Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity
Resveratrol is a plant‐derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age‐associated diseases as well as blood disorders in cultured cells and/or animal models. However, whether resveratrol has any impact specifically on norm...
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| Published in | American journal of hematology Vol. 89; no. 12; pp. E235 - E238 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.12.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0361-8609 1096-8652 1096-8652 |
| DOI | 10.1002/ajh.23837 |
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| Abstract | Resveratrol is a plant‐derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age‐associated diseases as well as blood disorders in cultured cells and/or animal models. However, whether resveratrol has any impact specifically on normal blood stem cells remains unknown. Here, we show that a 3‐week treatment of resveratrol increases the frequency and total numbers of normal bone marrow hematopoietic stem cells (HSC) without any impact on their competitive repopulation capacity. In addition, we show that resveratrol enhances the bone marrow multipotent progenitor capacity in vivo. These results have therapeutic value for disorders of hematopoietic stem and progenitor cells (HSPC) as well as for bone marrow transplantation settings. Am. J. Hematol. 89:E235–E238, 2014. © 2014 Wiley Periodicals, Inc. |
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| AbstractList | Resveratrol is a plant-derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age-associated diseases as well as blood disorders in cultured cells and/or animal models. However, whether resveratrol has any impact specifically on normal blood stem cells remains unknown. Here we show that a three-week treatment of resveratrol increases the frequency and total numbers of normal bone marrow hematopoietic stem cells (HSC) without any impact on their competitive repopulation capacity. In addition, we show that resveratrol enhances the bone marrow multipotent progenitor capacity
in vivo
. These results have therapeutic value for disorders of hematopoietic stem and progenitor cells (HSPC) as well as for bone marrow transplantation settings. Resveratrol is a plant-derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age-associated diseases as well as blood disorders in cultured cells and/or animal models. However, whether resveratrol has any impact specifically on normal blood stem cells remains unknown. Here, we show that a 3-week treatment of resveratrol increases the frequency and total numbers of normal bone marrow hematopoietic stem cells (HSC) without any impact on their competitive repopulation capacity. In addition, we show that resveratrol enhances the bone marrow multipotent progenitor capacity in vivo. These results have therapeutic value for disorders of hematopoietic stem and progenitor cells (HSPC) as well as for bone marrow transplantation settings. Resveratrol is a plant‐derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age‐associated diseases as well as blood disorders in cultured cells and/or animal models. However, whether resveratrol has any impact specifically on normal blood stem cells remains unknown. Here, we show that a 3‐week treatment of resveratrol increases the frequency and total numbers of normal bone marrow hematopoietic stem cells (HSC) without any impact on their competitive repopulation capacity. In addition, we show that resveratrol enhances the bone marrow multipotent progenitor capacity in vivo. These results have therapeutic value for disorders of hematopoietic stem and progenitor cells (HSPC) as well as for bone marrow transplantation settings. Am. J. Hematol. 89:E235–E238, 2014. © 2014 Wiley Periodicals, Inc. Resveratrol is a plant-derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age-associated diseases as well as blood disorders in cultured cells and/or animal models. However, whether resveratrol has any impact specifically on normal blood stem cells remains unknown. Here, we show that a 3-week treatment of resveratrol increases the frequency and total numbers of normal bone marrow hematopoietic stem cells (HSC) without any impact on their competitive repopulation capacity. In addition, we show that resveratrol enhances the bone marrow multipotent progenitor capacity in vivo. These results have therapeutic value for disorders of hematopoietic stem and progenitor cells (HSPC) as well as for bone marrow transplantation settings.Resveratrol is a plant-derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age-associated diseases as well as blood disorders in cultured cells and/or animal models. However, whether resveratrol has any impact specifically on normal blood stem cells remains unknown. Here, we show that a 3-week treatment of resveratrol increases the frequency and total numbers of normal bone marrow hematopoietic stem cells (HSC) without any impact on their competitive repopulation capacity. In addition, we show that resveratrol enhances the bone marrow multipotent progenitor capacity in vivo. These results have therapeutic value for disorders of hematopoietic stem and progenitor cells (HSPC) as well as for bone marrow transplantation settings. |
| Author | Ghaffari, Saghi Lofek‐Czubek, Sébastien Rimmelé, Pauline |
| AuthorAffiliation | 3 Department of Medicine, Division of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, New York 10029 4 Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029 2 Developmental and Stem Cell Biology, Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, New York 10029 1 Department of Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029 5 Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029 |
| AuthorAffiliation_xml | – name: 2 Developmental and Stem Cell Biology, Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, New York 10029 – name: 3 Department of Medicine, Division of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, New York 10029 – name: 4 Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029 – name: 1 Department of Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029 – name: 5 Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029 |
| Author_xml | – sequence: 1 givenname: Pauline surname: Rimmelé fullname: Rimmelé, Pauline organization: Icahn School of Medicine at Mount Sinai – sequence: 2 givenname: Sébastien surname: Lofek‐Czubek fullname: Lofek‐Czubek, Sébastien organization: Icahn School of Medicine at Mount Sinai – sequence: 3 givenname: Saghi surname: Ghaffari fullname: Ghaffari, Saghi organization: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25163926$$D View this record in MEDLINE/PubMed |
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| Snippet | Resveratrol is a plant‐derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age‐associated... Resveratrol is a plant-derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age-associated... |
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| SubjectTerms | Animals Antioxidants - pharmacology Biomarkers - metabolism Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cell Proliferation - drug effects Gamma Rays Hematology Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Injections, Intraperitoneal Leukocyte Common Antigens - metabolism Mice Mice, Inbred C57BL Stilbenes Whole-Body Irradiation |
| Title | Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity |
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