Genetic architecture supports mosaic brain evolution and independent brain–body size regulation
The mammalian brain consists of distinct parts that fulfil different functions. Finlay and Darlington have argued that evolution of the mammalian brain is constrained by developmental programs, suggesting that different brain parts are not free to respond individually to selection and evolve indepen...
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| Published in | Nature communications Vol. 3; no. 1; p. 1079 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
2012
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2041-1723 2041-1723 |
| DOI | 10.1038/ncomms2086 |
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| Abstract | The mammalian brain consists of distinct parts that fulfil different functions. Finlay and Darlington have argued that evolution of the mammalian brain is constrained by developmental programs, suggesting that different brain parts are not free to respond individually to selection and evolve independent of other parts or overall brain size. However, comparisons among mammals with matched brain weights often reveal greater differences in brain part size, arguing against strong developmental constraints. Here we test these hypotheses using a quantitative genetic approach involving over 10,000 mice. We identify independent loci for size variation in seven key parts of the brain, and observe that brain parts show low or no phenotypic correlation, as is predicted by a mosaic scenario. We also demonstrate that variation in brain size is independently regulated from body size. The allometric relations seen at higher phylogenetic levels are thus unlikely to be the product of strong developmental constraints.
It has been controversial whether the sizes of different regions of the brain can evolve independently of each other. This study identifies genetic loci responsible for independent size regulation in different brain regions, and finds brain size to be regulated independently of body size. |
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| AbstractList | The mammalian brain consists of distinct parts that fulfil different functions. Finlay and Darlington have argued that evolution of the mammalian brain is constrained by developmental programs, suggesting that different brain parts are not free to respond individually to selection and evolve independent of other parts or overall brain size. However, comparisons among mammals with matched brain weights often reveal greater differences in brain part size, arguing against strong developmental constraints. Here we test these hypotheses using a quantitative genetic approach involving over 10,000 mice. We identify independent loci for size variation in seven key parts of the brain, and observe that brain parts show low or no phenotypic correlation, as is predicted by a mosaic scenario. We also demonstrate that variation in brain size is independently regulated from body size. The allometric relations seen at higher phylogenetic levels are thus unlikely to be the product of strong developmental constraints. The mammalian brain consists of distinct parts that fulfil different functions. Finlay and Darlington have argued that evolution of the mammalian brain is constrained by developmental programs, suggesting that different brain parts are not free to respond individually to selection and evolve independent of other parts or overall brain size. However, comparisons among mammals with matched brain weights often reveal greater differences in brain part size, arguing against strong developmental constraints. Here we test these hypotheses using a quantitative genetic approach involving over 10,000 mice. We identify independent loci for size variation in seven key parts of the brain, and