Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board

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Bibliographic Details
Published inMovement disorders Vol. 33; no. 12; pp. 1871 - 1875
Main Authors Albin, Roger L., Surmeier, D. James, Tubert, Cecilia, Sarter, Martin, Müller, Martijn L.T.M., Bohnen, Nicolaas I., Dauer, William T.
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.12.2018
Subjects
Deep Brain Stimulation
Humans
Movement disorders
Nerve Net - physiopathology
Neurodegenerative diseases
Neurons - physiology
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson's disease
Pedunculopontine tegmental nucleus
Pedunculopontine Tegmental Nucleus - physiopathology
Pedunculopontine Tegmental Nucleus - surgery
Subthalamic Nucleus - physiopathology
Subthalamic Nucleus - surgery
Online AccessGet full text
ISSN0885-3185
1531-8257
1531-8257
DOI10.1002/mds.27540

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Author Dauer, William T.
Albin, Roger L.
Surmeier, D. James
Tubert, Cecilia
Sarter, Martin
Bohnen, Nicolaas I.
Müller, Martijn L.T.M.
AuthorAffiliation 2 Dept. of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA
8 Dept of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA
5 Northwestern University Morris K. Udall Center of Excellence for Parkinson’s Disease Research, Chicago, IL, 60611, USA
4 Dept. of Physiology, Northwestern University, Chicago, IL, 60611, USA
6 Dept. of Psychology, University of Michigan, Ann Arbor, MI, 48109, USA
7 Dept of Radiology, University of Michigan, Ann Arbor, MI, 48109, USA
1 Neurology Service & GRECC, VAAAHS GRECC, Ann Arbor, MI, 48105, USA
3 University of Michigan Morris K. Udall Center of Excellence for Parkinson’s Disease Research, Ann Arbor, MI, 48109, USA
AuthorAffiliation_xml – name: 1 Neurology Service & GRECC, VAAAHS GRECC, Ann Arbor, MI, 48105, USA
– name: 3 University of Michigan Morris K. Udall Center of Excellence for Parkinson’s Disease Research, Ann Arbor, MI, 48109, USA
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– name: 6 Dept. of Psychology, University of Michigan, Ann Arbor, MI, 48109, USA
– name: 8 Dept of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA
– name: 2 Dept. of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA
– name: 5 Northwestern University Morris K. Udall Center of Excellence for Parkinson’s Disease Research, Chicago, IL, 60611, USA
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  givenname: Roger L.
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Cites_doi 10.1523/JNEUROSCI.1839-17.2017
10.1093/brain/awl346
10.1007/s00702-006-0547-x
10.1111/j.1460-9568.2007.05360.x
10.1172/JCI42642
10.1212/WNL.0b013e3181c1ded6
10.1007/0-387-28066-9_51
10.1037/bne0000048
10.14802/jmd.16062
10.1016/S0006-8993(99)01268-8
10.1016/j.cell.2015.12.037
10.1017/cjn.2015.318
10.1016/S0306-4522(00)00011-7
10.1093/brain/awt247
10.1097/00001756-199011000-00008
10.1016/j.ajpath.2013.09.002
10.1007/s00429-006-0130-0
10.1111/j.1460-9568.2008.06576.x
10.1093/brain/awf259
10.1523/JNEUROSCI.15-09-05859.1995
10.1046/j.0953-816x.2001.01800.x
10.1111/j.1460-9568.2005.04402.x
10.1073/pnas.84.16.5976
10.1523/JNEUROSCI.2514-15.2016
10.1177/1073858416682471
10.1016/j.neuron.2016.03.028
10.1016/j.wneu.2017.02.110
10.1016/0301-0082(91)90016-T
10.3389/fneur.2015.00140
10.1007/s00702-014-1243-x
10.1523/JNEUROSCI.1568-13.2013
10.1038/nature25448
10.1016/j.neuroimage.2017.02.006
10.1186/s13024-015-0044-5
10.1038/jcbfm.2012.60
10.1097/WNR.0000000000000697
10.1523/JNEUROSCI.3646-14.2015
10.3171/jns.2003.99.4.0762
10.1038/nature24064
10.1016/j.neuroscience.2012.06.069
10.1093/brain/awp229
10.1002/mds.27098
10.1016/j.neuron.2017.02.027
10.1093/brain/aws039
10.7554/eLife.30352
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Author Roles: RLA, WTD, and DJS conceived this article. RLA prepared the initial draft. RLA, DJS, CT, WTD, NIB, MTLMM, and MS all participated in critical revisions and preparation of the final version.
