A population pharmacodynamic Markov mixed‐effects model for determining remimazolam‐induced sedation when co‐administered with fentanyl in procedural sedation - Zhou, Jie; Curd, Laura; Lohmer, Lauren R. L.; Delpratt, Natalie; Ossig, Joachim; Schippers, Frank; Stoehr, Thomas; Schmith, Virginia D. (Clinical and translational science, 2021)
Keywords: Age Factors; Aged; Benzodiazepines; Benzodiazepines - administration & dosage; Benzodiazepines - pharmacokinetics; Biological Variation, Population; Body mass index; Clinical trials; Clinical Trials as Topic; Computer Simulation; Deep Sedation - methods; Dosage; Dose-Response Relationship, Drug; Drug dosages; Drug Synergism; Female; Fentanyl; Fentanyl - administration & dosage; Fentanyl - pharmacokinetics; General anesthesia; Healthy Volunteers; Humans; Infusions, Intravenous; Male; Markov Chains; Middle Aged; Models, Biological; Pain, Procedural - prevention & control; Patients; Pharmacodynamics; Pharmacokinetics; Placebos; Population; Probability; United States--US; Japan