observe that brain parts show low or no phenotypic correlation, as is predicted by a mosaic scenario. We also demonstrate that variation in brain size is independently regulated from body size. The allometric relations seen at higher phylogenetic levels are thus unlikely to be the product of strong developmental constraints.The mammalian brain consists of distinct parts that fulfil different functions. Finlay and Darlington have argued that evolution of the mammalian brain is constrained by developmental programs, suggesting that different brain parts are not free to respond individually to selection and evolve independent of other parts or overall brain size. However, comparisons among mammals with matched brain weights often reveal greater differences in brain part size, arguing against strong developmental constraints. Here we test these hypotheses using a quantitative genetic approach involving over 10,000 mice. We identify independent loci for size variation in seven key parts of the brain, and observe that brain parts show low or no phenotypic correlation, as is predicted by a mosaic scenario. We also demonstrate that variation in brain size is independently regulated from body size. The allometric relations seen at higher phylogenetic levels are thus unlikely to be the product of strong developmental constraints. The mammalian brain consists of distinct parts that fulfil different functions. Finlay and Darlington have argued that evolution of the mammalian brain is constrained by developmental programs, suggesting that different brain parts are not free to respond individually to selection and evolve independent of other parts or overall brain size. However, comparisons among mammals with matched brain weights often reveal greater differences in brain part size, arguing against strong developmental constraints. Here we test these hypotheses using a quantitative genetic approach involving over 10,000 mice. We identify independent loci for size variation in seven key parts of the brain, and observe that brain parts show low or no phenotypic correlation, as is predicted by a mosaic scenario. We also demonstrate that variation in brain size is independently regulated from body size. The allometric relations seen at higher phylogenetic levels are thus unlikely to be the product of strong developmental constraints. It has been controversial whether the sizes of different regions of the brain can evolve independently of each other. This study identifies genetic loci responsible for independent size regulation in different brain regions, and finds brain size to be regulated independently of body size. |
| ArticleNumber | 1079 |
| Author | Williams, Robert W. Rosen, Glenn D. Lu, Lu Hager, Reinmar |
| AuthorAffiliation | 1 Computational and Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK 2 Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA 4 Department of Neurology, Beth Isreal Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA 3 Jiangsu Key Laboratory of Neuroregeneration, Nantong University, China |
| AuthorAffiliation_xml | – name: 2 Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA – name: 3 Jiangsu Key Laboratory of Neuroregeneration, Nantong University, China – name: 4 Department of Neurology, Beth Isreal Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA – name: 1 Computational and Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK |
