Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein - Fox, Jonathan H.; Connor, Teal; Stiles, Megan; Kama, Jibrin; Lu, Zhen; Dorsey, Kathryn; Liebermann, Gregory; Sapp, Ellen; Cherny, Robert A.; Banks, Mary; Volitakis, Irene; DiFiglia, Marian; et al. (The Journal of biological chemistry, 2011)
Keywords: Animals; Chlorocebus aethiops; Copper; COS Cells; Cysteine - genetics; Cysteine - metabolism; Disease Models, Animal; Humans; Huntingtin; Huntingtin Protein; Huntington Disease - genetics; Huntington Disease - metabolism; Huntington Disease - pathology; Mice; Molecular Bases of Disease; Mutation, Missense; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurodegeneration; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Oxidation-Reduction; Polyglutamine Disease; Protein Multimerization; Protein Oligomer; Protein Structure, Tertiary; Solubility; Thiol; Thiol; Oxidation-Reduction; Huntingtin; Neurodegeneration; Polyglutamine Disease; Copper; Protein Oligomer