The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure - Hein, David W.; Salazar-González, Raúl A.; Doll, Mark A.; Zang, Yu (Archives of toxicology, 2023)
Keywords: Acetylation; Acetyltransferase; Acetyltransferases; Alleles; Amines; Amines - toxicity; Animals; Arylamine N-Acetyltransferase - genetics; Asia; Biomedical and Life Sciences; Biomedicine; Carcinogens; Carcinogens - toxicity; CHO Cells; Cricetinae; Cricetulus; Cricetulus griseus; CYP1A2 protein; Cytochrome P-450 CYP1A2; Cytochrome P450; Damage; Deoxyribonucleic acid; DNA; DNA Damage; DNA repair; Environmental Health; Europe; Gene polymorphism; Genetic diversity; genetic polymorphism; Genetic variance; Genotoxicity; Heterocyclic amines; Human populations; Humans; Intelligence; Metabolism; Metabolites; N-Acetyltransferase; N-Acetyltransferase 2; Nucleotides; Occupational Medicine/Industrial Medicine; Pharmacology/Toxicology; Polymorphism; Polymorphism, Single Nucleotide; Population genetics; pyridines; Quinoline; Quinoxaline; Quinoxalines; Reactive Oxygen Species; Single-nucleotide polymorphism; Substrates; Toxicogenomics and Omics Technologies; Transfection; Yeast; yeasts; Asia; Europe; acetylation; acetyltransferase 2; Heterocyclic amines; Reactive oxygen species; Single nucleotide polymorphism; DNA damage; O-acetylation; N-acetyltransferase 2