| Author_xml | – sequence: 1 givenname: Reinmar surname: Hager fullname: Hager, Reinmar email: reinmar.hager@manchester.ac.uk organization: Computational and Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester – sequence: 2 givenname: Lu surname: Lu fullname: Lu, Lu organization: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Jiangsu Key Laboratory of Neuroregeneration, Nantong University – sequence: 3 givenname: Glenn D. surname: Rosen fullname: Rosen, Glenn D. organization: Department of Neurology, Beth Isreal Deaconess Medical Center – sequence: 4 givenname: Robert W. surname: Williams fullname: Williams, Robert W. organization: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23011133$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0165-0270(90)90101-K 10.1111/j.1601-183X.2009.00473.x 10.1038/nature07922 10.1073/pnas.1002195107 10.1159/000155963 10.1016/j.tree.2010.12.010 10.1017/S0140525X01003958 10.1007/s10519-006-9122-3 10.1126/science.7777856 10.1007/s00114-004-0515-y 10.1126/science.1210879 10.1186/1741-7007-8-9 10.1371/journal.pbio.0040395 10.1111/j.1365-2818.1987.tb02837.x 10.1126/science.2196673 10.1016/j.cub.2007.01.051 10.1086/201571 10.1038/35016580 10.1038/35075564 10.1038/nature10629 10.1038/ng1518 10.1385/NI:1:4:299 10.7551/mitpress/9780262513678.001.0001 10.1093/genetics/138.3.963 10.1016/B978-012547626-3/50002-8 10.1093/genetics/121.1.185 10.1093/oso/9780195122343.003.0008 10.5962/bhl.title.11332 10.4159/harvard.9780674865327 |
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| References | Jerison (CR14) 1975; 16 Wang, Williams, Manly (CR15) 2003; 1 Gaglani, Lu, Williams, Rosen (CR30) 2009; 9 Montgomery, Capellini, Barton, Mundy (CR18) 2010; 8 Harvey, Krebs (CR19) 1990; 249 CR13 Yopak (CR10) 2010; 107 Laland, Sterelny, Odling-Smee, Hoppitt, Uller (CR28) 2011; 334 Rosen (CR31) 2009; 8 Navarrete, van Schaik, Isler (CR9) 2011; 480 Gould, Lewontin (CR26) 1979; 205 Shifman (CR34) 2006; 4 Finlay, Darlington, Nicastor (CR2) 2001; 24 Stephan, Frahm, Baron (CR11) 1981; 35 Churchill, Doerge (CR35) 1994; 138 Schwander, Leimar (CR24) 2011; 26 Gundersen, Jensen (CR32) 1987; 147 Clark, Mitra, Wang (CR7) 2001; 411 CR4 CR3 Chesler (CR17) 2005; 37 CR5 Kutschera, Niklas (CR23) 2004; 91 CR27 Lander, Botstein (CR16) 1989; 121 CR25 Protas, Conrad, Gross, Tabin, Borowsky (CR12) 2007; 17 CR22 CR21 Mozhui, Hamre, Holmes, Lu, Williams (CR29) 2007; 37 CR20 Finlay, Darlington (CR1) 1995; 268 Rosen, Harry (CR33) 1990; 35 Weston, Lister (CR8) 2009; 459 Barton, Harvey (CR6) 2000; 405 PH Harvey (BFncomms2086_CR19) 1990; 249 K Mozhui (BFncomms2086_CR29) 2007; 37 HJ Jerison (BFncomms2086_CR14) 1975; 16 BFncomms2086_CR27 BFncomms2086_CR25 BFncomms2086_CR3 DA Clark (BFncomms2086_CR7) 2001; 411 BFncomms2086_CR4 A Navarrete (BFncomms2086_CR9) 2011; 480 EJ Chesler (BFncomms2086_CR17) 2005; 37 BFncomms2086_CR21 BFncomms2086_CR22 BL Finlay (BFncomms2086_CR2) 2001; 24 BFncomms2086_CR20 GA Churchill (BFncomms2086_CR35) 1994; 138 U Kutschera (BFncomms2086_CR23) 2004; 91 GD Rosen (BFncomms2086_CR31) 2009; 8 HJG Gundersen (BFncomms2086_CR32) 1987; 147 KN Laland (BFncomms2086_CR28) 2011; 334 M Protas (BFncomms2086_CR12) 2007; 17 SH Montgomery (BFncomms2086_CR18) 2010; 8 RA Barton (BFncomms2086_CR6) 2000; 405 SM Gaglani (BFncomms2086_CR30) 2009; 9 BFncomms2086_CR13 EM Weston (BFncomms2086_CR8) 2009; 459 ES Lander (BFncomms2086_CR16) 1989; 121 KE Yopak (BFncomms2086_CR10) 2010; 107 BFncomms2086_CR5 T Schwander (BFncomms2086_CR24) 2011; 26 GD Rosen (BFncomms2086_CR33) 1990; 35 BL Finlay (BFncomms2086_CR1) 1995; 268 H Stephan (BFncomms2086_CR11) 1981; 35 J Wang (BFncomms2086_CR15) 2003; 1 S Shifman (BFncomms2086_CR34) 2006; 4 SJ Gould (BFncomms2086_CR26) 1979; 205 10890446 - Nature. 2000 Jun 29;405(6790):1055-8 22174243 - Science. 2011 Dec 16;334(6062):1512-6 2196673 - Science. 1990 Jul 13;249(4965):140-6 7777856 - Science. 1995 Jun 16;268(5217):1578-84 3430576 - J Microsc. 1987 Sep;147(Pt 3):229-63 17105354 - PLoS Biol. 2006 Nov;4(12):e395 15711545 - Nat Genet. 2005 Mar;37(3):233-42 19191878 - Genes Brain Behav. 2009 Apr;8(3):296-308 20616012 - Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12946-51 21257223 - Trends Ecol Evol. 2011 Mar;26(3):143-51 11346794 - Nature. 