Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease
Background: Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been proposed as a driver of disease pathology, and evaluation of inflammatory mediators in stool could possibly identify valuable ear...
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| Published in | Movement disorders Vol. 33; no. 5; pp. 793 - 804 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.05.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0885-3185 1531-8257 1531-8257 |
| DOI | 10.1002/mds.27326 |
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| Abstract | Background: Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been proposed as a driver of disease pathology, and evaluation of inflammatory mediators in stool could possibly identify valuable early‐stage biomarkers. We measured immune‐ and angiogenesis‐related proteins in human stool to examine inflammatory profiles associated with Parkinson's disease.
Methods: Stool samples and subjects' self‐reported metadata were obtained from 156 individuals with Parkinson's disease and 110 without, including spouse and nonhousehold controls. Metadata were probed for disease‐associated differences, and levels of 37 immune and angiogenesis factors in stool homogenates were measured by multiplexed immunoassay and compared across experimental groups.
Results: Parkinson's disease patients reported greater incidence of intestinal disease and digestive problems than controls. Direct comparison of levels of stool analytes in patients and controls revealed elevated vascular endothelial growth factor receptor 1, interleukin‐1α, and CXCL8 in patients' stool. Paired comparison of patients and spouses suggested higher levels of multiple factors in patients, but this was complicated by sex differences. Sex, body mass index, a history of smoking, and use of probiotics were found to strongly influence levels of stool analytes. Multivariate analysis accounting for these and other potential confounders confirmed elevated levels of interleukin‐1α and CXCL8 and also revealed increased interleukin‐1β and C‐reactive protein in stool in Parkinson's disease. These differences were not dependent on subject age or disease duration.
Conclusions: Levels of stool immune factors indicate that intestinal inflammation is present in patients with Parkinson's disease. © 2018 International Parkinson and Movement Disorder Society |
|---|---|
| AbstractList | Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been proposed as a driver of disease pathology, and evaluation of inflammatory mediators in stool could possibly identify valuable early-stage biomarkers. We measured immune- and angiogenesis-related proteins in human stool to examine inflammatory profiles associated with Parkinson's disease.
Stool samples and subjects' self-reported metadata were obtained from 156 individuals with Parkinson's disease and 110 without, including spouse and nonhousehold controls. Metadata were probed for disease-associated differences, and levels of 37 immune and angiogenesis factors in stool homogenates were measured by multiplexed immunoassay and compared across experimental groups.
Parkinson's disease patients reported greater incidence of intestinal disease and digestive problems than controls. Direct comparison of levels of stool analytes in patients and controls revealed elevated vascular endothelial growth factor receptor 1, interleukin-1α, and CXCL8 in patients' stool. Paired comparison of patients and spouses suggested higher levels of multiple factors in patients, but this was complicated by sex differences. Sex, body mass index, a history of smoking, and use of probiotics were found to strongly influence levels of stool analytes. Multivariate analysis accounting for these and other potential confounders confirmed elevated levels of interleukin-1α and CXCL8 and also revealed increased interleukin-1β and C-reactive protein in stool in Parkinson's disease. These differences were not dependent on subject age or disease duration.