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References 2015; 35
2017; 6
1999; 828
2015; 6
2012; 221
1991; 36
1995; 15
2015; 122
2017; 23
2015; 10
2010; 120
2005
2004
2015; 129
2017; 551
2013; 183
1966; 11
2012; 32
2016; 164
2005; 22
2006; 211
2016; 36
2009; 29
2003; 99
2017; 95
2007; 114
1990; 1
2009; 73
1987; 84
2012; 135
2013; 33
2016; 90
2017; 37
1988; 281
2018; 553
2017; 10
2002; 125
2007; 130
2000; 97
2016; 43
2010; 133
2013; 136
2018; 33
2017; 102
2016; 27
2001; 14
2017; 149
2007; 25
e_1_2_8_28_1
e_1_2_8_24_1
e_1_2_8_47_1
e_1_2_8_26_1
e_1_2_8_49_1
e_1_2_8_5_1
Goetz L (e_1_2_8_40_1)
e_1_2_8_7_1
e_1_2_8_9_1
e_1_2_8_20_1
e_1_2_8_43_1
e_1_2_8_22_1
e_1_2_8_45_1
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Goetz L (e_1_2_8_48_1)
e_1_2_8_17_1
e_1_2_8_19_1
e_1_2_8_13_1
e_1_2_8_36_1
e_1_2_8_15_1
e_1_2_8_38_1
Mesulam MM (e_1_2_8_39_1) 1988; 281
e_1_2_8_32_1
e_1_2_8_11_1
e_1_2_8_34_1
e_1_2_8_51_1
e_1_2_8_30_1
e_1_2_8_29_1
e_1_2_8_25_1
e_1_2_8_46_1
e_1_2_8_27_1
e_1_2_8_2_1
e_1_2_8_4_1
e_1_2_8_6_1
e_1_2_8_8_1
e_1_2_8_21_1
e_1_2_8_42_1
e_1_2_8_23_1
e_1_2_8_44_1
e_1_2_8_18_1
Jenkinson N (e_1_2_8_50_1) 2004
e_1_2_8_14_1
e_1_2_8_35_1
e_1_2_8_16_1
e_1_2_8_37_1
e_1_2_8_10_1
e_1_2_8_31_1
Shik ML (e_1_2_8_3_1) 1966; 11
e_1_2_8_12_1
e_1_2_8_33_1
e_1_2_8_52_1
References_xml – volume: 22
  start-page: 2283
  year: 2005
  end-page: 2294
  article-title: Unilateral lesion of the nigrostriatal pathway induces hyperactivity in the subthalamic nucleus and subtantia nigra in the rat
  publication-title: Eur J Neurosci
– volume: 97
  start-page: 79
  year: 2000
  end-page: 88
  article-title: Metabolic activity of excitatory parafascicular and pedunculopontine inputs to the subthalamic nucleus in a rat model of Parkinson's disease
  publication-title: Neuroscience
– start-page: 15‐2621
  year: 2004
  end-page: 2624
  article-title: Pedunculopontine nucleus stimulation improves akinesia in a parkinsonian monkey
  publication-title: NeuroReport
– start-page: 523
  year: 2005
  end-page: 532
– volume: 120
  start-page: 2745
  year: 2010
  end-page: 2754
  article-title: Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease
  publication-title: J Clin Invest
– volume: 136
  start-page: 3282
  year: 2013
  end-page: 3289
  article-title: Thalamic cholinergic innervation and postural sensory integration function in Parkinson's disease
  publication-title: Brain
– volume: 33
  start-page: 10
  year: 2018
  end-page: 20
  article-title: Pedunculopontine nucleus deep brain stimulation in Parkinson's disease: a clinical review
  publication-title: Mov Disord
– volume: 33
  start-page: 11986
  year: 2013
  end-page: 11993
  article-title: Gait disorders in parkinsonian monkeys with pedunculopontine nucleus lesions: a tale of two systems
  publication-title: J Neurosci
– volume: 6
  start-page: 140
  year: 2015
  article-title: Anatomical localization of the mesencephalic locomotor region and its possible role in locomotion, posture, cataplexy, and Parkinsonism
  publication-title: Front Neurol
– volume: 114
  start-page: 319
  year: 2007
  end-page: 326
  article-title: Changes in the neuronal activity in the pedunculopontine nucleus in chronic MPTP‐treated primates: an in situ hybridization study of cytochrome oxidase subunit I, choline acetyl transferase and substance P mRNA expression
