Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?
As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral orga...
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| Published in | Frontiers in aging neuroscience Vol. 14; p. 903455 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
16.06.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1663-4365 1663-4365 |
| DOI | 10.3389/fnagi.2022.903455 |
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| Abstract | As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress, metabolic disorders, and lifestyle. In particular, the effects of neuroinflammation caused by inflammation of peripheral organs have yet unclear mechanisms. Many diseases, such as gastrointestinal inflammation, chronic obstructive pulmonary disease, rheumatoid arthritis, dermatitis, chronic fatigue syndrome, or myalgic encephalomyelitis (CFS/ME), trigger neuroinflammation through several pathways. The mechanisms of action for peripheral inflammation-induced neuroinflammation include disruption of the blood-brain barrier, activation of glial cells associated with systemic immune activation, and effects on autonomic nerves via the organ-brain axis. In this review, we consider previous studies on the relationship between systemic inflammation and neuroinflammation, focusing on the brain regions susceptible to inflammation. |
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| AbstractList | As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress, metabolic disorders, and lifestyle. In particular, the effects of neuroinflammation caused by inflammation of peripheral organs have yet unclear mechanisms. Many diseases, such as gastrointestinal inflammation, chronic obstructive pulmonary disease, rheumatoid arthritis, dermatitis, chronic fatigue syndrome, or myalgic encephalomyelitis (CFS/ME), trigger neuroinflammation through several pathways. The mechanisms of action for peripheral inflammation-induced neuroinflammation include disruption of the blood-brain barrier, activation of glial cells associated with systemic immune activation, and effects on autonomic nerves via the organ-brain axis. In this review, we consider previous studies on the relationship between systemic inflammation and neuroinflammation, focusing on the brain regions susceptible to inflammation.As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress, metabolic disorders, and lifestyle. In particular, the effects of neuroinflammation caused by inflammation of peripheral organs have yet unclear mechanisms. Many diseases, such as gastrointestinal inflammation, chronic obstructive pulmonary disease, rheumatoid arthritis, dermatitis, chronic fatigue syndrome, or myalgic encephalomyelitis (CFS/ME), trigger neuroinflammation through several pathways. The mechanisms of action for peripheral inflammation-induced neuroinflammation include disruption of the blood-brain barrier, activation of glial cells associated with systemic immune activation, and effects on autonomic nerves via the organ-brain axis. In this review, we consider previous studies on the relationship between systemic inflammation and neuroinflammation, focusing on the brain regions susceptible to inflammation. As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress, metabolic disorders, and lifestyle. In particular, the effects of neuroinflammation caused by inflammation of peripheral organs have yet unclear mechanisms. Many diseases, such as gastrointestinal inflammation, chronic obstructive pulmonary disease, rheumatoid arthritis, dermatitis, chronic fatigue syndrome, or myalgic encephalomyelitis (CFS/ME), trigger neuroinflammation through several pathways. The mechanisms of action for peripheral inflammation-induced neuroinflammation include disruption of the blood-brain barrier, activation of glial cells associated with systemic immune activation, and effects on autonomic nerves via the organ-brain axis. In this review, we consider previous studies on the relationship between systemic inflammation and neuroinflammation, focusing on the brain regions susceptible to inflammation. |
| Author | Shimada, Shoichi Sun, Yuanjie Koyama, Yoshihisa |
| AuthorAffiliation | 2 Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center , Osaka , Japan 1 Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine , Osaka , Japan |
| AuthorAffiliation_xml | – name: 2 Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center , Osaka , Japan – name: 1 Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine , Osaka , Japan |
| Author_xml | – sequence: 1 givenname: Yuanjie surname: Sun fullname: Sun, Yuanjie – sequence: 2 givenname: Yoshihisa surname: Koyama fullname: Koyama, Yoshihisa – sequence: 3 givenname: Shoichi surname: Shimada fullname: Shimada, Shoichi |
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| ContentType | Journal Article |
| Copyright | Copyright © 2022 Sun, Koyama and Shimada. Copyright © 2022 Sun, Koyama and Shimada. 2022 Sun, Koyama and Shimada |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Ana Maria Marques Orellana, University of São Paulo, Brazil; Monique Michels, Universidade do Extremo Sul Catarinense, Brazil Edited by: Fernanda Laezza, University of Texas Medical Branch at Galveston, United States This article was submitted to Neuroinflammation and Neuropathy, a section of the journal Frontiers in Aging Neuroscience |
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| Title | Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation? |
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