Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single‐center, randomized, double‐blind, placebo‐controlled multiple‐ascending‐dose study - Li, Lijun; Gao, Hongzhi; Lou, Kun; Luo, Hongmei; Hao, Sheng; Yuan, Jing; Liu, Zeyuan; Dong, Ruihua (Clinical and translational science, 2021)
Keywords: Administration, Oral; Adult; Adverse events; Area Under Curve; Body mass index; China; Clinical trials; Dose-Response Relationship, Drug; Double-Blind Method; Double-blind studies; Drug dosages; Female; Fever; Flavanones - administration & dosage; Flavanones - adverse effects; Flavanones - pharmacokinetics; Flavonoids; Half-Life; Healthy Volunteers; Hepatitis; Humans; Influenza; Male; Medical laboratories; Metabolites; Pharmacokinetics; Placebos; Placebos - administration & dosage; Placebos - adverse effects; Plasma; Plasma levels; Renal Elimination; Safety; Statistical analysis; Tablets; Urine; Vital signs; Young Adult; China