  publication-title: J Neural Transm
– article-title: Deep brain stimulation of the pedunculopontine nucleus area in Parkinson disease: MRI‐based anatomoclinical correlations and optimal target [published online ahead of print 2018]
  publication-title: Neurosurg
– volume: 36
  start-page: 363
  year: 1991
  end-page: 389
  article-title: The pedunculopontine nucleus
  publication-title: Prog Neurobiol
– volume: 14
  start-page: 1833
  year: 2001
  end-page: 1842
  article-title: Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal activity of the pedunculopontine nucleus, which is reversed by the lesion of the subthalamic nucleus in the rat
  publication-title: Eur J Neurosci
– volume: 221
  start-page: 125
  year: 2012
  end-page: 139
  article-title: Movement‐ and behavioral state‐dependent activity of pontine reticulospinal neurons
  publication-title: Neurosci
– volume: 102
  start-page: 72
  year: 2017
  end-page: 78
  article-title: Deep brain stimulation of pedunculopontine nucleus for postural instability and gait disorder after Parkinson disease: a meta‐analysis of individual patient data
  publication-title: World Neurosurg
– volume: 36
  start-page: 4917
  year: 2016
  end-page: 4929
  article-title: On the role of the pedunculopontine nucleus and mesencephalic reticular formation in locomotion in nonhuman primates
  publication-title: J Neurosci
– volume: 122
  start-page: 225
  year: 2015
  end-page: 235
  article-title: The physiology of the pedunculopontine nucleus: implications for deep brain stimulation
  publication-title: J Neural Transm
– volume: 281
  start-page: 611
  year: 1988
  end-page: 633
  article-title: Human reticular formation: cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons with forebrain cholinergic neurons
  publication-title: J Comp Neurol
– volume: 129
  start-page: 96
  year: 2015
  end-page: 104
  article-title: Modeling Parkinson's disease falls associated with brainstem cholinergic systems decline
  publication-title: Behav Neurosci
– volume: 164
  start-page: 526
  year: 2016
  end-page: 537
  article-title: Cell‐type‐specific control of brainstem locomotor circuits by basal ganglia
  publication-title: Cell
– volume: 15
  start-page: 5859
  year: 1995
  end-page: 5869
  article-title: Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area
  publication-title: J Neurosci
– volume: 10
  start-page: 1
  year: 2017
  end-page: 17
  article-title: Functional neuroanatomy for posture and gait control
  publication-title: J Mov Disord
– volume: 1
  start-page: 207
  year: 1990
  end-page: 210
  article-title: Locomotor projections from the pedunculopontine nucleus to the medioventral medulla
  publication-title: Neuroreport
– volume: 73
  start-page: 1670
  year: 2009
  end-page: 1676
  article-title: History of falls in Parkinson disease is associated with reduced cholinergic activity
  publication-title: Neurology
– volume: 125
  start-page: 2418
  year: 2002
  end-page: 2430
  article-title: Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus
  publication-title: Brain
– volume: 29
  start-page: 340
  year: 2009