2001 May 10;411(6834):189-93 15043217 - Neuroinformatics. 2003;1(4):299-308 17131200 - Behav Genet. 2007 Jan;37(1):223-43 2283883 - J Neurosci Methods. 1990 Nov;35(2):115-24 11530543 - Behav Brain Sci. 2001 Apr;24(2):263-78; discussion 278-308 42062 - Proc R Soc Lond B Biol Sci. 1979 Sep 21;205(1161):581-98 7014398 - Folia Primatol (Basel). 1981;35(1):1-29 22080949 - Nature. 2011 Dec 1;480(7375):91-3 19424156 - Nature. 2009 May 7;459(7243):85-8 17306543 - Curr Biol. 2007 Mar 6;17(5):452-4 20105283 - BMC Biol. 2010;8:9 7851788 - Genetics. 1994 Nov;138(3):963-71 2563713 - Genetics. 1989 Jan;121(1):185-99 19426526 - BMC Neurosci. 2009;10:44 15241603 - Naturwissenschaften. 2004 Jun;91(6):255-76 |
| References_xml | – ident: CR22 – volume: 9 start-page: 10 year: 2009 end-page: 44 ident: CR30 article-title: The genetic control of neocortex volume and covariation with neocortical gene expression in mice publication-title: BMC Neurosci. – volume: 35 start-page: 115 year: 1990 end-page: 124 ident: CR33 article-title: Brain volume estimation from serial section measurements: a comparison of methodologies publication-title: J. Neurosci. Methods doi: 10.1016/0165-0270(90)90101-K – volume: 8 start-page: 296 year: 2009 end-page: 308 ident: CR31 article-title: Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice publication-title: Genes Brain Behav. doi: 10.1111/j.1601-183X.2009.00473.x – volume: 459 start-page: 85 year: 2009 end-page: 88 ident: CR8 article-title: Insular dwarfism in hippos and a model for brain size reduction in publication-title: Nature doi: 10.1038/nature07922 – volume: 107 start-page: 12946 year: 2010 end-page: 12951 ident: CR10 article-title: A conserved pattern of brain scaling from sharks to primates publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1002195107 – volume: 35 start-page: 1 year: 1981 end-page: 29 ident: CR11 article-title: New and revised data on volumes of brain structures in insectivores and primates publication-title: Folia Primatol. doi: 10.1159/000155963 – ident: CR4 – volume: 26 start-page: 143 year: 2011 end-page: 151 ident: CR24 article-title: Genes as leaders and followers in evolution publication-title: Trends Ecol. Evol. doi: 10.1016/j.tree.2010.12.010 – volume: 24 start-page: 263 year: 2001 end-page: 308 ident: CR2 article-title: Developmental structure in brain evolution publication-title: Behav. Brain Sci. doi: 10.1017/S0140525X01003958 – volume: 37 start-page: 223 year: 2007 end-page: 243 ident: CR29 article-title: Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice publication-title: Behav. Genet. doi: 10.1007/s10519-006-9122-3 – volume: 268 start-page: 1578 year: 1995 end-page: 1584 ident: CR1 article-title: Linked regularities in the development and evolution of mammalian brains publication-title: Science doi: 10.1126/science.7777856 – volume: 121 start-page: 185 year: 1989 end-page: 199 ident: CR16 article-title: Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps publication-title: Genetics – volume: 91 start-page: 255 year: 2004 end-page: 276 ident: CR23 article-title: The modern theory of biological evolution: an expanded synthesis publication-title: Naturwissenschaften doi: 10.1007/s00114-004-0515-y – volume: 334 start-page: 1512 year: 2011 end-page: 1516 ident: CR28 article-title: Cause and effect in biology revisited: is Mayr's proximate-ultimate dichotomy still useful? publication-title: Science doi: 10.1126/science.1210879 – volume: 8 start-page: 9 year: 2010 ident: CR18 article-title: Reconstructing the ups and downs of primate brain evolution: implications for adaptive hypotheses and publication-title: BMC Biol. doi: 10.1186/1741-7007-8-9 – ident: CR25 – ident: CR27 – ident: CR21 – volume: 138 start-page: 963 year: 1994 end-page: 971 ident: CR35 article-title: