Zoledronate rescues immunosuppressed monocytes in sepsis patients - Raffray, Loïc; Burton, Ross J.; Baker, Sarah E.; Morgan, Matt P.; Eberl, Matthias (Immunology, 2020)
Keywords: Adult; Aged; Aged, 80 and over; Antigen-presenting cells; Antigens; Biomedical materials; Blood; Bone resorption; Case-Control Studies; CD40 antigen; Clinical outcomes; Cytokines; Female; gammadelta T‐cells; Histocompatibility antigen HLA; HLA-DR Antigens - immunology; HLA-DR Antigens - metabolism; Humans; Immunologic Factors - pharmacology; Immunosuppression; Infections; Inflammation; Interferon; Interferon-gamma - immunology; Interferon-gamma - metabolism; Lymphocytes; Lymphocytes T; Male; Middle Aged; Monocytes; Monocytes - drug effects; Monocytes - immunology; Monocytes - metabolism; Original; Osteoporosis; Paralysis; Peripheral blood; Receptors, Antigen, T-Cell, gamma-delta - immunology; Receptors, Antigen, T-Cell, gamma-delta - metabolism; Sepsis; Sepsis - blood; Sepsis - drug therapy; Sepsis - immunology; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tumor necrosis factor; Tumor Necrosis Factor-alpha - immunology; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumors; zoledronate; Zoledronic acid; Zoledronic Acid - pharmacology; monocytes; immunosuppression; gammadelta T-cells; zoledronate; sepsis