  end-page: 358
  article-title: Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat
  publication-title: Eur J Neurosci
– volume: 130
  start-page: 1596
  year: 2007
  end-page: 1607
  article-title: Bilateral deep brain stimulation of the pedunculopontine and subtalamic nuclei in severe Parkinson's disease
  publication-title: Brain
– volume: 43
  start-page: 120
  year: 2016
  end-page: 126
  article-title: Efficacy and safety of pedunculopontine nuclei (PPN) deep brain stimulation in the treatment of gait disorders: a meta‐analysis of clinical studies
  publication-title: Can J Neurol Sci
– volume: 551
  start-page: 373
  year: 2017
  end-page: 377
  article-title: Locomotor speed control circuits in the caudal brainstem
  publication-title: Nature
– volume: 828
  start-page: 12
  year: 1999
  end-page: 19
  article-title: Regional metabolic changes in the pedunculopontine nucleus of unilateral 6‐hydroxydopamine Parkinson's model rats
  publication-title: Brain Res
– volume: 84
  start-page: 5976
  year: 1987
  end-page: 5980
  article-title: Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy
  publication-title: Proc Natl Acad Sci U S A
– volume: 90
  start-page: 333
  year: 2016
  end-page: 347
  article-title: Cholinergic mesopontine signals govern locomotion and reward through dissociable midbrain pathways
  publication-title: Neuron
– volume: 37
  start-page: 10894
  year: 2017
  end-page: 10903
  article-title: Nonhuman primate optogenetics: recent advances and future directions
  publication-title: J Neurosci
– volume: 135
  start-page: 1446
  year: 2012
  end-page: 1454
  article-title: A spatiotemporal analysis of gait freezing and the impact of pedunculopontine nucleus stimulation
  publication-title: Brain
– volume: 95
  start-page: 7
  year: 2017
  end-page: 18
  article-title: rethinking the pedunculopontine nucleus: from cellular organization to function
  publication-title: Neuron
– volume: 6
  start-page: e30352
  year: 2017
  article-title: Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons
  publication-title: eLife
– volume: 553
  start-page: 455
  year: 2018
  end-page: 460
  article-title: Midbrain circuits that set locomotor speed and gait selection
  publication-title: Nature
– volume: 35
  start-page: 4792
  year: 2015
  end-page: 4803
  article-title: Deep brain stimulation of different pedunculopontine targets in a novel rodent model of parkinsonism
  publication-title: J Neurosci
– volume: 27
  start-page: 1336
  year: 2016
  end-page: 1344
  article-title: A meta‐analysis of the pedunculopontine nucleus deep‐brain stimulation effects on Parkinson's disease
  publication-title: Neuroreport
– article-title: Spike discharge characteristic of the caudal mesencephalic reticular formation and pedunculopontine nucleus in MPTP‐induced primate model of Parkinson disease [published online ahead of print 2018]
  publication-title: Neurobiol Dis
– volume: 10
  start-page: 47
  year: 2015
  article-title: Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease
  publication-title: Mol Neurodegener
– volume: 211
  start-page: 659
  year: 2006
  end-page: 671
  article-title: Fos immunoreactivity in some locomotor neural centers of 6‐OHDA‐lesioned rats
