Social network architecture of human immune cells unveiled by quantitative proteomics
Immune cells give rise to the most interconnected system in the body. Meissner and colleagues perform comprehensive proteomics and secretomics to describe in detail the ‘social network’ of human immune cells and throw light on previously unknown cell connectivities. The immune system is unique in it...
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| Published in | Nature immunology Vol. 18; no. 5; pp. 583 - 593 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.05.2017
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1529-2908 1529-2916 1529-2916 |
| DOI | 10.1038/ni.3693 |
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| Abstract | Immune cells give rise to the most interconnected system in the body. Meissner and colleagues perform comprehensive proteomics and secretomics to describe in detail the ‘social network’ of human immune cells and throw light on previously unknown cell connectivities.
The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not yet been established. We applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. Protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. By integrating total and secreted proteomes, we discovered fundamental intercellular communication structures and previously unknown connections between cell types. Our publicly accessible (
http://www.immprot.org/
) proteomic resource provides a framework for the orchestration of cellular interplay and a reference for altered communication associated with pathology. |
|---|---|
| AbstractList | The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not yet been established. We applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. Protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. By integrating total and secreted proteomes, we discovered fundamental intercellular communication structures and previously unknown connections between cell types. Our publicly accessible (http://www.immprot.org/) proteomic resource provides a framework for the orchestration of cellular interplay and a reference for altered communication associated with pathology. Immune cells give rise to the most interconnected system in the body. Meissner and colleagues perform comprehensive proteomics and secretomics to describe in detail the ‘social network’ of human immune cells and throw light on previously unknown cell connectivities. The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not yet been established. We applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. Protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. By integrating total and secreted proteomes, we discovered fundamental intercellular communication structures and previously unknown connections between cell types. Our publicly accessible ( http://www.immprot.org/ ) proteomic resource provides a framework for the orchestration of cellular interplay and a reference for altered communication associated with pathology. The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not yet been established. We applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of [greater than] 10,000 proteins in total. Protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. By integrating total and secreted proteomes, we discovered fundamental intercellular communication structures and previously unknown connections between cell types. Our publicly accessible ( The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not yet been established. We applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. Protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. By integrating total and secreted proteomes, we discovered fundamental intercellular communication structures and previously unknown connections between cell types. Our publicly accessible (http://www.immprot.org/) proteomic resource provides a framework for the orchestration of cellular interplay and a reference for altered communication associated with pathology.The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect against disease has not yet been established. We applied high-resolution mass-spectrometry-based proteomics to characterize 28 primary human hematopoietic cell populations in steady and activated states at a depth of >10,000 proteins in total. Protein copy numbers revealed a specialization of immune cells for ligand and receptor expression, thereby connecting distinct immune functions. By integrating total and secreted proteomes, we discovered fundamental intercellular communication structures and previously unknown connections between cell types. Our publicly accessible (http://www.immprot.org/) proteomic resource provides a framework for the orchestration of cellular interplay and a reference for altered communication associated with pathology. |
| Audience | Academic |
| Author | Jarrossay, David Lanzavecchia, Antonio Mann, Matthias Rieckmann, Jan C Kveler, Ksenya Hornburg, Daniel Sallusto, Federica Geiger, Roger Meissner, Felix Wolf, Tobias Shen-Orr, Shai S |
| Author_xml | – sequence: 1 givenname: Jan C surname: Rieckmann fullname: Rieckmann, Jan C organization: Experimental Systems Immunology, Max Planck Institute of Biochemistry – sequence: 2 givenname: Roger surname: Geiger fullname: Geiger, Roger organization: Institute for Research in Biomedicine, Università della Svizzera italiana, Institute of Microbiology, ETH Zürich – sequence: 3 givenname: Daniel surname: Hornburg fullname: Hornburg, Daniel organization: Experimental Systems Immunology, Max Planck Institute of Biochemistry – sequence: 4 givenname: Tobias surname: Wolf fullname: Wolf, Tobias organization: Institute for Research in Biomedicine, Università della Svizzera italiana, Institute of Microbiology, ETH Zürich – sequence: 5 givenname: Ksenya surname: Kveler fullname: Kveler, Ksenya organization: Department of Immunology, Faculty of Medicine, Technion-Israel Institute of Technology – sequence: 6 givenname: David surname: Jarrossay fullname: Jarrossay, David organization: Institute for Research in Biomedicine, Università della Svizzera italiana – sequence: 7 givenname: Federica surname: Sallusto fullname: Sallusto, Federica organization: Institute for Research in Biomedicine, Università della Svizzera italiana – sequence: 8 givenname: Shai S surname: Shen-Orr fullname: Shen-Orr, Shai S organization: Department of Immunology, Faculty of Medicine, Technion-Israel Institute of Technology – sequence: 9 givenname: Antonio surname: Lanzavecchia fullname: Lanzavecchia, Antonio organization: Institute for Research in Biomedicine, Università della Svizzera italiana, Institute of Microbiology, ETH Zürich – sequence: 10 givenname: Matthias surname: Mann fullname: Mann, Matthias email: mmann@biochem.mpg.de organization: Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry – sequence: 11 givenname: Felix orcidid: 0000-0003-1000-7989 surname: Meissner fullname: Meissner, Felix email: meissner@biochem.mpg.de organization: Experimental Systems Immunology, Max Planck Institute of Biochemistry |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28263321$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2017 COPYRIGHT 2017 Nature Publishing Group Copyright Nature Publishing Group May 2017 |
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| Snippet | Immune cells give rise to the most interconnected system in the body. Meissner and colleagues perform comprehensive proteomics and secretomics to describe in... The immune system is unique in its dynamic interplay between numerous cell types. However, a system-wide view of how immune cells communicate to protect... |
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| SubjectTerms | 631/250 631/45/612 82/58 96/21 Animals Biomedicine Blood Cells - physiology Bodily Secretions Cell Communication Cellular proteins Computer Simulation Genetic aspects Health aspects Humans Immune system Immunity, Cellular Immunology Infectious Diseases Mass Spectrometry Properties Protein Interaction Maps Protein synthesis Proteome Proteomics resource Social Support Spectrometry |
| Title | Social network architecture of human immune cells unveiled by quantitative proteomics |
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