognosis Medicine Medicine & Public Health Mutation Nervous system Oncology Patients Pediatrics Remission (Medicine) Runx1 protein Toxicity Transcription factors Transplants & implants |
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| Title | Prognostic impact of RUNX1 mutations and deletions in pediatric acute myeloid leukemia: results from the French ELAM02 study group |
| URI | https://link.springer.com/article/10.1038/s41375-023-01931-y https://www.ncbi.nlm.nih.gov/pubmed/37328541 https://www.proquest.com/docview/2845352319 https://www.proquest.com/docview/2827259777 https://hal.science/hal-04283874 https://pubmed.ncbi.nlm.nih.gov/PMC10400410 |
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