Empirical threshold values for quantitative trait mapping publication-title: Genetics – volume: 4 start-page: e395 year: 2006 ident: CR34 article-title: A high-resolution single nucleotide polymorphism genetic map of the mouse genome publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0040395 – volume: 205 start-page: 581 year: 1979 end-page: 598 ident: CR26 article-title: The spandrels of San Marco and the panglossian paradigm: a critique of the adaptationist programme publication-title: Proc. Roy. Soc. Ser. B Biol. Sci. – ident: CR3 – volume: 147 start-page: 229 year: 1987 end-page: 263 ident: CR32 article-title: The efficiency of systematic sampling in stereology and its prediction publication-title: J. Microscop. doi: 10.1111/j.1365-2818.1987.tb02837.x – ident: CR13 – volume: 249 start-page: 140 year: 1990 end-page: 146 ident: CR19 article-title: Comparing brains publication-title: Science doi: 10.1126/science.2196673 – volume: 17 start-page: 452 year: 2007 end-page: 454 ident: CR12 article-title: Regressive evolution in the Mexican Cave Tetra, publication-title: Curr. Biol. doi: 10.1016/j.cub.2007.01.051 – volume: 16 start-page: 403 year: 1975 end-page: 426 ident: CR14 article-title: Evolution of the brain and intelligence publication-title: Curr. Anthropol. doi: 10.1086/201571 – ident: CR5 – volume: 405 start-page: 1055 year: 2000 end-page: 1058 ident: CR6 article-title: Mosaic evolution of brain structure in mammals publication-title: Nature doi: 10.1038/35016580 – volume: 411 start-page: 189 year: 2001 end-page: 193 ident: CR7 article-title: Scalable architecture in mammalian brains publication-title: Nature doi: 10.1038/35075564 – volume: 480 start-page: 91 year: 2011 end-page: 94 ident: CR9 article-title: Energetics and the evolution of human brain size publication-title: Nature doi: 10.1038/nature10629 – volume: 37 start-page: 233 year: 2005 end-page: 242 ident: CR17 article-title: Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function publication-title: Nat. Genet. doi: 10.1038/ng1518 – ident: CR20 – volume: 1 start-page: 299 year: 2003 end-page: 308 ident: CR15 article-title: WebQTL: web-based complex trait analysis publication-title: Neuroinformatics doi: 10.1385/NI:1:4:299 – ident: BFncomms2086_CR4 – volume: 37 start-page: 233 year: 2005 ident: BFncomms2086_CR17 publication-title: Nat. Genet. doi: 10.1038/ng1518 – volume: 91 start-page: 255 year: 2004 ident: BFncomms2086_CR23 publication-title: Naturwissenschaften doi: 10.1007/s00114-004-0515-y – ident: BFncomms2086_CR25 doi: 10.7551/mitpress/9780262513678.001.0001 – volume: 24 start-page: 263 year: 2001 ident: BFncomms2086_CR2 publication-title: Behav. Brain Sci. doi: 10.1017/S0140525X01003958 – volume: 8 start-page: 296 year: 2009 ident: BFncomms2086_CR31 publication-title: Genes Brain Behav. doi: 10.1111/j.1601-183X.2009.00473.x – volume: 405 start-page: 1055 year: 2000 ident: BFncomms2086_CR6 publication-title: Nature doi: 10.1038/35016580 – ident: BFncomms2086_CR21 – volume: 1 start-page: 299 year: 2003 ident: BFncomms2086_CR15 publication-title: Neuroinformatics doi: 10.1385/NI:1:4:299 – volume: 37 start-page: 223 year: 2007 ident: BFncomms2086_CR29 publication-title: Behav. Genet. doi: 10.1007/s10519-006-9122-3 – volume: 249 start-page: 140 year: 1990 ident: BFncomms2086_CR19 publication-title: Science doi: 10.1126/science.2196673 – volume: 147 start-page: 229 year: 1987 ident: BFncomms2086_CR32 publication-title: J. Microscop. doi: 10.1111/j.1365-2818.1987.tb02837.x – volume: 9 start-page: 10 year: 2009 ident: BFncomms2086_CR30 publication-title: BMC Neurosci. – volume: 17 start-page: 452 year: 2007 ident: BFncomms2086_CR12 publication-title: Curr. Biol. doi: 10.1016/j.cub.2007.01.051 – volume: 138 start-page: 963 year: 1994 ident: BFncomms2086_CR35 publication-title: