An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level - Bauer, Daniel E; Kamran, Sophia C; Lessard, Samuel; Xu, Jian; Fujiwara, Yuko; Lin, Carrie; Shao, Zhen; Canver, Matthew C; Smith, Elenoe C; Pinello, Luca; Sabo, Peter J; Vierstra, Jeff; et al. (Science (American Association for the Advancement of Science), 2013)
Keywords: Animals; Carrier Proteins - genetics; Cell Line, Tumor; Cells, Cultured; Chromatin - genetics; Chromatin - metabolism; Chromatin Immunoprecipitation; Chromosome Mapping; Enhancer Elements, Genetic; Erythroid Cells - metabolism; Fetal Hemoglobin - biosynthesis; Fetal Hemoglobin - genetics; Gene Expression Regulation; Gene Targeting; Genetic Engineering; Genetic Variation; Genome-Wide Association Study; Hemoglobinopathies - genetics; Hemoglobinopathies - therapy; Humans; Mice; Nuclear Proteins - genetics; Precursor Cells, B-Lymphoid - metabolism; Repressor Proteins; Transcription Factors - genetics; Transcription Factors - metabolism