The COMT Val158Met polymorphism modulates working memory performance under acute stress

One of the most widely studied genetic polymorphisms regarding cognitive and emotional phenotypes is the COMT Val158Met polymorphism that influences dopamine availability in the prefrontal cortex (PFC). The PFC is the key brain structure for higher cognitive functions such as working memory, as well...

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Published inPsychoneuroendocrinology Vol. 37; no. 11; pp. 1810 - 1821
Main Authors Buckert, Magdalena, Kudielka, Brigitte M., Reuter, Martin, Fiebach, Christian J.
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.11.2012
Elsevier
Subjects
Acute stress
Adult
Behavioral psychophysiology
Biological and medical sciences
Catechol O-Methyltransferase - genetics
Catechol O-Methyltransferase - physiology
COMT Val158Met polymorphism
Cortisol
Dopamine
Endocrinology & Metabolism
Female
Fundamental and applied biological sciences. Psychology
Homozygote
Hormones and behavior
Humans
Male
Memory, Short-Term - physiology
Methionine - genetics
Neuropsychological Tests
Polymorphism, Genetic
Prefrontal Cortex - enzymology
Prefrontal Cortex - physiology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Stress, Psychological - enzymology
Stress, Psychological - genetics
Stress, Psychological - physiopathology
Valine - genetics
Working memory
Young Adult
Acute stress
Cortisol
Dopamine
Working memory
COMT Val158Met polymorphism
Corticosteroid
Enzyme
Steroid hormone
Transferases
Acute
Antiinflammatory agent
Catechol O-methyltransferase
Catecholamine
Hydrocortisone
Glucocorticoid
Stress
Methyltransferases
Adrenal hormone
Neurotransmitter
Performance
Polymorphism
Online AccessGet full text
ISSN0306-4530
1873-3360
1873-3360
DOI10.1016/j.psyneuen.2012.03.014