Levels of stool immune factors indicate that intestinal inflammation is present in patients with Parkinson's disease. © 2018 International Parkinson and Movement Disorder Society. Background: Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been proposed as a driver of disease pathology, and evaluation of inflammatory mediators in stool could possibly identify valuable early‐stage biomarkers. We measured immune‐ and angiogenesis‐related proteins in human stool to examine inflammatory profiles associated with Parkinson's disease. Methods: Stool samples and subjects' self‐reported metadata were obtained from 156 individuals with Parkinson's disease and 110 without, including spouse and nonhousehold controls. Metadata were probed for disease‐associated differences, and levels of 37 immune and angiogenesis factors in stool homogenates were measured by multiplexed immunoassay and compared across experimental groups. Results: Parkinson's disease patients reported greater incidence of intestinal disease and digestive problems than controls. Direct comparison of levels of stool analytes in patients and controls revealed elevated vascular endothelial growth factor receptor 1, interleukin‐1α, and CXCL8 in patients' stool. Paired comparison of patients and spouses suggested higher levels of multiple factors in patients, but this was complicated by sex differences. Sex, body mass index, a history of smoking, and use of probiotics were found to strongly influence levels of stool analytes. Multivariate analysis accounting for these and other potential confounders confirmed elevated levels of interleukin‐1α and CXCL8 and also revealed increased interleukin‐1β and C‐reactive protein in stool in Parkinson's disease. These differences were not dependent on subject age or disease duration. Conclusions: Levels of stool immune factors indicate that intestinal inflammation is present in patients with Parkinson's disease. © 2018 International Parkinson and Movement Disorder Society Background: Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been proposed as a driver of disease pathology, and evaluation of inflammatory mediators in stool could possibly identify valuable early‐stage biomarkers. We measured immune‐ and angiogenesis‐related proteins in human stool to examine inflammatory profiles associated with Parkinson's disease. Methods: Stool samples and subjects' self‐reported metadata were obtained from 156 individuals with Parkinson's disease and 110 without, including spouse and nonhousehold controls. Metadata were probed for disease‐associated differences, and levels of 37 immune and angiogenesis factors in stool homogenates were measured by multiplexed immunoassay and compared across experimental groups. Results: Parkinson's disease patients reported greater incidence of intestinal disease and digestive problems than controls. Direct comparison of levels of stool analytes in patients and controls revealed elevated vascular endothelial growth factor receptor 1, interleukin‐1α, and CXCL8 in patients' stool. Paired comparison of patients and spouses suggested higher levels of multiple factors in patients, but this was complicated by sex differences. Sex, body mass index, a history of smoking, and use of probiotics were found to strongly influence levels of stool analytes. Multivariate analysis accounting for these and other potential confounders confirmed elevated levels of interleukin‐1α and CXCL8 and also revealed increased interleukin‐1β and C‐reactive protein in stool in Parkinson's disease. These differences were not dependent on subject age or disease duration. Conclusions: Levels of stool immune factors indicate that intestinal inflammation is present in patients with Parkinson's disease. © 2018 International Parkinson and Movement Disorder Society Background: Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been proposed as a driver of disease pathology, and evaluation of inflammatory mediators in stool could possibly identify valuable early‐stage biomarkers. We measured immune‐ and angiogenesis‐related proteins in human stool to examine inflammatory profiles associated with Parkinson's disease.Methods: Stool samples and subjects' self‐reported metadata were obtained from 156 individuals with Parkinson's disease and 110 without, including spouse and nonhousehold controls. Metadata were probed for disease‐associated differences, and levels of 37 immune and angiogenesis factors in stool homogenates were measured by multiplexed immunoassay and compared across experimental groups.Results: Parkinson's disease patients reported greater incidence of intestinal disease and digestive problems than controls. Direct comparison of levels of stool analytes in patients and controls revealed elevated vascular endothelial growth factor receptor 1, interleukin‐1α, and CXCL8 in patients' stool. Paired comparison of patients and spouses