Genetics doi: 10.1093/genetics/138.3.963 – volume: 26 start-page: 143 year: 2011 ident: BFncomms2086_CR24 publication-title: Trends Ecol. Evol. doi: 10.1016/j.tree.2010.12.010 – volume: 268 start-page: 1578 year: 1995 ident: BFncomms2086_CR1 publication-title: Science doi: 10.1126/science.7777856 – volume: 16 start-page: 403 year: 1975 ident: BFncomms2086_CR14 publication-title: Curr. Anthropol. doi: 10.1086/201571 – ident: BFncomms2086_CR3 – volume: 205 start-page: 581 year: 1979 ident: BFncomms2086_CR26 publication-title: Proc. Roy. Soc. Ser. B Biol. Sci. – ident: BFncomms2086_CR5 doi: 10.1016/B978-012547626-3/50002-8 – volume: 121 start-page: 185 year: 1989 ident: BFncomms2086_CR16 publication-title: Genetics doi: 10.1093/genetics/121.1.185 – volume: 334 start-page: 1512 year: 2011 ident: BFncomms2086_CR28 publication-title: Science doi: 10.1126/science.1210879 – volume: 4 start-page: e395 year: 2006 ident: BFncomms2086_CR34 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0040395 – ident: BFncomms2086_CR27 doi: 10.1093/oso/9780195122343.003.0008 – volume: 459 start-page: 85 year: 2009 ident: BFncomms2086_CR8 publication-title: Nature doi: 10.1038/nature07922 – volume: 411 start-page: 189 year: 2001 ident: BFncomms2086_CR7 publication-title: Nature doi: 10.1038/35075564 – ident: BFncomms2086_CR22 – volume: 35 start-page: 115 year: 1990 ident: BFncomms2086_CR33 publication-title: J. Neurosci. Methods doi: 10.1016/0165-0270(90)90101-K – volume: 480 start-page: 91 year: 2011 ident: BFncomms2086_CR9 publication-title: Nature doi: 10.1038/nature10629 – volume: 8 start-page: 9 year: 2010 ident: BFncomms2086_CR18 publication-title: BMC Biol. doi: 10.1186/1741-7007-8-9 – volume: 107 start-page: 12946 year: 2010 ident: BFncomms2086_CR10 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1002195107 – ident: BFncomms2086_CR20 doi: 10.5962/bhl.title.11332 – ident: BFncomms2086_CR13 doi: 10.4159/harvard.9780674865327 – volume: 35 start-page: 1 year: 1981 ident: BFncomms2086_CR11 publication-title: Folia Primatol. doi: 10.1159/000155963 – reference: 42062 - Proc R Soc Lond B Biol Sci. 1979 Sep 21;205(1161):581-98 – reference: 3430576 - J Microsc. 1987 Sep;147(Pt 3):229-63 – reference: 10890446 - Nature. 2000 Jun 29;405(6790):1055-8 – reference: 7777856 - Science. 1995 Jun 16;268(5217):1578-84 – reference: 7851788 - Genetics. 1994 Nov;138(3):963-71 – reference: 2283883 - J Neurosci Methods. 1990 Nov;35(2):115-24 – reference: 15043217 - Neuroinformatics. 2003;1(4):299-308 – reference: 17105354 - PLoS Biol. 2006 Nov;4(12):e395 – reference: 17306543 - Curr Biol. 2007 Mar 6;17(5):452-4 – reference: 22174243 - Science. 2011 Dec 16;334(6062):1512-6 – reference: 19424156 - Nature. 2009 May 7;459(7243):85-8 – reference: 19426526 - BMC Neurosci. 2009;10:44 – reference: 19191878 - Genes Brain Behav. 2009 Apr;8(3):296-308 – reference: 22080949 - Nature. 2011 Dec 1;480(7375):91-3 – reference: 11530543 - Behav Brain Sci. 2001 Apr;24(2):263-78; discussion 278-308 – reference: 2563713 - Genetics. 1989 Jan;121(1):185-99 – reference: 15241603 - Naturwissenschaften. 2004 Jun;91(6):255-76 – reference: 2196673 - Science. 1990 Jul 13;249(4965):140-6 – reference: 15711545 - Nat Genet. 2005 Mar;37(3):233-42 – reference: 7014398 - Folia Primatol (Basel). 1981;35(1):1-29 – reference: 11346794 - Nature. 2001 May 10;411(6834):189-93 – reference: 20105283 - BMC Biol. 2010;8:9 – reference: 17131200 - Behav Genet. 2007 Jan;37(1):223-43 – reference: 20616012 - Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12946-51 – reference: 21257223 - Trends Ecol Evol. 2011 Mar;26(3):143-51 |
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| Title | Genetic architecture supports mosaic brain evolution and independent brain–body size regulation |
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