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Abstract One of the most widely studied genetic polymorphisms regarding cognitive and emotional phenotypes is the COMT Val158Met polymorphism that influences dopamine availability in the prefrontal cortex (PFC). The PFC is the key brain structure for higher cognitive functions such as working memory, as well as an important regulatory site and target of the psychoendocrine stress response. Dopamine is thought to influence PFC functions in an inverted u-shaped manner. Thus, a stress-related increase in prefrontal dopamine is hypothesized to exert differential effects on working memory performance depending on the genetically determined baseline dopamine level in the PFC. Thirty-three healthy young subjects homozygous for the COMT Val158Met polymorphism were selected from a larger pre-genotyped sample. They performed an n-back working memory task after exposure to a laboratory psychosocial stress induction paradigm (The Trier Social Stress Test for Groups; TSST-G). Under stress, working memory performance of Met homozygotes was significantly worse than working memory performance of Val homozygotes. Importantly, this genotype effect was restricted to the medium difficulty level of the n-back task. Our results demonstrate that working memory performance under stress is influenced by genetic variation in prefrontal dopamine levels. More generally, our results point to the importance of considering the complex interaction of genes, environment, and task variables.
AbstractList One of the most widely studied genetic polymorphisms regarding cognitive and emotional phenotypes is the COMT Val158Met polymorphism that influences dopamine availability in the prefrontal cortex (PFC). The PFC is the key brain structure for higher cognitive functions such as working memory, as well as an important regulatory site and target of the psychoendocrine stress response. Dopamine is thought to influence PFC functions in an inverted u-shaped manner. Thus, a stress-related increase in prefrontal dopamine is hypothesized to exert differential effects on working memory performance depending on the genetically determined baseline dopamine level in the PFC. Thirty-three healthy young subjects homozygous for the COMT Val158Met polymorphism were selected from a larger pre-genotyped sample. They performed an n-back working memory task after exposure to a laboratory psychosocial stress induction paradigm (The Trier Social Stress Test for Groups; TSST-G). Under stress, working memory performance of Met homozygotes was significantly worse than working memory performance of Val homozygotes. Importantly, this genotype effect was restricted to the medium difficulty level of the n-back task. Our results demonstrate that working memory performance under stress is influenced by genetic variation in prefrontal dopamine levels. More generally, our results point to the importance of considering the complex interaction of genes, environment, and task variables.
One of the most widely studied genetic polymorphisms regarding cognitive and emotional phenotypes is the COMT Val158Met polymorphism that influences dopamine availability in the prefrontal cortex (PFC). The PFC is the key brain structure for higher cognitive functions such as working memory, as well as an important regulatory site and target of the psychoendocrine stress response. Dopamine is thought to influence PFC functions in an inverted u-shaped manner. Thus, a stress-related increase in prefrontal dopamine is hypothesized to exert differential effects on working memory performance depending on the genetically determined baseline dopamine level in the PFC.BACKGROUNDOne of the most widely studied genetic polymorphisms regarding cognitive and emotional phenotypes is the COMT Val158Met polymorphism that influences dopamine availability in the prefrontal cortex (PFC). The PFC is the key brain structure for higher cognitive functions such as working memory, as well as an important regulatory site and target of the psychoendocrine stress response. Dopamine is thought to influence PFC functions in an inverted u-shaped manner. Thus, a stress-related increase in prefrontal dopamine is hypothesized to exert differential effects on working memory performance depending on the genetically determined baseline dopamine level in the PFC.Thirty-three healthy young subjects homozygous for the COMT Val158Met polymorphism were selected from a larger pre-genotyped sample. They performed an n-back working memory task after exposure to a laboratory psychosocial stress induction paradigm (The Trier Social Stress Test for Groups; TSST-G).METHODThirty-three healthy young subjects homozygous for the COMT Val158Met polymorphism were selected from a larger pre-genotyped sample. They performed an n-back working memory task after exposure to a laboratory psychosocial stress induction paradigm (The Trier Social Stress Test for Groups; TSST-G).Under stress, working memory performance of Met homozygotes was significantly worse than working memory performance of Val homozygotes. Importantly, this genotype effect was restricted to the medium difficulty level of the n-back task.RESULTSUnder stress, working memory performance of Met homozygotes was significantly worse than working memory performance of Val homozygotes. Importantly, this genotype effect was restricted to the medium difficulty level of the n-back task.Our results demonstrate that working memory performance under stress is influenced by genetic variation in prefrontal dopamine levels. More generally, our results point to the importance of considering the complex interaction of genes, environment, and task variables.CONCLUSIONOur results demonstrate that working memory performance under stress is influenced by genetic variation in prefrontal dopamine levels. More generally, our results point to the importance of considering the complex interaction of genes, environment, and task variables.
Summary Background One of the most widely studied genetic polymorphisms regarding cognitive and emotional phenotypes is the COMT Val158Met polymorphism that influences dopamine availability in the prefrontal cortex (PFC). The PFC is the key brain structure for higher cognitive functions such as working memory, as well as an important regulatory site and target of the psychoendocrine stress response. Dopamine is thought to influence PFC functions in an inverted u-shaped manner. Thus, a stress-related increase in prefrontal dopamine is hypothesized to exert differential effects on working memory performance depending on the genetically determined baseline dopamine level in the PFC. Method Thirty-three healthy young subjects homozygous for the COMT Val158Met polymorphism were selected from a larger pre-genotyped sample. They performed an n-back working memory task after exposure to a laboratory psychosocial stress induction paradigm (The Trier Social Stress Test for Groups; TSST-G). Results Under stress, working memory performance of Met homozygotes was significantly worse than working memory performance of Val homozygotes. Importantly, this genotype effect was restricted to the medium difficulty level of the n-back task. Conclusion Our results demonstrate that working memory performance under stress is influenced by genetic variation in prefrontal dopamine levels. More generally, our results point to the importance of considering the complex interaction of genes, environment, and task variables.
Author Reuter, Martin
Buckert, Magdalena
Kudielka, Brigitte M.
Fiebach, Christian J.
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  givenname: Christian J.
  surname: Fiebach
  fullname: Fiebach, Christian J.
  organization: Department of Psychology, Goethe University Frankfurt am Main, 60325 Frankfurt am Main, Germany
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Issue 11
Keywords Acute stress
Cortisol
Dopamine
Working memory
COMT Val158Met polymorphism
Corticosteroid
Enzyme
Steroid hormone
Transferases
Acute
Antiinflammatory agent
Catechol O-methyltransferase
Catecholamine
Hydrocortisone
Glucocorticoid
Stress
Methyltransferases
Adrenal hormone
Neurotransmitter
Performance
Polymorphism
Language English
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Snippet One of the most widely studied genetic polymorphisms regarding cognitive and emotional phenotypes is the COMT Val158Met polymorphism that influences dopamine...
Summary Background One of the most widely studied genetic polymorphisms regarding cognitive and emotional phenotypes is the COMT Val158Met polymorphism that...
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SubjectTerms Acute stress
Adult
Behavioral psychophysiology
Biological and medical sciences
Catechol O-Methyltransferase - genetics
Catechol O-Methyltransferase - physiology
COMT Val158Met polymorphism
Cortisol
Dopamine
Endocrinology & Metabolism
Female
Fundamental and applied biological sciences. Psychology
Homozygote
Hormones and behavior
Humans
Male
Memory, Short-Term - physiology
Methionine - genetics
Neuropsychological Tests
Polymorphism, Genetic
Prefrontal Cortex - enzymology
Prefrontal Cortex - physiology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Stress, Psychological - enzymology
Stress, Psychological - genetics
Stress, Psychological - physiopathology
Valine - genetics
Working memory
Young Adult
Title The COMT Val158Met polymorphism modulates working memory performance under acute stress
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https://www.ncbi.nlm.nih.gov/pubmed/22503421
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