Leptin, a tool of parasites?
One common physiological phenomenon that is involved both in infectious and in malignant processes is the reduction in appetite: disease anorexia. An increase in plasma levels of leptin with inflammation is thought to be involved in this process. However, from an evolutionary perspective, in certain...
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| Published in | Biology letters (2005) Vol. 8; no. 5; pp. 849 - 852 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
The Royal Society
23.10.2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1744-9561 1744-957X 1744-957X |
| DOI | 10.1098/rsbl.2012.0385 |
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| Abstract | One common physiological phenomenon that is involved both in infectious and in malignant processes is the reduction in appetite: disease anorexia. An increase in plasma levels of leptin with inflammation is thought to be involved in this process. However, from an evolutionary perspective, in certain cases, it would be more adaptive for an internal parasite to stimulate the appetite of the host instead of causing its suppression. We tested whether a parasitic infection with the larvae of the helminth parasite Taenia taeniaformis affects the levels of appetite-regulating proteins, such as leptin, ghrelin and neuropeptide-Y (NPY) in wild yellow-necked mouse (Apodemus flavicollis). We found that infected mice had lower plasma levels of leptin and increased levels of NPY than the uninfected subjects. Ghrelin levels were not associated with the occurrence of the parasites; however, these levels strongly correlated with the levels of NPY. This study suggests a possible manipulation by parasitic larvae of appetite regulation in infected subjects. |
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| AbstractList | One common physiological phenomenon that is involved both in infectious and in malignant processes is the reduction in appetite: disease anorexia. An increase in plasma levels of leptin with inflammation is thought to be involved in this process. However, from an evolutionary perspective, in certain cases, it would be more adaptive for an internal parasite to stimulate the appetite of the host instead of causing its suppression. We tested whether a parasitic infection with the larvae of the helminth parasite Taenia taeniaformis affects the levels of appetite-regulating proteins, such as leptin, ghrelin and neuropeptide-Y (NPY) in wild yellow-necked mouse (Apodemus flavicollis). We found that infected mice had lower plasma levels of leptin and increased levels of NPY than the uninfected subjects. Ghrelin levels were not associated with the occurrence of the parasites; however, these levels strongly correlated with the levels of NPY. This study suggests a possible manipulation by parasitic larvae of appetite regulation in infected subjects. One common physiological phenomenon that is involved both in infectious and in malignant processes is the reduction in appetite: disease anorexia. An increase in plasma levels of leptin with inflammation is thought to be involved in this process. However, from an evolutionary perspective, in certain cases, it would be more adaptive for an internal parasite to stimulate the appetite of the host instead of causing its suppression. We tested whether a parasitic infection with the larvae of the helminth parasite Taenia taeniaformis affects the levels of appetite-regulating proteins, such as leptin, ghrelin and neuropeptide-Y (NPY) in wild yellow-necked mouse ( Apodemus flavicollis ). We found that infected mice had lower plasma levels of leptin and increased levels of NPY than the uninfected subjects. Ghrelin levels were not associated with the occurrence of the parasites; however, these levels strongly correlated with the levels of NPY. This study suggests a possible manipulation by parasitic larvae of appetite regulation in infected subjects. One common physiological phenomenon that is involved both in infectious and in malignant processes is the reduction in appetite: disease anorexia. An increase in plasma levels of leptin with inflammation is thought to be involved in this process. However, from an evolutionary perspective, in certain cases, it would be more adaptive for an internal parasite to stimulate the appetite of the host instead of causing its suppression. We tested whether a parasitic infection with the larvae of the helminth parasite Taenia taeniaformis affects the levels of appetite-regulating proteins, such as leptin, ghrelin and neuropeptide-Y (NPY) in wild yellow-necked mouse (Apodemus flavicollis). We found that infected mice had lower plasma levels of leptin and increased levels of NPY than the uninfected subjects. Ghrelin levels were not associated with the occurrence of the parasites; however, these levels strongly correlated with the levels of NPY. This study suggests a possible manipulation by parasitic larvae of appetite regulation in infected subjects.One common physiological phenomenon that is involved both in infectious and in malignant processes is the reduction in appetite: disease anorexia. An increase in plasma levels of leptin with inflammation is thought to be involved in this process. However, from an evolutionary perspective, in certain cases, it would be more adaptive for an internal parasite to stimulate the appetite of the host instead of causing its suppression. We tested whether a parasitic infection with the larvae of the helminth parasite Taenia taeniaformis affects the levels of appetite-regulating proteins, such as leptin, ghrelin and neuropeptide-Y (NPY) in wild yellow-necked mouse (Apodemus flavicollis). We found that infected mice had lower plasma levels of leptin and increased levels of NPY than the uninfected subjects. Ghrelin levels were not associated with the occurrence of the parasites; however, these levels strongly correlated with the levels of NPY. This study suggests a possible manipulation by parasitic larvae of appetite regulation in infected subjects. |
| Author | Moalem, Sharon Björklund, Mats Lõhmus, Mare |
| AuthorAffiliation | 1 Department for Chemistry, Environment and Feed Hygiene , National Veterinary Institute , Ulls väg 2B 751 89, Uppsala 2 The Hospital for Sick Children , University of Toronto , Toronto, Ontario , Canada 3 Department of Animal Ecology, Evolutionary Biology Centre , Uppsala University , Norbyvägen 18 D, 752 72 Uppsala , Sweden |
| AuthorAffiliation_xml | – name: 3 Department of Animal Ecology, Evolutionary Biology Centre , Uppsala University , Norbyvägen 18 D, 752 72 Uppsala , Sweden – name: 1 Department for Chemistry, Environment and Feed Hygiene , National Veterinary Institute , Ulls väg 2B 751 89, Uppsala – name: 2 The Hospital for Sick Children , University of Toronto , Toronto, Ontario , Canada |
| Author_xml | – sequence: 1 givenname: Mare surname: Lõhmus fullname: Lõhmus, Mare email: mare.lohmus@sva.se organization: Department for Chemistry, Environment and Feed Hygiene, National Veterinary Institute, Ulls väg 2B 751 89, Uppsala – sequence: 2 givenname: Sharon surname: Moalem fullname: Moalem, Sharon organization: The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada – sequence: 3 givenname: Mats surname: Björklund fullname: Björklund, Mats organization: Department of Animal Ecology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18 D, 752 72 Uppsala, Sweden |
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| SubjectTerms | Animals Anorexia - etiology Appetite Appetite Regulation - physiology Appetite-Regulating Peptides Disease Anorexia Ghrelin - blood Host-Parasite Interactions Hunger Leptin - blood Leptin - physiology Male Mice Neuropeptide Y - blood Parasite Parasitic Diseases - complications Parasitic Diseases - physiopathology Pathogen Biology Taenia Yellow-Necked Mouse |
| Title | Leptin, a tool of parasites? |
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