  publication-title: Anar Embryol (Berl)
– volume: 11
  start-page: 659
  year: 1966
  end-page: 666
  article-title: Control of walking and running by means of electrical stimulation of the midbrain
  publication-title: Biofizika
– volume: 32
  start-page: 1609
  year: 2012
  end-page: 1617
  article-title: Heterogeneity of cholinergic denervation in Parkinson's disease without dementia
  publication-title: J Cereb Blood Flow Metab
– volume: 183
  start-page: 1826
  year: 2013
  end-page: 1840
  article-title: Mitochondrial abnormality associates with type‐specific neuronal loss and cell morphology changes in the pedunculopontine nucleus in Parkinson disease
  publication-title: Am J Pathol
– volume: 23
  start-page: 415
  year: 2017
  end-page: 431
  article-title: The cellular diversity of the pedunculopontine nucleus: relevance to behavior in health and aspects of Parkinson's disease
  publication-title: Neuroscientist
– volume: 99
  start-page: 762
  year: 2003
  end-page: 767
  article-title: Effect of ipsilateral subthalamic nucleus lesioning in a rat parkinsonian model: study of behavior correlated with neuronal activity in the pedunculopontine nucleus
  publication-title: J Neurosurg
– volume: 149
  start-page: 295
  year: 2017
  end-page: 204
  article-title: Thalamic cholinergic innervation makes a specific bottom‐up contribution to signal detection: Evidence from Parkinson's disease patients with defined cholinergic losses
  publication-title: Neuroimage
– volume: 25
  start-page: 1174
  year: 2007
  end-page: 1186
  article-title: High‐frequency stimulation of the subthalamic nucleus modulates the activity of pedunculopontine neurons through direct activation of excitatory fibres as well as through indirect activation of inhibitory pallidal fibres in the rat
  publication-title: Eur J Neurosci
– volume: 133
  start-page: 205
  year: 2010
  end-page: 214
  article-title: Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease
  publication-title: Brain
– ident: e_1_2_8_51_1
  doi: 10.1523/JNEUROSCI.1839-17.2017
– ident: e_1_2_8_35_1
  doi: 10.1093/brain/awl346
– ident: e_1_2_8_45_1
  doi: 10.1007/s00702-006-0547-x
– ident: e_1_2_8_44_1
  doi: 10.1111/j.1460-9568.2007.05360.x
– ident: e_1_2_8_12_1
  doi: 10.1172/JCI42642
– ident: e_1_2_8_15_1
  doi: 10.1212/WNL.0b013e3181c1ded6
– ident: e_1_2_8_46_1
  doi: 10.1007/0-387-28066-9_51
– ident: e_1_2_8_22_1
  doi: 10.1037/bne0000048
– ident: e_1_2_8_23_1
  doi: 10.14802/jmd.16062
– ident: e_1_2_8_18_1
  doi: 10.1016/S0006-8993(99)01268-8
– ident: e_1_2_8_26_1
  doi: 10.1016/j.cell.2015.12.037
– ident: e_1_2_8_38_1
  doi: 10.1017/cjn.2015.318
– ident: e_1_2_8_20_1
  doi: 10.1016/S0306-4522(00)00011-7
– ident: e_1_2_8_13_1
  doi: 10.1093/brain/awt247
– ident: e_1_2_8_6_1
  doi: 10.1097/00001756-199011000-00008
– ident: e_1_2_8_49_1
  doi: 10.1016/j.ajpath.2013.09.002
– ident: e_1_2_8_47_1
  doi: 10.1007/s00429-006-0130-0
– ident: e_1_2_8_9_1
  doi: 10.1111/j.1460-9568.2008.06576.x
– ident: e_1_2_8_41_1
  doi: 10.1093/brain/awf259
– ident: e_1_2_8_10_1
  doi: 10.1523/JNEUROSCI.15-09-05859.1995
– ident: e_1_2_8_19_1
  doi: 10.1046/j.0953-816x.2001.01800.x
– ident: e_1_2_8_42_1
  doi: 10.1111/j.1460-9568.2005.04402.x