suggested higher levels of multiple factors in patients, but this was complicated by sex differences. Sex, body mass index, a history of smoking, and use of probiotics were found to strongly influence levels of stool analytes. Multivariate analysis accounting for these and other potential confounders confirmed elevated levels of interleukin‐1α and CXCL8 and also revealed increased interleukin‐1β and C‐reactive protein in stool in Parkinson's disease. These differences were not dependent on subject age or disease duration.Conclusions: Levels of stool immune factors indicate that intestinal inflammation is present in patients with Parkinson's disease. © 2018 International Parkinson and Movement Disorder Society Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been proposed as a driver of disease pathology, and evaluation of inflammatory mediators in stool could possibly identify valuable early-stage biomarkers. We measured immune- and angiogenesis-related proteins in human stool to examine inflammatory profiles associated with Parkinson's disease.BACKGROUNDGastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been proposed as a driver of disease pathology, and evaluation of inflammatory mediators in stool could possibly identify valuable early-stage biomarkers. We measured immune- and angiogenesis-related proteins in human stool to examine inflammatory profiles associated with Parkinson's disease.Stool samples and subjects' self-reported metadata were obtained from 156 individuals with Parkinson's disease and 110 without, including spouse and nonhousehold controls. Metadata were probed for disease-associated differences, and levels of 37 immune and angiogenesis factors in stool homogenates were measured by multiplexed immunoassay and compared across experimental groups.METHODSStool samples and subjects' self-reported metadata were obtained from 156 individuals with Parkinson's disease and 110 without, including spouse and nonhousehold controls. Metadata were probed for disease-associated differences, and levels of 37 immune and angiogenesis factors in stool homogenates were measured by multiplexed immunoassay and compared across experimental groups.Parkinson's disease patients reported greater incidence of intestinal disease and digestive problems than controls. Direct comparison of levels of stool analytes in patients and controls revealed elevated vascular endothelial growth factor receptor 1, interleukin-1α, and CXCL8 in patients' stool. Paired comparison of patients and spouses suggested higher levels of multiple factors in patients, but this was complicated by sex differences. Sex, body mass index, a history of smoking, and use of probiotics were found to strongly influence levels of stool analytes. Multivariate analysis accounting for these and other potential confounders confirmed elevated levels of interleukin-1α and CXCL8 and also revealed increased interleukin-1β and C-reactive protein in stool in Parkinson's disease. These differences were not dependent on subject age or disease duration.RESULTSParkinson's disease patients reported greater incidence of intestinal disease and digestive problems than controls. Direct comparison of levels of stool analytes in patients and controls revealed elevated vascular endothelial growth factor receptor 1, interleukin-1α, and CXCL8 in patients' stool. Paired comparison of patients and spouses suggested higher levels of multiple factors in patients, but this was complicated by sex differences. Sex, body mass index, a history of smoking, and use of probiotics were found to strongly influence levels of stool analytes. Multivariate analysis accounting for these and other potential confounders confirmed elevated levels of interleukin-1α and CXCL8 and also revealed increased interleukin-1β and C-reactive protein in stool in Parkinson's disease. These differences were not dependent on subject age or disease duration.Levels of stool immune factors indicate that intestinal inflammation is present in patients with Parkinson's disease. © 2018 International Parkinson and Movement Disorder Society.CONCLUSIONSLevels of stool immune factors indicate that intestinal inflammation is present in patients with Parkinson's disease. © 2018 International Parkinson and Movement Disorder Society. |
| Author | Hertzberg, Vicki S. Payami, Haydeh Molho, Eric S. Factor, Stewart A. Zabetian, Cyrus P. Chang, Jianjun Houser, Madelyn C. Hill‐Burns, Erin M. Tansey, Malú G. |
| AuthorAffiliation | 3 Department of Neurology, Albany Medical College, Albany, NY 2 Department of Neurology, Emory University School of Medicine 7 Center for Nursing Data Science, Nell Hodgson Woodruff School of Nursing, Emory University 6 HudsonAlpha Institute for Biotechnology, Huntsville, AL 1 Department of Physiology, Emory University School of Medicine 5 Department of Neurology, University of Alabama at Birmingham, AL 4 Veterans Affairs Puget Sound Health Care System and Department of Neurology, University of Washington School of Medicine, Seattle, WA |
