Relationships between QUS and HR-pQCT, DXA, and bone turnover markers

• Published in: Journal of bone and mineral metabolism Vol. 40; no. 5; pp. 790 - 800
• Main Authors: Niimi, Ryuji, Chiba, Ko, Okazaki, Narihiro, Yonekura, Akihiko, Tomita, Masato, Osaki, Makoto
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.09.2022; Springer Nature B.V
• Subjects: Acid phosphatase (tartrate-resistant); Biochemical markers; Bone density; Bone mineral density; Bone turnover; Calcaneus; Cancellous bone; Computed tomography; Cortical bone; Dual energy X-ray absorptiometry; Femur; Medicine; Medicine & Public Health; Metabolic Diseases; Original Article; Orthopedics; Pentosidine; Porosity; Radius; Spine (lumbar); Tibia; Ultrasound; Vitamin D; Bone turnover marker; High-resolution peripheral quantitative CT (HR-pQCT); Dual X-ray absorptiometry (DXA); Quantitative ultrasound (QUS); Bone microarchitecture
• ISSN: 0914-8779; 1435-5604; 1435-5604
• DOI: 10.1007/s00774-022-01346-2

Introduction Relationship of quantitative ultrasound (QUS) with high-resolution peripheral quantitative computed tomography (HR-pQCT), dual-energy X-ray absorptiometry (DXA), and bone-related biochemical markers was analyzed. Materials and methods The subjects were 480 individuals. Speed of sound (SOS) was measured by calcaneal QUS. Volumetric bone mineral density (vBMD) and microarchitecture of trabecular and cortical bone in the distal radius and tibia were assessed by HR-pQCT. Areal bone mineral density (aBMD) in the lumbar spine and proximal femur were measured by DXA. TRACP-5b, P1NP, 25 (OH) vitamin D, and pentosidine were evaluated by biochemical tests. The correlation of each parameter was analyzed for all subjects and by sex and age group. Results QUS was moderately correlated with Tb.vBMD and Tb.BV/TV in the radius and tibia. No correlation was seen with Ct.vBMD or cortical porosity (Ct.Po). Although a correlation was seen with cortical thickness (Ct.Th) in the tibia in all subjects, no correlation was seen in women aged ≥ 60 years. QUS showed moderate correlations with aBMD in the proximal femur. Although moderate correlation was seen with aBMD in the lumbar spine in all subjects, no correlation was seen in subjects aged ≥ 60 years. No significant correlations were seen between QUS and biochemical markers. Conclusions Moderate correlations were seen between QUS and Tb.vBMD and microarchitecture in the radius and tibia and aBMD of the proximal femur. On the other hand, practically no correlations were seen with Ct.vBMD or Ct.Po and the bone-related biochemical markers. Only in middle age, moderate correlations were seen with Ct.Th in the tibia and with aBMD of the lumbar spine.