– start-page: 15‐2621
  year: 2004
  ident: e_1_2_8_50_1
  article-title: Pedunculopontine nucleus stimulation improves akinesia in a parkinsonian monkey
  publication-title: NeuroReport
– volume: 11
  start-page: 659
  year: 1966
  ident: e_1_2_8_3_1
  article-title: Control of walking and running by means of electrical stimulation of the midbrain
  publication-title: Biofizika
– ident: e_1_2_8_11_1
  doi: 10.1073/pnas.84.16.5976
– ident: e_1_2_8_52_1
  doi: 10.1523/JNEUROSCI.2514-15.2016
– ident: e_1_2_8_8_1
  doi: 10.1177/1073858416682471
– ident: e_1_2_8_32_1
  doi: 10.1016/j.neuron.2016.03.028
– ident: e_1_2_8_36_1
  doi: 10.1016/j.wneu.2017.02.110
– ident: e_1_2_8_5_1
  doi: 10.1016/0301-0082(91)90016-T
– ident: e_1_2_8_25_1
  doi: 10.3389/fneur.2015.00140
– ident: e_1_2_8_4_1
  doi: 10.1007/s00702-014-1243-x
– ident: e_1_2_8_16_1
  doi: 10.1523/JNEUROSCI.1568-13.2013
– ident: e_1_2_8_28_1
  doi: 10.1038/nature25448
– ident: e_1_2_8_30_1
  doi: 10.1016/j.neuroimage.2017.02.006
– ident: e_1_2_8_17_1
  doi: 10.1186/s13024-015-0044-5
– ident: e_1_2_8_14_1
  doi: 10.1038/jcbfm.2012.60
– ident: e_1_2_8_37_1
  doi: 10.1097/WNR.0000000000000697
– volume: 281
  start-page: 611
  year: 1988
  ident: e_1_2_8_39_1
  article-title: Human reticular formation: cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons with forebrain cholinergic neurons
  publication-title: J Comp Neurol
– ident: e_1_2_8_29_1
  doi: 10.1093/brain/awt247
– ident: e_1_2_8_48_1
  article-title: Spike discharge characteristic of the caudal mesencephalic reticular formation and pedunculopontine nucleus in MPTP‐induced primate model of Parkinson disease [published online ahead of print 2018]
  publication-title: Neurobiol Dis
– ident: e_1_2_8_21_1
  doi: 10.1523/JNEUROSCI.3646-14.2015
– ident: e_1_2_8_43_1
  doi: 10.3171/jns.2003.99.4.0762
– ident: e_1_2_8_27_1
  doi: 10.1038/nature24064
– ident: e_1_2_8_24_1
  doi: 10.1016/j.neuroscience.2012.06.069
– ident: e_1_2_8_34_1
  doi: 10.1093/brain/awp229
– ident: e_1_2_8_2_1
  doi: 10.1002/mds.27098
– ident: e_1_2_8_7_1
  doi: 10.1016/j.neuron.2017.02.027
– ident: e_1_2_8_33_1
  doi: 10.1093/brain/aws039
– ident: e_1_2_8_31_1
  doi: 10.7554/eLife.30352
– ident: e_1_2_8_40_1
  article-title: Deep brain stimulation of the pedunculopontine nucleus area in Parkinson disease: MRI‐based anatomoclinical correlations and optimal target [published online ahead of print 2018]
  publication-title: Neurosurg
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SubjectTerms Deep Brain Stimulation
Humans
Movement disorders
Nerve Net - physiopathology
Neurodegenerative diseases
Neurons - physiology
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson's disease
Pedunculopontine tegmental nucleus
Pedunculopontine Tegmental Nucleus - physiopathology
Pedunculopontine Tegmental Nucleus - surgery
Subthalamic Nucleus - physiopathology
Subthalamic Nucleus - surgery
Title Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmds.27540
https://www.ncbi.nlm.nih.gov/pubmed/30398673
https://www.proquest.com/docview/2159706451
https://www.proquest.com/docview/2130304412
https://pubmed.ncbi.nlm.nih.gov/PMC6448144
Volume 33
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