| AuthorAffiliation_xml | – name: 3 Department of Neurology, Albany Medical College, Albany, NY – name: 5 Department of Neurology, University of Alabama at Birmingham, AL – name: 7 Center for Nursing Data Science, Nell Hodgson Woodruff School of Nursing, Emory University – name: 1 Department of Physiology, Emory University School of Medicine – name: 2 Department of Neurology, Emory University School of Medicine – name: 4 Veterans Affairs Puget Sound Health Care System and Department of Neurology, University of Washington School of Medicine, Seattle, WA – name: 6 HudsonAlpha Institute for Biotechnology, Huntsville, AL |
| Author_xml | – sequence: 1 givenname: Madelyn C. surname: Houser fullname: Houser, Madelyn C. organization: Emory University School of Medicine – sequence: 2 givenname: Jianjun surname: Chang fullname: Chang, Jianjun organization: Emory University School of Medicine – sequence: 3 givenname: Stewart A. surname: Factor fullname: Factor, Stewart A. organization: Emory University School of Medicine – sequence: 4 givenname: Eric S. surname: Molho fullname: Molho, Eric S. organization: Albany Medical College – sequence: 5 givenname: Cyrus P. orcidid: 0000-0002-7739-4306 surname: Zabetian fullname: Zabetian, Cyrus P. organization: University of Washington School of Medicine – sequence: 6 givenname: Erin M. surname: Hill‐Burns fullname: Hill‐Burns, Erin M. organization: University of Alabama at Birmingham – sequence: 7 givenname: Haydeh surname: Payami fullname: Payami, Haydeh organization: HudsonAlpha Institute for Biotechnology – sequence: 8 givenname: Vicki S. surname: Hertzberg fullname: Hertzberg, Vicki S. email: vhertzb@emory.edu organization: Emory University – sequence: 9 givenname: Malú G. surname: Tansey fullname: Tansey, Malú G. email: malu.tansey@emory.edu organization: Emory University School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29572994$$D View this record in MEDLINE/PubMed |
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| Copyright | 2018 International Parkinson and Movement Disorder Society 2018 International Parkinson and Movement Disorder Society. |
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| ISSN | 0885-3185 1531-8257 |
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| Issue | 5 |
| Keywords | stool Parkinson's disease intestine biomarker inflammation |
| Language | English |
| License | 2018 International Parkinson and Movement Disorder Society. |
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| Notes | M.G.T. is a member of the Executive Scientific Advisory Board for the Michael J. Fox Foundation for Parkinson's Research, a member of the Scientific Review Board for the Alzheimer's Drug Discovery Foundation, and a consultant for Celgene Corporation. E.S.M. is supported by the Riley Family Chair in Parkinson's Disease. Relevant conflicts of interest/financial disclosures Funding agencies Subject recruitment and characterization, stool and metadata collection, and multiplexed immunoassays were funded by NIH grants NS036960 (to H.P.), NS067469 (to H.P.), and P50 NS062684 (to C.P.Z.). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-7739-4306 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/5992021 |
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| PublicationDate | May 2018 |
| PublicationDateYYYYMMDD | 2018-05-01 |
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| PublicationPlace | United States |
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| PublicationTitle | Movement disorders |
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| PublicationYear | 2018 |
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| Snippet | Background: Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation... Background: Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation... Gastrointestinal symptoms are common in Parkinson's disease and frequently precede the development of motor impairments. Intestinal inflammation has been... |
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| SubjectTerms | Adult Aged Aged, 80 and over Angiogenesis Angiogenesis Inducing Agents - metabolism biomarker Body mass index C-Reactive Protein - metabolism Cytokines Cytokines - metabolism Feces - chemistry Female Gastroenteritis - etiology Gastroenteritis - metabolism Humans Inflammation Intestine Male Metadata Middle Aged Mood Disorders - etiology Movement disorders Multivariate analysis Neurodegenerative diseases Parkinson Disease - complications Parkinson Disease - psychology Parkinson's disease Probiotics Sex Characteristics Sex differences Smoking stool Vascular endothelial growth factor |
| Title | Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease |
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