Discovery and development of orexin receptor antagonists as therapeutics for insomnia - Winrow, C J; Renger, J J (British journal of pharmacology, 2014)
Keywords: Acetamides - adverse effects; Acetamides - pharmacokinetics; Acetamides - pharmacology; Acetamides - therapeutic use; Animals; Biological Availability; Digestive system; Drug Design; Drug therapy; GABA; High-Throughput Screening Assays; Humans; Hypnotics and Sedatives - adverse effects; Hypnotics and Sedatives - pharmacokinetics; Hypnotics and Sedatives - pharmacology; Hypnotics and Sedatives - therapeutic use; Insomnia; Intracellular Signaling Peptides and Proteins - physiology; Isoquinolines - adverse effects; Isoquinolines - pharmacokinetics; Isoquinolines - pharmacology; Isoquinolines - therapeutic use; Neuropeptides - physiology; orexin receptor antagonist; Orexin Receptor Antagonists; Orexins; Signal Transduction - drug effects; Sleep; Sleep Initiation and Maintenance Disorders - drug therapy; Themed Section: Orexin Receptors; sleep; GABA; orexin receptor antagonist; insomnia