Multiplicative fitness, rapid haplotype discovery, and fitness decay explain evolution of human MHC - Lobkovsky, Alexander E.; Levi, Lee; Wolf, Yuri I.; Maiers, Martin; Gragert, Loren; Alter, Idan; Louzoun, Yoram; Koonin, Eugene V. (Proceedings of the National Academy of Sciences - PNAS, 2019)
Keywords: Alleles; Biological Sciences; Decay; Evolution; Evolution, Molecular; Female; Fitness; Frequency dependence; Frequency distribution; Genetic Variation - genetics; Genetics, Population; Haplotypes; Haplotypes - genetics; Haplotypes - immunology; Histocompatibility antigen HLA; HLA Antigens - genetics; HLA Antigens - immunology; Human populations; Humans; Immune system; Major histocompatibility complex; Major Histocompatibility Complex - genetics; Major Histocompatibility Complex - immunology; Male; Phenotype; Physical Fitness; PNAS Plus; Polymorphism, Genetic; Population genetics; Reproductive fitness; Selection, Genetic; Substructures; Tissue Donors; Vertebrates; multiplicative fitness; fitness decay; haplotype evolution; haplotype discovery; frequency-dependent selection